MOUSE:GATA3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Gata3 (synonyms: Gata-3)
Protein Name(s)	Trans-acting T-cell-specific transcription factor GATA-3 GATA-binding factor 3
External Links
UniProt	P23772
EMBL	X55123 BC062915
CCDS	CCDS15674.1
PIR	B39794
RefSeq	NP_032117.1 XP_006497416.1 XP_006497417.1
UniGene	Mm.313866
PDB	3DFV 3DFX
PDBsum	3DFV 3DFX
ProteinModelPortal	P23772
SMR	P23772
BioGrid	199840
DIP	DIP-29712N
IntAct	P23772
PhosphoSite	P23772
PRIDE	P23772
Ensembl	ENSMUST00000102976
GeneID	14462
KEGG	mmu:14462
UCSC	uc008ihf.1
CTD	2625
MGI	MGI:95663
eggNOG	COG5641
HOGENOM	HOG000047701
HOVERGEN	HBG051705
InParanoid	P23772
KO	K17895
OMA	QRYPPTH
OrthoDB	EOG7CCBRF
PhylomeDB	P23772
TreeFam	TF315391
Reactome	REACT_198649
EvolutionaryTrace	P23772
NextBio	286100
PRO	PR:P23772
Proteomes	UP000000589
Bgee	P23772
CleanEx	MM_GATA3
ExpressionAtlas	P23772
Genevestigator	P23772
GO	GO:0000790 GO:0005730 GO:0005634 GO:0000987 GO:0070888 GO:0001158 GO:0005134 GO:0046983 GO:0001078 GO:0001077 GO:0000979 GO:0000977 GO:0043565 GO:0003700 GO:0003713 GO:0044212 GO:0008270 GO:0048646 GO:0003180 GO:0007411 GO:0061290 GO:0003215 GO:0001775 GO:0001709 GO:0048469 GO:0000902 GO:0071773 GO:0071345 GO:0035457 GO:0071353 GO:0071356 GO:0048589 GO:0043583 GO:0035162 GO:0048568 GO:0030218 GO:0048872 GO:0006959 GO:0001701 GO:0045087 GO:0042472 GO:0072643 GO:0072602 GO:0002088 GO:0072676 GO:0008584 GO:0060374 GO:0060231 GO:0001823 GO:0045786 GO:2000146 GO:0008285 GO:2000607 GO:2000352 GO:0045599 GO:2000703 GO:0010629 GO:2000734 GO:0050728 GO:0032689 GO:0032703 GO:0033600 GO:0000122 GO:0045892 GO:0072179 GO:0072178 GO:0007399 GO:0030182 GO:0001764 GO:0042421 GO:0071599 GO:0060017 GO:0035898 GO:0060037 GO:0014065 GO:0045597 GO:0001819 GO:0010595 GO:0032736 GO:2000667 GO:0032753 GO:0032754 GO:2000664 GO:0051897 GO:0009967 GO:0045582 GO:2000611 GO:0045944 GO:2000679 GO:0045893 GO:0072107 GO:0009791 GO:0002572 GO:0043370 GO:2000683 GO:0042035 GO:2000114 GO:0061085 GO:0051569 GO:0072182 GO:0043523 GO:0010975 GO:0006357 GO:0072001 GO:0042493 GO:0043627 GO:0045471 GO:0010332 GO:0009615 GO:0007165 GO:0048485 GO:0030217 GO:0033077 GO:0050852 GO:0045064 GO:0045061 GO:0048538 GO:0031929 GO:0001806 GO:0035799 GO:0060676 GO:0060065 GO:0003281
Gene3D	3.30.50.10
InterPro	IPR029521 IPR016374 IPR000679 IPR013088
PANTHER	PTHR10071:SF106
Pfam	PF00320
PIRSF	PIRSF003027
PRINTS	PR00619
SMART	SM00401
PROSITE	PS00344 PS50114

