GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

MOUSE:PARK7

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Park7
Protein Name(s) Protein DJ-1

Parkinson disease protein 7 homolog

External Links
UniProt Q99LX0
EMBL AB015652
AK146368
AK153948
AK168341
AL607084
BC002187
CCDS CCDS18975.1
RefSeq NP_065594.2
UniGene Mm.277349
ProteinModelPortal Q99LX0
SMR Q99LX0
BioGrid 208257
IntAct Q99LX0
MINT MINT-1869265
STRING 10090.ENSMUSP00000101300
MEROPS C56.002
PhosphoSite Q99LX0
REPRODUCTION-2DPAGE Q99LX0
UCD-2DPAGE Q99LX0
MaxQB Q99LX0
PaxDb Q99LX0
PRIDE Q99LX0
Ensembl ENSMUST00000030805
ENSMUST00000105673
ENSMUST00000105674
ENSMUST00000105675
GeneID 57320
KEGG mmu:57320
UCSC uc008vxz.2
CTD 11315
MGI MGI:2135637
eggNOG COG0693
GeneTree ENSGT00390000001231
HOGENOM HOG000063194
HOVERGEN HBG053511
InParanoid Q99LX0
KO K05687
OMA MAGDHYK
OrthoDB EOG7CVPZX
PhylomeDB Q99LX0
TreeFam TF300119
NextBio 313682
PRO PR:Q99LX0
Proteomes UP000000589
Bgee Q99LX0
ExpressionAtlas Q99LX0
Genevestigator Q99LX0
GO GO:0044297
GO:0005737
GO:0005829
GO:0005783
GO:0070062
GO:0045121
GO:0005758
GO:0005759
GO:0005739
GO:0043005
GO:0005634
GO:0005886
GO:0016605
GO:1903135
GO:1903136
GO:1990422
GO:0019172
GO:0003729
GO:0008233
GO:0051920
GO:0042803
GO:0003723
GO:0016532
GO:0008344
GO:0006914
GO:0008283
GO:0036471
GO:0070301
GO:0034599
GO:0034614
GO:0051583
GO:0018323
GO:0046295
GO:1903190
GO:0042743
GO:0006954
GO:0019249
GO:0051899
GO:0060081
GO:0019243
GO:0007005
GO:0043066
GO:0060548
GO:2001268
GO:1903208
GO:1901299
GO:0043524
GO:1903204
GO:1901984
GO:0032091
GO:0042177
GO:0046826
GO:1903094
GO:0006469
GO:0031397
GO:1903122
GO:0051444
GO:2000157
GO:2000825
GO:0010628
GO:0032757
GO:1902958
GO:2000277
GO:1902177
GO:0090073
GO:1900182
GO:1903428
GO:1901671
GO:0045944
GO:0050821
GO:0050727
GO:0051881
GO:0043523
GO:0042542
GO:0007338
GO:0001963
Gene3D 3.40.50.880
InterPro IPR029062
IPR006287
IPR002818
Pfam PF01965
SUPFAM SSF52317
TIGRFAMs TIGR01383

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0051583

dopamine uptake

PMID:15799973[1]

ECO:0000315

P

Figure 4: the loss of DJ-1 function in mice can lead to motor deficits as well as alterations in nigrostriatal dopaminergic function

complete

involved_in

GO:0002866

positive regulation of acute inflammatory response to antigenic stimulus

PMID:26021615[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033864

positive regulation of NAD(P)H oxidase activity

PMID:26021615[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0106046

guanine deglycation, glyoxal removal

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

involved_in

GO:0106045

guanine deglycation, methylglyoxal removal

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

involved_in

GO:0106044

guanine deglycation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

involved_in

GO:1903189

glyoxal metabolic process

PMID:22523093[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903427

negative regulation of reactive oxygen species biosynthetic process

PMID:22611253[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030073

insulin secretion

PMID:22611253[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042593

glucose homeostasis

PMID:22611253[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|involved_in

GO:0036530

protein deglycation, methylglyoxal removal

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

NOT|involved_in

GO:0009438

methylglyoxal metabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

NOT|involved_in

GO:0006517

protein deglycosylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

involved_in

GO:0006517

protein deglycosylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

enables

GO:0045340

mercury ion binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

enables

GO:0005507

copper ion binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

involved_in

GO:0050787

detoxification of mercury ion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

involved_in

GO:0010273

detoxification of copper ion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

involved_in

GO:0010273

detoxification of copper ion

PMID:23792957[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050787

detoxification of mercury ion

PMID:23792957[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

PMID:14652021[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903384

negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway

PMID:14652021[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050821

protein stabilization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

involved_in

GO:0050821

protein stabilization

PMID:19229105[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:17015834[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:22492997[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P10639)

