HUMAN:LYRIC

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MTDH (synonyms: AEG1, LYRIC)
Protein Name(s)	Protein LYRIC 3D3/LYRIC Astrocyte elevated gene-1 protein AEG-1 Lysine-rich CEACAM1 co-isolated protein Metadherin Metastasis adhesion protein
External Links
UniProt	Q86UE4
EMBL	AF501310 AY082966 AF411226 AY974040 BC009324 BC014977 BC045642 AK000745
CCDS	CCDS6274.1
RefSeq	NP_848927.2
UniGene	Hs.377155
PDB	4QMG
PDBsum	4QMG
ProteinModelPortal	Q86UE4
BioGrid	124913
IntAct	Q86UE4
STRING	9606.ENSP00000338235
PhosphoSite	Q86UE4
DMDM	56749088
MaxQB	Q86UE4
PaxDb	Q86UE4
PeptideAtlas	Q86UE4
PRIDE	Q86UE4
DNASU	92140
Ensembl	ENST00000336273
GeneID	92140
KEGG	hsa:92140
UCSC	uc003yhz.3
CTD	92140
GeneCards	GC08P098658
HGNC	HGNC:29608
HPA	HPA010932 HPA015104
MIM	610323
neXtProt	NX_Q86UE4
PharmGKB	PA142671307
eggNOG	NOG45896
GeneTree	ENSGT00390000004343
HOGENOM	HOG000113417
HOVERGEN	HBG052379
InParanoid	Q86UE4
OMA	GWNEKSV
OrthoDB	EOG7XWPPV
PhylomeDB	Q86UE4
TreeFam	TF331350
ChiTaRS	MTDH
GeneWiki	MTDH
GenomeRNAi	92140
NextBio	77609
PRO	PR:Q86UE4
Proteomes	UP000005640
Bgee	Q86UE4
CleanEx	HS_MTDH
ExpressionAtlas	Q86UE4
Genevestigator	Q86UE4
GO	GO:0016324 GO:0005737 GO:0005783 GO:0005789 GO:0016021 GO:0046581 GO:0016604 GO:0031965 GO:0005730 GO:0005634 GO:0048471 GO:0005923 GO:0003725 GO:0051059 GO:0044822 GO:0001085 GO:0003713 GO:0031663 GO:0043066 GO:0000122 GO:0045766 GO:0010508 GO:0043123 GO:0051092 GO:0051897 GO:0070830