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005634	nucleus	PMID:15662016^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000734	negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	PMID:19112489^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000703	negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	PMID:19112489^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000683	regulation of cellular response to X-ray	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:2000679	positive regulation of transcription regulatory region DNA binding	PMID:20636338^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000667	positive regulation of interleukin-13 secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:2000664	positive regulation of interleukin-5 secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:2000611	positive regulation of thyroid hormone generation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:2000607	negative regulation of cell proliferation involved in mesonephros development	PMID:16319112^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000352	negative regulation of endothelial cell apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:2000146	negative regulation of cell motility	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0072676	lymphocyte migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0072182	regulation of nephron tubule epithelial cell differentiation	PMID:19112489^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072179	nephric duct formation	PMID:16319112^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072178	nephric duct morphogenesis	PMID:19112489^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072107	positive regulation of ureteric bud formation	PMID:19112489^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071353	cellular response to interleukin-4	PMID:20696860^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	F		Seeded From UniProt	complete
involved_in	GO:0061290	canonical Wnt signaling pathway involved in metanephric kidney development	PMID:19112489^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060676	ureteric bud formation	PMID:16319112^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060231	mesenchymal to epithelial transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0060065	uterus development	PMID:19112489^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	PMID:18955134^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	PMID:20696860^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16319112^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19112489^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20636338^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0045582	positive regulation of T cell differentiation	PMID:20696860^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:20636338^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043583	ear development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0031929	TOR signaling	PMID:20696860^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	PMID:20696860^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0009967	positive regulation of signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	PMID:19112489^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:16319112^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20696860^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	F		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	PMID:20636338^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0003281	ventricular septum development	PMID:18955134^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003215	cardiac right ventricle morphogenesis	PMID:18955134^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003180	aortic valve morphogenesis	PMID:18955134^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001158	enhancer sequence-specific DNA binding	PMID:20855530^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	F		Seeded From UniProt	complete
involved_in	GO:0048568	embryonic organ development	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95663 PANTHER:PTN002560228 ZFIN:ZDB-GENE-990415-82	P		Seeded From UniProt	complete
involved_in	GO:0030856	regulation of epithelial cell differentiation	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95663 PANTHER:PTN002560228	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003117 FB:FBgn0032223 FB:FBgn0038391 MGI:MGI:107516 MGI:MGI:109497 MGI:MGI:95661 MGI:MGI:95662 MGI:MGI:95663 MGI:MGI:95664 PANTHER:PTN001600628 PomBase:SPAC23E2.01 PomBase:SPCC1902.01 RGD:2663 RGD:2664 RGD:2665 RGD:2666 RGD:621250 SGD:S000000842 SGD:S000001742 SGD:S000001873 SGD:S000003646 UniProtKB:E1C9C6 UniProtKB:I3LUZ9 UniProtKB:P15976 UniProtKB:P17429 UniProtKB:P23769 UniProtKB:P23771 UniProtKB:P43691 UniProtKB:P43692 UniProtKB:P43694 UniProtKB:Q92908 UniProtKB:Q9BWX5 WB:WBGene00001186 WB:WBGene00001249 WB:WBGene00001250 WB:WBGene00001251 WB:WBGene00001252 WB:WBGene00001253 WB:WBGene00001310 WB:WBGene00001311 WB:WBGene00015981 ZFIN:ZDB-GENE-980526-340	C		Seeded From UniProt	complete
involved_in	GO:0002520	immune system development	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95663 PANTHER:PTN002560228	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003117 MGI:MGI:95661 MGI:MGI:95664 PANTHER:PTN001600628 RGD:2665 SGD:S000001742 SGD:S000003646 UniProtKB:P23769 UniProtKB:P43694 UniProtKB:Q92908 WB:WBGene00001249 WB:WBGene00001310	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107516 MGI:MGI:95661 MGI:MGI:95662 MGI:MGI:95663 MGI:MGI:95664 PANTHER:PTN001600628 PomBase:SPAC23E2.01 PomBase:SPCC1902.01 SGD:S000000842 UniProtKB:P15976 UniProtKB:P23771	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000683	regulation of cellular response to X-ray	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000679	positive regulation of transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000667	positive regulation of interleukin-13 secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000664	positive regulation of interleukin-5 secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000617	positive regulation of histone H3-K9 acetylation	PMID:15087456^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000617	positive regulation of histone H3-K9 acetylation	PMID:15087456^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000611	positive regulation of thyroid hormone generation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000553	positive regulation of T-helper 2 cell cytokine production	PMID:15087456^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000352	negative regulation of endothelial cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000146	negative regulation of cell motility	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000114	regulation of establishment of cell polarity	PMID:21613615^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901536	negative regulation of DNA demethylation	PMID:15087456^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901536	negative regulation of DNA demethylation	PMID:15087456^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072676	lymphocyte migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072643	interferon-gamma secretion	PMID:17658279^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3719568	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072602	interleukin-4 secretion	PMID:17658279^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3719568	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072197	ureter morphogenesis	PMID:21731775^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95388 MGI:MGI:95457 MGI:MGI:97486 MGI:MGI:99783	P		Seeded From UniProt	complete