Seeded From UniProt

complete

involved_in

GO:0051444

negative regulation of ubiquitin-protein transferase activity

PMID:24899725[10]

ECO:0000305

curator inference used in manual assertion

GO:0031397

P

has_regulation_target:(UniProtKB:P40338)

Seeded From UniProt

complete

involved_in

GO:0042177

negative regulation of protein catabolic process

PMID:24899725[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903204

negative regulation of oxidative stress-induced neuron death

PMID:24899725[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1902958

positive regulation of mitochondrial electron transport, NADH to ubiquinone

PMID:19822128[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:22523093[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

part_of:(GO:0036471)

Seeded From UniProt

complete

involved_in

GO:0046295

glycolate biosynthetic process

PMID:22523093[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031397

negative regulation of protein ubiquitination

PMID:24899725[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q61221)

Seeded From UniProt

complete

involved_in

GO:0036471

cellular response to glyoxal

PMID:22523093[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:20969476[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:20969476[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1903208

negative regulation of hydrogen peroxide-induced neuron death

PMID:24947010[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0002609)

Seeded From UniProt

complete

part_of

GO:0044297

cell body

PMID:24947010[13]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002609)

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

PMID:24947010[13]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002609)

Seeded From UniProt

complete

part_of

GO:0005758

mitochondrial intermembrane space

PMID:15944198[14]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0000955)

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

PMID:15944198[14]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0000955)

Seeded From UniProt

complete

involved_in

GO:0018323

enzyme active site formation via L-cysteine sulfinic acid

PMID:17766438[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:15944198[14]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0002435)
  • part_of:(UBERON:0002038)
  • part_of:(UBERON:0000956)

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:15944198[14]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0002435)
  • part_of:(UBERON:0002038)
  • part_of:(UBERON:0000956)

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21097510[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P13597)

Seeded From UniProt

complete

involved_in

GO:2000277

positive regulation of oxidative phosphorylation uncoupler activity

PMID:21068725[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070301

cellular response to hydrogen peroxide

PMID:15784737[18]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060548

negative regulation of cell death

PMID:15784737[18]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050821

protein stabilization

PMID:17015834[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050727

regulation of inflammatory response

PMID:19276172[19]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043523

regulation of neuron apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

involved_in

GO:0034599

cellular response to oxidative stress

PMID:21068725[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032091

negative regulation of protein binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

involved_in

GO:0007005

mitochondrion organization

PMID:20186336[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

C

Seeded From UniProt

complete

enables

GO:0003729

mRNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

involved_in

GO:0106046

guanine deglycation, glyoxal removal

PMID:21873635[21]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000111103
UniProtKB:Q99497

P

Seeded From UniProt

complete

involved_in

GO:0036529

protein deglycation, glyoxal removal

PMID:21873635[21]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000111103
UniProtKB:Q99497

P

Seeded From UniProt

complete

enables

GO:0036524

protein deglycase activity

PMID:21873635[21]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13272
PANTHER:PTN000111103
UniProtKB:Q99497

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[21]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13272
MGI:MGI:2135637
PANTHER:PTN000111103
PomBase:SPAC22E12.03c
RGD:621808
TAIR:locus:2086295
UniProtKB:C6KTB1
UniProtKB:Q99497

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[21]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2135637
PANTHER:PTN000111108
PomBase:SPAC22E12.03c
RGD:621808
TAIR:locus:2086295
UniProtKB:Q99497
WB:WBGene00015184

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001268

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000825

positive regulation of androgen receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000679

positive regulation of transcription regulatory region DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000157

negative regulation of ubiquitin-specific protease activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

enables

GO:1990381

ubiquitin-specific protease binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1905516

positive regulation of fertilization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621808

