HUMAN:ABL1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ABL1 (synonyms: ABL, JTK7)
Protein Name(s)	Tyrosine-protein kinase ABL1 Abelson murine leukemia viral oncogene homolog 1 Abelson tyrosine-protein kinase 1 Proto-oncogene c-Abl p150
External Links
UniProt	P00519
EMBL	M14752 X16416 U07563 U07563 U07561 DQ145721 AL359092 AL161733 AL161733 AL161733 AL359092 CH471090 BC117451 S69223
CCDS	CCDS35165.1 CCDS35166.1
PIR	S08519
RefSeq	NP_005148.2 NP_009297.2
UniGene	Hs.431048
PDB	1AB2 1ABL 1AWO 1BBZ 1JU5 1OPL 1ZZP 2ABL 2E2B 2F4J 2FO0 2G1T 2G2F 2G2H 2G2I 2GQG 2HIW 2HYY 2HZ0 2HZ4 2HZI 2O88 2V7A 3CS9 3EG0 3EG1 3EG2 3EG3 3EGU 3K2M 3PYY 3QRI 3QRJ 3QRK 3T04 3UE4 3UYO 4J9B 4J9C 4J9D 4J9E 4J9F 4J9G 4J9H 4J9I 4JJB 4JJC 4JJD
PDBsum	1AB2 1ABL 1AWO 1BBZ 1JU5 1OPL 1ZZP 2ABL 2E2B 2F4J 2FO0 2G1T 2G2F 2G2H 2G2I 2GQG 2HIW 2HYY 2HZ0 2HZ4 2HZI 2O88 2V7A 3CS9 3EG0 3EG1 3EG2 3EG3 3EGU 3K2M 3PYY 3QRI 3QRJ 3QRK 3T04 3UE4 3UYO 4J9B 4J9C 4J9D 4J9E 4J9F 4J9G 4J9H 4J9I 4JJB 4JJC 4JJD
ProteinModelPortal	P00519
SMR	P00519
BioGrid	106543
DIP	DIP-1042N
IntAct	P00519
MINT	MINT-7236141
STRING	9606.ENSP00000361423
BindingDB	P00519
ChEMBL	CHEMBL2111414
DrugBank	DB00171 DB06616 DB01254 DB00619 DB04868 DB08901 DB08896
GuidetoPHARMACOLOGY	1923
PhosphoSite	P00519
DMDM	85681908
MaxQB	P00519
PaxDb	P00519
PRIDE	P00519
DNASU	25
Ensembl	ENST00000318560 ENST00000372348
GeneID	25
KEGG	hsa:25
UCSC	uc004bzv.3 uc004bzw.3
CTD	25
GeneCards	GC09P133589
HGNC	HGNC:76
HPA	CAB002686 HPA027251 HPA027280 HPA028409
MIM	189980 608232
neXtProt	NX_P00519
Orphanet	521 99860 99861
PharmGKB	PA24413
eggNOG	COG0515
GeneTree	ENSGT00760000118938
HOVERGEN	HBG004162
InParanoid	P00519
KO	K06619
OMA	GAFRESG
OrthoDB	EOG7GTT2V
PhylomeDB	P00519
TreeFam	TF105081
BRENDA	2.7.10.2
Reactome	REACT_160086 REACT_19230 REACT_21402 REACT_24970
SignaLink	P00519
ChiTaRS	ABL1
EvolutionaryTrace	P00519
GeneWiki	ABL_(gene)
GenomeRNAi	25
NextBio	79
PMAP-CutDB	P00519
PRO	PR:P00519
Proteomes	UP000005640
Bgee	P00519
CleanEx	HS_ABL1
ExpressionAtlas	P00519
Genevestigator	P00519
GO	GO:0015629 GO:0031252 GO:0005737 GO:0005829 GO:0005739 GO:0031965 GO:0005730 GO:0005634 GO:0048471 GO:0003785 GO:0005524 GO:0003677 GO:0000287 GO:0030145 GO:0051019 GO:0004515 GO:0004715 GO:0070064 GO:0008022 GO:0004672 GO:0004713 GO:0017124 GO:0019905 GO:0030036 GO:0006914 GO:0007411 GO:0007596 GO:0007155 GO:0007050 GO:0006464 GO:0006974 GO:1903351 GO:0034599 GO:0006975 GO:0038096 GO:0045087 GO:0008630 GO:0006298 GO:0051882 GO:0007067 GO:0042692 GO:1900275 GO:0071901 GO:0051444 GO:0018108 GO:0048008 GO:0043065 GO:0007204 GO:0051149 GO:0051353 GO:0050731 GO:2000249 GO:0010506 GO:0030155 GO:2000145 GO:0030100 GO:2001020 GO:0006355 GO:0006979 GO:0042770
Gene3D	3.30.505.10
InterPro	IPR015015 IPR011009 IPR000719 IPR017441 IPR001245 IPR000980 IPR001452 IPR008266 IPR020635
Pfam	PF08919 PF07714 PF00017 PF00018
PRINTS	PR00401 PR00109
SMART	SM00808 SM00252 SM00326 SM00219
SUPFAM	SSF50044 SSF55550 SSF56112
PROSITE	PS00107 PS50011 PS00109 PS50001 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0071901	negative regulation of protein serine/threonine kinase activity	PMID 11121037	ECO:0000314			P		Figure 4 c and d	Missing: reference
	GO:0004713	protein tyrosine kinase activity	PMID 11121037	ECO:0000314			F		Figure 5 b lane 3 compared to lane 1	Missing: reference
NOT\|enables	GO:0097100	supercoiled DNA binding	PMID:9558345^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071103	DNA conformation change	PMID:9558345^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:1990837	sequence-specific double-stranded DNA binding	PMID:9558345^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000400	four-way junction DNA binding	PMID:9558345^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000405	bubble DNA binding	PMID:9558345^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045580	regulation of T cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00520	P		Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	PMID:24863063^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	PMID:24863063^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000251	positive regulation of actin cytoskeleton reorganization	PMID:24863063^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038189	neuropilin signaling pathway	PMID:24863063^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051894	positive regulation of focal adhesion assembly	PMID:24863063^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	PMID:24863063^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0043065	positive regulation of apoptosis	PMID:9037071^[3]	ECO:0000314			P		Figures 1,3,4: Activation of c-Abl protein tyrosine kinase regulates DNA damage-induced apoptosis; an overexpression shows a significant difference in number of dead cells.	complete CACAO 3588
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:28428613^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:28428613^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9BZL6)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9168116^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:24863063^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	part_of:(GO:0007229) part_of:(GO:0038189) occurs_in:(CL:0000115) causally_upstream_of:(GO:0043542) has_input:(UniProtKB:P49023)	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:28288113^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043542	endothelial cell migration	PMID:24863063^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0038191	neuropilin binding	PMID:24863063^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14786	F	part_of:(GO:0007229) part_of:(GO:0038189) occurs_in:(CL:0000115)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17515907^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:12384576^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P46108	C		Seeded From UniProt	complete
