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HUMAN:ABL1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ABL1 (synonyms: ABL, JTK7)
Protein Name(s) Tyrosine-protein kinase ABL1

Abelson murine leukemia viral oncogene homolog 1 Abelson tyrosine-protein kinase 1 Proto-oncogene c-Abl p150

External Links
UniProt P00519
EMBL M14752
X16416
U07563
U07563
U07561
DQ145721
AL359092
AL161733
AL161733
AL161733
AL359092
CH471090
BC117451
S69223
CCDS CCDS35165.1
CCDS35166.1
PIR S08519
RefSeq NP_005148.2
NP_009297.2
UniGene Hs.431048
PDB 1AB2
1ABL
1AWO
1BBZ
1JU5
1OPL
1ZZP
2ABL
2E2B
2F4J
2FO0
2G1T
2G2F
2G2H
2G2I
2GQG
2HIW
2HYY
2HZ0
2HZ4
2HZI
2O88
2V7A
3CS9
3EG0
3EG1
3EG2
3EG3
3EGU
3K2M
3PYY
3QRI
3QRJ
3QRK
3T04
3UE4
3UYO
4J9B
4J9C
4J9D
4J9E
4J9F
4J9G
4J9H
4J9I
4JJB
4JJC
4JJD
PDBsum 1AB2
1ABL
1AWO
1BBZ
1JU5
1OPL
1ZZP
2ABL
2E2B
2F4J
2FO0
2G1T
2G2F
2G2H
2G2I
2GQG
2HIW
2HYY
2HZ0
2HZ4
2HZI
2O88
2V7A
3CS9
3EG0
3EG1
3EG2
3EG3
3EGU
3K2M
3PYY
3QRI
3QRJ
3QRK
3T04
3UE4
3UYO
4J9B
4J9C
4J9D
4J9E
4J9F
4J9G
4J9H
4J9I
4JJB
4JJC
4JJD
ProteinModelPortal P00519
SMR P00519
BioGrid 106543
DIP DIP-1042N
IntAct P00519
MINT MINT-7236141
STRING 9606.ENSP00000361423
BindingDB P00519
ChEMBL CHEMBL2111414
DrugBank DB00171
DB06616
DB01254
DB00619
DB04868
DB08901
DB08896
GuidetoPHARMACOLOGY 1923
PhosphoSite P00519
DMDM 85681908
MaxQB P00519
PaxDb P00519
PRIDE P00519
DNASU 25
Ensembl ENST00000318560
ENST00000372348
GeneID 25
KEGG hsa:25
UCSC uc004bzv.3
uc004bzw.3
CTD 25
GeneCards GC09P133589
HGNC HGNC:76
HPA CAB002686
HPA027251
HPA027280
HPA028409
MIM 189980
608232
neXtProt NX_P00519
Orphanet 521
99860
99861
PharmGKB PA24413
eggNOG COG0515
GeneTree ENSGT00760000118938
HOVERGEN HBG004162
InParanoid P00519
KO K06619
OMA GAFRESG
OrthoDB EOG7GTT2V
PhylomeDB P00519
TreeFam TF105081
BRENDA 2.7.10.2
Reactome REACT_160086
REACT_19230
REACT_21402
REACT_24970
SignaLink P00519
ChiTaRS ABL1
EvolutionaryTrace P00519
GeneWiki ABL_(gene)
GenomeRNAi 25
NextBio 79
PMAP-CutDB P00519
PRO PR:P00519
Proteomes UP000005640
Bgee P00519
CleanEx HS_ABL1
ExpressionAtlas P00519
Genevestigator P00519
GO GO:0015629
GO:0031252
GO:0005737
GO:0005829
GO:0005739
GO:0031965
GO:0005730
GO:0005634
GO:0048471
GO:0003785
GO:0005524
GO:0003677
GO:0000287
GO:0030145
GO:0051019
GO:0004515
GO:0004715
GO:0070064
GO:0008022
GO:0004672
GO:0004713
GO:0017124
GO:0019905
GO:0030036
GO:0006914
GO:0007411
GO:0007596
GO:0007155
GO:0007050
GO:0006464
GO:0006974
GO:1903351
GO:0034599
GO:0006975
GO:0038096
GO:0045087
GO:0008630
GO:0006298
GO:0051882
GO:0007067
GO:0042692
GO:1900275
GO:0071901
GO:0051444
GO:0018108
GO:0048008
GO:0043065
GO:0007204
GO:0051149
GO:0051353
GO:0050731
GO:2000249
GO:0010506
GO:0030155
GO:2000145
GO:0030100
GO:2001020
GO:0006355
GO:0006979
GO:0042770
Gene3D 3.30.505.10
InterPro IPR015015
IPR011009
IPR000719
IPR017441
IPR001245
IPR000980
IPR001452
IPR008266
IPR020635
Pfam PF08919
PF07714
PF00017
PF00018
PRINTS PR00401
PR00109
SMART SM00808
SM00252
SM00326
SM00219
SUPFAM SSF50044
SSF55550
SSF56112
PROSITE PS00107
PS50011
PS00109
PS50001
PS50002

