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MOUSE:PARK7
Contents
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0051583 |
dopamine uptake |
ECO:0000315 |
P |
Figure 4: the loss of DJ-1 function in mice can lead to motor deficits as well as alterations in nigrostriatal dopaminergic function |
complete | |||||
involved_in |
GO:0002866 |
positive regulation of acute inflammatory response to antigenic stimulus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0033864 |
positive regulation of NAD(P)H oxidase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0106046 |
guanine deglycation, glyoxal removal |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0106045 |
guanine deglycation, methylglyoxal removal |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0106044 |
guanine deglycation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1903189 |
glyoxal metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1903427 |
negative regulation of reactive oxygen species biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030073 |
insulin secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042593 |
glucose homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
NOT|involved_in |
GO:0036530 |
protein deglycation, methylglyoxal removal |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
NOT|involved_in |
GO:0009438 |
methylglyoxal metabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
NOT|involved_in |
GO:0006517 |
protein deglycosylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006517 |
protein deglycosylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0045340 |
mercury ion binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005507 |
copper ion binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050787 |
detoxification of mercury ion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010273 |
detoxification of copper ion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010273 |
detoxification of copper ion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050787 |
detoxification of mercury ion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1902236 |
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1903384 |
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050821 |
protein stabilization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050821 |
protein stabilization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P10639) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051444 |
negative regulation of ubiquitin-protein transferase activity |
ECO:0000305 |
curator inference used in manual assertion |
GO:0031397 |
P |
has_regulation_target:(UniProtKB:P40338) |
Seeded From UniProt |
complete | |
involved_in |
GO:0042177 |
negative regulation of protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:1903204 |
negative regulation of oxidative stress-induced neuron death |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1902958 |
positive regulation of mitochondrial electron transport, NADH to ubiquinone |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
part_of:(GO:0036471) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046295 |
glycolate biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031397 |
negative regulation of protein ubiquitination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q61221) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0036471 |
cellular response to glyoxal |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:1903208 |
negative regulation of hydrogen peroxide-induced neuron death |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0002609) |
Seeded From UniProt |
complete | ||
part_of |
GO:0044297 |
cell body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0002609) |
Seeded From UniProt |
complete | ||
part_of |
GO:0043005 |
neuron projection |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0002609) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005758 |
mitochondrial intermembrane space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0000955) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0000955) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0018323 |
enzyme active site formation via L-cysteine sulfinic acid |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P13597) |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000277 |
positive regulation of oxidative phosphorylation uncoupler activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070301 |
cellular response to hydrogen peroxide |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060548 |
negative regulation of cell death |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050821 |
protein stabilization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050727 |
regulation of inflammatory response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043523 |
regulation of neuron apoptotic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034599 |
cellular response to oxidative stress |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032091 |
negative regulation of protein binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008233 |
peptidase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007005 |
mitochondrion organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003729 |
mRNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0106046 |
guanine deglycation, glyoxal removal |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000111103 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0036529 |
protein deglycation, glyoxal removal |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000111103 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0036524 |
protein deglycase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG13272 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG13272 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2135637 |
C |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:2001268 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:2001237 |
negative regulation of extrinsic apoptotic signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:2000825 |
positive regulation of androgen receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:2000679 |
positive regulation of transcription regulatory region DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:2000157 |
negative regulation of ubiquitin-specific protease activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:1990381 |
ubiquitin-specific protease binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1905516 |
positive regulation of fertilization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621808 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:1905259 |
negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1904782 |
negative regulation of NMDA glutamate receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621808 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:1903428 |