enables	GO:0042169	SH2 domain binding	PMID:12384576^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P46108	F		Seeded From UniProt	complete
involved_in	GO:1900272	negative regulation of long-term synaptic potentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00520	P	regulates_o_occurs_in:(UBERON:0003881)	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9PT20	C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9PT20	C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9PT20	C	part_of:(CL:0002608)	Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00520	F	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:1905244	regulation of modification of synaptic structure	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00520	P	regulates_o_occurs_in:(CL:0002608) causally_upstream_of:(GO:1900271) regulates_o_occurs_in:(GO:0043197)	Seeded From UniProt	complete
involved_in	GO:1905244	regulation of modification of synaptic structure	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9PT20	P	regulates_o_occurs_in:(CL:0002608) causally_upstream_of:(GO:1900271) regulates_o_occurs_in:(GO:0043197)	Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:10518561^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:24520051^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0035791)	Seeded From UniProt	complete
involved_in	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	PMID:24520051^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	causally_upstream_of:(GO:0038083)	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:24520051^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(UniProtKB:O75122-1) happens_during:(GO:0035791) has_direct_input:(UniProtKB:O75122-3)	Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:24520051^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:O75122) happens_during:(GO:0035791)	Seeded From UniProt	complete
involved_in	GO:0030516	regulation of axon extension	PMID:24520051^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O75122) occurs_in:(GO:0044295)	Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	PMID:24520051^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O75122) occurs_in:(GO:0044295)	Seeded From UniProt	complete
involved_in	GO:0031113	regulation of microtubule polymerization	PMID:24520051^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O75122) occurs_in:(GO:0044295)	Seeded From UniProt	complete
involved_in	GO:0045184	establishment of protein localization	PMID:24520051^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O75122) occurs_at:(GO:1903754)	Seeded From UniProt	complete
involved_in	GO:1904531	positive regulation of actin filament binding	PMID:24520051^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O75122)	Seeded From UniProt	complete
involved_in	GO:1904528	positive regulation of microtubule binding	PMID:24520051^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O75122)	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:24700464^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q14247)	Seeded From UniProt	complete
involved_in	GO:1990051	activation of protein kinase C activity	PMID:10713049^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q05655)	Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	PMID:10713049^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:10713049^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:10713049^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q05655) part_of:(GO:0070301) part_of:(GO:1900020)	Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	PMID:10713049^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q05655	F	part_of:(GO:0070301)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:24522549^[13]	ECO:0000303	author statement without traceable support used in manual assertion		C	exists_during:(GO:0034599)	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:9037071^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	PMID:20624904^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q6GX35	F		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	PMID:20624904^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O84462	F		Seeded From UniProt	complete
involved_in	GO:0071901	negative regulation of protein serine/threonine kinase activity	PMID:11121037^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051353	positive regulation of oxidoreductase activity	PMID:12893824^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051019	mitogen-activated protein kinase binding	PMID:11121037^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13177	F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:11121037^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:11121037^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032489	regulation of Cdc42 protein signal transduction	PMID:26051942^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0038189) part_of:(GO:0007229)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:24863063^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0007229) part_of:(GO:0038189) occurs_in:(CL:0000115) causally_upstream_of:(GO:0043542) has_direct_input:(UniProtKB:P49023)	Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	PMID:24863063^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001020	regulation of response to DNA damage stimulus	PMID:9461559^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070064	proline-rich region binding	PMID:7590236^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NYB9	F		Seeded From UniProt	complete
