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HUMAN:NCOA4
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | NCOA4 (synonyms: ARA70, ELE1, RFG) | |
| Protein Name(s) | Nuclear receptor coactivator 4
NCoA-4 Androgen receptor coactivator 70 kDa protein 70 kDa AR-activator 70 kDa androgen receptor coactivator Androgen receptor-associated protein of 70 kDa Ret-activating protein ELE1 | |
| External Links | ||
| UniProt | Q13772 | |
| EMBL | L49399 X77548 AK292480 AK304123 AK310849 AL162047 AL450342 CH471260 BC001562 X71413 | |
| CCDS | CCDS73092.1 CCDS73093.1 CCDS73094.1 | |
| PIR | S61532 | |
| RefSeq | NP_001138732.1 NP_001138733.1 NP_001138734.1 NP_001138735.1 NP_005428.1 | |
| UniGene | Hs.643658 Hs.709644 | |
| PDB | 1T5Z | |
| PDBsum | 1T5Z | |
| ProteinModelPortal | Q13772 | |
| BioGrid | 113726 | |
| DIP | DIP-5957N | |
| IntAct | Q13772 | |
| MINT | MINT-2864695 | |
| STRING | 9606.ENSP00000395465 | |
| PhosphoSite | Q13772 | |
| DMDM | 8928226 | |
| MaxQB | Q13772 | |
| PaxDb | Q13772 | |
| PRIDE | Q13772 | |
| DNASU | 8031 | |
| Ensembl | ENST00000578454 ENST00000579039 ENST00000581486 ENST00000583565 ENST00000585132 | |
| GeneID | 8031 | |
| KEGG | hsa:8031 | |
| UCSC | uc001jis.4 | |
| CTD | 8031 | |
| GeneCards | GC10P051565 | |
| HGNC | HGNC:7671 | |
| HPA | HPA051260 | |
| MIM | 188550 601984 | |
| neXtProt | NX_Q13772 | |
| Orphanet | 146 | |
| PharmGKB | PA31473 | |
| eggNOG | NOG40301 | |
| GeneTree | ENSGT00390000008403 | |
| HOGENOM | HOG000013175 | |
| HOVERGEN | HBG052584 | |
| InParanoid | Q13772 | |
| KO | K09289 | |
| OMA | ECVCDEN | |
| PhylomeDB | Q13772 | |
| TreeFam | TF333204 | |
| EvolutionaryTrace | Q13772 | |
| GeneWiki | NCOA4 | |
| GenomeRNAi | 8031 | |
| NextBio | 30615 | |
| PRO | PR:Q13772 | |
| Proteomes | UP000005640 | |
| Bgee | Q13772 | |
| CleanEx | HS_NCOA4 | |
| ExpressionAtlas | Q13772 | |
| Genevestigator | Q13772 | |
| GO | GO:0005634 GO:0050681 GO:0003713 GO:0030521 GO:0008584 GO:0045893 GO:0009725 GO:0006351 | |
| InterPro | IPR022174 | |
| Pfam | PF12489 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0050681 |
androgen receptor binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030521 |
androgen receptor signaling pathway |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003713 |
transcription coactivator activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044754 |
autolysosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006622 |
protein targeting to lysosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009725 |
response to hormone |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B1H215 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006879 |
cellular iron ion homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5U4H9 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003713 |
transcription coactivator activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006879 |
cellular iron ion homeostasis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008584 |
male gonad development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003713 |
transcription coactivator activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Lin, DY et al. (2004) Negative modulation of androgen receptor transcriptional activity by Daxx. Mol. Cell. Biol. 24 10529-41 PubMed GONUTS page
- ↑ 2.0 2.1 Dowdle, WE et al. (2014) Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat. Cell Biol. 16 1069-79 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Yeh, S & Chang, C (1996) Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. Proc. Natl. Acad. Sci. U.S.A. 93 5517-21 PubMed GONUTS page
