MOUSE:LPIN1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Lpin1 (synonyms: Fld)
Protein Name(s)	Phosphatidate phosphatase LPIN1 Fatty liver dystrophy protein Lipin-1
External Links
UniProt	Q91ZP3
EMBL	AF412811 AF180471 AK019539 AK014526
CCDS	CCDS25822.1 CCDS25823.1
RefSeq	NP_001123884.1 NP_056578.2 NP_766538.2 XP_006515051.1
UniGene	Mm.153625
ProteinModelPortal	Q91ZP3
BioGrid	199700
IntAct	Q91ZP3
MINT	MINT-4610704
STRING	10090.ENSMUSP00000070583
PhosphoSite	Q91ZP3
MaxQB	Q91ZP3
PaxDb	Q91ZP3
PRIDE	Q91ZP3
GeneID	14245
KEGG	mmu:14245
UCSC	uc007nbs.2
CTD	23175
MGI	MGI:1891340
eggNOG	COG5083
HOGENOM	HOG000230954
HOVERGEN	HBG052338
InParanoid	Q91ZP3
KO	K15728
PhylomeDB	Q91ZP3
TreeFam	TF314095
BRENDA	3.1.3.4
Reactome	R-MMU-1483191 R-MMU-1483213 R-MMU-4419969 R-MMU-75109
ChiTaRS	Lpin1
NextBio	285549
PRO	PR:Q91ZP3
Proteomes	UP000000589
Bgee	Q91ZP3
CleanEx	MM_LPIN1
Genevisible	Q91ZP3
GO	GO:0005737 GO:0005789 GO:0005741 GO:0031965 GO:0005634 GO:0005667 GO:0042826 GO:0042975 GO:0008195 GO:0001085 GO:0003713 GO:0031532 GO:0032869 GO:0016311 GO:0045444 GO:0009062 GO:0006629 GO:0000266 GO:0000122 GO:0031065 GO:0045944 GO:0045598 GO:1903506 GO:0031529 GO:0006351 GO:0019432 GO:0006642
Gene3D	3.40.50.1000
InterPro	IPR023214 IPR007651 IPR013209 IPR031315 IPR028794
PANTHER	PTHR12181:SF10
Pfam	PF04571 PF08235
SMART	SM00775
SUPFAM	SSF56784

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005783	endoplasmic reticulum	PMID:26475860^[1]	ECO:0000314			C		Figure 6b,e and f	complete CACAO 11041
	GO:0005634	nucleus	PMID:26475860^[1]	ECO:0000314			C		Figure 5b	complete CACAO 11042
	GO:0005737	cytoplasm	PMID:26475860^[1]	ECO:0000314			C		Figure 5b	complete CACAO 11043
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:23028044^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045444	fat cell differentiation	PMID:11138012^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11138012^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1891340 MGI:MGI:1891341 PANTHER:PTN000953144	P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0263593 MGI:MGI:1891340 PANTHER:PTN000953144 RGD:1307646	P		Seeded From UniProt	complete
involved_in	GO:0019432	triglyceride biosynthetic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0263593 PANTHER:PTN000256565 SGD:S000004775	P		Seeded From UniProt	complete
involved_in	GO:0009062	fatty acid catabolic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1891340 PANTHER:PTN000256565	P		Seeded From UniProt	complete
enables	GO:0008195	phosphatidate phosphatase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0263593 MGI:MGI:1891340 MGI:MGI:1891341 MGI:MGI:1891342 PANTHER:PTN000256564 SGD:S000004775 TAIR:locus:2075019 UniProtKB:Q14693 UniProtKB:Q92539 UniProtKB:Q9BQK8 UniProtKB:Q9FMN2	F		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1891340 PANTHER:PTN000256572	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0263593 MGI:MGI:1891340 PANTHER:PTN000256565	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1891340 MGI:MGI:1891341 PANTHER:PTN000953144	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20385772^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104740	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045598	regulation of fat cell differentiation	PMID:11138012^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856603 MGI:MGI:1857584	P	occurs_in:(EMAPA:35112) results_in_acquisition_of_features_of:(CL:0000136)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044255	cellular lipid metabolic process	PMID:22337502^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3799353	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:20385772^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032869	cellular response to insulin stimulus	PMID:10438476^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856603	P	occurs_in:(EMAPA:36555) occurs_in:(CL:0000136)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032869	cellular response to insulin stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307646	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031532	actin cytoskeleton reorganization	PMID:10438476^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856603	P	occurs_in:(EMAPA:36555) occurs_in:(CL:0000136)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031529	ruffle organization	PMID:10438476^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856603	P	occurs_in:(EMAPA:36555) occurs_in:(CL:0000136)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031065	positive regulation of histone deacetylation	PMID:20385772^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008195	phosphatidate phosphatase activity	PMID:17158099^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006955	immune response	PMID:22337502^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3799353	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006629	lipid metabolic process	PMID:2722772^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856603	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006629	lipid metabolic process	PMID:14522948^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856603	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:20385772^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20385772^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11138012^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:20385772^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20385772^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1920431	P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008195	P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008195	P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008195	P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008195	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028794	P		Seeded From UniProt	complete
enables	GO:0008195	phosphatidate phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028794	F		Seeded From UniProt	complete
involved_in	GO:0009062	fatty acid catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028794	P		Seeded From UniProt	complete
involved_in	GO:0019432	triglyceride biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028794	P		Seeded From UniProt	complete
enables	GO:0008195	phosphatidate phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.4	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16950137^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042975	peroxisome proliferator activated receptor binding	PMID:16950137^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P23204	F		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	PMID:22134922^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0009062	fatty acid catabolic process	PMID:16950137^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008195	phosphatidate phosphatase activity	PMID:21397848^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006642	triglyceride mobilization	PMID:16950137^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:21397848^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22134922^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21397848^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19753306^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:16950137^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	PMID:21397848^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008195	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19753306^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19753306^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:19753306^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1903508	positive regulation of nucleic acid-templated transcription	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003713	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0182	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Cardozo Gizzi, AM et al. (2015) The Catalytic Efficiency of Lipin 1β Increases by Physically Interacting with the Proto-oncoprotein c-Fos. J. Biol. Chem. 290 29578-92 PubMed GONUTS page
↑ Nadra, K et al. (2012) Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue. Mol. Cell. Biol. 32 4794-810 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Péterfy, M et al. (2001) Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat. Genet. 27 121-4 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Kim, HB et al. (2010) Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. Mol. Cell. Biol. 30 3126-39 PubMed GONUTS page
↑ ^6.0 ^6.1 Verdier, V et al. (2012) Aging of myelinating glial cells predominantly affects lipid metabolism and immune response pathways. Glia 60 751-60 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Klingenspor, M et al. (1999) Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics. J. Biol. Chem. 274 23078-84 PubMed GONUTS page
↑ Donkor, J et al. (2007) Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. J. Biol. Chem. 282 3450-7 PubMed GONUTS page
↑ Langner, CA et al. (1989) The fatty liver dystrophy (fld) mutation. A new mutant mouse with a developmental abnormality in triglyceride metabolism and associated tissue-specific defects in lipoprotein lipase and hepatic lipase activities. J. Biol. Chem. 264 7994-8003 PubMed GONUTS page
↑ Verheijen, MH et al. (2003) Local regulation of fat metabolism in peripheral nerves. Genes Dev. 17 2450-64 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Finck, BN et al. (2006) Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab. 4 199-210 PubMed GONUTS page
↑ ^12.0 ^12.1 Han, S et al. (2012) Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway. J. Biol. Chem. 287 3123-37 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Huang, H et al. (2011) piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling. Dev. Cell 20 376-87 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Liu, GH & Gerace, L (2009) Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells. PLoS ONE 4 e7031 PubMed GONUTS page

