MOUSE:BRCA1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Brca1
Protein Name(s)	Breast cancer type 1 susceptibility protein homolog
External Links
UniProt	P48754
EMBL	U31625 U35641 U32446 U36475 AL590996 U33835
CCDS	CCDS25474.1
PIR	I49350
RefSeq	NP_033894.3
UniGene	Mm.244975
ProteinModelPortal	P48754
SMR	P48754
BioGrid	198383
DIP	DIP-41981N
IntAct	P48754
STRING	10090.ENSMUSP00000102847
PhosphoSite	P48754
MaxQB	P48754
PRIDE	P48754
Ensembl	ENSMUST00000017290
GeneID	12189
KEGG	mmu:12189
UCSC	uc007lpd.2
CTD	672
MGI	MGI:104537
eggNOG	NOG274496
GeneTree	ENSGT00440000034289
HOGENOM	HOG000230969
HOVERGEN	HBG050730
InParanoid	P48754
KO	K10605
OMA	KGPSQCP
OrthoDB	EOG79CXXK
TreeFam	TF105060
Reactome	REACT_198626 REACT_198629 REACT_230172 REACT_232842 REACT_251314 REACT_27235 REACT_75800
UniPathway	UPA00143
NextBio	280581
PRO	PR:P48754
Proteomes	UP000000589
CleanEx	MM_BRCA1
ExpressionAtlas	P48754
Genevestigator	P48754
GO	GO:0031436 GO:0005813 GO:0005694 GO:0000793 GO:0000794 GO:0005737 GO:0005654 GO:0005886 GO:0030529 GO:0003684 GO:0016874 GO:0003723 GO:0044212 GO:0004842 GO:0008270 GO:0006974 GO:0007098 GO:0051298 GO:0043009 GO:0006310 GO:0006281 GO:0006260 GO:0009048 GO:0006633 GO:0008630 GO:0045717 GO:0035067 GO:0051572 GO:0051573 GO:0035066 GO:0051571 GO:2000617 GO:0051574 GO:2000620 GO:0070512 GO:0045944 GO:0051865 GO:0085020 GO:0044030 GO:0006349
Gene3D	3.30.40.10 3.40.50.10190
InterPro	IPR011364 IPR025994 IPR001357 IPR018957 IPR001841 IPR013083 IPR017907
PANTHER	PTHR13763
Pfam	PF00533 PF12820 PF00097
PIRSF	PIRSF001734
PRINTS	PR00493
SMART	SM00292 SM00184
SUPFAM	SSF52113
PROSITE	PS50172 PS00518 PS50089