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0071901

negative regulation of protein serine/threonine kinase activity

PMID 11121037

ECO:0000314

P

Figure 4 c and d

Missing: reference

GO:0004713

protein tyrosine kinase activity

PMID 11121037

ECO:0000314

F

Figure 5 b lane 3 compared to lane 1

Missing: reference

NOT|enables

GO:0097100

supercoiled DNA binding

PMID:9558345[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0071103

DNA conformation change

PMID:9558345[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:1990837

sequence-specific double-stranded DNA binding

PMID:9558345[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000400

four-way junction DNA binding

PMID:9558345[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000405

bubble DNA binding

PMID:9558345[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045580

regulation of T cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00520

P

Seeded From UniProt

complete

involved_in

GO:0051496

positive regulation of stress fiber assembly

PMID:24863063[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1900026

positive regulation of substrate adhesion-dependent cell spreading

PMID:24863063[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000251

positive regulation of actin cytoskeleton reorganization

PMID:24863063[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0038189

neuropilin signaling pathway

PMID:24863063[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051894

positive regulation of focal adhesion assembly

PMID:24863063[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010595

positive regulation of endothelial cell migration

PMID:24863063[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0043065

positive regulation of apoptosis

PMID:9037071[3]

ECO:0000314

P

Figures 1,3,4: Activation of c-Abl protein tyrosine kinase regulates DNA damage-induced apoptosis; an overexpression shows a significant difference in number of dead cells.

complete
CACAO 3588

enables

GO:0004715

non-membrane spanning protein tyrosine kinase activity

PMID:28428613[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

PMID:28428613[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q9BZL6)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:9168116[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:24863063[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

PMID:28288113[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043542

endothelial cell migration

PMID:24863063[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0038191

neuropilin binding

PMID:24863063[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O14786

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:17515907[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:12384576[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P46108

C

Seeded From UniProt

complete

enables

GO:0042169

SH2 domain binding

PMID:12384576[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P46108

F

Seeded From UniProt

complete

involved_in

GO:1900272

negative regulation of long-term synaptic potentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00520

P

regulates_o_occurs_in:(UBERON:0003881)

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:E9PT20

C

part_of:(CL:0002608)

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:E9PT20

C

part_of:(CL:0002608)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:E9PT20

C

part_of:(CL:0002608)

Seeded From UniProt

complete

enables

GO:0046875

ephrin receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00520

F

occurs_in:(CL:0002608)

Seeded From UniProt

complete

involved_in

GO:1905244

regulation of modification of synaptic structure

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00520

P

  • regulates_o_occurs_in:(CL:0002608)
  • causally_upstream_of:(GO:1900271)
  • regulates_o_occurs_in:(GO:0043197)

