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PMID:15809036
| Citation |
Firth, LC and Baker, NE (2005) Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev. Cell 8:541-51 |
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| Abstract |
Spatially and temporally choreographed cell cycles accompany the differentiation of the Drosophila retina. The extracellular signals that control these patterns have been identified through mosaic analysis of mutations in signal transduction pathways. All cells arrest in G1 prior to the start of neurogenesis. Arrest depends on Dpp and Hh, acting redundantly. Most cells then go through a synchronous round of cell division before fate specification and terminal cell cycle exit. Cell cycle entry is induced by Notch signaling and opposed in subsets of cells by EGF receptor activity. Unusually, Cyclin E levels are not limiting for retinal cell cycles. Rbf/E2F and the Cyclin E antagonist Dacapo are important, however. All retinal cells, including the postmitotic photoreceptor neurons, continue dividing when rbf and dacapo are mutated simultaneously. These studies identify the specific extracellular signals that pattern the retinal cell cycles and show how differentiation can be uncoupled from cell cycle exit. |
| Links |
PubMed Online version:10.1016/j.devcel.2005.01.017 |
| Keywords |
Animals; Cell Cycle/physiology; Cell Differentiation; Cell Proliferation; Cyclin E/antagonists & inhibitors; Cyclin E/metabolism; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila melanogaster/cytology; Drosophila melanogaster/growth & development; Hedgehog Proteins; Membrane Proteins/genetics; Membrane Proteins/metabolism; Morphogenesis; Nuclear Proteins/genetics; Nuclear Proteins/metabolism; Photoreceptor Cells, Invertebrate/cytology; Photoreceptor Cells, Invertebrate/growth & development; Receptor, Epidermal Growth Factor/metabolism; Receptors, G-Protein-Coupled/genetics; Receptors, G-Protein-Coupled/metabolism; Receptors, Notch; Retina/cytology; Retina/growth & development; Retinoblastoma Protein; Signal Transduction/physiology; Transcription Factors/genetics; Transcription Factors/metabolism |
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Significance
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| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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