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1905259

negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1904782

negative regulation of NMDA glutamate receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621808

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903428

positive regulation of reactive oxygen species biosynthetic process

PMID:22555455[22]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903384

negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903377

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903208

negative regulation of hydrogen peroxide-induced neuron death

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903206

negative regulation of hydrogen peroxide-induced cell death

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903202

negative regulation of oxidative stress-induced cell death

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903200

positive regulation of L-dopa decarboxylase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903197

positive regulation of L-dopa biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903189

glyoxal metabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903181

positive regulation of dopamine biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903178

positive regulation of tyrosine 3-monooxygenase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903168

positive regulation of pyrroline-5-carboxylate reductase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

enables

GO:1903136

cuprous ion binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

enables

GO:1903135

cupric ion binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903122

negative regulation of TRAIL-activated apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903094

negative regulation of protein K48-linked deubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902958

positive regulation of mitochondrial electron transport, NADH to ubiquinone

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902177

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

PMID:22555455[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901984

negative regulation of protein acetylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901671

positive regulation of superoxide dismutase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901215

negative regulation of neuron death

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901215

negative regulation of neuron death

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621808

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1900182

positive regulation of protein localization to nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0106046

guanine deglycation, glyoxal removal

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0106045

guanine deglycation, methylglyoxal removal

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0106044

guanine deglycation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

enables

GO:0097110

scaffold protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090073

positive regulation of protein homodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

enables

GO:0070491

repressing transcription factor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070301

cellular response to hydrogen peroxide

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

part_of

GO:0061827

sperm head

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621808

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060765

regulation of androgen receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060548

negative regulation of cell death

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060081

membrane hyperpolarization

PMID:16624565[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3579140

P

Seeded From UniProt

complete

enables

GO:0051920

peroxiredoxin activity

PMID:17766438[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3514165

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051899

membrane depolarization

PMID:16624565[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3579140

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051881

regulation of mitochondrial membrane potential

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051583

dopamine uptake involved in synaptic transmission

PMID:15721235[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3579140

P

occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051444

negative regulation of ubiquitin-protein transferase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051091

positive regulation of DNA-binding transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050821

protein stabilization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050787

detoxification of mercury ion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

enables

GO:0050681

androgen receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046826

negative regulation of protein export from nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046295

glycolate biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

enables

GO:0045340

mercury ion binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621808

C

Seeded From UniProt

complete

enables

GO:0044390

ubiquitin-like protein conjugating enzyme binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

enables

GO:0044388

small protein activating enzyme binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043523

regulation of neuron apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042743

hydrogen peroxide metabolic process

PMID:17766438[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3514165

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042743

hydrogen peroxide metabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042542

response to hydrogen peroxide

PMID:15784737[18]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3576227

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042542

response to hydrogen peroxide

PMID:15784737[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0036531

glutathione deglycation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0036529

protein deglycation, glyoxal removal

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0036528

peptidyl-lysine deglycation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0036527

peptidyl-arginine deglycation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0036526

peptidyl-cysteine deglycation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

enables

GO:0036524

protein deglycase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

enables

GO:0036478

L-dopa decarboxylase activator activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0036471

cellular response to glyoxal

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

enables

GO:0036470

tyrosine 3-monooxygenase activator activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034614

cellular response to reactive oxygen species

PMID:16624565[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3579140

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034599

cellular response to oxidative stress

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033234

negative regulation of protein sumoylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033138

positive regulation of peptidyl-serine phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032757

positive regulation of interleukin-8 production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032435

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032091

negative regulation of protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031397

negative regulation of protein ubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621808

C

Seeded From UniProt

complete

enables

GO:0019955

cytokine binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

enables

GO:0019900

kinase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019249

lactate biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

enables

GO:0016684

oxidoreductase activity, acting on peroxide as acceptor

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

part_of

GO:0016605

PML body

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

C

Seeded From UniProt

complete

enables

GO:0016532

superoxide dismutase copper chaperone activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010629

negative regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010273

detoxification of copper ion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008344

adult locomotory behavior

PMID:15799973[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3586448

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008344

adult locomotory behavior

PMID:15721235[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3579140

P

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006979

response to oxidative stress

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621808

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006469

negative regulation of protein kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006281