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006302	double-strand break repair	PMID:22186889^[1]	ECO:0000315			P		Figure 4e. Higher levels of γH2A.X signal for double strand break repair.	complete CACAO 3907
enables	GO:0070063	RNA polymerase binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P38398	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P38398	F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:22186889^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000620	positive regulation of histone H4-K16 acetylation	PMID:20820192^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000617	positive regulation of histone H3-K9 acetylation	PMID:20820192^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070512	positive regulation of histone H4-K20 methylation	PMID:20820192^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051574	positive regulation of histone H3-K9 methylation	PMID:20820192^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051573	negative regulation of histone H3-K9 methylation	PMID:20820192^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051572	negative regulation of histone H3-K4 methylation	PMID:20820192^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051571	positive regulation of histone H3-K4 methylation	PMID:20820192^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20820192^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:20820192^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0044030	regulation of DNA methylation	PMID:20820192^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035067	negative regulation of histone acetylation	PMID:20820192^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035066	positive regulation of histone acetylation	PMID:20820192^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006349	regulation of gene expression by genetic imprinting	PMID:20820192^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0085020	protein K6-linked ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
involved_in	GO:0045717	negative regulation of fatty acid biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
part_of	GO:0031436	BRCA1-BARD1 complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P38398	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	PMID:22549958^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	PMID:23039116^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P38398	F		Seeded From UniProt	complete
involved_in	GO:0071158	positive regulation of cell cycle arrest	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000349139 UniProtKB:P38398	P		Seeded From UniProt	complete
part_of	GO:0070531	BRCA1-A complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000349139 UniProtKB:P38398	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104537 PANTHER:PTN000349139 UniProtKB:P38398	P		Seeded From UniProt	complete
involved_in	GO:0045717	negative regulation of fatty acid biosynthetic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000349139 UniProtKB:P38398	P		Seeded From UniProt	complete
involved_in	GO:0043009	chordate embryonic development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104537 PANTHER:PTN000349142	P		Seeded From UniProt	complete
involved_in	GO:0035067	negative regulation of histone acetylation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104537 PANTHER:PTN000349139	P		Seeded From UniProt	complete
involved_in	GO:0035066	positive regulation of histone acetylation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104537 PANTHER:PTN000349139 UniProtKB:P38398	P		Seeded From UniProt	complete
part_of	GO:0031436	BRCA1-BARD1 complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000349139 UniProtKB:P38398 WB:WBGene00000264	C		Seeded From UniProt	complete
involved_in	GO:0009048	dosage compensation by inactivation of X chromosome	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104537 PANTHER:PTN000349142	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000349139 UniProtKB:P38398	C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000349139 TAIR:locus:2133109 UniProtKB:P38398	F		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000349139 TAIR:locus:2133109 UniProtKB:P38398 WB:WBGene00000264	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000620	positive regulation of histone H4-K16 acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000617	positive regulation of histone H3-K9 acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000378	negative regulation of reactive oxygen species metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	PMID:18809582^[6]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0085020	protein K6-linked ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072425	signal transduction involved in G2 DNA damage checkpoint	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071681	cellular response to indole-3-methanol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071158	positive regulation of cell cycle arrest	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
part_of	GO:0070531	BRCA1-A complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070512	positive regulation of histone H4-K20 methylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
enables	GO:0070063	RNA polymerase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051865	protein autoubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051573	negative regulation of histone H3-K9 methylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051571	positive regulation of histone H3-K4 methylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045766	positive regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045739	positive regulation of DNA repair	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045717	negative regulation of fatty acid biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044818	mitotic G2/M transition checkpoint	PMID:15254237^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043627	response to estrogen	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043009	chordate embryonic development	PMID:9171368^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930613	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035066	positive regulation of histone acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:16951165^[9]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	F		Seeded From UniProt	complete
part_of	GO:0031436	BRCA1-BARD1 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010575	positive regulation of vascular endothelial growth factor production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010212	response to ionizing radiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009048	dosage compensation by inactivation of X chromosome	PMID:12419249^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:14654789^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007098	centrosome cycle	PMID:15123655^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107799	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007059	chromosome segregation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	PMID:23271346^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3696057	P	occurs_in:(EMAPA:35246) occurs_in:(CL:1000428)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006302	double-strand break repair	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006301	postreplication repair	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	C		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2218	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11172592^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:12419249^[10]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	F		Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:11934988^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2218	F		Seeded From UniProt	complete
part_of	GO:0000800	lateral element	PMID:9774970^[16]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	C		Seeded From UniProt	complete
part_of	GO:0000794	condensed nuclear chromosome	PMID:26490168^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000794	condensed nuclear chromosome	PMID:20551173^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0000793	condensed chromosome	PMID:12913077^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17972) part_of:(CL:0000017)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000724	double-strand break repair via homologous recombination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P38398	P		Seeded From UniProt	complete
involved_in	GO:2000620	positive regulation of histone H4-K16 acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:2000617	positive regulation of histone H3-K9 acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:2000378	negative regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	C		Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0085020	protein K6-linked ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0072425	signal transduction involved in G2 DNA damage checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0071681	cellular response to indole-3-methanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0071158	positive regulation of cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
part_of	GO:0070531	BRCA1-A complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	C		Seeded From UniProt	complete
involved_in	GO:0070512	positive regulation of histone H4-K20 methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
enables	GO:0070063	RNA polymerase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	F		Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0051573	negative regulation of histone H3-K9 methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0051571	positive regulation of histone H3-K4 methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0045739	positive regulation of DNA repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0045717	negative regulation of fatty acid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	F		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	F		Seeded From UniProt	complete
involved_in	GO:0035066	positive regulation of histone acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	F		Seeded From UniProt	complete
part_of	GO:0031436	BRCA1-BARD1 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	C		Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	F		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0007059	chromosome segregation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
involved_in	GO:0006301	postreplication repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	F		Seeded From UniProt	complete
part_of	GO:0000800	lateral element	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	C		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P38398 ensembl:ENSP00000418960	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011364	F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011364	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011364	C		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011364 InterPro:IPR031099	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031099	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011364	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018957	F		Seeded From UniProt	complete
involved_in	GO:0051298	centrosome duplication	PMID:10855792^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:10855792^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-912468 Reactome:R-MMU-912449 Reactome:R-MMU-912431 Reactome:R-MMU-912423 Reactome:R-MMU-912421	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0275	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0233	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Shukla, PC et al. (2011) BRCA1 is an essential regulator of heart function and survival following myocardial infarction. Nat Commun 2 593 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 Shukla, V et al. (2010) BRCA1 affects global DNA methylation through regulation of DNMT1. Cell Res. 20 1201-15 PubMed GONUTS page
↑ Wojtasz, L et al. (2012) Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms. Genes Dev. 26 958-73 PubMed GONUTS page
↑ Kogo, H et al. (2012) HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Genes Cells 17 897-912 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Maggi, LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol. Cell. Biol. 28 7050-65 PubMed GONUTS page
↑ Arlt, MF et al. (2004) BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function. Mol. Cell. Biol. 24 6701-9 PubMed GONUTS page
↑ Ludwig, T et al. (1997) Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev. 11 1226-41 PubMed GONUTS page
↑ Hulit, J et al. (2006) p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling. Cancer Res. 66 8529-41 PubMed GONUTS page
↑ ^10.0 ^10.1 Ganesan, S et al. (2002) BRCA1 supports XIST RNA concentration on the inactive X chromosome. Cell 111 393-405 PubMed GONUTS page
↑ Aglipay, JA et al. (2003) A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. Oncogene 22 8931-8 PubMed GONUTS page
↑ Wang, X et al. (2004) Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure. J. Biol. Chem. 279 29606-14 PubMed GONUTS page
↑ Sotiropoulou, PA et al. (2013) BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny. Genes Dev. 27 39-51 PubMed GONUTS page
↑ Bernard-Gallon, DJ et al. (2001) Brca1 and Brca2 protein expression patterns in different tissues of murine origin. Int. J. Oncol. 18 271-80 PubMed GONUTS page
↑ Celeste, A et al. (2002) Genomic instability in mice lacking histone H2AX. Science 296 922-7 PubMed GONUTS page
↑ Chen, J et al. (1998) Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol. Cell 2 317-28 PubMed GONUTS page
↑ Sun, X et al. (2016) FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice. Chromosoma 125 237-52 PubMed GONUTS page
↑ Kumar, R et al. (2010) Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. Genes Dev. 24 1266-80 PubMed GONUTS page
↑ Wong, JC et al. (2003) Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia. Hum. Mol. Genet. 12 2063-76 PubMed GONUTS page
↑ ^20.0 ^20.1 Zhang, H et al. (2000) VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells. DNA Cell Biol. 19 253-63 PubMed GONUTS page

