HUMAN:PRGC1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PPARGC1A (synonyms: LEM6, PGC1, PGC1A, PPARGC1)
Protein Name(s)	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha PGC-1-alpha PPAR-gamma coactivator 1-alpha PPARGC-1-alpha Ligand effect modulator 6
External Links
UniProt	Q9UBK2
EMBL	AF108205 AF108193 AF108194 AF108195 AF108196 AF108197 AF108198 AF108199 AF108200 AF108201 AF108202 AF108203 AF108204 AF106698 AF159714 AF186379 HQ695733 JQ772116 JQ772117 JQ772118 JQ772119 JQ772120 AB061325 EU280319 AK296591 AC092834 AC097508 CH471069
CCDS	CCDS3429.1
RefSeq	NP_037393.1 XP_005248187.1
UniGene	Hs.527078
PDB	1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V 4QJR 4QK4
PDBsum	1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V 4QJR 4QK4
ProteinModelPortal	Q9UBK2
SMR	Q9UBK2
BioGrid	116097
DIP	DIP-38449N
IntAct	Q9UBK2
MINT	MINT-6824612
STRING	9606.ENSP00000264867
ChEMBL	CHEMBL6116
PhosphoSite	Q9UBK2
DMDM	47117335
MaxQB	Q9UBK2
PaxDb	Q9UBK2
PRIDE	Q9UBK2
DNASU	10891
Ensembl	ENST00000264867 ENST00000506055 ENST00000513205 ENST00000613098
GeneID	10891
KEGG	hsa:10891
UCSC	uc003gqs.3
CTD	10891
GeneCards	GC04M023793
HGNC	HGNC:9237
MIM	604517
neXtProt	NX_Q9UBK2
Orphanet	803
PharmGKB	PA33558
eggNOG	NOG78353
GeneTree	ENSGT00530000063196
HOGENOM	HOG000037431
HOVERGEN	HBG053678
InParanoid	Q9UBK2
KO	K07202
OMA	SPPKSLF
OrthoDB	EOG7S4X5H
PhylomeDB	Q9UBK2
TreeFam	TF343068
Reactome	REACT_111118 REACT_116145 REACT_118659 REACT_118789 REACT_200608 REACT_200686 REACT_24941 REACT_27161
ChiTaRS	PPARGC1A
EvolutionaryTrace	Q9UBK2
GeneWiki	PPARGC1A
GenomeRNAi	10891
NextBio	35533615
PRO	PR:Q9UBK2
Proteomes	UP000005640
Bgee	Q9UBK2
CleanEx	HS_PPARGC1A
ExpressionAtlas	Q9UBK2
Genevestigator	Q9UBK2
GO	GO:0005829 GO:0005665 GO:0005654 GO:0005634 GO:0016605 GO:0050681 GO:0031490 GO:0003677 GO:0016922 GO:0030374 GO:0000166 GO:0003723 GO:0001104 GO:0043565 GO:0003713 GO:0008134 GO:0031625 GO:0008209 GO:0030521 GO:0050873 GO:0001678 GO:0045333 GO:0071398 GO:0071456 GO:0071250 GO:0034599 GO:0097067 GO:0071356 GO:0032922 GO:0007586 GO:0019395 GO:0051552 GO:0006012 GO:0006094 GO:0007005 GO:0006397 GO:0045820 GO:0043524 GO:1901215 GO:2000272 GO:2001171 GO:1901857 GO:2000507 GO:0046321 GO:0045722 GO:0035066 GO:1901860 GO:0010822 GO:1901863 GO:0051091 GO:0048661 GO:0045944 GO:0045893 GO:0006461 GO:0050821 GO:0042752 GO:2000310 GO:0006355 GO:0022904 GO:0009409 GO:0071871 GO:0043201 GO:0014850 GO:0071873 GO:0042594 GO:0036273 GO:0008380 GO:0001659 GO:0006367
Gene3D	3.30.70.330
InterPro	IPR012677 IPR000504
Pfam	PF00076
SMART	SM00360
PROSITE	PS50102