DNA repair

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:22555455[22]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621808

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:22555455[22]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

colocalizes_with

GO:0005747

mitochondrial respiratory chain complex I

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:18614015[25]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:22555455[22]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:17766438[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:22555455[22]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621808

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

C

Seeded From UniProt

complete

enables

GO:0005507

copper ion binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

enables

GO:0003729

mRNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001963

synaptic transmission, dopaminergic

PMID:15799973[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3586448

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001933

negative regulation of protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

part_of

GO:0000785

chromatin

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

C

Seeded From UniProt

complete

part_of

GO:0098793

presynapse

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0051583

C

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0051920

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

C

Seeded From UniProt

complete

part_of

GO:0005747

mitochondrial respiratory chain complex I

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

C

Seeded From UniProt

complete

enables

GO:0005507

copper ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

enables

GO:0003729

mRNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

involved_in

GO:0001933

negative regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

part_of

GO:0000785

chromatin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

C

Seeded From UniProt

complete

involved_in

GO:2001268

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:2000825

positive regulation of androgen receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:2000679

positive regulation of transcription regulatory region DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:2000157

negative regulation of ubiquitin-specific protease activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

enables

GO:1990381

ubiquitin-specific protease binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

involved_in

GO:1905259

negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:1903384

negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:1903377

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:1903208

negative regulation of hydrogen peroxide-induced neuron death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:1903206

negative regulation of hydrogen peroxide-induced cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:1903202

negative regulation of oxidative stress-induced cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:1903200

positive regulation of L-dopa decarboxylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:1903197

positive regulation of L-dopa biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:1903189

glyoxal metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:1903181

positive regulation of dopamine biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:1903178

positive regulation of tyrosine 3-monooxygenase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:1903168

positive regulation of pyrroline-5-carboxylate reductase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

enables

GO:1903136

cuprous ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

enables

GO:1903135

cupric ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

involved_in

GO:1903122

negative regulation of TRAIL-activated apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:1903094

negative regulation of protein K48-linked deubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:1902958

positive regulation of mitochondrial electron transport, NADH to ubiquinone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:1901984

negative regulation of protein acetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:1901671

positive regulation of superoxide dismutase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:1901215

negative regulation of neuron death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:1900182

positive regulation of protein localization to nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0106046

guanine deglycation, glyoxal removal

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0106044

guanine deglycation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

enables

GO:0097110

scaffold protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

involved_in

GO:0090073

positive regulation of protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

enables

GO:0070491

repressing transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

involved_in

GO:0070301

cellular response to hydrogen peroxide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0060765

regulation of androgen receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0060548

negative regulation of cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0051881

regulation of mitochondrial membrane potential

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0051444

negative regulation of ubiquitin-protein transferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0051091

positive regulation of DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0050821

protein stabilization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0050787

detoxification of mercury ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

enables

GO:0050681

androgen receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

C

Seeded From UniProt

complete

involved_in

GO:0046826

negative regulation of protein export from nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0046295

glycolate biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

enables

GO:0045340

mercury ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

enables

GO:0044390

ubiquitin-like protein conjugating enzyme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

enables

GO:0044388

small protein activating enzyme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

involved_in

GO:0043524

negative regulation of neuron apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0043523

regulation of neuron apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

involved_in

GO:0042743

hydrogen peroxide metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0036531

glutathione deglycation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0036529

protein deglycation, glyoxal removal

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0036528

peptidyl-lysine deglycation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0036527

peptidyl-arginine deglycation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0036526

peptidyl-cysteine deglycation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

enables

GO:0036524

protein deglycase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

enables

GO:0036478

L-dopa decarboxylase activator activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

involved_in

GO:0036471

cellular response to glyoxal

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

enables

GO:0036470

tyrosine 3-monooxygenase activator activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

involved_in

GO:0034599

cellular response to oxidative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0033234

negative regulation of protein sumoylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0033138

positive regulation of peptidyl-serine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0032757

positive regulation of interleukin-8 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0032435