enables	GO:0070064	proline-rich region binding	PMID:15657060^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:15657060^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:17888034^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:9037071^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042770	signal transduction in response to DNA damage	PMID:15657060^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042770	signal transduction in response to DNA damage	PMID:9037071^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030145	manganese ion binding	PMID:9144171^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00520	P		Seeded From UniProt	complete
enables	GO:0019905	syntaxin binding	PMID:23006999^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Z158	F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:7590236^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:9144171^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	PMID:7590236^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NYB9	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:11971963^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99638	F		Seeded From UniProt	complete
involved_in	GO:0006975	DNA damage induced protein phosphorylation	PMID:18280240^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:15657060^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006464	cellular protein modification process	PMID:8242749^[26]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17888034^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8242749^[26]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:9144171^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:9461559^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:15657060^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:7590236^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:17888034^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:9144171^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:8242749^[26]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	PMID:9144171^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87859 PANTHER:PTN001975310 UniProtKB:Q05397	P		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95481 PANTHER:PTN001975310 RGD:628758 UniProtKB:P00519 UniProtKB:Q14289	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001975310 RGD:628758	P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000017 MGI:MGI:104908 MGI:MGI:1930958 MGI:MGI:95481 PANTHER:PTN001975310 UniProtKB:P00519 UniProtKB:Q05397 UniProtKB:Q14289 WB:WBGene00002213	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:15657136^[28]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1900275	negative regulation of phospholipase C activity	PMID:24367707^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051444	negative regulation of ubiquitin-protein transferase activity	PMID:20823226^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:24367707^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:17626041^[31]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q03468	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:11120811^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:17626041^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:12944467^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17626041^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:20823226^[30]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:12944467^[33]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:11120811^[32]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000773	negative regulation of cellular senescence	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:2000772	regulation of cellular senescence	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:2000352	negative regulation of endothelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:1905555	positive regulation blood vessel branching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:1905244	regulation of modification of synaptic structure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:1903053	regulation of extracellular matrix organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:1902715	positive regulation of interferon-gamma secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:1900272	negative regulation of long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:1900042	positive regulation of interleukin-2 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0090135	actin filament branching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0072358	cardiovascular system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0060563	neuroepithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0060020	Bergmann glial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	F		Seeded From UniProt	complete
involved_in	GO:0050885	neuromuscular process controlling balance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0050798	activated T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0048668	collateral sprouting	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0048536	spleen development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	F		Seeded From UniProt	complete