enables	GO:0071837	HMG box domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071773	cellular response to BMP stimulus	PMID:20501701^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071599	otic vesicle development	PMID:11135239^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181200	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071442	positive regulation of histone H3-K14 acetylation	PMID:15087456^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071442	positive regulation of histone H3-K14 acetylation	PMID:15087456^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071353	cellular response to interleukin-4	PMID:18997793^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071345	cellular response to cytokine stimulus	PMID:19666510^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000546)	Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061085	regulation of histone H3-K27 methylation	PMID:21867929^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060374	mast cell differentiation	PMID:17603486^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060231	mesenchymal to epithelial transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060017	parathyroid gland development	PMID:20484821^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181201	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051569	regulation of histone H3-K4 methylation	PMID:21867929^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050728	negative regulation of inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048872	homeostasis of number of cells	PMID:19934022^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4418042	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048646	anatomical structure formation involved in morphogenesis	PMID:16319112^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3720332	P	results_in_formation_of:(EMAPA:16577)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048589	developmental growth	PMID:7550312^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153826	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048568	embryonic organ development	PMID:11135239^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181200	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048538	thymus development	PMID:17082577^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2683927	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048538	thymus development	PMID:14670303^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2683927	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048485	sympathetic nervous system development	PMID:15329349^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153826	P	results_in_development_of:(EMAPA:17157)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048469	cell maturation	PMID:17082577^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2683927	P	results_in_maturation_of:(CL:0000623)	Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	PMID:18621058^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9819382^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102812 MGI:MGI:98480	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9043071^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153826	P	regulates_o_occurs_in:(EMAPA:35689)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22588720^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3487291	P	has_regulation_target:(MGI:MGI:1919404)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21217760^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:103060)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:7720565^[30]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:97606)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24831988^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21867929^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:2017177^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18776904^[33]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:102755)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12127263^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:2017177^[32]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04234	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621250	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11093124^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045786	negative regulation of cell cycle	PMID:19623612^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181200	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045786	negative regulation of cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045597	positive regulation of cell differentiation	PMID:19623612^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181200	P	occurs_in:(EMAPA:17841)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045064	T-helper 2 cell differentiation	PMID:20706986^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045061	thymic T cell selection	PMID:14670303^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2683927	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043583	ear development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21867929^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:18621058^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621250	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043523	regulation of neuron apoptotic process	PMID:20702712^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3696958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043370	regulation of CD4-positive, alpha-beta T cell differentiation	PMID:18776904^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3487291	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000492)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:21553382^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153826	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:11135239^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181200	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042421	norepinephrine biosynthetic process	PMID:10835639^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153826	P	occurs_in:(EMAPA:16985)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042035	regulation of cytokine biosynthetic process	PMID:11093124^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035898	