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0032091

negative regulation of protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0031397

negative regulation of protein ubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

enables

GO:0019955

cytokine binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

enables

GO:0019900

kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

involved_in

GO:0019249

lactate biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

enables

GO:0016684

oxidoreductase activity, acting on peroxide as acceptor

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

part_of

GO:0016605

PML body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

C

Seeded From UniProt

complete

enables

GO:0016532

superoxide dismutase copper chaperone activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0010273

detoxification of copper ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

involved_in

GO:0006469

negative regulation of protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:V9HWC2
ensembl:ENSP00000340278

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:V9HWC2
ensembl:ENSP00000340278

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:11223268[26]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0072

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0395

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

involved_in

GO:0007338

single fertilization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0278

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0370

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Chen, L et al. (2005) Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. J. Biol. Chem. 280 21418-26 PubMed GONUTS page
  2. 2.0 2.1 Liu, W et al. (2015) Park7 interacts with p47(phox) to direct NADPH oxidase-dependent ROS production and protect against sepsis. Cell Res. 25 691-706 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Lee, JY et al. (2012) Human DJ-1 and its homologs are novel glyoxalases. Hum. Mol. Genet. 21 3215-25 PubMed GONUTS page
  4. 4.0 4.1 4.2 Jain, D et al. (2012) Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes. J Mol Cell Biol 4 221-30 PubMed GONUTS page
  5. 5.0 5.1 Björkblom, B et al. (2013) Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity. J. Biol. Chem. 288 22809-20 PubMed GONUTS page
  6. 6.0 6.1 Yokota, T et al. (2003) Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition. Biochem. Biophys. Res. Commun. 312 1342-8 PubMed GONUTS page
  7. Xiong, H et al. (2009) Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J. Clin. Invest. 119 650-60 PubMed GONUTS page
  8. 8.0 8.1 Clements, CM et al. (2006) DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc. Natl. Acad. Sci. U.S.A. 103 15091-6 PubMed GONUTS page
  9. Im, JY et al. (2012) DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway. Hum. Mol. Genet. 21 3013-24 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 Parsanejad, M et al. (2014) Regulation of the VHL/HIF-1 pathway by DJ-1. J. Neurosci. 34 8043-50 PubMed GONUTS page
  11. Hayashi, T et al. (2009) DJ-1 binds to mitochondrial complex I and maintains its activity. Biochem. Biophys. Res. Commun. 390 667-72 PubMed GONUTS page
  12. 12.0 12.1 Choi, DH et al. (2011) DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell death. Antioxid. Redox Signal. 14 2137-50 PubMed GONUTS page
  13. 13.0 13.1 13.2 Ma, J et al. (2014) DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis. Biochem. J. 462 489-97 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 Zhang, L et al. (2005) Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis. Hum. Mol. Genet. 14 2063-73 PubMed GONUTS page
  15. 15.0 15.1 15.2 15.3 Andres-Mateos, E et al. (2007) DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc. Natl. Acad. Sci. U.S.A. 104 14807-12 PubMed GONUTS page
  16. McNally, RS et al. (2011) DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. J. Biol. Chem. 286 4098-106 PubMed GONUTS page
  17. 17.0 17.1 Guzman, JN et al. (2010) Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature 468 696-700 PubMed GONUTS page
  18. 18.0 18.1 18.2 18.3 Kim, RH et al. (2005) Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc. Natl. Acad. Sci. U.S.A. 102 5215-20 PubMed GONUTS page
  19. Waak, J et al. (2009) Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1. FASEB J. 23 2478-89 PubMed GONUTS page
  20. Krebiehl, G et al. (2010) Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS ONE 5 e9367 PubMed GONUTS page
  21. 21.0 21.1 21.2 21.3 21.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  22. 22.0 22.1 22.2 22.3 22.4 22.5 Robert, G et al. (2012) The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production. Cell Death Differ. 19 1769-78 PubMed GONUTS page
  23. 23.0 23.1 23.2 Pisani, A et al. (2006) Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase. Neurobiol. Dis. 23 54-60 PubMed GONUTS page
  24. 24.0 24.1 Goldberg, MS et al. (2005) Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 45 489-96 PubMed GONUTS page
  25. Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
  26. Taira, T et al. (2001) Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter. Gene 263 285-92 PubMed GONUTS page