involved_in	GO:0046632	alpha-beta T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0045931	positive regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0045930	negative regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0045580	regulation of T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0042100	B cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
enables	GO:0038191	neuropilin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	F		Seeded From UniProt	complete
involved_in	GO:0034446	substrate adhesion-dependent cell spreading	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0033690	positive regulation of osteoblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
part_of	GO:0031252	cell leading edge	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	C		Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
enables	GO:0030145	manganese ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	F		Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0030035	microspike assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0022408	negative regulation of cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0021587	cerebellum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	F		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	C		Seeded From UniProt	complete
involved_in	GO:0009791	post-embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	F		Seeded From UniProt	complete
involved_in	GO:0002333	transitional one stage B cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0002322	B cell proliferation involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0001922	B-1 B cell homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
involved_in	GO:0001843	neural tube closure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	P		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00520 ensembl:ENSMUSP00000075167	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635 InterPro:IPR033221	F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015015	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR015015 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR015015 InterPro:IPR020635	P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15865930^[34]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:15865930^[34]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	has_direct_input:(UniProtKB:P04637) part_of:(GO:0006974)	Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	PMID:24658113^[35]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051444	negative regulation of ubiquitin-protein transferase activity	PMID:23626584^[36] PMID:24522549^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_regulation_target:(UniProtKB:O60260)	Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:23626584^[36] PMID:24522549^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_input:(UniProtKB:O60260) part_of:(GO:0051444)	Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	PMID:24522549^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(GO:0005737)	Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	PMID:24522549^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(GO:0005634)	Seeded From UniProt	complete
involved_in	GO:0051882	mitochondrial depolarization	PMID:24522549^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(GO:0005739)	Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:24522549^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903351	cellular response to dopamine	PMID:24522549^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:10391249^[37] PMID:20841568^[38]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:8242749^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:10391249^[37]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:10391249^[37] Reactome:R-HSA-8956659 Reactome:R-HSA-5686587 Reactome:R-HSA-428888	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000249	regulation of actin cytoskeleton reorganization	PMID:20841568^[38]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000145	regulation of cell motility	PMID:20841568^[38]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030155	regulation of cell adhesion	PMID:20841568^[38]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030100	regulation of endocytosis	PMID:20841568^[38]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	PMID:20841568^[38]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010506	regulation of autophagy	PMID:20841568^[38]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20841568^[38]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20841568^[38]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004515	nicotinate-nucleotide adenylyltransferase activity	PMID:20841568^[38]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003785	actin monomer binding	PMID:20841568^[38]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1902036	regulation of hematopoietic stem cell differentiation	Reactome:R-HSA-8939236	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051149	positive regulation of muscle cell differentiation	Reactome:R-HSA-375170	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	Reactome:R-HSA-2029480	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-448958 Reactome:R-HSA-428888 Reactome:R-HSA-376141 Reactome:R-HSA-2130194	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8956659 Reactome:R-HSA-5686587 Reactome:R-HSA-5686578	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0182	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 David-Cordonnier, MH et al. (1998) The DNA binding domain of the human c-Abl tyrosine kinase preferentially binds to DNA sequences containing an AAC motif and to distorted DNA structures. Biochemistry 37 6065-76 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Raimondi, C et al. (2014) Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. J. Exp. Med. 211 1167-83 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Yuan, ZM et al. (1997) Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase. Proc. Natl. Acad. Sci. U.S.A. 94 1437-40 PubMed GONUTS page