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0010628	positive regulation of gene expression	PMID:23525105^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000119912)\|regulates_expression_of:(ENSEMBL:ENSG00000106459)	Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:15454086^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70343	P		Seeded From UniProt	complete
involved_in	GO:0010822	positive regulation of mitochondrion organization	PMID:25118933^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:22064484^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q969K3	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21376232^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(ENSEMBL:ENSG00000106459) occurs_in:(UBERON:0002435)\|has_regulation_target(ENSEMBL:ENSG00000106459) occurs_in:(UBERON:0002038)	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:19651776^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70343	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16488887^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19651776^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	PMID:16488887^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0014850	response to muscle activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70343	P		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:19651776^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2001171	positive regulation of ATP biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70343	P		Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70343	P		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	PMID:15572661^[8]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15572661^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:23836911^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70343	P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70343	P		Seeded From UniProt	complete
involved_in	GO:0042594	response to starvation	PMID:11854298^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70343	P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70343	P		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70343	F		Seeded From UniProt	complete
involved_in	GO:0030521	androgen receptor signaling pathway	PMID:15572661^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0022904	respiratory electron transport chain	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70343	P		Seeded From UniProt	complete
involved_in	GO:0019395	fatty acid oxidation	PMID:11854298^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016922	nuclear receptor binding	PMID:18798693^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P24468	F		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	PMID:21376232^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q6NUN9	P		Seeded From UniProt	complete
involved_in	GO:0010822	positive regulation of mitochondrion organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70343	P		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	PMID:11854298^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:23836911^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006094	gluconeogenesis	PMID:11854298^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23836911^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70343	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:21376232^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70343	F		Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	PMID:11854298^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1342774 PANTHER:PTN000399017 UniProtKB:Q9UBK2	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1342774 PANTHER:PTN000399017 RGD:620925 UniProtKB:Q86YN6 UniProtKB:Q9UBK2	P		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000399017 UniProtKB:Q86YN6 UniProtKB:Q9UBK2	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1342774 PANTHER:PTN000399017 RGD:620925	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037248 MGI:MGI:1342774 PANTHER:PTN000399017 RGD:620925 UniProtKB:Q86YN6 UniProtKB:Q9UBK2	C		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000399017 UniProtKB:Q86YN6	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2001171	positive regulation of ATP biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	P		Seeded From UniProt	complete
involved_in	GO:1901863	positive regulation of muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	P		Seeded From UniProt	complete
involved_in	GO:1901860	positive regulation of mitochondrial DNA metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	P		Seeded From UniProt	complete
involved_in	GO:1901857	positive regulation of cellular respiration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	P		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	P		Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	P		Seeded From UniProt	complete
involved_in	GO:0060612	adipose tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	P		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	F		Seeded From UniProt	complete
involved_in	GO:0022904	respiratory electron transport chain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	P		Seeded From UniProt	complete
involved_in	GO:0014850	response to muscle activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	P		Seeded From UniProt	complete
involved_in	GO:0010822	positive regulation of mitochondrion organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	F		Seeded From UniProt	complete
involved_in	GO:0002021	response to dietary excess	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70343 ensembl:ENSMUSP00000117040	P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:2000272	negative regulation of signaling receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:2000184	positive regulation of progesterone biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:1990845	adaptive thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
part_of	GO:1990844	interfibrillar mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	C		Seeded From UniProt	complete
part_of	GO:1990843	subsarcolemmal mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	C		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	F		Seeded From UniProt	complete
involved_in	GO:1904640	response to methionine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:1904639	cellular response to resveratrol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:1904637	cellular response to ionomycin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:1904635	positive regulation of glomerular visceral epithelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:1901558	response to metformin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
part_of	GO:0097440	apical dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	C		Seeded From UniProt	complete
involved_in	GO:0097067	cellular response to thyroid hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0097066	response to thyroid hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0090258	negative regulation of mitochondrial fission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071873	response to norepinephrine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071871	response to epinephrine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071398	cellular response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071392	cellular response to estradiol stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071372	cellular response to follicle-stimulating hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071354	cellular response to interleukin-6	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071332	cellular response to fructose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071313	cellular response to caffeine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071250	cellular response to nitrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0051602	response to electrical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0051552	flavone metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0046321	positive regulation of fatty acid oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0045820	negative regulation of glycolytic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0043201	response to leucine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	C		Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	F		Seeded From UniProt	complete
enables	GO:0042975	peroxisome proliferator activated receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	F		Seeded From UniProt	complete
involved_in	GO:0042594	response to starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0035865	cellular response to potassium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0031325	positive regulation of cellular metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	F		Seeded From UniProt	complete
part_of	GO:0022626	cytosolic ribosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	C		Seeded From UniProt	complete
involved_in	GO:0021549	cerebellum development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0019395	fatty acid oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0014912	negative regulation of smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0014878	response to electrical stimulus involved in regulation of muscle adaptation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0014850	response to muscle activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0014732	skeletal muscle atrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0009750	response to fructose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0009409	response to cold	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0008209	androgen metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	F		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0006094	gluconeogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0006012	galactose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	C		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	F		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0000422	autophagy of mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0000302	response to reactive oxygen species	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000504 InterPro:IPR035979	F		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034605 InterPro:IPR034625	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034625	F		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034625	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034605 InterPro:IPR034625	F		Seeded From UniProt	complete
involved_in	GO:0050873	brown fat cell differentiation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034625	P		Seeded From UniProt	complete
involved_in	GO:0050873	brown fat cell differentiation	PMID:12588810^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:14636573^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046321	positive regulation of fatty acid oxidation	PMID:12588810^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045722	positive regulation of gluconeogenesis	PMID:12588810^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045333	cellular respiration	PMID:11551810^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035066	positive regulation of histone acetylation	PMID:14636573^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008380	RNA splicing	PMID:12588810^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:12588810^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007586	digestion	PMID:10585775^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	PMID:14636573^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	PMID:12588810^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	PMID:14636573^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12588810^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:12588810^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:10713165^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001659	temperature homeostasis	PMID:1258810^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	PMID:14636573^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	Reactome:R-HSA-400253	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	Reactome:R-HSA-1592230	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8939929 Reactome:R-HSA-2466392 Reactome:R-HSA-2466391 Reactome:R-HSA-1592236 Reactome:R-HSA-1368140	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Leal, MC et al. (2013) Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid β (Aβ) peptide catabolism and functionality. J. Biol. Chem. 288 12920-31 PubMed GONUTS page
↑ Lin, J et al. (2004) Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 119 121-35 PubMed GONUTS page
↑ Xu, R et al. (2014) The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway. Cell Death Dis 5 e1373 PubMed GONUTS page
↑ Wei, P et al. (2012) RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1α and modulates brown fat cell metabolism. Mol. Cell. Biol. 32 266-75 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Shin, JH et al. (2011) PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease. Cell 144 689-702 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Nedumaran, B et al. (2009) DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression. J. Biol. Chem. 284 27511-23 PubMed GONUTS page
↑ ^7.0 ^7.1 Song, KH et al. (2006) A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene. J. Biol. Chem. 281 10081-8 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Lin, DY et al. (2004) Negative modulation of androgen receptor transcriptional activity by Daxx. Mol. Cell. Biol. 24 10529-41 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Cho, Y et al. (2013) Peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells. J. Biol. Chem. 288 25207-18 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Kressler, D et al. (2002) The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. J. Biol. Chem. 277 13918-25 PubMed GONUTS page
↑ Kruse, SW et al. (2008) Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor. PLoS Biol. 6 e227 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Puigserver, P & Spiegelman, BM (2003) Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr. Rev. 24 78-90 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 Wallberg, AE et al. (2003) Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. Mol. Cell 12 1137-49 PubMed GONUTS page
↑ Knutti, D & Kralli, A (2001) PGC-1, a versatile coactivator. Trends Endocrinol. Metab. 12 360-5 PubMed GONUTS page
↑ Esterbauer, H et al. (1999) Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. Genomics 62 98-102 PubMed GONUTS page
↑ Knutti, D et al. (2000) A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. Mol. Cell. Biol. 20 2411-22 PubMed GONUTS page
↑ Spanos, NP et al. (1976) Cognitive strategies and response to suggestion in hypnotic and task-motivated subjects. Am J Clin Hypn 18 254-62 PubMed GONUTS page

