HUMAN:UB2L3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	UBE2L3 (synonyms: UBCE7, UBCH7)
Protein Name(s)	Ubiquitin-conjugating enzyme E2 L3 L-UBC UbcH7 Ubiquitin carrier protein L3 Ubiquitin-conjugating enzyme E2-F1 Ubiquitin-protein ligase L3
External Links
UniProt	P68036
EMBL	S81003 X92962 AJ000519 AF300336 CR456606 AK293179 AK299985 AK311761 AP000553 AP000557 AP000558 CH471095 BC053368
CCDS	CCDS13790.1 CCDS58795.1 CCDS58796.1
RefSeq	NP_001243284.1 NP_001243285.1 NP_003338.1
UniGene	Hs.108104
PDB	1C4Z 1FBV 3SQV 3SY2 4Q5E 4Q5H
PDBsum	1C4Z 1FBV 3SQV 3SY2 4Q5E 4Q5H
ProteinModelPortal	P68036
SMR	P68036
BioGrid	113180
DIP	DIP-6124N
IntAct	P68036
MINT	MINT-5002693
STRING	9606.ENSP00000344259
PhosphoSite	P68036
DMDM	54039805
OGP	P51966
UCD-2DPAGE	P68036
MaxQB	P68036
PaxDb	P68036
PRIDE	P68036
DNASU	7332
Ensembl	ENST00000342192 ENST00000458578 ENST00000545681
GeneID	7332
KEGG	hsa:7332
UCSC	uc002zuz.2 uc011aig.3
CTD	7332
GeneCards	GC22P021903
HGNC	HGNC:12488
HPA	HPA045609
MIM	603721
neXtProt	NX_P68036
Orphanet	536
PharmGKB	PA37137
eggNOG	COG5078
GeneTree	ENSGT00760000119012
HOGENOM	HOG000233455
HOVERGEN	HBG063308
InParanoid	P68036
KO	K04552
OMA	IALVNDX
OrthoDB	EOG7GXPD8
PhylomeDB	P68036
TreeFam	TF313043
Reactome	REACT_75842
SignaLink	P68036
UniPathway	UPA00143
ChiTaRS	UBE2L3
EvolutionaryTrace	P68036
GeneWiki	UBE2L3
GenomeRNAi	7332
NextBio	28696
PRO	PR:P68036
Proteomes	UP000005640
Bgee	P68036
CleanEx	HS_UBE2L3
ExpressionAtlas	P68036
Genevestigator	P68036
GO	GO:0005737 GO:0070062 GO:0005634 GO:0000151 GO:0016881 GO:0005524 GO:0019899 GO:0044822 GO:0003713 GO:0031625 GO:0097027 GO:0004842 GO:0044770 GO:0008283 GO:0006464 GO:0071385 GO:0071383 GO:0031398 GO:0051443 GO:0070979 GO:0000209 GO:0016567 GO:0006355 GO:0006351 GO:0006511
Gene3D	3.10.110.10
InterPro	IPR000608 IPR023313 IPR016135
Pfam	PF00179
SUPFAM	SSF54495
PROSITE	PS00183 PS50127