positive regulation of reactive oxygen species biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1903384 |
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1903377 |
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1903208 |
negative regulation of hydrogen peroxide-induced neuron death |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1903206 |
negative regulation of hydrogen peroxide-induced cell death |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1903202 |
negative regulation of oxidative stress-induced cell death |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1903200 |
positive regulation of L-dopa decarboxylase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1903197 |
positive regulation of L-dopa biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1903189 |
glyoxal metabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1903181 |
positive regulation of dopamine biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1903178 |
positive regulation of tyrosine 3-monooxygenase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1903168 |
positive regulation of pyrroline-5-carboxylate reductase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:1903136 |
cuprous ion binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:1903135 |
cupric ion binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1903122 |
negative regulation of TRAIL-activated apoptotic signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1903094 |
negative regulation of protein K48-linked deubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1902958 |
positive regulation of mitochondrial electron transport, NADH to ubiquinone |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1902236 |
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1902177 |
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1901984 |
negative regulation of protein acetylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1901671 |
positive regulation of superoxide dismutase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1901215 |
negative regulation of neuron death |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1901215 |
negative regulation of neuron death |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621808 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:1900182 |
positive regulation of protein localization to nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0106046 |
guanine deglycation, glyoxal removal |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0106045 |
guanine deglycation, methylglyoxal removal |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0106044 |
guanine deglycation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0097110 |
scaffold protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0090073 |
positive regulation of protein homodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0070491 |
repressing transcription factor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0070301 |
cellular response to hydrogen peroxide |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0061827 |
sperm head |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621808 |
C |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0060765 |
regulation of androgen receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0060548 |
negative regulation of cell death |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0060081 |
membrane hyperpolarization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3579140 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0051920 |
peroxiredoxin activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3514165 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0051899 |
membrane depolarization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3579140 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0051881 |
regulation of mitochondrial membrane potential |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051583 |
dopamine uptake involved in synaptic transmission |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3579140 |
P |
occurs_in:(EMAPA:17549) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0051444 |
negative regulation of ubiquitin-protein transferase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0050821 |
protein stabilization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0050787 |
detoxification of mercury ion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0050681 |
androgen receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0046826 |
negative regulation of protein export from nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0046295 |
glycolate biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0045340 |
mercury ion binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0045121 |
membrane raft |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621808 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0044390 |
ubiquitin-like protein conjugating enzyme binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0044388 |
small protein activating enzyme binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043523 |
regulation of neuron apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0042743 |
hydrogen peroxide metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3514165 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0042743 |
hydrogen peroxide metabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0042542 |
response to hydrogen peroxide |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3576227 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0042542 |
response to hydrogen peroxide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0036531 |
glutathione deglycation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0036529 |
protein deglycation, glyoxal removal |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0036528 |
peptidyl-lysine deglycation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0036527 |
peptidyl-arginine deglycation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0036526 |
peptidyl-cysteine deglycation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0036524 |
protein deglycase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0036478 |
L-dopa decarboxylase activator activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0036471 |
cellular response to glyoxal |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0036470 |
tyrosine 3-monooxygenase activator activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0034614 |
cellular response to reactive oxygen species |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3579140 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0034599 |
cellular response to oxidative stress |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0033234 |
negative regulation of protein sumoylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0032757 |
positive regulation of interleukin-8 production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0032435 |
negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0032091 |
negative regulation of protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0031397 |
negative regulation of protein ubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0030424 |
axon |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621808 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0019955 |
cytokine binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019900 |
kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019899 |
enzyme binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0019249 |
lactate biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016684 |
oxidoreductase activity, acting on peroxide as acceptor |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016605 |
PML body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0016532 |
superoxide dismutase copper chaperone activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0010629 |
negative regulation of gene expression |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0010273 |
detoxification of copper ion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0008344 |
adult locomotory behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3586448 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008344 |
adult locomotory behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3579140 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008233 |
peptidase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008134 |
transcription factor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006979 |
response to oxidative stress |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621808 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0006469 |
negative regulation of protein kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006281 |
DNA repair |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621808 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
colocalizes_with |
GO:0005747 |
mitochondrial respiratory chain complex I |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621808 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005507 |
copper ion binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003729 |
mRNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003713 |
transcription coactivator activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0001963 |
synaptic transmission, dopaminergic |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3586448 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0001933 |
negative regulation of protein phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0000785 |
chromatin |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0098793 |
presynapse |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0051583 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0098869 |
cellular oxidant detoxification |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0051920 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005747 |
mitochondrial respiratory chain complex I |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005507 |
copper ion binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003729 |
mRNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003713 |
transcription coactivator activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001933 |
negative regulation of protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0000785 |
chromatin |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:2001268 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:2001237 |
negative regulation of extrinsic apoptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000825 |
positive regulation of androgen receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000679 |
positive regulation of transcription regulatory region DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000157 |
negative regulation of ubiquitin-specific protease activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:1990381 |
ubiquitin-specific protease binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:1905259 |
negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903384 |
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903377 |
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903208 |
negative regulation of hydrogen peroxide-induced neuron death |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903206 |
negative regulation of hydrogen peroxide-induced cell death |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903202 |
negative regulation of oxidative stress-induced cell death |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903200 |
positive regulation of L-dopa decarboxylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903197 |
positive regulation of L-dopa biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903189 |
glyoxal metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903181 |
positive regulation of dopamine biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903178 |
positive regulation of tyrosine 3-monooxygenase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903168 |
positive regulation of pyrroline-5-carboxylate reductase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:1903136 |
cuprous ion binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:1903135 |
cupric ion binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903122 |
negative regulation of TRAIL-activated apoptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903094 |
negative regulation of protein K48-linked deubiquitination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1902958 |
positive regulation of mitochondrial electron transport, NADH to ubiquinone |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1902236 |
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1901984 |
negative regulation of protein acetylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1901671 |
positive regulation of superoxide dismutase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1901215 |
negative regulation of neuron death |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1900182 |
positive regulation of protein localization to nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0106046 |
guanine deglycation, glyoxal removal |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0106044 |
guanine deglycation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0097110 |
scaffold protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090073 |
positive regulation of protein homodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0070491 |
repressing transcription factor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070301 |
cellular response to hydrogen peroxide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060765 |
regulation of androgen receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060548 |
negative regulation of cell death |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051881 |
