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PMID:15767674

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Citation

Gómez-del Arco, P, Koipally, J and Georgopoulos, K (2005) Ikaros SUMOylation: switching out of repression. Mol. Cell. Biol. 25:2688-97

Abstract

Ikaros plays a key role in lymphocyte development and homeostasis by both potentiating and repressing gene expression. Here we show that Ikaros interacts with components of the SUMO pathway and is SUMOylated in vivo. Two SUMOylation sites are identified on Ikaros whose simultaneous modification results in a loss of Ikaros' repression function. Ikaros SUMOylation disrupts its participation in both histone deacetylase (HDAC)-dependent and HDAC-independent repression but does not influence its nuclear localization into pericentromeric heterochromatin. These studies reveal a new dynamic way by which Ikaros-mediated gene repression is controlled by SUMOylation.

Links

PubMed PMC1061640 Online version:10.1128/MCB.25.7.2688-2697.2005

Keywords

Active Transport, Cell Nucleus; Animals; Binding Sites; Carbon-Nitrogen Lyases/metabolism; Cells, Cultured; Centromere/metabolism; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Heterochromatin/metabolism; Humans; Ikaros Transcription Factor; Lymphocytes/metabolism; Mice; Mutation/genetics; Repressor Proteins/genetics; Repressor Proteins/metabolism; SUMO-1 Protein/genetics; SUMO-1 Protein/metabolism; Transcription Factors/genetics; Transcription Factors/metabolism; Transcription, Genetic/genetics; Ubiquitin-Protein Ligases/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:IKZF3

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:P63166
PR:P63280
PR:Q9Z1F9

F

Seeded From UniProt

complete

MOUSE:PIAS3

acts_upstream_of_or_within

GO:0016925: protein sumoylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:PIAS3

enables

GO:0019789: SUMO transferase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:SENP1

acts_upstream_of_or_within

GO:0016926: protein desumoylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SUMO2

acts_upstream_of_or_within

GO:0016925: protein sumoylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SUMO2

enables

GO:0019789: SUMO transferase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:SUMO1

acts_upstream_of_or_within

GO:0016925: protein sumoylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SUMO1

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:SUMO1

acts_upstream_of_or_within

GO:0006355: regulation of transcription, DNA-templated

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SUMO1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q03267

F

Seeded From UniProt

complete

MOUSE:UBC9

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:O08900

F

Seeded From UniProt

complete

MOUSE:IKZF1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:O88712
PR:P63166
PR:P63280
PR:Q3TKT4
PR:Q60520
PR:Q62141
PR:Q6PDQ2
PR:Q9Z1F9

F

Seeded From UniProt

complete

MOUSE:IKZF1

located_in

GO:0005721: pericentric heterochromatin

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:IKZF1

acts_upstream_of_or_within

GO:0045892: negative regulation of transcription, DNA-templated

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:IKZF1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P63166

F

Seeded From UniProt

complete

MOUSE:PIAS2

acts_upstream_of_or_within

GO:0016925: protein sumoylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:PIAS2

enables

GO:0019789: SUMO transferase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:SENP2

acts_upstream_of_or_within

GO:0016926: protein desumoylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SUMO3

acts_upstream_of_or_within

GO:0016925: protein sumoylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SUMO3

enables

GO:0019789: SUMO transferase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:SAE2

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:O08900

F

Seeded From UniProt

complete

MOUSE:SMCA4

enables

GO:0008134: transcription factor binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q03267

F

Seeded From UniProt

complete

See also

References

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