↑ ^4.0 ^4.1 Cobbaut, M et al. (2017) Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop. Sci Rep 7 887 PubMed GONUTS page
↑ Baskaran, R et al. (1997) Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature 387 516-9 PubMed GONUTS page
↑ Wang, X et al. (2017) Germline mutations in ABL1 cause an autosomal dominant syndrome characterized by congenital heart defects and skeletal malformations. Nat. Genet. 49 613-617 PubMed GONUTS page
↑ Kobashigawa, Y et al. (2007) Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. Nat. Struct. Mol. Biol. 14 503-10 PubMed GONUTS page
↑ ^8.0 ^8.1 Donaldson, LW et al. (2002) Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide. Proc. Natl. Acad. Sci. U.S.A. 99 14053-8 PubMed GONUTS page
↑ Ohya, K et al. (1999) Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. Proc. Natl. Acad. Sci. U.S.A. 96 11976-81 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 ^10.9 Engel, U et al. (2014) Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin. Cytoskeleton (Hoboken) 71 195-209 PubMed GONUTS page
↑ Wang, R et al. (2014) The association of cortactin with profilin-1 is critical for smooth muscle contraction. J. Biol. Chem. 289 14157-69 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Sun, X et al. (2000) Interaction between protein kinase C delta and the c-Abl tyrosine kinase in the cellular response to oxidative stress. J. Biol. Chem. 275 7470-3 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Gaki, GS & Papavassiliou, AG (2014) Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease. Neuromolecular Med. 16 217-30 PubMed GONUTS page
↑ ^14.0 ^14.1 Mehlitz, A et al. (2010) Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1. J. Cell Biol. 190 143-57 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Roig, J et al. (2000) Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK. Proc. Natl. Acad. Sci. U.S.A. 97 14346-51 PubMed GONUTS page
↑ Cao, C et al. (2003) Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases. J. Biol. Chem. 278 39609-14 PubMed GONUTS page
↑ Fantin, A et al. (2015) NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells. Cell Rep 11 1577-90 PubMed GONUTS page
↑ ^18.0 ^18.1 Yuan, ZM et al. (1998) Regulation of Rad51 function by c-Abl in response to DNA damage. J. Biol. Chem. 273 3799-802 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Dai, Z & Pendergast, AM (1995) Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. Genes Dev. 9 2569-82 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 Raina, D et al. (2005) c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. J. Biol. Chem. 280 11147-51 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Mano, Y et al. (2007) Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. Cancer Sci. 98 1902-13 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 Han, L et al. (1997) Protein binding and signaling properties of RIN1 suggest a unique effector function. Proc. Natl. Acad. Sci. U.S.A. 94 4954-9 PubMed GONUTS page
↑ Muppirala, M et al. (2012) Tyrosine phosphorylation of a SNARE protein, syntaxin 17: implications for membrane trafficking in the early secretory pathway. Biochim. Biophys. Acta 1823 2109-19 PubMed GONUTS page
↑ Yoshida, K et al. (2002) c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage. Mol. Cell. Biol. 22 3292-300 PubMed GONUTS page
↑ Levy, D et al. (2008) Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol. Cell 29 350-61 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 Welch, PJ & Wang, JY (1993) A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. Cell 75 779-90 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Leng, Y et al. (2005) Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation. Proc. Natl. Acad. Sci. U.S.A. 102 1098-103 PubMed GONUTS page
↑ ^29.0 ^29.1 Chislock, EM & Pendergast, AM (2013) Abl family kinases regulate endothelial barrier function in vitro and in mice. PLoS ONE 8 e85231 PubMed GONUTS page
↑ ^30.0 ^30.1 Ko, HS et al. (2010) Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function. Proc. Natl. Acad. Sci. U.S.A. 107 16691-6 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 Imam, SZ et al. (2007) Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase. Nucleic Acids Res. 35 4941-51 PubMed GONUTS page
↑ ^32.0 ^32.1 Zipfel, PA et al. (2000) The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19. J. Immunol. 165 6872-9 PubMed GONUTS page
↑ ^33.0 ^33.1 Cheng, WH et al. (2003) Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution. Mol. Cell. Biol. 23 6385-95 PubMed GONUTS page
↑ ^34.0 ^34.1 Levav-Cohen, Y et al. (2005) C-Abl as a modulator of p53. Biochem. Biophys. Res. Commun. 331 737-49 PubMed GONUTS page
↑ Vargas, LM et al. (2014) EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers. PLoS ONE 9 e92309 PubMed GONUTS page
↑ ^36.0 ^36.1 Trempe, JF & Fon, EA (2013) Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection. Front Neurol 4 38 PubMed GONUTS page
↑ ^37.0 ^37.1 ^37.2 Gong, JG et al. (1999) The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399 806-9 PubMed GONUTS page
↑ ^38.00 ^38.01 ^38.02 ^38.03 ^38.04 ^38.05 ^38.06 ^38.07 ^38.08 ^38.09 ^38.10 Colicelli, J (2010) ABL tyrosine kinases: evolution of function, regulation, and specificity. Sci Signal 3 re6 PubMed GONUTS page

