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PMID:18440794

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Citation

Lan, F, Nottke, AC and Shi, Y (2008) Mechanisms involved in the regulation of histone lysine demethylases. Curr. Opin. Cell Biol. 20:316-25

Abstract

Since the first histone lysine demethylase KDM1 (LSD1) was discovered in 2004, a great number of histone demethylases have been recognized and shown to play important roles in gene expression, as well as cellular differentiation and animal development. The chemical mechanisms and substrate specificities have already been extensively discussed elsewhere. This review focuses primarily on regulatory mechanisms that modulate demethylase recruitment and activity.

Links

PubMed PMC2674377 Online version:10.1016/j.ceb.2008.03.004

Keywords

Animals; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Epigenesis, Genetic/genetics; Gene Expression Regulation/genetics; Histone Demethylases; Histones/genetics; Histones/metabolism; Humans; Methylation; Oxidoreductases, N-Demethylating/metabolism; Protein Processing, Post-Translational/genetics; Transcription Factors/genetics; Transcription Factors/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:KDM1A

GO:0070076: histone lysine demethylation

ECO:0000315:

P

Table 1 shows the demethylation developmental expression patterns

complete
CACAO 5024


See also

References

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