Seeded From UniProt

complete

involved_in

GO:1905244

regulation of modification of synaptic structure

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:E9PT20

P

  • regulates_o_occurs_in:(CL:0002608)
  • causally_upstream_of:(GO:1900271)
  • regulates_o_occurs_in:(GO:0043197)

Seeded From UniProt

complete

involved_in

GO:0038083

peptidyl-tyrosine autophosphorylation

PMID:10518561[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0038083

peptidyl-tyrosine autophosphorylation

PMID:24520051[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

happens_during:(GO:0035791)

Seeded From UniProt

complete

involved_in

GO:0035791

platelet-derived growth factor receptor-beta signaling pathway

PMID:24520051[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

causally_upstream_of:(GO:0038083)

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:24520051[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

PMID:24520051[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030516

regulation of axon extension

PMID:24520051[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032956

regulation of actin cytoskeleton organization

PMID:24520051[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031113

regulation of microtubule polymerization

PMID:24520051[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045184

establishment of protein localization

PMID:24520051[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1904531

positive regulation of actin filament binding

PMID:24520051[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:O75122)

Seeded From UniProt

complete

involved_in

GO:1904528

positive regulation of microtubule binding

PMID:24520051[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:O75122)

Seeded From UniProt

complete

involved_in

GO:0001934

positive regulation of protein phosphorylation

PMID:24700464[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_direct_input:(UniProtKB:Q14247)

Seeded From UniProt

complete

involved_in

GO:1990051

activation of protein kinase C activity

PMID:10713049[12]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q05655)

Seeded From UniProt

complete

involved_in

GO:0070301

cellular response to hydrogen peroxide

PMID:10713049[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046777

protein autophosphorylation

PMID:10713049[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

PMID:10713049[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005080

protein kinase C binding

PMID:10713049[12]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q05655

F

part_of:(GO:0070301)

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:24522549[13]

ECO:0000303

author statement without traceable support used in manual assertion

C

exists_during:(GO:0034599)

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:9037071[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0001784

phosphotyrosine residue binding

PMID:20624904[14]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q6GX35

F

Seeded From UniProt

complete

enables

GO:0001784

phosphotyrosine residue binding

PMID:20624904[14]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O84462

F

Seeded From UniProt

complete

involved_in

GO:0071901

negative regulation of protein serine/threonine kinase activity

PMID:11121037[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051353

positive regulation of oxidoreductase activity

PMID:12893824[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051019

mitogen-activated protein kinase binding

PMID:11121037[15]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13177

F

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

PMID:11121037[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:11121037[15]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0032489

regulation of Cdc42 protein signal transduction

PMID:26051942[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:24863063[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007229

integrin-mediated signaling pathway

PMID:24863063[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2001020

regulation of response to DNA damage stimulus

PMID:9461559[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070064

proline-rich region binding

PMID:7590236[19]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9NYB9

F

Seeded From UniProt

complete

enables

GO:0070064

proline-rich region binding

PMID:15657060[20]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

PMID:15657060[20]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:17888034[21]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:9037071[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042770

signal transduction in response to DNA damage

PMID:15657060[20]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042770

signal transduction in response to DNA damage

PMID:9037071[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030145

manganese ion binding

PMID:9144171[22]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0030036

actin cytoskeleton organization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00520

P

Seeded From UniProt

complete

enables

GO:0019905

syntaxin binding

PMID:23006999[23]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9Z158

F

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

PMID:7590236[19]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

PMID:9144171[22]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0017124

SH3 domain binding

PMID:7590236[19]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9NYB9

F

Seeded From UniProt

complete

enables

GO:0008022

protein C-terminus binding

PMID:11971963[24]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99638

F

Seeded From UniProt

complete

involved_in

GO:0006975

DNA damage induced protein phosphorylation

PMID:18280240[25]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:15657060[20]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006464

cellular protein modification process

PMID:8242749[26]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17888034[21]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:8242749[26]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:9144171[22]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004715

non-membrane spanning protein tyrosine kinase activity

PMID:9461559[18]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:15657060[20]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:7590236[19]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:17888034[21]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:9144171[22]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:8242749[26]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