regulation of mitochondrial membrane potential |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051444 |
negative regulation of ubiquitin-protein transferase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050821 |
protein stabilization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050787 |
detoxification of mercury ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0050681 |
androgen receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046826 |
negative regulation of protein export from nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046295 |
glycolate biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0045340 |
mercury ion binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0044390 |
ubiquitin-like protein conjugating enzyme binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0044388 |
small protein activating enzyme binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043523 |
regulation of neuron apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0042802 |
identical protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042743 |
hydrogen peroxide metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0036531 |
glutathione deglycation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0036529 |
protein deglycation, glyoxal removal |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0036528 |
peptidyl-lysine deglycation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0036527 |
peptidyl-arginine deglycation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0036526 |
peptidyl-cysteine deglycation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0036524 |
protein deglycase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0036478 |
L-dopa decarboxylase activator activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0036471 |
cellular response to glyoxal |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0036470 |
tyrosine 3-monooxygenase activator activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034599 |
cellular response to oxidative stress |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033234 |
negative regulation of protein sumoylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032757 |
positive regulation of interleukin-8 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032435 |
negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032091 |
negative regulation of protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031397 |
negative regulation of protein ubiquitination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0019955 |
cytokine binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0019900 |
kinase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0019899 |
enzyme binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019249 |
lactate biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0016684 |
oxidoreductase activity, acting on peroxide as acceptor |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0016605 |
PML body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0016532 |
superoxide dismutase copper chaperone activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010629 |
negative regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010273 |
detoxification of copper ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008233 |
peptidase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008134 |
transcription factor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006469 |
negative regulation of protein kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99497 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:V9HWC2 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:V9HWC2 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003723 |
RNA binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006914 |
autophagy |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007338 |
single fertilization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0045121 |
membrane raft |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Chen, L et al. (2005) Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. J. Biol. Chem. 280 21418-26 PubMed GONUTS page
- ↑ 2.0 2.1 Liu, W et al. (2015) Park7 interacts with p47(phox) to direct NADPH oxidase-dependent ROS production and protect against sepsis. Cell Res. 25 691-706 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Lee, JY et al. (2012) Human DJ-1 and its homologs are novel glyoxalases. Hum. Mol. Genet. 21 3215-25 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Jain, D et al. (2012) Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes. J Mol Cell Biol 4 221-30 PubMed GONUTS page
- ↑ 5.0 5.1 Björkblom, B et al. (2013) Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity. J. Biol. Chem. 288 22809-20 PubMed GONUTS page
- ↑ 6.0 6.1 Yokota, T et al. (2003) Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition. Biochem. Biophys. Res. Commun. 312 1342-8 PubMed GONUTS page
- ↑ Xiong, H et al. (2009) Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J. Clin. Invest. 119 650-60 PubMed GONUTS page
- ↑ 8.0 8.1 Clements, CM et al. (2006) DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc. Natl. Acad. Sci. U.S.A. 103 15091-6 PubMed GONUTS page
- ↑ Im, JY et al. (2012) DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway. Hum. Mol. Genet. 21 3013-24 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Parsanejad, M et al. (2014) Regulation of the VHL/HIF-1 pathway by DJ-1. J. Neurosci. 34 8043-50 PubMed GONUTS page
- ↑ Hayashi, T et al. (2009) DJ-1 binds to mitochondrial complex I and maintains its activity. Biochem. Biophys. Res. Commun. 390 667-72 PubMed GONUTS page
- ↑ 12.0 12.1 Choi, DH et al. (2011) DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell death. Antioxid. Redox Signal. 14 2137-50 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 Ma, J et al. (2014) DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis. Biochem. J. 462 489-97 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 Zhang, L et al. (2005) Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis. Hum. Mol. Genet. 14 2063-73 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 15.3 Andres-Mateos, E et al. (2007) DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc. Natl. Acad. Sci. U.S.A. 104 14807-12 PubMed GONUTS page
- ↑ McNally, RS et al. (2011) DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. J. Biol. Chem. 286 4098-106 PubMed GONUTS page
- ↑ 17.0 17.1 Guzman, JN et al. (2010) Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature 468 696-700 PubMed GONUTS page
- ↑ 18.0 18.1 18.2 18.3 Kim, RH et al. (2005) Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc. Natl. Acad. Sci. U.S.A. 102 5215-20 PubMed GONUTS page
- ↑ Waak, J et al. (2009) Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1. FASEB J. 23 2478-89 PubMed GONUTS page
- ↑ Krebiehl, G et al. (2010) Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS ONE 5 e9367 PubMed GONUTS page