[PMID:9558345-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 David-Cordonnier, MH et al. (1998) The DNA binding domain of the human c-Abl tyrosine kinase preferentially binds to DNA sequences containing an AAC motif and to distorted DNA structures. Biochemistry 37 6065-76 PubMed GONUTS page

[PMID:24863063-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Raimondi, C et al. (2014) Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. J. Exp. Med. 211 1167-83 PubMed GONUTS page

[PMID:9037071-3] 3.0 ^3.1 ^3.2 ^3.3 Yuan, ZM et al. (1997) Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase. Proc. Natl. Acad. Sci. U.S.A. 94 1437-40 PubMed GONUTS page

[PMID:28428613-4] 4.0 ^4.1 Cobbaut, M et al. (2017) Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop. Sci Rep 7 887 PubMed GONUTS page

[PMID:9168116-5] Baskaran, R et al. (1997) Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature 387 516-9 PubMed GONUTS page

[PMID:28288113-6] Wang, X et al. (2017) Germline mutations in ABL1 cause an autosomal dominant syndrome characterized by congenital heart defects and skeletal malformations. Nat. Genet. 49 613-617 PubMed GONUTS page

[PMID:17515907-7] Kobashigawa, Y et al. (2007) Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. Nat. Struct. Mol. Biol. 14 503-10 PubMed GONUTS page

[PMID:12384576-8] 8.0 ^8.1 Donaldson, LW et al. (2002) Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide. Proc. Natl. Acad. Sci. U.S.A. 99 14053-8 PubMed GONUTS page

[PMID:10518561-9] Ohya, K et al. (1999) Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. Proc. Natl. Acad. Sci. U.S.A. 96 11976-81 PubMed GONUTS page

[PMID:24520051-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 ^10.9 Engel, U et al. (2014) Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin. Cytoskeleton (Hoboken) 71 195-209 PubMed GONUTS page

[PMID:24700464-11] Wang, R et al. (2014) The association of cortactin with profilin-1 is critical for smooth muscle contraction. J. Biol. Chem. 289 14157-69 PubMed GONUTS page

[PMID:10713049-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Sun, X et al. (2000) Interaction between protein kinase C delta and the c-Abl tyrosine kinase in the cellular response to oxidative stress. J. Biol. Chem. 275 7470-3 PubMed GONUTS page

[PMID:24522549-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Gaki, GS & Papavassiliou, AG (2014) Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease. Neuromolecular Med. 16 217-30 PubMed GONUTS page

[PMID:20624904-14] 14.0 ^14.1 Mehlitz, A et al. (2010) Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1. J. Cell Biol. 190 143-57 PubMed GONUTS page

[PMID:11121037-15] 15.0 ^15.1 ^15.2 ^15.3 Roig, J et al. (2000) Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK. Proc. Natl. Acad. Sci. U.S.A. 97 14346-51 PubMed GONUTS page

[PMID:12893824-16] Cao, C et al. (2003) Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases. J. Biol. Chem. 278 39609-14 PubMed GONUTS page

[PMID:26051942-17] Fantin, A et al. (2015) NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells. Cell Rep 11 1577-90 PubMed GONUTS page