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1903955	positive regulation of protein targeting to mitochondrion	PMID:24270810^[1]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O60260)	Seeded From UniProt	complete
enables	GO:0097027	ubiquitin-protein transferase activator activity	PMID:12628165^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q969H0	F	has_input:(UniProtKB:O60260)	Seeded From UniProt	complete
involved_in	GO:0051443	positive regulation of ubiquitin-protein transferase activity	PMID:12628165^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q969H0	P	has_regulation_target:(UniProtKB:O60260)	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:12628165^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O60260	F	occurs_in:(UBERON:0001870)	Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	PMID:12628165^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:9990509^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9990509^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0044770	cell cycle phase transition	PMID:18946090^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071385	cellular response to glucocorticoid stimulus	PMID:17003263^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071383	cellular response to steroid hormone stimulus	PMID:15367689^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070979	protein K11-linked ubiquitination	PMID:20061386^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:21532592^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:21532592^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y4X5	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:11278816^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y4X5	F		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:21532592^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:18946090^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:15367689^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:17003263^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11278816^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17003263^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11278816^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17003263^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:10888878^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:21532592^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:20061386^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:14765125^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:15367689^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:10888878^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:14765125^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070979	protein K11-linked ubiquitination	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002374306 UniProtKB:P68036	P		Seeded From UniProt	complete
enables	GO:0061631	ubiquitin conjugating enzyme activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000173 FB:FBgn0011217 FB:FBgn0026316 FB:FBgn0035601 FB:FBgn0264848 MGI:MGI:104632 MGI:MGI:107411 MGI:MGI:107412 MGI:MGI:109240 MGI:MGI:1913839 MGI:MGI:1914049 MGI:MGI:1917343 MGI:MGI:1917870 MGI:MGI:1934835 MGI:MGI:2384911 MGI:MGI:2388672 PANTHER:PTN002514495 PomBase:SPAC11E3.04c PomBase:SPBC119.02 PomBase:SPCC1259.15c PomBase:SPCC338.05c UniProtKB:A1L167 UniProtKB:O00762 UniProtKB:P51668 UniProtKB:P51965 UniProtKB:P61077 UniProtKB:P61085 UniProtKB:P62837 UniProtKB:P68036 UniProtKB:Q16763 UniProtKB:Q8N2K1 UniProtKB:Q96LR5 UniProtKB:Q9NPD8 UniProtKB:Q9Y2X8 UniProtKB:Q9Y385 WB:WBGene00006713	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011217 FB:FBgn0026316 PANTHER:PTN000630862 UniProtKB:P68036 WB:WBGene00002344 WB:WBGene00006713	F		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011217 MGI:MGI:109240 PANTHER:PTN000631055 PomBase:SPBC119.02 RGD:619912 UniProtKB:P51668	P		Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000630862 UniProtKB:P51668 UniProtKB:P62837	C		Seeded From UniProt	complete
enables	GO:0061631	ubiquitin conjugating enzyme activity	PMID:20061386^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1903508	positive regulation of nucleic acid-templated transcription	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003713	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:8563171^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:8672131^[15] PMID:8563171^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006464	cellular protein modification process	PMID:8576257^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:8576257^[16] PMID:8563171^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	PMID:8563171^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	Reactome:R-HSA-8866654 Reactome:R-HSA-8866652	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8938773 Reactome:R-HSA-8938770 Reactome:R-HSA-8852129 Reactome:R-HSA-8852127	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8852130	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Hasson, SA et al. (2013) High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Nature 504 291-5 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Staropoli, JF et al. (2003) Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity. Neuron 37 735-49 PubMed GONUTS page
↑ ^3.0 ^3.1 Anan, T et al. (1998) Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. Genes Cells 3 751-63 PubMed GONUTS page
↑ ^4.0 ^4.1 Whitcomb, EA et al. (2009) Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7. Mol. Biol. Cell 20 1-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Garside, H et al. (2006) UbcH7 interacts with the glucocorticoid receptor and mediates receptor autoregulation. J. Endocrinol. 190 621-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Verma, S et al. (2004) The ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptors. Mol. Cell. Biol. 24 8716-26 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 David, Y et al. (2010) The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. J. Biol. Chem. 285 8595-604 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Wenzel, DM et al. (2011) UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids. Nature 474 105-8 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Ardley, HC et al. (2001) Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7. J. Biol. Chem. 276 19640-7 PubMed GONUTS page
↑ ^11.0 ^11.1 Shimura, H et al. (2000) Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat. Genet. 25 302-5 PubMed GONUTS page
↑ ^12.0 ^12.1 Qiu, XB et al. (2004) Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. EMBO J. 23 800-10 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Robinson, PA et al. (1995) A human ubiquitin conjugating enzyme, L-UBC, maps in the Alzheimer's disease locus on chromosome 14q24.3. Mamm. Genome 6 725-31 PubMed GONUTS page
↑ Moynihan, TP et al. (1996) Characterization of a human ubiquitin-conjugating enzyme gene UBE2L3. Mamm. Genome 7 520-5 PubMed GONUTS page
↑ ^16.0 ^16.1 Nuber, U et al. (1996) Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5. J. Biol. Chem. 271 2795-800 PubMed GONUTS page

[PMID:24270810-1] Hasson, SA et al. (2013) High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Nature 504 291-5 PubMed GONUTS page

[PMID:12628165-2] 2.0 ^2.1 ^2.2 ^2.3 Staropoli, JF et al. (2003) Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity. Neuron 37 735-49 PubMed GONUTS page

[PMID:9990509-3] 3.0 ^3.1 Anan, T et al. (1998) Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. Genes Cells 3 751-63 PubMed GONUTS page

[PMID:18946090-4] 4.0 ^4.1 Whitcomb, EA et al. (2009) Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7. Mol. Biol. Cell 20 1-9 PubMed GONUTS page

[PMID:17003263-5] 5.0 ^5.1 ^5.2 ^5.3 Garside, H et al. (2006) UbcH7 interacts with the glucocorticoid receptor and mediates receptor autoregulation. J. Endocrinol. 190 621-9 PubMed GONUTS page

[PMID:15367689-6] 6.0 ^6.1 ^6.2 Verma, S et al. (2004) The ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptors. Mol. Cell. Biol. 24 8716-26 PubMed GONUTS page

[PMID:20061386-7] 7.0 ^7.1 ^7.2 David, Y et al. (2010) The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. J. Biol. Chem. 285 8595-604 PubMed GONUTS page

[PMID:22658674-8] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:21532592-9] 9.0 ^9.1 ^9.2 ^9.3 Wenzel, DM et al. (2011) UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids. Nature 474 105-8 PubMed GONUTS page

[PMID:11278816-10] 10.0 ^10.1 ^10.2 Ardley, HC et al. (2001) Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7. J. Biol. Chem. 276 19640-7 PubMed GONUTS page

[PMID:10888878-11] 11.0 ^11.1 Shimura, H et al. (2000) Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat. Genet. 25 302-5 PubMed GONUTS page

[PMID:14765125-12] 12.0 ^12.1 Qiu, XB et al. (2004) Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. EMBO J. 23 800-10 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8563171-14] 14.0 ^14.1 ^14.2 ^14.3 Robinson, PA et al. (1995) A human ubiquitin conjugating enzyme, L-UBC, maps in the Alzheimer's disease locus on chromosome 14q24.3. Mamm. Genome 6 725-31 PubMed GONUTS page

[PMID:8672131-15] Moynihan, TP et al. (1996) Characterization of a human ubiquitin-conjugating enzyme gene UBE2L3. Mamm. Genome 7 520-5 PubMed GONUTS page

[PMID:8576257-16] 16.0 ^16.1 Nuber, U et al. (1996) Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5. J. Biol. Chem. 271 2795-800 PubMed GONUTS page

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HUMAN:UB2L3

Contents

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References

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