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PMID:11598957

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Citation

Bradley, PL, Haberman, AS and Andrew, DJ (2001) Organ formation in Drosophila: specification and morphogenesis of the salivary gland. Bioessays 23:901-11

Abstract

The Drosophila salivary gland has emerged as an outstanding model system for the process of organ formation. Many of the component steps, from initial regional specification through cell specialization and morphogenesis, are known and many of the genes required for these different processes have been identified. The salivary gland is a relatively simple organ; the entire gland comprises of only two major cell types, which derive from a single contiguous primordium. Salivary cells cease dividing once they are specified, and organ growth is achieved simply by an increase in size of individual cells, thus eliminating concerns about the potential unequal distribution of determinants during mitosis. Drosophila salivary glands form by the same cellular mechanisms as organs in higher organisms, including regulated cell shape changes, cell intercalation and directed cell migration. Thus, learning how these events are coordinated for tissue morphogenesis in an organism for which the genetic and molecular tools are unsurpassed should provide excellent paradigms for dissecting related processes in the more intricate organs of more complicated species.

Links

PubMed Online version:10.1002/bies.1131

Keywords

Animals; Drosophila melanogaster/embryology; Morphogenesis; Salivary Glands/embryology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:A0A0B4KFC0

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:A0A0B4KFC4

involved_in

GO:0008360: regulation of cell shape

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:A0A0B4KFC4

involved_in

GO:0016477: cell migration

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:A0A0B4KG59

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:A1Z8F4

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:HTH

involved_in

GO:0007432: salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:O61458

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:O62609

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:O76259

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:O77069

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:O77238

involved_in

GO:0007435: salivary gland morphogenesis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:HUNB

involved_in

GO:0007431: salivary gland development

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:DECA

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:SCR

involved_in

GO:0007432: salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:ABDB

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:FKH

involved_in

GO:0000122: negative regulation of transcription by RNA polymerase II

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:TSH

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:GIANT

involved_in

GO:0007431: salivary gland development

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:EXD

involved_in

GO:0007432: salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q0E9C5

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q24107

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q24229

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q24326

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q24468

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q24605

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q27933

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q3YNE2

involved_in

GO:0007435: salivary gland morphogenesis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q5BHV4

involved_in

GO:0007435: salivary gland morphogenesis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q7JQ37

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q7KF43

involved_in

GO:0008360: regulation of cell shape

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q7KF43

involved_in

GO:0016477: cell migration

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q7KPL1

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q7KTP1

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q7YSG8

involved_in

GO:0007435: salivary gland morphogenesis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IMG6

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IPK9

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8MQL7

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8MTJ1

involved_in

GO:0007435: salivary gland morphogenesis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8SZT5

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q95SI0

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q95T01

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9U010

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VMT1

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VTX7

involved_in

GO:0007435: salivary gland morphogenesis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:DECA

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

DROME:MAD

involved_in

GO:0045705: negative regulation of salivary gland boundary specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:TRH

involved_in

GO:0007424: open tracheal system development

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:TRH

involved_in

GO:0007435: salivary gland morphogenesis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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