GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:RNF4

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) RNF4 (synonyms: SNURF)
Protein Name(s) E3 ubiquitin-protein ligase RNF4

RING finger protein 4 Small nuclear ring finger protein Protein SNURF

External Links
UniProt P78317
EMBL AB000468
U95140
AK128038
AK309509
AK312534
AL110117
AL645924
BX322586
CR450722
CR545473
BC031935
CCDS CCDS47001.1
CCDS54713.1
RefSeq NP_001171938.1
NP_001171939.1
NP_002929.1
UniGene Hs.66394
PDB 2EA6
2XEU
4PPE
PDBsum 2EA6
2XEU
4PPE
ProteinModelPortal P78317
SMR P78317
BioGrid 111974
IntAct P78317
MINT MINT-271054
STRING 9606.ENSP00000315212
PhosphoSite P78317
DMDM 18202358
MaxQB P78317
PaxDb P78317
PRIDE P78317
DNASU 6047
Ensembl ENST00000314289
ENST00000506706
ENST00000511600
ENST00000511859
ENST00000541204
GeneID 6047
KEGG hsa:6047
UCSC uc003gfb.3
CTD 6047
GeneCards GC04P002463
HGNC HGNC:10067
HPA HPA049356
MIM 602850
neXtProt NX_P78317
PharmGKB PA34439
eggNOG NOG327779
GeneTree ENSGT00390000010318
HOGENOM HOG000059548
HOVERGEN HBG018577
InParanoid P78317
OMA THRQYHP
PhylomeDB P78317
TreeFam TF328387
Reactome REACT_75842
UniPathway UPA00143
ChiTaRS RNF4
EvolutionaryTrace P78317
GeneWiki RNF4
GenomeRNAi 6047
NextBio 23561
PRO PR:P78317
Proteomes UP000005640
Bgee P78317
CleanEx HS_RNF4
ExpressionAtlas P78317
Genevestigator P78317
GO GO:0005737
GO:0005634
GO:0016605
GO:0050681
GO:0003677
GO:0016874
GO:0031491
GO:0003700
GO:0032184
GO:0003713
GO:0004842
GO:0008270
GO:0030521
GO:0045944
GO:0045893
GO:0043161
GO:0051865
GO:0070979
GO:0070936
GO:0085020
GO:0070534
GO:0090234
GO:0090169
GO:0046685
GO:0006351
Gene3D 3.30.40.10
InterPro IPR001841
IPR013083
IPR017907
Pfam PF13639
SMART SM00184
PROSITE PS00518
PS50089

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0090234

regulation of kinetochore assembly

PMID:20212317[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090169

regulation of spindle assembly

PMID:20212317[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0085020

protein K6-linked ubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88846

P

Seeded From UniProt

complete

involved_in

GO:0070979

protein K11-linked ubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88846

P

Seeded From UniProt

complete

involved_in

GO:0070936

protein K48-linked ubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88846

P

Seeded From UniProt

complete

involved_in

GO:0070534

protein K63-linked ubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88846

P

Seeded From UniProt

complete

involved_in

GO:0051865

protein autoubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88846

P

Seeded From UniProt

complete

enables

GO:0050681

androgen receptor binding

PMID:15572661[2]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0046685

response to arsenic-containing substance

PMID:20943951[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:12885770[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88846

P

Seeded From UniProt

complete

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:20943951[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:20212317[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:18408734[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0032184

SUMO polymer binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88846

F

Seeded From UniProt

complete

enables

GO:0031491

nucleosome binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88846

F

Seeded From UniProt

complete

involved_in

GO:0030521

androgen receptor signaling pathway

PMID:15572661[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0016605

PML body

PMID:20943951[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:12885770[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:12885770[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88846

F

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

PMID:15572661[2]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88846

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1201691
PANTHER:PTN000548416
RGD:3583
UniProtKB:P78317

P

Seeded From UniProt

complete

colocalizes_with

GO:0016605

PML body

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000548419
RGD:3583
UniProtKB:P78317

C

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1201691
PANTHER:PTN000548416

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:24714598[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P78317

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9QZS2
ensembl:ENSMUSP00000138555

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9QZS2
ensembl:ENSMUSP00000138555

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9QZS2
ensembl:ENSMUSP00000138555

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9QZS2
ensembl:ENSMUSP00000138555

C

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

PMID:9710597[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0030374

nuclear receptor transcription coactivator activity

PMID:9710597[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-5684071

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0190

C

Seeded From UniProt

complete

part_of

GO:0016605

PML body

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0465

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Mukhopadhyay, D et al. (2010) The SUMO protease SENP6 is essential for inner kinetochore assembly. J. Cell Biol. 188 681-92 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Lin, DY et al. (2004) Negative modulation of androgen receptor transcriptional activity by Daxx. Mol. Cell. Biol. 24 10529-41 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Geoffroy, MC et al. (2010) Arsenic-induced SUMO-dependent recruitment of RNF4 into PML nuclear bodies. Mol. Biol. Cell 21 4227-39 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Kaiser, FJ et al. (2003) The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor. J. Biol. Chem. 278 38780-5 PubMed GONUTS page
  5. ↑ Tatham, MH et al. (2008) RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat. Cell Biol. 10 538-46 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ Groocock, LM et al. (2014) RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response. EMBO Rep. 15 601-8 PubMed GONUTS page
  8. ↑ 8.0 8.1 Moilanen, AM et al. (1998) Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription. Mol. Cell. Biol. 18 5128-39 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:RNF4&oldid=5940489"