[PMID:22186889-1] 1.0 ^1.1 Shukla, PC et al. (2011) BRCA1 is an essential regulator of heart function and survival following myocardial infarction. Nat Commun 2 593 PubMed GONUTS page

[PMID:20820192-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 Shukla, V et al. (2010) BRCA1 affects global DNA methylation through regulation of DNMT1. Cell Res. 20 1201-15 PubMed GONUTS page

[PMID:22549958-3] Wojtasz, L et al. (2012) Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms. Genes Dev. 26 958-73 PubMed GONUTS page

[PMID:23039116-4] Kogo, H et al. (2012) HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Genes Cells 17 897-912 PubMed GONUTS page

[PMID:21873635-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18809582-6] Maggi, LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol. Cell. Biol. 28 7050-65 PubMed GONUTS page

[PMID:15254237-7] Arlt, MF et al. (2004) BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function. Mol. Cell. Biol. 24 6701-9 PubMed GONUTS page

[PMID:9171368-8] Ludwig, T et al. (1997) Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev. 11 1226-41 PubMed GONUTS page

[PMID:16951165-9] Hulit, J et al. (2006) p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling. Cancer Res. 66 8529-41 PubMed GONUTS page

[PMID:12419249-10] 10.0 ^10.1 Ganesan, S et al. (2002) BRCA1 supports XIST RNA concentration on the inactive X chromosome. Cell 111 393-405 PubMed GONUTS page

[PMID:14654789-11] Aglipay, JA et al. (2003) A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. Oncogene 22 8931-8 PubMed GONUTS page

[PMID:15123655-12] Wang, X et al. (2004) Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure. J. Biol. Chem. 279 29606-14 PubMed GONUTS page

[PMID:23271346-13] Sotiropoulou, PA et al. (2013) BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny. Genes Dev. 27 39-51 PubMed GONUTS page

[PMID:11172592-14] Bernard-Gallon, DJ et al. (2001) Brca1 and Brca2 protein expression patterns in different tissues of murine origin. Int. J. Oncol. 18 271-80 PubMed GONUTS page

[PMID:11934988-15] Celeste, A et al. (2002) Genomic instability in mice lacking histone H2AX. Science 296 922-7 PubMed GONUTS page

[PMID:9774970-16] Chen, J et al. (1998) Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol. Cell 2 317-28 PubMed GONUTS page

[PMID:26490168-17] Sun, X et al. (2016) FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice. Chromosoma 125 237-52 PubMed GONUTS page

[PMID:20551173-18] Kumar, R et al. (2010) Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. Genes Dev. 24 1266-80 PubMed GONUTS page

[PMID:12913077-19] Wong, JC et al. (2003) Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia. Hum. Mol. Genet. 12 2063-76 PubMed GONUTS page

[PMID:10855792-20] 20.0 ^20.1 Zhang, H et al. (2000) VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells. DNA Cell Biol. 19 253-63 PubMed GONUTS page

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