DROME:MAD

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Mad
Protein Name(s)	Protein mothers against dpp
External Links
UniProt	P42003
EMBL	U10328 AE014134 BT004845
PIR	S55019
RefSeq	NP_477017.1
UniGene	Dm.7367
PDB	3DIT 3GMJ
PDBsum	3DIT 3GMJ
ProteinModelPortal	P42003
SMR	P42003
BioGrid	59745
DIP	DIP-18256N
IntAct	P42003
MINT	MINT-280063
STRING	7227.FBpp0077302
PaxDb	P42003
PRIDE	P42003
EnsemblMetazoa	FBtr0077616
GeneID	33529
KEGG	dme:Dmel_CG12399
CTD	33529
FlyBase	FBgn0011648
eggNOG	NOG330956
GeneTree	ENSGT00760000119091
InParanoid	P42003
KO	K04676
OrthoDB	EOG7W1540
PhylomeDB	P42003
Reactome	REACT_263672
SignaLink	P42003
EvolutionaryTrace	P42003
GenomeRNAi	33529
NextBio	784055
Proteomes	UP000000803
Bgee	P42003
ExpressionAtlas	P42003
GO	GO:0005737 GO:0005634 GO:0005667 GO:0003677 GO:0046872 GO:0001102 GO:0000980 GO:0003705 GO:0001105 GO:0043565 GO:0000976 GO:0030618 GO:0061353 GO:0001745 GO:0007391 GO:0042078 GO:0030718 GO:0007507 GO:0007488 GO:0007480 GO:0007476 GO:0008586 GO:0035556 GO:2000134 GO:0010629 GO:0045705 GO:0007424 GO:0030707 GO:0045887 GO:0045944 GO:0045595 GO:0006357 GO:0035019 GO:0006366 GO:0007179 GO:0035290 GO:0048100
Gene3D	2.60.200.10 3.90.520.10
InterPro	IPR013790 IPR003619 IPR013019 IPR017855 IPR001132 IPR008984
PANTHER	PTHR13703
Pfam	PF03165 PF03166
SMART	SM00523 SM00524
SUPFAM	SSF49879 SSF56366
PROSITE	PS51075 PS51076

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005634	nucleus	PMID:21696798^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007419	ventral cord development	PMID:26092715^[2]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045887	positive regulation of synaptic growth at neuromuscular junction	PMID:24553921^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:24321690^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24321690^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050803	regulation of synapse structure or activity	PMID:24353060^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24046358^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060799	transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification	PMID:23733344^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007488	histoblast morphogenesis	PMID:20226662^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045595	regulation of cell differentiation	PMID:20056890^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:20010841^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:14507783^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:14507783^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035290	trunk segmentation	PMID:19657393^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045887	positive regulation of synaptic growth at neuromuscular junction	PMID:19451277^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001745	compound eye morphogenesis	PMID:17428827^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:17092951^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007476	imaginal disc-derived wing morphogenesis	PMID:16648592^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16510868^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16510868^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035019	somatic stem cell population maintenance	PMID:16256740^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030707	ovarian follicle cell development	PMID:16256740^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	PMID:15809036^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048100	wing disc anterior/posterior pattern formation	PMID:15708556^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045887	positive regulation of synaptic growth at neuromuscular junction	PMID:15046722^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007391	dorsal closure	PMID:12147138^[22]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:11432817^[23]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007480	imaginal disc-derived leg morphogenesis	PMID:11290719^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008586	imaginal disc-derived wing vein morphogenesis	PMID:11290719^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	PMID:11071761^[25]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0003396	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:11071761^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:9694800^[26]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9694800^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030718	germ-line stem cell population maintenance	PMID:9695953^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042078	germ-line stem cell division	PMID:9695953^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9230443^[28]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9230443^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:9230443^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:8681796^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0284084	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:8681796^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003716	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:8681796^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0000490	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:8681791^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:20010841^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:20010841^[10]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0011655	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20010841^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:20010841^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0030509)	Seeded From UniProt	complete
involved_in	GO:0007560	imaginal disc morphogenesis	PMID:7768443^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:7768443^[31]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0000490	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:7705627^[32]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0000490	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:8681791^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0000490	P		Seeded From UniProt	complete
involved_in	GO:0001745	compound eye morphogenesis	PMID:8681796^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0000490	P		Seeded From UniProt	complete
involved_in	GO:0007476	imaginal disc-derived wing morphogenesis	PMID:8632795^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:8632795^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001132 InterPro:IPR003619 InterPro:IPR013019 InterPro:IPR013790	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019 InterPro:IPR036578	P		Seeded From UniProt	complete
involved_in	GO:0042078	germ-line stem cell division	PMID:12459723^[34]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:12027431^[35]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:11700289^[36]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045705	negative regulation of salivary gland boundary specification	PMID:11598957^[37]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11432817^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030707	ovarian follicle cell development	PMID:10822261^[38]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Colozza, G et al. (2011) Drosophila nucleoporin Nup154 controls cell viability, proliferation and nuclear accumulation of Mad transcription factor. Tissue Cell 43 254-61 PubMed GONUTS page
↑ Bivik, C et al. (2015) Novel Genes Involved in Controlling Specification of Drosophila FMRFamide Neuropeptide Cells. Genetics 200 1229-44 PubMed GONUTS page
↑ Liu, Z et al. (2014) dAcsl, the Drosophila ortholog of acyl-CoA synthetase long-chain family member 3 and 4, inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling. J. Neurosci. 34 2785-96 PubMed GONUTS page
↑ ^4.0 ^4.1 Hodar, C et al. (2014) Comparative gene expression analysis of Dtg, a novel target gene of Dpp signaling pathway in the early Drosophila melanogaster embryo. Gene 535 210-7 PubMed GONUTS page
↑ Sulkowski, M et al. (2014) Postsynaptic glutamate receptors regulate local BMP signaling at the Drosophila neuromuscular junction. Development 141 436-47 PubMed GONUTS page
↑ Friedman, SH et al. (2013) Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila. Dis Model Mech 6 1400-13 PubMed GONUTS page
↑ Guo, Z et al. (2013) Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis. J. Cell Biol. 201 945-61 PubMed GONUTS page
↑ Ninov, N et al. (2010) Dpp signaling directs cell motility and invasiveness during epithelial morphogenesis. Curr. Biol. 20 513-20 PubMed GONUTS page
↑ Mathur, D et al. (2010) A transient niche regulates the specification of Drosophila intestinal stem cells. Science 327 210-3 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Weiss, A et al. (2010) A conserved activation element in BMP signaling during Drosophila development. Nat. Struct. Mol. Biol. 17 69-76 PubMed GONUTS page
↑ ^11.0 ^11.1 Grienenberger, A et al. (2003) Tgfbeta signaling acts on a Hox response element to confer specificity and diversity to Hox protein function. Development 130 5445-55 PubMed GONUTS page
↑ Eivers, E et al. (2009) Mad is required for wingless signaling in wing development and segment patterning in Drosophila. PLoS ONE 4 e6543 PubMed GONUTS page
↑ Merino, C et al. (2009) Nemo kinase interacts with Mad to coordinate synaptic growth at the Drosophila neuromuscular junction. J. Cell Biol. 185 713-25 PubMed GONUTS page
↑ Cordero, JB et al. (2007) Dynamic decapentaplegic signaling regulates patterning and adhesion in the Drosophila pupal retina. Development 134 1861-71 PubMed GONUTS page
↑ Lin, MC et al. (2006) Threshold response of C15 to the Dpp gradient in Drosophila is established by the cumulative effect of Smad and Zen activators and negative cues. Development 133 4805-13 PubMed GONUTS page
↑ Dworkin, I & Gibson, G (2006) Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster. Genetics 173 1417-31 PubMed GONUTS page
↑ ^17.0 ^17.1 Chen, HB et al. (2006) Identification of phosphatases for Smad in the BMP/DPP pathway. Genes Dev. 20 648-53 PubMed GONUTS page
↑ ^18.0 ^18.1 Kirilly, D et al. (2005) BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. Dev. Cell 9 651-62 PubMed GONUTS page
↑ Firth, LC & Baker, NE (2005) Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev. Cell 8 541-51 PubMed GONUTS page
↑ Shen, J & Dahmann, C (2005) The role of Dpp signaling in maintaining the Drosophila anteroposterior compartment boundary. Dev. Biol. 279 31-43 PubMed GONUTS page
↑ McCabe, BD et al. (2004) Highwire regulates presynaptic BMP signaling essential for synaptic growth. Neuron 41 891-905 PubMed GONUTS page
↑ Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page
↑ ^23.0 ^23.1 Affolter, M et al. (2001) Nuclear interpretation of Dpp signaling in Drosophila. EMBO J. 20 3298-305 PubMed GONUTS page
↑ ^24.0 ^24.1 Marquez, RM et al. (2001) Transgenic analysis of the Smad family of TGF-beta signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members. Genetics 157 1639-48 PubMed GONUTS page
↑ ^25.0 ^25.1 Dai, H et al. (2000) The zinc finger protein schnurri acts as a Smad partner in mediating the transcriptional response to decapentaplegic. Dev. Biol. 227 373-87 PubMed GONUTS page
↑ ^26.0 ^26.1 Xu, X et al. (1998) Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. Genes Dev. 12 2354-70 PubMed GONUTS page
↑ ^27.0 ^27.1 Xie, T & Spradling, AC (1998) decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. Cell 94 251-60 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 Kim, J et al. (1997) Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388 304-8 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 ^29.3 Wiersdorff, V et al. (1996) Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye. Development 122 2153-62 PubMed GONUTS page
↑ ^30.0 ^30.1 Newfeld, SJ et al. (1996) Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-beta responsive cells. Development 122 2099-108 PubMed GONUTS page
↑ ^31.0 ^31.1 Sekelsky, JJ et al. (1995) Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139 1347-58 PubMed GONUTS page
↑ Raftery, LA et al. (1995) Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. Genetics 139 241-54 PubMed GONUTS page
↑ ^33.0 ^33.1 Lecuit, T et al. (1996) Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing. Nature 381 387-93 PubMed GONUTS page
↑ Lin, H (2002) The stem-cell niche theory: lessons from flies. Nat. Rev. Genet. 3 931-40 PubMed GONUTS page
↑ Cripps, RM & Olson, EN (2002) Control of cardiac development by an evolutionarily conserved transcriptional network. Dev. Biol. 246 14-28 PubMed GONUTS page
↑ Lall, S & Patel, NH (2001) Conservation and divergence in molecular mechanisms of axis formation. Annu. Rev. Genet. 35 407-37 PubMed GONUTS page
↑ Bradley, PL et al. (2001) Organ formation in Drosophila: specification and morphogenesis of the salivary gland. Bioessays 23 901-11 PubMed GONUTS page
↑ Dobens, LL & Raftery, LA (2000) Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells. Dev. Dyn. 218 80-93 PubMed GONUTS page

[PMID:21696798-1] Colozza, G et al. (2011) Drosophila nucleoporin Nup154 controls cell viability, proliferation and nuclear accumulation of Mad transcription factor. Tissue Cell 43 254-61 PubMed GONUTS page

[PMID:26092715-2] Bivik, C et al. (2015) Novel Genes Involved in Controlling Specification of Drosophila FMRFamide Neuropeptide Cells. Genetics 200 1229-44 PubMed GONUTS page

[PMID:24553921-3] Liu, Z et al. (2014) dAcsl, the Drosophila ortholog of acyl-CoA synthetase long-chain family member 3 and 4, inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling. J. Neurosci. 34 2785-96 PubMed GONUTS page

[PMID:24321690-4] 4.0 ^4.1 Hodar, C et al. (2014) Comparative gene expression analysis of Dtg, a novel target gene of Dpp signaling pathway in the early Drosophila melanogaster embryo. Gene 535 210-7 PubMed GONUTS page

[PMID:24353060-5] Sulkowski, M et al. (2014) Postsynaptic glutamate receptors regulate local BMP signaling at the Drosophila neuromuscular junction. Development 141 436-47 PubMed GONUTS page

[PMID:24046358-6] Friedman, SH et al. (2013) Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila. Dis Model Mech 6 1400-13 PubMed GONUTS page

[PMID:23733344-7] Guo, Z et al. (2013) Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis. J. Cell Biol. 201 945-61 PubMed GONUTS page

[PMID:20226662-8] Ninov, N et al. (2010) Dpp signaling directs cell motility and invasiveness during epithelial morphogenesis. Curr. Biol. 20 513-20 PubMed GONUTS page

[PMID:20056890-9] Mathur, D et al. (2010) A transient niche regulates the specification of Drosophila intestinal stem cells. Science 327 210-3 PubMed GONUTS page

[PMID:20010841-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Weiss, A et al. (2010) A conserved activation element in BMP signaling during Drosophila development. Nat. Struct. Mol. Biol. 17 69-76 PubMed GONUTS page

[PMID:14507783-11] 11.0 ^11.1 Grienenberger, A et al. (2003) Tgfbeta signaling acts on a Hox response element to confer specificity and diversity to Hox protein function. Development 130 5445-55 PubMed GONUTS page

[PMID:19657393-12] Eivers, E et al. (2009) Mad is required for wingless signaling in wing development and segment patterning in Drosophila. PLoS ONE 4 e6543 PubMed GONUTS page

[PMID:19451277-13] Merino, C et al. (2009) Nemo kinase interacts with Mad to coordinate synaptic growth at the Drosophila neuromuscular junction. J. Cell Biol. 185 713-25 PubMed GONUTS page

[PMID:17428827-14] Cordero, JB et al. (2007) Dynamic decapentaplegic signaling regulates patterning and adhesion in the Drosophila pupal retina. Development 134 1861-71 PubMed GONUTS page

[PMID:17092951-15] Lin, MC et al. (2006) Threshold response of C15 to the Dpp gradient in Drosophila is established by the cumulative effect of Smad and Zen activators and negative cues. Development 133 4805-13 PubMed GONUTS page

[PMID:16648592-16] Dworkin, I & Gibson, G (2006) Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster. Genetics 173 1417-31 PubMed GONUTS page

[PMID:16510868-17] 17.0 ^17.1 Chen, HB et al. (2006) Identification of phosphatases for Smad in the BMP/DPP pathway. Genes Dev. 20 648-53 PubMed GONUTS page

[PMID:16256740-18] 18.0 ^18.1 Kirilly, D et al. (2005) BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. Dev. Cell 9 651-62 PubMed GONUTS page

[PMID:15809036-19] Firth, LC & Baker, NE (2005) Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev. Cell 8 541-51 PubMed GONUTS page

[PMID:15708556-20] Shen, J & Dahmann, C (2005) The role of Dpp signaling in maintaining the Drosophila anteroposterior compartment boundary. Dev. Biol. 279 31-43 PubMed GONUTS page

[PMID:15046722-21] McCabe, BD et al. (2004) Highwire regulates presynaptic BMP signaling essential for synaptic growth. Neuron 41 891-905 PubMed GONUTS page

[PMID:12147138-22] Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page

[PMID:11432817-23] 23.0 ^23.1 Affolter, M et al. (2001) Nuclear interpretation of Dpp signaling in Drosophila. EMBO J. 20 3298-305 PubMed GONUTS page

[PMID:11290719-24] 24.0 ^24.1 Marquez, RM et al. (2001) Transgenic analysis of the Smad family of TGF-beta signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members. Genetics 157 1639-48 PubMed GONUTS page

[PMID:11071761-25] 25.0 ^25.1 Dai, H et al. (2000) The zinc finger protein schnurri acts as a Smad partner in mediating the transcriptional response to decapentaplegic. Dev. Biol. 227 373-87 PubMed GONUTS page

[PMID:9694800-26] 26.0 ^26.1 Xu, X et al. (1998) Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. Genes Dev. 12 2354-70 PubMed GONUTS page

[PMID:9695953-27] 27.0 ^27.1 Xie, T & Spradling, AC (1998) decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. Cell 94 251-60 PubMed GONUTS page

[PMID:9230443-28] 28.0 ^28.1 ^28.2 Kim, J et al. (1997) Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388 304-8 PubMed GONUTS page

[PMID:8681796-29] 29.0 ^29.1 ^29.2 ^29.3 Wiersdorff, V et al. (1996) Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye. Development 122 2153-62 PubMed GONUTS page

[PMID:8681791-30] 30.0 ^30.1 Newfeld, SJ et al. (1996) Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-beta responsive cells. Development 122 2099-108 PubMed GONUTS page

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[PMID:7705627-32] Raftery, LA et al. (1995) Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. Genetics 139 241-54 PubMed GONUTS page

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DROME:MAD

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