HUMAN:FOXC1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FOXC1 (synonyms: FKHL7, FREAC3)
Protein Name(s)	Forkhead box protein C1 Forkhead-related protein FKHL7 Forkhead-related transcription factor 3 FREAC-3
External Links
UniProt	Q12948
EMBL	AF048693 AF078096 AY228704 AL034344 L12143 U13221
CCDS	CCDS4473.1
PIR	S51626
RefSeq	NP_001444.2
UniGene	Hs.348883
ProteinModelPortal	Q12948
SMR	Q12948
BioGrid	108585
IntAct	Q12948
STRING	9606.ENSP00000370256
PhosphoSite	Q12948
DMDM	13638267
MaxQB	Q12948
PaxDb	Q12948
PRIDE	Q12948
Ensembl	ENST00000380874
GeneID	2296
KEGG	hsa:2296
UCSC	uc003mtp.3
CTD	2296
GeneCards	GC06P001610
H-InvDB	HIX0032962
HGNC	HGNC:3800
HPA	HPA040670
MIM	601090 601631 602482 604229
neXtProt	NX_Q12948
Orphanet	98978 782 708 91483
PharmGKB	PA28217
eggNOG	COG5025
HOVERGEN	HBG051640
InParanoid	Q12948
KO	K09396
OMA	YSSPCSQ
OrthoDB	EOG7C8GHD
PhylomeDB	Q12948
TreeFam	TF316127
SignaLink	Q12948
GeneWiki	Forkhead_box_C1
GenomeRNAi	2296
NextBio	9319
PRO	PR:Q12948
Proteomes	UP000005640
Bgee	Q12948
CleanEx	HS_FOXC1
ExpressionAtlas	Q12948
Genevestigator	Q12948
GO	GO:0005737 GO:0005720 GO:0005634 GO:0003677 GO:0008301 GO:0003705 GO:0000977 GO:0001228 GO:0043565 GO:0003700 GO:0008134 GO:0044212 GO:0048844 GO:0001974 GO:0007420 GO:0043010 GO:0060038 GO:0030199 GO:0035050 GO:0001654 GO:0008354 GO:0030203 GO:0007507 GO:0001701 GO:0032808 GO:0001945 GO:1902257 GO:0045930 GO:0014032 GO:0007219 GO:0042475 GO:0001503 GO:0001541 GO:0048341 GO:0045944 GO:0045893 GO:0050880 GO:0046620 GO:0006355 GO:0001501 GO:0001756 GO:0001657 GO:0048010 GO:0055010
Gene3D	1.10.10.10
InterPro	IPR001766 IPR018122 IPR011991
Pfam	PF00250
PRINTS	PR00053
SMART	SM00339
PROSITE	PS00657 PS00658 PS50039

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001766	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q61660	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:14578375^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:14578375^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:14578375^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14578375^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:25786029^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25786029^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:25786029^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:25786029^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1990869	cellular response to chemokine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	P		Seeded From UniProt	complete
involved_in	GO:0070098	chemokine-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19793056^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:19793056^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19793056^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:27804176^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:27804176^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:27804176^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045618	positive regulation of keratinocyte differentiation	PMID:27907090^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:27907090^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	F		Seeded From UniProt	complete
enables	GO:0001223	transcription coactivator binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	F		Seeded From UniProt	complete
involved_in	GO:1904798	positive regulation of core promoter binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	P		Seeded From UniProt	complete
involved_in	GO:0001958	endochondral ossification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:27804176^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19279310^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:19279310^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:19279310^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19279310^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17210863^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17210863^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:17210863^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:17210863^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0021549	cerebellum development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61850	P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61850	P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	P		Seeded From UniProt	complete
involved_in	GO:1902038	positive regulation of hematopoietic stem cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	P		Seeded From UniProt	complete
involved_in	GO:1901534	positive regulation of hematopoietic progenitor cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	P		Seeded From UniProt	complete
involved_in	GO:0014031	mesenchymal cell development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	P		Seeded From UniProt	complete
involved_in	GO:1901491	negative regulation of lymphangiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	P		Seeded From UniProt	complete
involved_in	GO:0038084	vascular endothelial growth factor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	P		Seeded From UniProt	complete
involved_in	GO:0036438	maintenance of lens transparency	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	P		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20406990^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14506133^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	PMID:14506133^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:14506133^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:14506133^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11782474^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15299087^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:15299087^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:15299087^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:11782474^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:11782474^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:20406990^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:20406990^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:16449236^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17993506^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:2308)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000036	ECO:0000305	curator inference used in manual assertion	GO:0000977,GO:0045944	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:7957066^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0072010	glomerular epithelium development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16449236^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61572	F		Seeded From UniProt	complete
involved_in	GO:0043388	positive regulation of DNA binding	PMID:26565916^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26565916^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:26565916^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10070	F		Seeded From UniProt	complete