parathyroid hormone secretion	PMID:20484821^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181201	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035799	ureter maturation	PMID:21521737^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3719568	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035162	embryonic hemopoiesis	PMID:10631184^[42]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035162	embryonic hemopoiesis	PMID:7550312^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153826	P	has_participant:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033600	negative regulation of mammary gland epithelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033077	T cell differentiation in thymus	PMID:18776904^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88127	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033077	T cell differentiation in thymus	PMID:8945476^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153825	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033077	T cell differentiation in thymus	PMID:19934022^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4418042	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033077	T cell differentiation in thymus	PMID:14670303^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2683927	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032754	positive regulation of interleukin-5 production	PMID:10549629^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032753	positive regulation of interleukin-4 production	PMID:10549629^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032753	positive regulation of interleukin-4 production	PMID:17658278^[45]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032736	positive regulation of interleukin-13 production	PMID:10549629^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032703	negative regulation of interleukin-2 production	PMID:18792410^[46]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032689	negative regulation of interferon-gamma production	PMID:20399120^[47]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3487291	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032689	negative regulation of interferon-gamma production	PMID:18792410^[46]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030218	erythrocyte differentiation	PMID:9576834^[48]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030217	T cell differentiation	PMID:7956841^[49]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030217	T cell differentiation	PMID:8088776^[50]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04234	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	PMID:20818386^[51]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3487291	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010975	regulation of neuron projection development	PMID:23426694^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3487291,MGI:MGI:4440745	P	regulates_o_occurs_in:(EMAPA:17598) regulates_o_occurs_in:(CL:0011113)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	PMID:17357106^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3696958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:24802759^[54]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1922855	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009967	positive regulation of signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009791	post-embryonic development	PMID:7550312^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153826	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:19623612^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181200	P	regulates_o_occurs_in:(EMAPA:17841)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:16319112^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3720332	P	regulates_o_occurs_in:(EMAPA:16744)	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:11135239^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181200	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007399	nervous system development	PMID:7550312^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153826	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006959	humoral immune response	PMID:17658279^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3719568	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:18997793^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1891436	P	has_regulation_target:(MGI:MGI:96557)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:20484821^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181201	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:15306564^[55]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153826	P	has_regulation_target:(MGI:MGI:101926)\|has_regulation_target:(MGI:MGI:103580)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21536806^[56]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:19796622^[57]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006338	chromatin remodeling	PMID:15087456^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006338	chromatin remodeling	PMID:15087456^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23426694^[52]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:19151) part_of:(CL:0002490)\|part_of:(EMAPA:17597) part_of:(CL:0011113)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15003631^[58]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16669) part_of:(CL:0000031)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12923059^[59]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10447238^[60]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:19061) part_of:(CL:0000635)\|part_of:(EMAPA:19061) part_of:(CL:0000631)\|part_of:(EMAPA:17600) part_of:(CL:0000066)\|part_of:(EMAPA:17600) part_of:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22529382^[61]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621250	C		Seeded From UniProt	complete
enables	GO:0005134	interleukin-2 receptor binding	PMID:21217760^[29]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P01590	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:2017177^[32]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:2017177^[32]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04234	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:24831988^[31]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621250	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002572	pro-T cell differentiation	PMID:19934022^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181200 MGI:MGI:3696958 MGI:MGI:4418042	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002088	lens development in camera-type eye	PMID:19623612^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181200	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001823	mesonephros development	PMID:16319112^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3720332	P	results_in_development_of:(EMAPA:16744)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001819	positive regulation of cytokine production	PMID:18792410^[46]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001775	cell activation	PMID:17082577^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2683927	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:10556076^[62]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181200	P	occurs_in:(EMAPA:16939)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001709	cell fate determination	PMID:12923059^[59]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_determination_of:(CL:0000362)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:20702712^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3696958	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:7720565^[30]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:97606)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	F		Seeded From UniProt	complete