[PMID:9461559-18] 18.0 ^18.1 Yuan, ZM et al. (1998) Regulation of Rad51 function by c-Abl in response to DNA damage. J. Biol. Chem. 273 3799-802 PubMed GONUTS page

[PMID:7590236-19] 19.0 ^19.1 ^19.2 ^19.3 Dai, Z & Pendergast, AM (1995) Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. Genes Dev. 9 2569-82 PubMed GONUTS page

[PMID:15657060-20] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 Raina, D et al. (2005) c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. J. Biol. Chem. 280 11147-51 PubMed GONUTS page

[PMID:17888034-21] 21.0 ^21.1 ^21.2 Mano, Y et al. (2007) Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. Cancer Sci. 98 1902-13 PubMed GONUTS page

[PMID:9144171-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 Han, L et al. (1997) Protein binding and signaling properties of RIN1 suggest a unique effector function. Proc. Natl. Acad. Sci. U.S.A. 94 4954-9 PubMed GONUTS page

[PMID:23006999-23] Muppirala, M et al. (2012) Tyrosine phosphorylation of a SNARE protein, syntaxin 17: implications for membrane trafficking in the early secretory pathway. Biochim. Biophys. Acta 1823 2109-19 PubMed GONUTS page

[PMID:11971963-24] Yoshida, K et al. (2002) c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage. Mol. Cell. Biol. 22 3292-300 PubMed GONUTS page

[PMID:18280240-25] Levy, D et al. (2008) Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol. Cell 29 350-61 PubMed GONUTS page

[PMID:8242749-26] 26.0 ^26.1 ^26.2 ^26.3 Welch, PJ & Wang, JY (1993) A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. Cell 75 779-90 PubMed GONUTS page

[PMID:21873635-27] 27.0 ^27.1 ^27.2 ^27.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15657136-28] Leng, Y et al. (2005) Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation. Proc. Natl. Acad. Sci. U.S.A. 102 1098-103 PubMed GONUTS page

[PMID:24367707-29] 29.0 ^29.1 Chislock, EM & Pendergast, AM (2013) Abl family kinases regulate endothelial barrier function in vitro and in mice. PLoS ONE 8 e85231 PubMed GONUTS page

[PMID:20823226-30] 30.0 ^30.1 Ko, HS et al. (2010) Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function. Proc. Natl. Acad. Sci. U.S.A. 107 16691-6 PubMed GONUTS page

[PMID:17626041-31] 31.0 ^31.1 ^31.2 Imam, SZ et al. (2007) Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase. Nucleic Acids Res. 35 4941-51 PubMed GONUTS page

[PMID:11120811-32] 32.0 ^32.1 Zipfel, PA et al. (2000) The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19. J. Immunol. 165 6872-9 PubMed GONUTS page

[PMID:12944467-33] 33.0 ^33.1 Cheng, WH et al. (2003) Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution. Mol. Cell. Biol. 23 6385-95 PubMed GONUTS page

[PMID:15865930-34] 34.0 ^34.1 Levav-Cohen, Y et al. (2005) C-Abl as a modulator of p53. Biochem. Biophys. Res. Commun. 331 737-49 PubMed GONUTS page

[PMID:24658113-35] Vargas, LM et al. (2014) EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers. PLoS ONE 9 e92309 PubMed GONUTS page

[PMID:23626584-36] 36.0 ^36.1 Trempe, JF & Fon, EA (2013) Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection. Front Neurol 4 38 PubMed GONUTS page

[PMID:10391249-37] 37.0 ^37.1 ^37.2 Gong, JG et al. (1999) The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399 806-9 PubMed GONUTS page

[PMID:20841568-38] 38.00 ^38.01 ^38.02 ^38.03 ^38.04 ^38.05 ^38.06 ^38.07 ^38.08 ^38.09 ^38.10 Colicelli, J (2010) ABL tyrosine kinases: evolution of function, regulation, and specificity. Sci Signal 3 re6 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

[34]

[35]

[36]

[37]

[38]

HUMAN:ABL1

Contents

Annotations

Notes

References

a

b

c

d

e

f

h

i

k

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools