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DROME:MAD

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Mad
Protein Name(s) Protein mothers against dpp
External Links
UniProt P42003
EMBL U10328
AE014134
BT004845
PIR S55019
RefSeq NP_477017.1
UniGene Dm.7367
PDB 3DIT
3GMJ
PDBsum 3DIT
3GMJ
ProteinModelPortal P42003
SMR P42003
BioGrid 59745
DIP DIP-18256N
IntAct P42003
MINT MINT-280063
STRING 7227.FBpp0077302
PaxDb P42003
PRIDE P42003
EnsemblMetazoa FBtr0077616
GeneID 33529
KEGG dme:Dmel_CG12399
CTD 33529
FlyBase FBgn0011648
eggNOG NOG330956
GeneTree ENSGT00760000119091
InParanoid P42003
KO K04676
OrthoDB EOG7W1540
PhylomeDB P42003
Reactome REACT_263672
SignaLink P42003
EvolutionaryTrace P42003
GenomeRNAi 33529
NextBio 784055
Proteomes UP000000803
Bgee P42003
ExpressionAtlas P42003
GO GO:0005737
GO:0005634
GO:0005667
GO:0003677
GO:0046872
GO:0001102
GO:0000980
GO:0003705
GO:0001105
GO:0043565
GO:0000976
GO:0030618
GO:0061353
GO:0001745
GO:0007391
GO:0042078
GO:0030718
GO:0007507
GO:0007488
GO:0007480
GO:0007476
GO:0008586
GO:0035556
GO:2000134
GO:0010629
GO:0045705
GO:0007424
GO:0030707
GO:0045887
GO:0045944
GO:0045595
GO:0006357
GO:0035019
GO:0006366
GO:0007179
GO:0035290
GO:0048100
Gene3D 2.60.200.10
3.90.520.10
InterPro IPR013790
IPR003619
IPR013019
IPR017855
IPR001132
IPR008984
PANTHER PTHR13703
Pfam PF03165
PF03166
SMART SM00523
SM00524
SUPFAM SSF49879
SSF56366
PROSITE PS51075
PS51076

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

PMID:9694800[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0001102

RNA polymerase II activating transcription factor binding

PMID:11071761[2]

IPI: Inferred from Physical Interaction

FB:FBgn0003396

F

Seeded From UniProt

complete

GO:0001105

RNA polymerase II transcription coactivator activity

PMID:11071761[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0001745

compound eye morphogenesis

PMID:17428827[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0003677

DNA binding

PMID:9880789[4]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013019

F

Seeded From UniProt

complete

GO:0003705

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

PMID:24321690[5]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0003705

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

PMID:9230443[6]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11703946[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q9V853

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12754252[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q9V853

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:14645536[9]

IPI: Inferred from Physical Interaction

FB:FBgn0033748

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19914168[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q45VV3

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:9502724[11]

IPI: Inferred from Physical Interaction

FB:FBgn0011655

F

Seeded From UniProt

complete

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001132
InterPro:IPR003619
InterPro:IPR013019
InterPro:IPR013790

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:11432817[12]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:16510868[13]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:24046358[14]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:9230443[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:9880789[4]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005667

transcription factor complex

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013019

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:16510868[13]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:8681791[15]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:9880789[4]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001132
InterPro:IPR003619
InterPro:IPR013019
InterPro:IPR013790

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0006357

regulation of transcription from RNA polymerase II promoter

PMID:11432817[12]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013019

P

Seeded From UniProt

complete

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:11700289[16]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:8681796[17]

IGI: Inferred from Genetic Interaction

FB:FBgn0000490

P

Seeded From UniProt

complete

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:8681796[17]

IGI: Inferred from Genetic Interaction

FB:FBgn0003716

P

Seeded From UniProt

complete

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:8681796[17]

IGI: Inferred from Genetic Interaction

FB:FBgn0004009

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007391

dorsal closure

PMID:12147138[18]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007424

open tracheal system development

PMID:14570584[19]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007476

imaginal disc-derived wing morphogenesis

PMID:16648592[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007480

imaginal disc-derived leg morphogenesis

PMID:11290719[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007488

histoblast morphogenesis

PMID:20226662[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007507

heart development

PMID:12027431[23]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008586

imaginal disc-derived wing vein morphogenesis

PMID:11290719[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010629

negative regulation of gene expression

PMID:16780828[24]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0030618

transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity

PMID:9880789[4]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0030707

ovarian follicle cell development

PMID:10822261[25]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0030707

ovarian follicle cell development

PMID:16256740[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030718

germ-line stem cell maintenance

PMID:9695953[27]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035019

somatic stem cell maintenance

PMID:16256740[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035290

trunk segmentation

PMID:19657393[28]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035556

intracellular signal transduction

PMID:9880789[4]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0042078

germ-line stem cell division

PMID:12459723[29]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0042078

germ-line stem cell division

PMID:9695953[27]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

PMID:14507783[30]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

PMID:17092951[31]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

PMID:20010841[32]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0045595

regulation of cell differentiation

PMID:20056890[33]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045705

negative regulation of salivary gland boundary specification

PMID:11598957[34]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0045887

positive regulation of synaptic growth at neuromuscular junction

PMID:15046722[35]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045887

positive regulation of synaptic growth at neuromuscular junction

PMID:19451277[36]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045887

positive regulation of synaptic growth at neuromuscular junction

PMID:24553921[37]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:14507783[30]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:24321690[5]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:9230443[6]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:9694800[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0048100

wing disc anterior/posterior pattern formation

PMID:15708556[38]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050803

regulation of synapse structure or activity

PMID:24353060[39]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0060799

transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification

PMID:23733344[40]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0061353

BMP signaling pathway involved in Malpighian tubule cell chemotaxis

PMID:20708591[41]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

PMID:15809036[42]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Xu, X et al. (1998) Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. Genes Dev. 12 2354-70 PubMed GONUTS page
  2. 2.0 2.1 Dai, H et al. (2000) The zinc finger protein schnurri acts as a Smad partner in mediating the transcriptional response to decapentaplegic. Dev. Biol. 227 373-87 PubMed GONUTS page
  3. Cordero, JB et al. (2007) Dynamic decapentaplegic signaling regulates patterning and adhesion in the Drosophila pupal retina. Development 134 1861-71 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 Kawabata, M & Miyazono, K (1999) Signal transduction of the TGF-beta superfamily by Smad proteins. J. Biochem. 125 9-16 PubMed GONUTS page
  5. 5.0 5.1 Hodar, C et al. (2014) Comparative gene expression analysis of Dtg, a novel target gene of Dpp signaling pathway in the early Drosophila melanogaster embryo. Gene 535 210-7 PubMed GONUTS page
  6. 6.0 6.1 6.2 Kim, J et al. (1997) Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388 304-8 PubMed GONUTS page
  7. Podos, SD et al. (2001) The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis. Dev. Cell 1 567-78 PubMed GONUTS page
  8. Liang, YY et al. (2003) dSmurf selectively degrades decapentaplegic-activated MAD, and its overexpression disrupts imaginal disc development. J. Biol. Chem. 278 26307-10 PubMed GONUTS page
  9. Hyman, CA et al. (2003) Drosophila TGIF proteins are transcriptional activators. Mol. Cell. Biol. 23 9262-74 PubMed GONUTS page
  10. Alarcón, C et al. (2009) Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell 139 757-69 PubMed GONUTS page
  11. Wisotzkey, RG et al. (1998) Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses. Development 125 1433-45 PubMed GONUTS page
  12. 12.0 12.1 Affolter, M et al. (2001) Nuclear interpretation of Dpp signaling in Drosophila. EMBO J. 20 3298-305 PubMed GONUTS page
  13. 13.0 13.1 Chen, HB et al. (2006) Identification of phosphatases for Smad in the BMP/DPP pathway. Genes Dev. 20 648-53 PubMed GONUTS page
  14. Friedman, SH et al. (2013) Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila. Dis Model Mech 6 1400-13 PubMed GONUTS page
  15. Newfeld, SJ et al. (1996) Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-beta responsive cells. Development 122 2099-108 PubMed GONUTS page
  16. Lall, S & Patel, NH (2001) Conservation and divergence in molecular mechanisms of axis formation. Annu. Rev. Genet. 35 407-37 PubMed GONUTS page
  17. 17.0 17.1 17.2 Wiersdorff, V et al. (1996) Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye. Development 122 2153-62 PubMed GONUTS page
  18. Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page
  19. Ghabrial, A et al. (2003) Branching morphogenesis of the Drosophila tracheal system. Annu. Rev. Cell Dev. Biol. 19 623-47 PubMed GONUTS page
  20. Dworkin, I & Gibson, G (2006) Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster. Genetics 173 1417-31 PubMed GONUTS page
  21. 21.0 21.1 Marquez, RM et al. (2001) Transgenic analysis of the Smad family of TGF-beta signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members. Genetics 157 1639-48 PubMed GONUTS page
  22. Ninov, N et al. (2010) Dpp signaling directs cell motility and invasiveness during epithelial morphogenesis. Curr. Biol. 20 513-20 PubMed GONUTS page
  23. Cripps, RM & Olson, EN (2002) Control of cardiac development by an evolutionarily conserved transcriptional network. Dev. Biol. 246 14-28 PubMed GONUTS page
  24. Anderson, J et al. (2006) Regulation of the retinal determination gene dachshund in the embryonic head and developing eye of Drosophila. Dev. Biol. 297 536-49 PubMed GONUTS page
  25. Dobens, LL & Raftery, LA (2000) Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells. Dev. Dyn. 218 80-93 PubMed GONUTS page
  26. 26.0 26.1 Kirilly, D et al. (2005) BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. Dev. Cell 9 651-62 PubMed GONUTS page
  27. 27.0 27.1 Xie, T & Spradling, AC (1998) decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. Cell 94 251-60 PubMed GONUTS page
  28. Eivers, E et al. (2009) Mad is required for wingless signaling in wing development and segment patterning in Drosophila. PLoS ONE 4 e6543 PubMed GONUTS page
  29. Lin, H (2002) The stem-cell niche theory: lessons from flies. Nat. Rev. Genet. 3 931-40 PubMed GONUTS page
  30. 30.0 30.1 Grienenberger, A et al. (2003) Tgfbeta signaling acts on a Hox response element to confer specificity and diversity to Hox protein function. Development 130 5445-55 PubMed GONUTS page
  31. Lin, MC et al. (2006) Threshold response of C15 to the Dpp gradient in Drosophila is established by the cumulative effect of Smad and Zen activators and negative cues. Development 133 4805-13 PubMed GONUTS page
  32. Weiss, A et al. (2010) A conserved activation element in BMP signaling during Drosophila development. Nat. Struct. Mol. Biol. 17 69-76 PubMed GONUTS page
  33. Mathur, D et al. (2010) A transient niche regulates the specification of Drosophila intestinal stem cells. Science 327 210-3 PubMed GONUTS page
  34. Bradley, PL et al. (2001) Organ formation in Drosophila: specification and morphogenesis of the salivary gland. Bioessays 23 901-11 PubMed GONUTS page
  35. McCabe, BD et al. (2004) Highwire regulates presynaptic BMP signaling essential for synaptic growth. Neuron 41 891-905 PubMed GONUTS page
  36. Merino, C et al. (2009) Nemo kinase interacts with Mad to coordinate synaptic growth at the Drosophila neuromuscular junction. J. Cell Biol. 185 713-25 PubMed GONUTS page
  37. Liu, Z et al. (2014) dAcsl, the Drosophila ortholog of acyl-CoA synthetase long-chain family member 3 and 4, inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling. J. Neurosci. 34 2785-96 PubMed GONUTS page
  38. Shen, J & Dahmann, C (2005) The role of Dpp signaling in maintaining the Drosophila anteroposterior compartment boundary. Dev. Biol. 279 31-43 PubMed GONUTS page
  39. Sulkowski, M et al. (2014) Postsynaptic glutamate receptors regulate local BMP signaling at the Drosophila neuromuscular junction. Development 141 436-47 PubMed GONUTS page
  40. Guo, Z et al. (2013) Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis. J. Cell Biol. 201 945-61 PubMed GONUTS page
  41. Bunt, S et al. (2010) Hemocyte-secreted type IV collagen enhances BMP signaling to guide renal tubule morphogenesis in Drosophila. Dev. Cell 19 296-306 PubMed GONUTS page
  42. Firth, LC & Baker, NE (2005) Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev. Cell 8 541-51 PubMed GONUTS page