enables	GO:0001158	enhancer sequence-specific DNA binding	PMID:19666510^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:20484821^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:10549629^[44]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:96557)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:20176728^[63]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:18776904^[33]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:102755)	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000902	cell morphogenesis	PMID:8945476^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153825	P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23771	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:18792410^[46]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:103038)\|has_regulation_target:(MGI:MGI:103062)\|has_regulation_target:(MGI:MGI:102463)\|has_regulation_target:(MGI:MGI:104856)	Seeded From UniProt	complete
involved_in	GO:2000683	regulation of cellular response to X-ray	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:2000679	positive regulation of transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:2000667	positive regulation of interleukin-13 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:2000664	positive regulation of interleukin-5 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:2000611	positive regulation of thyroid hormone generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:2000352	negative regulation of endothelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:2000146	negative regulation of cell motility	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:0072676	lymphocyte migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
enables	GO:0071837	HMG box domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	F		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:0071353	cellular response to interleukin-4	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	F		Seeded From UniProt	complete
involved_in	GO:0060231	mesenchymal to epithelial transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	F		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:0043583	ear development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:0035457	cellular response to interferon-alpha	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:0033600	negative regulation of mammary gland epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:0009967	positive regulation of signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	F		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	F		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23771 ensembl:ENSP00000368632	C		Seeded From UniProt	complete
involved_in	GO:0090102	cochlea development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH5 ensembl:ENSRNOP00000026187	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH5 ensembl:ENSRNOP00000026187	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH5 ensembl:ENSRNOP00000026187	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH5 ensembl:ENSRNOP00000026187	F		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH5 ensembl:ENSRNOP00000026187	P		Seeded From UniProt	complete
involved_in	GO:0010332	response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH5 ensembl:ENSRNOP00000026187	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH5 ensembl:ENSRNOP00000026187	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH5 ensembl:ENSRNOP00000026187	F		Seeded From UniProt	complete
involved_in	GO:0001806	type IV hypersensitivity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH5 ensembl:ENSRNOP00000026187	P		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029521	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039355	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029521	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000679 InterPro:IPR013088	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000679 InterPro:IPR013088 InterPro:IPR039355	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000679	F		Seeded From UniProt	complete
involved_in	GO:0045582	positive regulation of T cell differentiation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029521	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Hwang, ES et al. (2005) T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 307 430-3 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Grote, D et al. (2008) Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction. PLoS Genet. 4 e1000316 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Hwang, SS et al. (2010) GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2. Immunology 131 50-8 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Grote, D et al. (2006) Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development 133 53-61 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Cook, KD & Miller, J (2010) TCR-dependent translational control of GATA-3 enhances Th2 differentiation. J. Immunol. 185 3209-16 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Raid, R et al. () Lack of Gata3 results in conotruncal heart anomalies in mouse. Mech. Dev. 126 80-9 PubMed GONUTS page
↑ Potvin, E et al. (2010) Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3. Mol. Cell. Biol. 30 5348-63 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 ^9.8 Yamashita, M et al. (2004) Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J. Biol. Chem. 279 26983-90 PubMed GONUTS page
↑ Stellato, C et al. (2011) Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR. J. Immunol. 187 441-9 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Amsen, D et al. (2007) Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity 27 89-99 PubMed GONUTS page
↑ Boualia, SK et al. (2011) Vesicoureteral reflux and other urinary tract malformations in mice compound heterozygous for Pax2 and Emx2. PLoS ONE 6 e21529 PubMed GONUTS page
↑ Karamboulas, K et al. (2010) Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals. J. Cell. Sci. 123 2068-76 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Karis, A et al. (2001) Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear. J. Comp. Neurol. 429 615-30 PubMed GONUTS page
