PMID:12459723

Citation	Lin, H (2002) The stem-cell niche theory: lessons from flies. Nat. Rev. Genet. 3:931-40
Abstract	Stem cells are characterized by their ability to self-renew and to produce numerous differentiated cell types, and are directly responsible for generating and maintaining tissues and organs. This property has long been attributed to the instructive signals that stem cells receive from their microenvironment - the so-called 'stem-cell niche'. Studies of stem cells in the Drosophila gonad have yielded much exciting insight into the structure of the niche and the signalling pathways that it produces to regulate the self-renewal of stem cells. These findings are illuminating our understanding of the self-renewing mechanisms of tissue stem cells in general.
Links	PubMed Online version:10.1038/nrg952
Keywords	Animals; Cell Differentiation/physiology; Drosophila/genetics; Drosophila/metabolism; Female; Male; Ovary/metabolism; Signal Transduction/genetics; Signal Transduction/physiology; Stem Cells/cytology; Stem Cells/physiology; Testis/metabolism
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
DROME:DECA	involved_in	GO:0008285: negative regulation of cell population proliferation	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
DROME:DECA	involved_in	GO:0042078: germ-line stem cell division	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
DROME:MAD	involved_in	GO:0042078: germ-line stem cell division	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete

References

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