PMID:9144171[22]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042127

regulation of cell population proliferation

PMID:21873635[27]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:87859
PANTHER:PTN001975310
UniProtKB:Q05397

P

Seeded From UniProt

complete

involved_in

GO:0038083

peptidyl-tyrosine autophosphorylation

PMID:21873635[27]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95481
PANTHER:PTN001975310
RGD:628758
UniProtKB:P00519
UniProtKB:Q14289

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:21873635[27]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001975310
RGD:628758

P

Seeded From UniProt

complete

enables

GO:0004715

non-membrane spanning protein tyrosine kinase activity

PMID:21873635[27]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000017
MGI:MGI:104908
MGI:MGI:1930958
MGI:MGI:95481
PANTHER:PTN001975310
UniProtKB:P00519
UniProtKB:Q05397
UniProtKB:Q14289
WB:WBGene00002213

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:15657136[28]

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1900275

negative regulation of phospholipase C activity

PMID:24367707[29]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051444

negative regulation of ubiquitin-protein transferase activity

PMID:20823226[30]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:24367707[29]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

PMID:17626041[31]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q03468

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:11120811[32]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:17626041[31]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:12944467[33]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17626041[31]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:20823226[30]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:12944467[33]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:11120811[32]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016604

nuclear body

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:2000773

negative regulation of cellular senescence

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:2000772

regulation of cellular senescence

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:2000352

negative regulation of endothelial cell apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:2000096

positive regulation of Wnt signaling pathway, planar cell polarity pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:1905555

positive regulation blood vessel branching

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:1905244

regulation of modification of synaptic structure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:1903053

regulation of extracellular matrix organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:1902715

positive regulation of interferon-gamma secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:1901216

positive regulation of neuron death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:1900272

negative regulation of long-term synaptic potentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:1900042

positive regulation of interleukin-2 secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0090135

actin filament branching

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0090050

positive regulation of cell migration involved in sprouting angiogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0072358

cardiovascular system development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0071222

cellular response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0070373

negative regulation of ERK1 and ERK2 cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0060563

neuroepithelial cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0060020

Bergmann glial cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0051726

regulation of cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

enables

GO:0051015

actin filament binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

F

Seeded From UniProt

complete

involved_in

GO:0050885

neuromuscular process controlling balance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0050853

B cell receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0050852

T cell receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0050798

activated T cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0048668

collateral sprouting

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0048538

thymus development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0048536

spleen development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0048008

platelet-derived growth factor receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

enables

GO:0046875

ephrin receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

F

Seeded From UniProt

complete

involved_in

GO:0046632

alpha-beta T cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0045931

positive regulation of mitotic cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0045930

negative regulation of mitotic cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0045580

regulation of T cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0042127

regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0042100

B cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

enables

GO:0038191

neuropilin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

F

Seeded From UniProt

complete

involved_in

GO:0034446

substrate adhesion-dependent cell spreading

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0033690

positive regulation of osteoblast proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0032956

regulation of actin cytoskeleton organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

part_of

GO:0031252

cell leading edge

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

C

Seeded From UniProt

complete

involved_in

GO:0030514

negative regulation of BMP signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

enables

GO:0030145

manganese ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

F

Seeded From UniProt

complete

involved_in

GO:0030036

actin cytoskeleton organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0030035

microspike assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0022408

negative regulation of cell-cell adhesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0021587

cerebellum morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

F

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

F

Seeded From UniProt

complete

part_of

GO:0015629

actin cytoskeleton

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

C

Seeded From UniProt

complete

involved_in

GO:0009791

post-embryonic development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0007173

epidermal growth factor receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0006909

phagocytosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

F

Seeded From UniProt

complete

involved_in

GO:0002333

transitional one stage B cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0002322