↑ ^15.0 ^15.1 Dardalhon, V et al. (2008) IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat. Immunol. 9 1347-55 PubMed GONUTS page
↑ ^16.0 ^16.1 Guo, L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc. Natl. Acad. Sci. U.S.A. 106 13463-8 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Wei, G et al. (2011) Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity 35 299-311 PubMed GONUTS page
↑ Taghon, T et al. (2007) Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3. Nat. Immunol. 8 845-55 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Grigorieva, IV et al. (2010) Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2. J. Clin. Invest. 120 2144-55 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Hosoya, T et al. (2009) GATA-3 is required for early T lineage progenitor development. J. Exp. Med. 206 2987-3000 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Pandolfi, PP et al. (1995) Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis. Nat. Genet. 11 40-4 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Kim, PJ et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J. Immunol. 177 6650-9 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Pai, SY et al. (2003) Critical roles for transcription factor GATA-3 in thymocyte development. Immunity 19 863-75 PubMed GONUTS page
↑ Tsarovina, K et al. (2004) Essential role of Gata transcription factors in sympathetic neuron development. Development 131 4775-86 PubMed GONUTS page
↑ ^25.0 ^25.1 Bates, DL et al. (2008) Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA. J. Mol. Biol. 381 1292-306 PubMed GONUTS page
↑ Ono, Y et al. (1998) TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. Mol. Cell. Biol. 18 6939-50 PubMed GONUTS page
↑ Ma, GT et al. (1997) GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo. Development 124 907-14 PubMed GONUTS page
↑ Oliver, CH et al. (2012) The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. Genes Dev. 26 1086-97 PubMed GONUTS page
↑ ^29.0 ^29.1 Li, Z et al. (2011) ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). Nat. Immunol. 12 178-85 PubMed GONUTS page
↑ ^30.0 ^30.1 Ng, YK et al. (1994) GATA factor activity is required for the trophoblast-specific transcriptional regulation of the mouse placental lactogen I gene. Development 120 3257-66 PubMed GONUTS page
↑ ^31.0 ^31.1 Tai, TS et al. (2014) Itm2a, a target gene of GATA-3, plays a minimal role in regulating the development and function of T cells. PLoS ONE 9 e96535 PubMed GONUTS page
↑ ^32.0 ^32.1 ^32.2 ^32.3 Ko, LJ et al. (1991) Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer. Mol. Cell. Biol. 11 2778-84 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 ^33.3 Wang, L et al. (2008) Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat. Immunol. 9 1122-30 PubMed GONUTS page
↑ Bull, RJ et al. (2002) Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene. Toxicol. Appl. Pharmacol. 182 55-65 PubMed GONUTS page
↑ ^35.0 ^35.1 Blanchard, AD et al. (2000) Identification and characterization of SKAT-2, a novel Th2-specific zinc finger gene. Eur. J. Immunol. 30 3100-10 PubMed GONUTS page
↑ ^36.0 ^36.1 ^36.2 ^36.3 Maeda, A et al. (2009) Transcription factor GATA-3 is essential for lens development. Dev. Dyn. 238 2280-91 PubMed GONUTS page
↑ Wang, L et al. (2010) The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells. Eur. J. Immunol. 40 2385-90 PubMed GONUTS page
↑ ^38.0 ^38.1 Tsarovina, K et al. (2010) The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neurons. J. Neurosci. 30 10833-43 PubMed GONUTS page
↑ Duncan, JS et al. (2011) Limited inner ear morphogenesis and neurosensory development are possible in the absence of GATA3. Int. J. Dev. Biol. 55 297-303 PubMed GONUTS page
↑ Lim, KC et al. (2000) Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. Nat. Genet. 25 209-12 PubMed GONUTS page
↑ Chia, I et al. (2011) Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice. Development 138 2089-97 PubMed GONUTS page
↑ Manaia, A et al. (2000) Lmo2 and GATA-3 associated expression in intraembryonic hemogenic sites. Development 127 643-53 PubMed GONUTS page
↑ ^43.0 ^43.1 Ting, CN et al. (1996) Transcription factor GATA-3 is required for development of the T-cell lineage. Nature 384 474-8 PubMed GONUTS page
↑ ^44.0 ^44.1 ^44.2 ^44.3 Zhang, DH et al. (1999) Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. Immunity 11 473-82 PubMed GONUTS page
↑ Fang, TC et al. (2007) Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity 27 100-10 PubMed GONUTS page
↑ ^46.0 ^46.1 ^46.2 ^46.3 van Hamburg, JP et al. (2008) Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology. Eur. J. Immunol. 38 2573-86 PubMed GONUTS page
↑ Yagi, R et al. (2010) The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity 32 507-17 PubMed GONUTS page
↑ Tsai, FY et al. (1998) Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: partial rescue of GATA-1 loss of function in erythroid cells. Dev. Biol. 196 218-27 PubMed GONUTS page
↑ George, KM et al. (1994) Embryonic expression and cloning of the murine GATA-3 gene. Development 120 2673-86 PubMed GONUTS page
↑ Labastie, MC et al. (1994) Structure and expression of the human GATA3 gene. Genomics 21 1-6 PubMed GONUTS page
↑ Liu, C et al. (2010) Pet-1 is required across different stages of life to regulate serotonergic function. Nat. Neurosci. 13 1190-8 PubMed GONUTS page
↑ ^52.0 ^52.1 Appler, JM et al. (2013) Gata3 is a critical regulator of cochlear wiring. J. Neurosci. 33 3679-91 PubMed GONUTS page
↑ Ling, KW et al. (2007) GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development. Eur. J. Immunol. 37 1043-52 PubMed GONUTS page
↑ Zou, MR et al. (2014) Histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genes. J. Biol. Chem. 289 17620-33 PubMed GONUTS page
↑ Ruest, LB et al. (2004) Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity. Development 131 4413-23 PubMed GONUTS page
↑ Horiuchi, S et al. (2011) Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3. J. Immunol. 186 6378-89 PubMed GONUTS page
↑ Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page
↑ Lawoko-Kerali, G et al. (2004) GATA3 and NeuroD distinguish auditory and vestibular neurons during development of the mammalian inner ear. Mech. Dev. 121 287-99 PubMed GONUTS page
↑ ^59.0 ^59.1 Kaufman, CK et al. (2003) GATA-3: an unexpected regulator of cell lineage determination in skin. Genes Dev. 17 2108-22 PubMed GONUTS page
↑ Rivolta, MN & Holley, MC (1998) GATA3 is downregulated during hair cell differentiation in the mouse cochlea. J. Neurocytol. 27 637-47 PubMed GONUTS page
↑ Home, P et al. (2012) Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment. Proc. Natl. Acad. Sci. U.S.A. 109 7362-7 PubMed GONUTS page
↑ Pata, I et al. (1999) The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4. Development 126 5523-31 PubMed GONUTS page
↑ Kidder, BL & Palmer, S (2010) Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance. Genome Res. 20 458-72 PubMed GONUTS page

