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PMID:11432817
| Citation |
Affolter, M, Marty, T, Vigano, MA and Jaźwińska, A (2001) Nuclear interpretation of Dpp signaling in Drosophila. EMBO J. 20:3298-305 |
|---|---|
| Abstract |
Signaling by Decapentaplegic (Dpp), a member of the TGFbeta superfamily of signaling molecules similar to vertebrate BMP2 and BMP4, has been implicated in many developmental processes in Drosophila melanogaster. Notably, Dpp acts as a long-range morphogen during imaginal disc growth and patterning. Genetic approaches led to the identification of a number of gene products that constitute the core signaling pathway. In addition to the ligand-activated heteromeric receptor complex and the signal-transducing intracellular Smad proteins, Dpp signaling requires two nuclear proteins, Schnurri (Shn) and Brinker (Brk), to prime cells for Dpp responsiveness. A complex interplay between the nuclear factors involved in Dpp signaling appears to control the transcriptional readout of the Dpp morphogen gradient. It remains to be seen whether similar molecular mechanisms operate in the nucleus in vertebrate systems. |
| Links |
PubMed PMC125521 Online version:10.1093/emboj/20.13.3298 |
| Keywords |
Animals; Body Patterning; Cell Nucleus/physiology; Drosophila Proteins; Drosophila melanogaster/embryology; Drosophila melanogaster/genetics; Drosophila melanogaster/physiology; Embryo, Nonmammalian/physiology; Insect Proteins/physiology; Models, Biological; Morphogenesis; Signal Transduction; Transforming Growth Factor beta/physiology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0016015: morphogen activity |
ECO:0000304: author statement supported by traceable reference used in manual assertion |
|
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001709: cell fate determination |
ECO:0000304: author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009950: dorsal/ventral axis specification |
ECO:0000303: author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007447: imaginal disc pattern formation |
ECO:0000303: author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007391: dorsal closure |
ECO:0000303: author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007448: anterior/posterior pattern specification, imaginal disc |
ECO:0000303: author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019827: stem cell population maintenance |
ECO:0000303: author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007424: open tracheal system development |
ECO:0000303: author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006357: regulation of transcription by RNA polymerase II |
ECO:0000303: author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634: nucleus |
ECO:0000304: author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
See also
References
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