CHICK:GATA3

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	GATA3
Protein Name(s)	GATA-binding factor 3 GATA-3 Transcription factor NF-E1c
External Links
UniProt	P23825
EMBL	X56931 S78787
PIR	B36389
RefSeq	NP_001008444.1
UniGene	Gga.744
ProteinModelPortal	P23825
SMR	P23825
BioGrid	680262
STRING	9031.ENSGALP00000010868
PaxDb	P23825
Ensembl	ENSGALT00000010882
GeneID	419106
KEGG	gga:419106
CTD	2625
eggNOG	COG5641
GeneTree	ENSGT00760000119221
HOGENOM	HOG000047701
HOVERGEN	HBG051705
InParanoid	P23825
KO	K17895
OMA	QRYPPTH
PhylomeDB	P23825
Reactome	REACT_286472
NextBio	20822212
PRO	PR:P23825
Proteomes	UP000000539
GO	GO:0000790 GO:0005730 GO:0005654 GO:0005634 GO:0000987 GO:0070888 GO:0001158 GO:0001078 GO:0001077 GO:0000979 GO:0003713 GO:0044212 GO:0008270 GO:0048646 GO:0003180 GO:0042491 GO:0007411 GO:0061290 GO:0003215 GO:0001709 GO:0048469 GO:0071773 GO:0035457 GO:0071353 GO:0071356 GO:0048589 GO:0043583 GO:0035162 GO:0030218 GO:0006959 GO:0042472 GO:0072643 GO:0072602 GO:0001822 GO:0002088 GO:0072676 GO:0008584 GO:0060374 GO:0060231 GO:0001823 GO:0045786 GO:2000146 GO:0008285 GO:2000607 GO:2000352 GO:0045599 GO:2000703 GO:2000734 GO:0050728 GO:0032689 GO:0032703 GO:0033600 GO:0045892 GO:0072179 GO:0072178 GO:0001764 GO:0042421 GO:0071599 GO:0060017 GO:0035898 GO:0060037 GO:0014065 GO:0010595 GO:2000667 GO:0032753 GO:2000664 GO:0051897 GO:0009967 GO:0045582 GO:2000611 GO:0045944 GO:2000679 GO:0045893 GO:0072107 GO:0009791 GO:0002572 GO:0043370 GO:2000683 GO:0042035 GO:2000114 GO:0061085 GO:0051569 GO:0072182 GO:0043523 GO:0010975 GO:0043627 GO:0009615 GO:0007165 GO:0048485 GO:0050852 GO:0045064 GO:0045061 GO:0048538 GO:0031929 GO:0035799 GO:0060676 GO:0060065 GO:0003281
Gene3D	3.30.50.10
InterPro	IPR029521 IPR016374 IPR000679 IPR013088
PANTHER	PTHR10071:SF106
Pfam	PF00320
PIRSF	PIRSF003027
PRINTS	PR00619
SMART	SM00401
PROSITE	PS00344 PS50114

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:2000734	negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:2000703	negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:2000683	regulation of cellular response to X-ray	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:2000679	positive regulation of transcription regulatory region DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:2000667	positive regulation of interleukin-13 secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:2000664	positive regulation of interleukin-5 secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:2000611	positive regulation of thyroid hormone generation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:2000607	negative regulation of cell proliferation involved in mesonephros development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:2000352	negative regulation of endothelial cell apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:2000146	negative regulation of cell motility	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0072676	lymphocyte migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0072182	regulation of nephron tubule epithelial cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0072179	nephric duct formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0072178	nephric duct morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0072107	positive regulation of ureteric bud formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	F		Seeded From UniProt	complete
involved_in	GO:0061290	canonical Wnt signaling pathway involved in metanephric kidney development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0060676	ureteric bud formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0060231	mesenchymal to epithelial transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0060065	uterus development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0048646	anatomical structure formation involved in morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0048485	sympathetic nervous system development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19924793^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:19924793^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0045582	positive regulation of T cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:19924793^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	F		Seeded From UniProt	complete
involved_in	GO:0043583	ear development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0042491	inner ear auditory receptor cell differentiation	PMID:19924793^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042421	norepinephrine biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0042035	regulation of cytokine biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0032753	positive regulation of interleukin-4 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0031929	TOR signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0009967	positive regulation of signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:19924793^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	F		Seeded From UniProt	complete
involved_in	GO:0003281	ventricular septum development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0003215	cardiac right ventricle morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0003180	aortic valve morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0001823	mesonephros development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	P		Seeded From UniProt	complete
involved_in	GO:0001709	cell fate determination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23772	P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23771	C		Seeded From UniProt	complete
involved_in	GO:0048568	embryonic organ development	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95663 PANTHER:PTN002560228 ZFIN:ZDB-GENE-990415-82	P		Seeded From UniProt	complete
involved_in	GO:0030856	regulation of epithelial cell differentiation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95663 PANTHER:PTN002560228	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003117 FB:FBgn0032223 FB:FBgn0038391 MGI:MGI:107516 MGI:MGI:109497 MGI:MGI:95661 MGI:MGI:95662 MGI:MGI:95663 MGI:MGI:95664 PANTHER:PTN001600628 PomBase:SPAC23E2.01 PomBase:SPCC1902.01 RGD:2663 RGD:2664 RGD:2665 RGD:2666 RGD:621250 SGD:S000000842 SGD:S000001742 SGD:S000001873 SGD:S000003646 UniProtKB:E1C9C6 UniProtKB:I3LUZ9 UniProtKB:P15976 UniProtKB:P17429 UniProtKB:P23769 UniProtKB:P23771 UniProtKB:P43691 UniProtKB:P43692 UniProtKB:P43694 UniProtKB:Q92908 UniProtKB:Q9BWX5 WB:WBGene00001186 WB:WBGene00001249 WB:WBGene00001250 WB:WBGene00001251 WB:WBGene00001252 WB:WBGene00001253 WB:WBGene00001310 WB:WBGene00001311 WB:WBGene00015981 ZFIN:ZDB-GENE-980526-340	C		Seeded From UniProt	complete
involved_in	GO:0002520	immune system development	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95663 PANTHER:PTN002560228	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003117 MGI:MGI:95661 MGI:MGI:95664 PANTHER:PTN001600628 RGD:2665 SGD:S000001742 SGD:S000003646 UniProtKB:P23769 UniProtKB:P43694 UniProtKB:Q92908 WB:WBGene00001249 WB:WBGene00001310	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107516 MGI:MGI:95661 MGI:MGI:95662 MGI:MGI:95663 MGI:MGI:95664 PANTHER:PTN001600628 PomBase:SPAC23E2.01 PomBase:SPCC1902.01 SGD:S000000842 UniProtKB:P15976 UniProtKB:P23771	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001227	P		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029521	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039355	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029521	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000679 InterPro:IPR013088	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000679 InterPro:IPR013088 InterPro:IPR039355	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000679	F		Seeded From UniProt	complete
involved_in	GO:0045582	positive regulation of T cell differentiation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029521	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Alvarado, DM et al. (2009) Downstream targets of GATA3 in the vestibular sensory organs of the inner ear. Dev. Dyn. 238 3093-102 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19924793-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Alvarado, DM et al. (2009) Downstream targets of GATA3 in the vestibular sensory organs of the inner ear. Dev. Dyn. 238 3093-102 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:GATA3

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