[PMID:23525105-1] Leal, MC et al. (2013) Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid β (Aβ) peptide catabolism and functionality. J. Biol. Chem. 288 12920-31 PubMed GONUTS page

[PMID:15454086-2] Lin, J et al. (2004) Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 119 121-35 PubMed GONUTS page

[PMID:25118933-3] Xu, R et al. (2014) The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway. Cell Death Dis 5 e1373 PubMed GONUTS page

[PMID:22064484-4] Wei, P et al. (2012) RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1α and modulates brown fat cell metabolism. Mol. Cell. Biol. 32 266-75 PubMed GONUTS page

[PMID:21376232-5] 5.0 ^5.1 ^5.2 Shin, JH et al. (2011) PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease. Cell 144 689-702 PubMed GONUTS page

[PMID:19651776-6] 6.0 ^6.1 ^6.2 Nedumaran, B et al. (2009) DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression. J. Biol. Chem. 284 27511-23 PubMed GONUTS page

[PMID:16488887-7] 7.0 ^7.1 Song, KH et al. (2006) A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene. J. Biol. Chem. 281 10081-8 PubMed GONUTS page

[PMID:15572661-8] 8.0 ^8.1 ^8.2 Lin, DY et al. (2004) Negative modulation of androgen receptor transcriptional activity by Daxx. Mol. Cell. Biol. 24 10529-41 PubMed GONUTS page

[PMID:23836911-9] 9.0 ^9.1 ^9.2 Cho, Y et al. (2013) Peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells. J. Biol. Chem. 288 25207-18 PubMed GONUTS page

[PMID:11854298-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Kressler, D et al. (2002) The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. J. Biol. Chem. 277 13918-25 PubMed GONUTS page

[PMID:18798693-11] Kruse, SW et al. (2008) Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor. PLoS Biol. 6 e227 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12588810-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Puigserver, P & Spiegelman, BM (2003) Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr. Rev. 24 78-90 PubMed GONUTS page

[PMID:14636573-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 Wallberg, AE et al. (2003) Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. Mol. Cell 12 1137-49 PubMed GONUTS page

[PMID:11551810-15] Knutti, D & Kralli, A (2001) PGC-1, a versatile coactivator. Trends Endocrinol. Metab. 12 360-5 PubMed GONUTS page

[PMID:10585775-16] Esterbauer, H et al. (1999) Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. Genomics 62 98-102 PubMed GONUTS page

[PMID:10713165-17] Knutti, D et al. (2000) A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. Mol. Cell. Biol. 20 2411-22 PubMed GONUTS page

[PMID:1258810-18] Spanos, NP et al. (1976) Cognitive strategies and response to suggestion in hypnotic and task-motivated subjects. Am J Clin Hypn 18 254-62 PubMed GONUTS page

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