B cell proliferation involved in immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0001922

B-1 B cell homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

involved_in

GO:0001843

neural tube closure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

P

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00520
ensembl:ENSMUSP00000075167

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020635
InterPro:IPR033221

F

Seeded From UniProt

complete

enables

GO:0004715

non-membrane spanning protein tyrosine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015015

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR015015
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266
InterPro:IPR015015
InterPro:IPR020635

P

Seeded From UniProt

complete

enables

GO:0004715

non-membrane spanning protein tyrosine kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.10.2

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:15865930[34]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

PMID:15865930[34]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0098794

postsynapse

PMID:24658113[35]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051444

negative regulation of ubiquitin-protein transferase activity

PMID:23626584[36]
PMID:24522549[13]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

has_regulation_target:(UniProtKB:O60260)

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

PMID:23626584[36]
PMID:24522549[13]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0000278

mitotic cell cycle

PMID:24522549[13]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

occurs_in:(GO:0005737)

Seeded From UniProt

complete

involved_in

GO:0007050

cell cycle arrest

PMID:24522549[13]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

occurs_in:(GO:0005634)

Seeded From UniProt

complete

involved_in

GO:0051882

mitochondrial depolarization

PMID:24522549[13]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

occurs_in:(GO:0005739)

Seeded From UniProt

complete

involved_in

GO:0034599

cellular response to oxidative stress

PMID:24522549[13]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903351

cellular response to dopamine

PMID:24522549[13]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:10391249[37]
PMID:20841568[38]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:8242749[26]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

PMID:10391249[37]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:10391249[37]
Reactome:R-HSA-8956659
Reactome:R-HSA-5686587
Reactome:R-HSA-428888

ECO:0000304

author statement supported by traceable reference used in manual assertion




F

Seeded From UniProt

complete

involved_in

GO:2000249

regulation of actin cytoskeleton reorganization

PMID:20841568[38]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000145

regulation of cell motility

PMID:20841568[38]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030155

regulation of cell adhesion

PMID:20841568[38]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030100

regulation of endocytosis

PMID:20841568[38]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0015629

actin cytoskeleton

PMID:20841568[38]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010506

regulation of autophagy

PMID:20841568[38]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:20841568[38]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:20841568[38]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004515

nicotinate-nucleotide adenylyltransferase activity

PMID:20841568[38]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003785

actin monomer binding

PMID:20841568[38]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1902036

regulation of hematopoietic stem cell differentiation

Reactome:R-HSA-8939236

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051149

positive regulation of muscle cell differentiation

Reactome:R-HSA-375170

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0038096

Fc-gamma receptor signaling pathway involved in phagocytosis

Reactome:R-HSA-2029480

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-448958
Reactome:R-HSA-428888
Reactome:R-HSA-376141
Reactome:R-HSA-2130194

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8956659
Reactome:R-HSA-5686587
Reactome:R-HSA-5686578

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

involved_in

GO:0006897

endocytosis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0254

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0829

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0072

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

part_of

GO:0031965

nuclear membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0182

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

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  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 Raimondi, C et al. (2014) Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. J. Exp. Med. 211 1167-83 PubMed GONUTS page
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  5. Baskaran, R et al. (1997) Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature 387 516-9 PubMed GONUTS page
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  7. Kobashigawa, Y et al. (2007) Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. Nat. Struct. Mol. Biol. 14 503-10 PubMed GONUTS page
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  9. Ohya, K et al. (1999) Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. Proc. Natl. Acad. Sci. U.S.A. 96 11976-81 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 10.4 10.5 10.6 10.7 10.8 10.9 Engel, U et al. (2014) Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin. Cytoskeleton (Hoboken) 71 195-209 PubMed GONUTS page
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