[PMID:15662016-1] Hwang, ES et al. (2005) T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 307 430-3 PubMed GONUTS page

[PMID:19112489-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Grote, D et al. (2008) Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction. PLoS Genet. 4 e1000316 PubMed GONUTS page

[PMID:20636338-3] 3.0 ^3.1 ^3.2 ^3.3 Hwang, SS et al. (2010) GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2. Immunology 131 50-8 PubMed GONUTS page

[PMID:16319112-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Grote, D et al. (2006) Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development 133 53-61 PubMed GONUTS page

[PMID:20696860-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Cook, KD & Miller, J (2010) TCR-dependent translational control of GATA-3 enhances Th2 differentiation. J. Immunol. 185 3209-16 PubMed GONUTS page

[PMID:18955134-6] 6.0 ^6.1 ^6.2 ^6.3 Raid, R et al. () Lack of Gata3 results in conotruncal heart anomalies in mouse. Mech. Dev. 126 80-9 PubMed GONUTS page

[PMID:20855530-7] Potvin, E et al. (2010) Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3. Mol. Cell. Biol. 30 5348-63 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15087456-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 ^9.8 Yamashita, M et al. (2004) Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J. Biol. Chem. 279 26983-90 PubMed GONUTS page

[PMID:21613615-10] Stellato, C et al. (2011) Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR. J. Immunol. 187 441-9 PubMed GONUTS page

[PMID:17658279-11] 11.0 ^11.1 ^11.2 Amsen, D et al. (2007) Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity 27 89-99 PubMed GONUTS page

[PMID:21731775-12] Boualia, SK et al. (2011) Vesicoureteral reflux and other urinary tract malformations in mice compound heterozygous for Pax2 and Emx2. PLoS ONE 6 e21529 PubMed GONUTS page

[PMID:20501701-13] Karamboulas, K et al. (2010) Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals. J. Cell. Sci. 123 2068-76 PubMed GONUTS page

[PMID:11135239-14] 14.0 ^14.1 ^14.2 ^14.3 Karis, A et al. (2001) Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear. J. Comp. Neurol. 429 615-30 PubMed GONUTS page

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MOUSE:GATA3

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