[PMID:26475860-1] 1.0 ^1.1 ^1.2 Cardozo Gizzi, AM et al. (2015) The Catalytic Efficiency of Lipin 1β Increases by Physically Interacting with the Proto-oncoprotein c-Fos. J. Biol. Chem. 290 29578-92 PubMed GONUTS page

[PMID:23028044-2] Nadra, K et al. (2012) Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue. Mol. Cell. Biol. 32 4794-810 PubMed GONUTS page

[PMID:11138012-3] 3.0 ^3.1 ^3.2 ^3.3 Péterfy, M et al. (2001) Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat. Genet. 27 121-4 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20385772-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Kim, HB et al. (2010) Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. Mol. Cell. Biol. 30 3126-39 PubMed GONUTS page

[PMID:22337502-6] 6.0 ^6.1 Verdier, V et al. (2012) Aging of myelinating glial cells predominantly affects lipid metabolism and immune response pathways. Glia 60 751-60 PubMed GONUTS page

[PMID:10438476-7] 7.0 ^7.1 ^7.2 Klingenspor, M et al. (1999) Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics. J. Biol. Chem. 274 23078-84 PubMed GONUTS page

[PMID:17158099-8] Donkor, J et al. (2007) Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. J. Biol. Chem. 282 3450-7 PubMed GONUTS page

[PMID:2722772-9] Langner, CA et al. (1989) The fatty liver dystrophy (fld) mutation. A new mutant mouse with a developmental abnormality in triglyceride metabolism and associated tissue-specific defects in lipoprotein lipase and hepatic lipase activities. J. Biol. Chem. 264 7994-8003 PubMed GONUTS page

[PMID:14522948-10] Verheijen, MH et al. (2003) Local regulation of fat metabolism in peripheral nerves. Genes Dev. 17 2450-64 PubMed GONUTS page

[PMID:16950137-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Finck, BN et al. (2006) Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab. 4 199-210 PubMed GONUTS page

[PMID:22134922-12] 12.0 ^12.1 Han, S et al. (2012) Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway. J. Biol. Chem. 287 3123-37 PubMed GONUTS page

[PMID:21397848-13] 13.0 ^13.1 ^13.2 ^13.3 Huang, H et al. (2011) piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling. Dev. Cell 20 376-87 PubMed GONUTS page

[PMID:19753306-14] 14.0 ^14.1 ^14.2 ^14.3 Liu, GH & Gerace, L (2009) Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells. PLoS ONE 4 e7031 PubMed GONUTS page

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MOUSE:LPIN1

Contents

Annotations

Notes

References

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