HUMAN:KDM1A

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	KDM1A (synonyms: AOF2, KDM1, KIAA0601, LSD1)
Protein Name(s)	Lysine-specific histone demethylase 1A BRAF35-HDAC complex protein BHC110 Flavin-containing amine oxidase domain-containing protein 2
External Links
UniProt	O60341
EMBL	AB011173 AL031428 AL031428 BC016639 BC025362 BC040194 BC048134 AL833812
CCDS	CCDS30627.1 CCDS53278.1
RefSeq	NP_001009999.1 NP_055828.2
UniGene	Hs.591518
PDB	2COM 2DW4 2EJR 2H94 2HKO 2IW5 2L3D 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48 2Z3Y 2Z5U 3ABT 3ABU 3ZMS 3ZMT 3ZMU 3ZMV 3ZMZ 3ZN0 3ZN1 4BAY 4CZZ 4KUM 4UV8 4UV9 4UVA 4UVB 4UVC
PDBsum	2COM 2DW4 2EJR 2H94 2HKO 2IW5 2L3D 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48 2Z3Y 2Z5U 3ABT 3ABU 3ZMS 3ZMT 3ZMU 3ZMV 3ZMZ 3ZN0 3ZN1 4BAY 4CZZ 4KUM 4UV8 4UV9 4UVA 4UVB 4UVC
ProteinModelPortal	O60341
SMR	O60341
BioGrid	116667
DIP	DIP-34641N
IntAct	O60341
MINT	MINT-1372817
BindingDB	O60341
ChEMBL	CHEMBL3137262
GuidetoPHARMACOLOGY	2669
PhosphoSite	O60341
MaxQB	O60341
PaxDb	O60341
PRIDE	O60341
Ensembl	ENST00000356634 ENST00000400181
GeneID	23028
KEGG	hsa:23028
UCSC	uc001bgi.2 uc001bgj.2
CTD	23028
GeneCards	GC01P023347
HGNC	HGNC:29079
HPA	CAB005884 HPA053660
MIM	609132
neXtProt	NX_O60341
PharmGKB	PA165751392
eggNOG	COG1231
GeneTree	ENSGT00530000062888
InParanoid	O60341
KO	K11450
OMA	HRIHSYL
OrthoDB	EOG7X9G66
PhylomeDB	O60341
TreeFam	TF312972
Reactome	REACT_228178 REACT_228222 REACT_24970
ChiTaRS	KDM1A
EvolutionaryTrace	O60341
GenomeRNAi	23028
NextBio	43998
PRO	PR:O60341
Proteomes	UP000005640
Bgee	O60341
CleanEx	HS_AOF2
ExpressionAtlas	O60341
Genevestigator	O60341
GO	GO:0000790 GO:0005654 GO:0005634 GO:0005667 GO:0050681 GO:0003682 GO:0032451 GO:0019899 GO:0050660 GO:0032452 GO:0034648 GO:0032453 GO:0032454 GO:0030374 GO:0043426 GO:0016491 GO:0002039 GO:0003700 GO:0008134 GO:0044212 GO:0007596 GO:0008283 GO:0030851 GO:0034720 GO:0033169 GO:0001701 GO:0055001 GO:0043392 GO:0043518 GO:0051572 GO:0051573 GO:1902166 GO:0032091 GO:0043433 GO:0000122 GO:0045892 GO:0021983 GO:0045648 GO:0046886 GO:0045654 GO:2000179 GO:0051091 GO:2000648 GO:0045944 GO:0006482 GO:0010725 GO:0006357 GO:0006351
Gene3D	1.10.10.10
InterPro	IPR002937 IPR017366 IPR009057 IPR007526 IPR011991
Pfam	PF01593 PF04433
PIRSF	PIRSF038051
SUPFAM	SSF46689
PROSITE	PS50934