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0016055	Wnt signaling pathway	PMID:24348829^[1]	ECO:0000315			P	According to figure 2A, 2D, and 2E, silencing the aeg1 gene accounted for suppressed HepG2 proliferation and decreased colony formation when compared to the vector control. Thus, aeg-1 inhibits cell growth and promotes apoptosis in hepatoma HepG2 cells.	complete CACAO 9844
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:17704808^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:18316612^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:16452207^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	PMID:16452207^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q04206	F	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:14980505^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:15927426^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0046581	intercellular canaliculus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z1W6	C	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:19940250^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22681889^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:18316612^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:16452207^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:17704808^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	PMID:19740331^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	PMID:19648967^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z1W6	C	Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	PMID:21127263^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z1W6	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80WJ7	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:14980505^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:15927426^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19648967^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16452207^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:18316612^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:18316612^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P16220	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15927426^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000583312 UniProtKB:Q86UE4	F	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1914404 PANTHER:PTN000583310	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1921740 PANTHER:PTN000583310 UniProtKB:Q86UE4	C	Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000583310 UniProtKB:Q86UE4	F	Seeded From UniProt	complete
enables	GO:0003725	double-stranded RNA binding	PMID:21266579^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0001650	fibrillar center	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1903508	positive regulation of nucleic acid-templated transcription	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003713	P	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80WJ7 ensembl:ENSMUSP00000022865	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80WJ7 ensembl:ENSMUSP00000022865	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80WJ7 ensembl:ENSMUSP00000022865	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80WJ7 ensembl:ENSMUSP00000022865	C	Seeded From UniProt	complete
involved_in	GO:0070830	bicellular tight junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1W6 ensembl:ENSRNOP00000009989	P	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1W6 ensembl:ENSRNOP00000009989	C	Seeded From UniProt	complete
part_of	GO:0046581	intercellular canaliculus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1W6 ensembl:ENSRNOP00000009989	C	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1W6 ensembl:ENSRNOP00000009989	C	Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1W6 ensembl:ENSRNOP00000009989	C	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031402	P	Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031402	P	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031402	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0796 UniProtKB-SubCell:SL-0265	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0182	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Deng, H et al. (2014) Knockdown of astrocyte elevated gene-1 inhibits growth through suppression of IL-6 secretion in HepG2 human hepatoma cells. Oncol Lett 7 101-106 PubMed GONUTS page
↑ ^2.0 ^2.1 Lee, SG et al. (2008) Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene 27 1114-21 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Sarkar, D et al. (2008) Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. Cancer Res. 68 1478-84 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Emdad, L et al. (2006) Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. Cancer Res. 66 1509-16 PubMed GONUTS page
↑ ^5.0 ^5.1 Sutherland, HG et al. (2004) 3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus. Exp. Cell Res. 294 94-105 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Kang, DC et al. (2005) Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene 353 8-15 PubMed GONUTS page
↑ Emdad, L et al. (2009) Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 106 21300-5 PubMed GONUTS page
↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ Khuda, II et al. (2009) Astrocyte elevated gene-1 (AEG-1) is induced by lipopolysaccharide as toll-like receptor 4 (TLR4) ligand and regulates TLR4 signalling. Immunology 128 e700-6 PubMed GONUTS page
↑ ^11.0 ^11.1 Thirkettle, HJ et al. (2009) Nuclear LYRIC/AEG-1 interacts with PLZF and relieves PLZF-mediated repression. Oncogene 28 3663-70 PubMed GONUTS page
↑ Bhutia, SK et al. (2010) Astrocyte elevated gene-1 induces protective autophagy. Proc. Natl. Acad. Sci. U.S.A. 107 22243-8 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Watanabe, A et al. (2011) Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation. J. Biol. Chem. 286 10702-11 PubMed GONUTS page

[PMID:24348829-1] Deng, H et al. (2014) Knockdown of astrocyte elevated gene-1 inhibits growth through suppression of IL-6 secretion in HepG2 human hepatoma cells. Oncol Lett 7 101-106 PubMed GONUTS page

[PMID:17704808-2] 2.0 ^2.1 Lee, SG et al. (2008) Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene 27 1114-21 PubMed GONUTS page

[PMID:18316612-3] 3.0 ^3.1 ^3.2 ^3.3 Sarkar, D et al. (2008) Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. Cancer Res. 68 1478-84 PubMed GONUTS page

[PMID:16452207-4] 4.0 ^4.1 ^4.2 ^4.3 Emdad, L et al. (2006) Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. Cancer Res. 66 1509-16 PubMed GONUTS page

[PMID:14980505-5] 5.0 ^5.1 Sutherland, HG et al. (2004) 3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus. Exp. Cell Res. 294 94-105 PubMed GONUTS page

[PMID:15927426-6] 6.0 ^6.1 ^6.2 Kang, DC et al. (2005) Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene 353 8-15 PubMed GONUTS page

[PMID:19940250-7] Emdad, L et al. (2009) Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 106 21300-5 PubMed GONUTS page

[PMID:22681889-8] Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page

[PMID:22658674-9] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:19740331-10] Khuda, II et al. (2009) Astrocyte elevated gene-1 (AEG-1) is induced by lipopolysaccharide as toll-like receptor 4 (TLR4) ligand and regulates TLR4 signalling. Immunology 128 e700-6 PubMed GONUTS page

[PMID:19648967-11] 11.0 ^11.1 Thirkettle, HJ et al. (2009) Nuclear LYRIC/AEG-1 interacts with PLZF and relieves PLZF-mediated repression. Oncogene 28 3663-70 PubMed GONUTS page

[PMID:21127263-12] Bhutia, SK et al. (2010) Astrocyte elevated gene-1 induces protective autophagy. Proc. Natl. Acad. Sci. U.S.A. 107 22243-8 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21266579-14] Watanabe, A et al. (2011) Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation. J. Biol. Chem. 286 10702-11 PubMed GONUTS page

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HUMAN:LYRIC

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