- ↑ 21.0 21.1 21.2 21.3 21.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 22.0 22.1 22.2 22.3 22.4 22.5 Robert, G et al. (2012) The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production. Cell Death Differ. 19 1769-78 PubMed GONUTS page
- ↑ 23.0 23.1 23.2 Pisani, A et al. (2006) Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase. Neurobiol. Dis. 23 54-60 PubMed GONUTS page
- ↑ 24.0 24.1 Goldberg, MS et al. (2005) Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 45 489-96 PubMed GONUTS page
- ↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
- ↑ Taira, T et al. (2001) Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter. Gene 263 285-92 PubMed GONUTS page
c
- GO:0098869 ! cellular oxidant detoxification
- GO:0036471 ! cellular response to glyoxal
- GO:0034614 ! cellular response to reactive oxygen species
- GO:0070301 ! cellular response to hydrogen peroxide
- GO:0034599 ! cellular response to oxidative stress
- GO:0044297 ! cell body
- Chordata
- GO:0000785 ! chromatin
- GO:0005507 ! copper ion binding
- Craniata
- GO:1903135 ! cupric ion binding
- GO:1903136 ! cuprous ion binding
- GO:0019955 ! cytokine binding
- GO:0005737 ! cytoplasm
- GO:0005829 ! cytosol
d
e
g
i
m
- Mammalia
- GO:0016020 ! membrane
- GO:0051899 ! membrane depolarization
- GO:0060081 ! membrane hyperpolarization
- GO:0045121 ! membrane raft
- GO:0045340 ! mercury ion binding
- Metazoa
- GO:0009438 ! methylglyoxal metabolic process
- GO:0005759 ! mitochondrial matrix
- GO:0005758 ! mitochondrial intermembrane space
- GO:0007005 ! mitochondrion organization
- GO:0005739 ! mitochondrion
- GO:0003729 ! mRNA binding
- Muridae
- Murinae
- Muroidea
- Mus
- Mus musculus
n
- GO:1904782 ! negative regulation of NMDA glutamate receptor activity
- GO:0001933 ! negative regulation of protein phosphorylation
- GO:0043524 ! negative regulation of neuron apoptotic process
- GO:2001237 ! negative regulation of extrinsic apoptotic signaling pathway
- GO:0033234 ! negative regulation of protein sumoylation
- GO:0032091 ! negative regulation of protein binding
- GO:0010629 ! negative regulation of gene expression
- GO:0006469 ! negative regulation of protein kinase activity
- GO:0043066 ! negative regulation of apoptotic process
- GO:2000157 ! negative regulation of ubiquitin-specific protease activity
- GO:0042177 ! negative regulation of protein catabolic process
- GO:0031397 ! negative regulation of protein ubiquitination
- GO:0051444 ! negative regulation of ubiquitin-protein transferase activity
- GO:1903384 ! negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
- GO:1902236 ! negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
- GO:1903427 ! negative regulation of reactive oxygen species biosynthetic process
- GO:0046826 ! negative regulation of protein export from nucleus
- GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process
- GO:1903094 ! negative regulation of protein K48-linked deubiquitination
- GO:1903122 ! negative regulation of TRAIL-activated apoptotic signaling pathway
- GO:1905259 ! negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
- GO:1903377 ! negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
- GO:1901984 ! negative regulation of protein acetylation
- GO:0043005 ! neuron projection
- GO:0050681 ! nuclear androgen receptor binding
- GO:0005634 ! nucleus
o
- GO:0018323 ! obsolete enzyme active site formation via L-cysteine sulfinic acid
- GO:0036531 ! obsolete glutathione deglycation
- GO:0005747 ! obsolete mitochondrial respiratory chain complex I
- GO:1901215 ! obsolete negative regulation of neuron death
- GO:1903206 ! obsolete negative regulation of hydrogen peroxide-induced cell death
- GO:2001268 ! obsolete negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
- GO:1903208 ! obsolete negative regulation of hydrogen peroxide-induced neuron death
- GO:0060548 ! obsolete negative regulation of cell death
- GO:1903204 ! obsolete negative regulation of oxidative stress-induced neuron death
- GO:1903202 ! obsolete negative regulation of oxidative stress-induced cell death
- GO:0090073 ! obsolete positive regulation of protein homodimerization activity
- GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor
p
- GO:0008233 ! peptidase activity
- GO:0036527 ! peptidyl-arginine deglycation
- GO:0036526 ! peptidyl-cysteine deglycation
- GO:0036528 ! peptidyl-lysine deglycation
- GO:0048471 ! perinuclear region of cytoplasm
- GO:0051920 ! peroxiredoxin activity
- GO:0005886 ! plasma membrane
- GO:0016605 ! PML body
- GO:1903168 ! positive regulation of pyrroline-5-carboxylate reductase activity
- GO:0002866 ! positive regulation of acute inflammatory response to antigenic stimulus
- GO:2000277 ! positive regulation of oxidative phosphorylation uncoupler activity
- GO:1902958 ! positive regulation of mitochondrial electron transport, NADH to ubiquinone
- GO:1903181 ! positive regulation of dopamine biosynthetic process
- GO:1903197 ! positive regulation of L-dopa biosynthetic process
- GO:1903200 ! positive regulation of L-dopa decarboxylase activity
- GO:0010628 ! positive regulation of gene expression
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0033864 ! positive regulation of NAD(P)H oxidase activity
- GO:1903178 ! positive regulation of tyrosine 3-monooxygenase activity
- GO:1905516 ! positive regulation of fertilization
- GO:1900182 ! positive regulation of protein localization to nucleus
- GO:2000825 ! positive regulation of androgen receptor activity
- GO:2000679 ! positive regulation of transcription regulatory region DNA binding
- GO:1901671 ! positive regulation of superoxide dismutase activity
- GO:0033138 ! positive regulation of peptidyl-serine phosphorylation
- GO:0051091 ! positive regulation of DNA-binding transcription factor activity
- GO:0032757 ! positive regulation of interleukin-8 production
- GO:1903428 ! positive regulation of reactive oxygen species biosynthetic process
- GO:1902177 ! positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
- GO:0098793 ! presynapse
- GO:0036529 ! protein deglycation, glyoxal removal
- GO:0006517 ! protein deglycosylation
- GO:0036524 ! protein deglycase activity
- GO:0036530 ! protein deglycation, methylglyoxal removal
- GO:0042803 ! protein homodimerization activity
- GO:0050821 ! protein stabilization
- GO:0006508 ! proteolysis
r
- GO:0051881 ! regulation of mitochondrial membrane potential
- GO:0060765 ! regulation of androgen receptor signaling pathway
- GO:0050727 ! regulation of inflammatory response
- GO:0043523 ! regulation of neuron apoptotic process
- GO:0070491 ! repressing transcription factor binding
- GO:0042542 ! response to hydrogen peroxide
- GO:0006979 ! response to oxidative stress
- GO:0003723 ! RNA binding
- Rodentia
s
- GO:0097110 ! scaffold protein binding
- Sciurognathi
- GO:0005102 ! signaling receptor binding
- GO:0007338 ! single fertilization
- GO:0044388 ! small protein activating enzyme binding
- GO:0061827 ! sperm head
- GO:0016532 ! superoxide dismutase copper chaperone activity
- GO:0001963 ! synaptic transmission, dopaminergic
t
u