PMID:9774970

Citation	Chen, J, Silver, DP, Walpita, D, Cantor, SB, Gazdar, AF, Tomlinson, G, Couch, FJ, Weber, BL, Ashley, T, Livingston, DM and Scully, R (1998) Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol. Cell 2:317-28
Abstract	BRCA1 and BRCA2 account for most cases of familial, early onset breast and/or ovarian cancer and encode products that each interact with hRAD51. Results presented here show that BRCA1 and BRCA2 coexist in a biochemical complex and colocalize in subnuclear foci in somatic cells and on the axial elements of developing synaptonemal complexes. Like BRCA1 and RAD51, BRCA2 relocates to PCNA+ replication sites following exposure of S phase cells to hydroxyurea or UV irradiation. Thus, BRCA1 and BRCA2 participate, together, in a pathway(s) associated with the activation of double-strand break repair and/or homologous recombination. Dysfunction of this pathway may be a general phenomenon in the majority of cases of hereditary breast and/or ovarian cancer.
Links	PubMed
Keywords	Antibodies, Monoclonal; BRCA1 Protein/analysis; BRCA1 Protein/metabolism; BRCA2 Protein; Breast Neoplasms/genetics; Breast Neoplasms/pathology; Cell Line; Cell Nucleus/ultrastructure; Chromosome Mapping; DNA Damage; DNA Repair; DNA Replication; DNA-Binding Proteins/analysis; DNA-Binding Proteins/genetics; Female; Genes, BRCA1; Genes, Tumor Suppressor; Humans; Meiosis; Mitosis; Neoplasm Proteins/analysis; Neoplasm Proteins/genetics; Neoplasm Proteins/metabolism; Ovarian Neoplasms/genetics; Rad51 Recombinase; Transcription Factors/analysis; Transcription Factors/genetics; Transcription Factors/metabolism; Transfection; Tumor Cells, Cultured; Zygote/cytology
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