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0002052	positive regulation of neuroblast proliferation	PMID:23400681^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:27566776^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZQ88	P		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZQ88	F		Seeded From UniProt	complete
involved_in	GO:2000648	positive regulation of stem cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZQ88	P		Seeded From UniProt	complete
involved_in	GO:2000179	positive regulation of neural precursor cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZQ88	P		Seeded From UniProt	complete
involved_in	GO:0051573	negative regulation of histone H3-K9 methylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZQ88	P		Seeded From UniProt	complete
involved_in	GO:0051572	negative regulation of histone H3-K4 methylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZQ88	P		Seeded From UniProt	complete
enables	GO:0061752	telomeric repeat-containing RNA binding	PMID:24529708^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(CHEBI:136721)	Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:24529708^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042162	telomeric DNA binding	PMID:24529708^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:17805299^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055001	muscle cell development	PMID:20833138^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZQ88	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:20833138^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20833138^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:19497860^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZQ88	F		Seeded From UniProt	complete
involved_in	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	PMID:17805299^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:17805299^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:19497860^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043426	MRF binding	PMID:20833138^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043392	negative regulation of DNA binding	PMID:17805299^[4]	ECO:0000305	curator inference used in manual assertion	GO:0043433	P		Seeded From UniProt	complete
enables	GO:0032452	histone demethylase activity	PMID:19497860^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0032451	demethylase activity	PMID:17805299^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032091	negative regulation of protein binding	PMID:17805299^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:17277772^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9H3R0	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:20833138^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
	GO:0070076	histone lysine demethylation	PMID:18440794^[8]	ECO:0000315			P		Table 1 shows the demethylation developmental expression patterns	complete CACAO 5024
involved_in	GO:0006482	protein demethylation	PMID:17805299^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0003713	transcription coactivator activity	PMID:23386436^[9]	ECO:0000314			F		Figure. 2 Shows that MAOIs such as tranylcypromine (TCP) were originally designed to target the MAO-A/B. While these compounds also inhibit LSD1. compound OG-L002, which is highly specific to LSD1 (IC50, ~0.02 µM), potently inhibited the expression of viral IE (ICP27 and ICP4) (genesmRNAs were quantitated by quantitative reverse transcription-PCR (qRT-PCR)). LSD1 shows to be an important co-activator for HCF-1 complex. The inhibition of LSD1 results in the inactivity of this enzyme.	complete CACAO 7772
part_of	GO:0005634	nucleus	PMID:19497860^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
	GO:0036208	negative regulation of histone gene expression	PMID:23386436^[9]	ECO:0000270			P		Figure. 2 Shows that MAOIs such as tranylcypromine (TCP) were originally designed to target the MAO-A/B. While these compounds also inhibit LSD1. compound OG-L002, which is highly specific to LSD1 (IC50, ~0.02 µM), potently inhibited the expression of viral IE (ICP27 and ICP4) (genesmRNAs were quantitated by quantitative reverse transcription-PCR (qRT-PCR)). The inhibition of LSD1 results in the inactivity of this enzyme, resulting in the repression of HSV-1 IE gene expression. Therefore suggesting that its original activity was to down regulate the IE gene expression	complete CACAO 7773
enables	GO:0002039	p53 binding	PMID:17805299^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:17277772^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:20833138^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZQ88	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17805299^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZQ88	P		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	PMID:16079795^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	PMID:15620353^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0034720	histone H3-K4 demethylation	PMID:20228790^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034720	histone H3-K4 demethylation	PMID:15620353^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)	PMID:20228790^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0033169	histone H3-K9 demethylation	PMID:20228790^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033169	histone H3-K9 demethylation	PMID:16079795^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0032454	histone demethylase activity (H3-K9 specific)	PMID:20228790^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0032454	histone demethylase activity (H3-K9 specific)	PMID:16079795^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0032453	histone demethylase activity (H3-K4 specific)	PMID:15620353^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	PMID:16079795^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	PMID:15620353^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:16079795^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O09106	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16079795^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:20228790^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16079795^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002473317 UniProtKB:O60341	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1196256 PANTHER:PTN002473317 RGD:1562975 UniProtKB:O60341	P		Seeded From UniProt	complete
enables	GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1196256 PANTHER:PTN002473317 UniProtKB:O60341	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000743742 UniProtKB:O60341	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1196256 PANTHER:PTN002473317 RGD:1562975 UniProtKB:O60341	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260397 MGI:MGI:1196256 PANTHER:PTN002473317 RGD:1562975 UniProtKB:O60341	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002473317 RGD:1562975 UniProtKB:O60341	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1196256 PANTHER:PTN002473317 RGD:1562975 UniProtKB:O60341	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1196256 PANTHER:PTN002473317 UniProtKB:O60341	P		Seeded From UniProt	complete
enables	GO:0032452	histone demethylase activity	PMID:18066052^[14]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0032452	histone demethylase activity	PMID:16079795^[10]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:1990391	DNA repair complex	PMID:24217620^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1903827	regulation of cellular protein localization	PMID:24217620^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071480	cellular response to gamma radiation	PMID:24217620^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034720	histone H3-K4 demethylation	PMID:24217620^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	PMID:24217620^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033184	positive regulation of histone ubiquitination	PMID:24217620^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:24217620^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010569	regulation of double-strand break repair via homologous recombination	PMID:24217620^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:24217620^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071320	cellular response to cAMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MA31 ensembl:ENSRNOP00000052846	P		Seeded From UniProt	complete
involved_in	GO:0060992	response to fungicide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MA31 ensembl:ENSRNOP00000052846	P		Seeded From UniProt	complete
involved_in	GO:0046098	guanine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MA31 ensembl:ENSRNOP00000052846	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MA31 ensembl:ENSRNOP00000052846	P		Seeded From UniProt	complete
involved_in	GO:0045793	positive regulation of cell size	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MA31 ensembl:ENSRNOP00000052846	P		Seeded From UniProt	complete
involved_in	GO:0042551	neuron maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MA31 ensembl:ENSRNOP00000052846	P		Seeded From UniProt	complete
involved_in	GO:0035563	positive regulation of chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MA31 ensembl:ENSRNOP00000052846	P		Seeded From UniProt	complete
involved_in	GO:0034720	histone H3-K4 demethylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MA31 ensembl:ENSRNOP00000052846	P		Seeded From UniProt	complete
involved_in	GO:0021987	cerebral cortex development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MA31 ensembl:ENSRNOP00000052846	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MA31 ensembl:ENSRNOP00000052846	P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MA31 ensembl:ENSRNOP00000052846	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MA31 ensembl:ENSRNOP00000052846	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MA31 ensembl:ENSRNOP00000052846	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MA31 ensembl:ENSRNOP00000052846	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MA31 ensembl:ENSRNOP00000052846	C		Seeded From UniProt	complete
involved_in	GO:0000380	alternative mRNA splicing, via spliceosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MA31 ensembl:ENSRNOP00000052846	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009057	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017366	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017366	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002937	F		Seeded From UniProt	complete
involved_in	GO:0034720	histone H3-K4 demethylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017366	P		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017366	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002937	P		Seeded From UniProt	complete
enables	GO:0032454	histone demethylase activity (H3-K9 specific)	Reactome:R-HSA-9011985	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	Reactome:R-HSA-109582	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-996727 Reactome:R-HSA-9011985 Reactome:R-HSA-9011984 Reactome:R-HSA-5661123 Reactome:R-HSA-5625870 Reactome:R-HSA-5625849 Reactome:R-HSA-5625848 Reactome:R-HSA-3769447 Reactome:R-HSA-3214912	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Althoff, K et al. (2013) MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A. Int. J. Cancer 133 1064-73 PubMed GONUTS page
↑ Zeng, X et al. (2016) Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation. Genes Dev. 30 1822-36 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Porro, A et al. (2014) TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres. Cell Rep 6 765-76 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Huang, J et al. (2007) p53 is regulated by the lysine demethylase LSD1. Nature 449 105-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Choi, J et al. (2010) Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors. Biochem. Biophys. Res. Commun. 401 327-32 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Hu, X et al. (2009) LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc. Natl. Acad. Sci. U.S.A. 106 10141-6 PubMed GONUTS page
↑ ^7.0 ^7.1 Wissmann, M et al. (2007) Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat. Cell Biol. 9 347-53 PubMed GONUTS page
↑ Lan, F et al. (2008) Mechanisms involved in the regulation of histone lysine demethylases. Curr. Opin. Cell Biol. 20 316-25 PubMed GONUTS page
↑ ^9.0 ^9.1 Liang, Y et al. (2013) A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. MBio 4 e00558-12 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 Metzger, E et al. (2005) LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 437 436-9 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Shi, Y et al. (2004) Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119 941-53 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Metzger, E et al. (2010) Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. Nature 464 792-6 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 ^13.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Metzger, E et al. (2008) Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation. Nat. Cell Biol. 10 53-60 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 ^15.8 Mosammaparast, N et al. (2013) The histone demethylase LSD1/KDM1A promotes the DNA damage response. J. Cell Biol. 203 457-70 PubMed GONUTS page

[PMID:23400681-1] Althoff, K et al. (2013) MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A. Int. J. Cancer 133 1064-73 PubMed GONUTS page

[PMID:27566776-2] Zeng, X et al. (2016) Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation. Genes Dev. 30 1822-36 PubMed GONUTS page

[PMID:24529708-3] 3.0 ^3.1 ^3.2 Porro, A et al. (2014) TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres. Cell Rep 6 765-76 PubMed GONUTS page

[PMID:17805299-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Huang, J et al. (2007) p53 is regulated by the lysine demethylase LSD1. Nature 449 105-8 PubMed GONUTS page

[PMID:20833138-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Choi, J et al. (2010) Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors. Biochem. Biophys. Res. Commun. 401 327-32 PubMed GONUTS page

[PMID:19497860-6] 6.0 ^6.1 ^6.2 ^6.3 Hu, X et al. (2009) LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc. Natl. Acad. Sci. U.S.A. 106 10141-6 PubMed GONUTS page

[PMID:17277772-7] 7.0 ^7.1 Wissmann, M et al. (2007) Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat. Cell Biol. 9 347-53 PubMed GONUTS page

[PMID:18440794-8] Lan, F et al. (2008) Mechanisms involved in the regulation of histone lysine demethylases. Curr. Opin. Cell Biol. 20 316-25 PubMed GONUTS page

[PMID:23386436-9] 9.0 ^9.1 Liang, Y et al. (2013) A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. MBio 4 e00558-12 PubMed GONUTS page

[PMID:16079795-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 Metzger, E et al. (2005) LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 437 436-9 PubMed GONUTS page

[PMID:15620353-11] 11.0 ^11.1 ^11.2 ^11.3 Shi, Y et al. (2004) Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119 941-53 PubMed GONUTS page

[PMID:20228790-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Metzger, E et al. (2010) Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. Nature 464 792-6 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 ^13.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18066052-14] Metzger, E et al. (2008) Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation. Nat. Cell Biol. 10 53-60 PubMed GONUTS page

[PMID:24217620-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 ^15.8 Mosammaparast, N et al. (2013) The histone demethylase LSD1/KDM1A promotes the DNA damage response. J. Cell Biol. 203 457-70 PubMed GONUTS page

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