involved_in	GO:0045930	negative regulation of mitotic cell cycle	PMID:12408963^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15277473^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:8499623^[19]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:15277473^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:7957066^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042475	odontogenesis of dentin-containing tooth	PMID:12614756^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	PMID:7957066^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:15684392^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P40424-1	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:15684392^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005720	nuclear heterochromatin	PMID:15684392^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16449236^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15277473^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7957066^[15]	ECO:0000305	curator inference used in manual assertion	GO:0043565	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:15277473^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:15684392^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15684392^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:22991501^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:22991501^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:22991501^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16492674^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	PMID:16492674^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000930906 WB:WBGene00004013	P		Seeded From UniProt	complete
involved_in	GO:0009653	anatomical structure morphogenesis	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347476 PANTHER:PTN000930906	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 MGI:MGI:1347472 MGI:MGI:1347477 PANTHER:PTN000930906 UniProtKB:O00358 UniProtKB:Q9Y261 ZFIN:ZDB-GENE-000616-15	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 FB:FBgn0003430 FB:FBgn0004895 FB:FBgn0014143 MGI:MGI:1347466 MGI:MGI:1347472 MGI:MGI:1347476 MGI:MGI:1347477 MGI:MGI:1349428 MGI:MGI:1353569 MGI:MGI:1927549 MGI:MGI:95546 PANTHER:PTN000930906 PomBase:SPBC32H8.11 PomBase:SPBC4C3.12 RGD:2807 RGD:2808 RGD:2809 SGD:S000000661 SGD:S000001393 UniProtKB:O00358 UniProtKB:P55317 UniProtKB:P58012 UniProtKB:Q12948 UniProtKB:Q13461 UniProtKB:Q5AS72 UniProtKB:Q99958 UniProtKB:Q9Y261 WB:WBGene00001434 WB:WBGene00001441 WB:WBGene00002601 WB:WBGene00003017 WB:WBGene00004013 WB:WBGene00006853	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 PANTHER:PTN000930906 RGD:621723 UniProtKB:O00358 WB:WBGene00004013 ZFIN:ZDB-GENE-000616-15	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11237714^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	PMID:7957066^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:10474162^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11562355^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11179011^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:11179011^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:7957066^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:11179011^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	PMID:9792859^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1990869	cellular response to chemokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	F		Seeded From UniProt	complete
involved_in	GO:1904798	positive regulation of core promoter binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:1902257	negative regulation of apoptotic process involved in outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:1902038	positive regulation of hematopoietic stem cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:1901534	positive regulation of hematopoietic progenitor cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:1901491	negative regulation of lymphangiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0072010	glomerular epithelium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0070098	chemokine-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0060038	cardiac muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0055010	ventricular cardiac muscle tissue morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0050880	regulation of blood vessel size	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0048844	artery morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0048762	mesenchymal cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0048341	paraxial mesoderm formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0046620	regulation of organ growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	F		Seeded From UniProt	complete
involved_in	GO:0043010	camera-type eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0038084	vascular endothelial growth factor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0036438	maintenance of lens transparency	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0035050	embryonic heart tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0032808	lacrimal gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0030203	glycosaminoglycan metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0030199	collagen fibril organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0021549	cerebellum development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0014032	neural crest cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0014031	mesenchymal cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0008354	germ cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	F		Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0001974	blood vessel remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0001958	endochondral ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0001945	lymph vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0001541	ovarian follicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
enables	GO:0001223	transcription coactivator binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61572 ensembl:ENSMUSP00000052196	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Saleem, RA et al. (2003) Identification and analysis of a novel mutation in the FOXC1 forkhead domain. Invest. Ophthalmol. Vis. Sci. 44 4608-12 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Medina-Trillo, C et al. (2015) Hypo- and hypermorphic FOXC1 mutations in dominant glaucoma: transactivation and phenotypic variability. PLoS ONE 10 e0119272 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Fetterman, CD et al. (2009) Characterization of a novel FOXC1 mutation, P297S, identified in two individuals with anterior segment dysgenesis. Clin. Genet. 76 296-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Seifi, M et al. (2017) Comparison of Bioinformatics Prediction, Molecular Modeling, and Functional Analyses of FOXC1 Mutations in Patients with Axenfeld-Rieger Syndrome. Hum. Mutat. 38 169-179 PubMed GONUTS page
↑ ^6.0 ^6.1 Bin, L et al. (2016) Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation. PLoS ONE 11 e0167392 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Ito, YA et al. (2009) Severe molecular defects of a novel FOXC1 W152G mutation result in aniridia. Invest. Ophthalmol. Vis. Sci. 50 3573-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Ito, YA et al. (2007) Analyses of a novel L130F missense mutation in FOXC1. Arch. Ophthalmol. 125 128-35 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Ray, PS et al. (2010) FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer. Cancer Res. 70 3870-6 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Saleem, RA et al. (2003) Structural and functional analyses of disease-causing missense mutations in the forkhead domain of FOXC1. Hum. Mol. Genet. 12 2993-3005 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Berry, FB et al. (2002) FOXC1 transcriptional regulation is mediated by N- and C-terminal activation domains and contains a phosphorylated transcriptional inhibitory domain. J. Biol. Chem. 277 10292-7 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Saleem, RA et al. (2004) Essential structural and functional determinants within the forkhead domain of FOXC1. Nucleic Acids Res. 32 4182-93 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Berry, FB et al. (2006) Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis. Hum. Mol. Genet. 15 905-19 PubMed GONUTS page
↑ Berry, FB et al. (2008) FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A. Hum. Mol. Genet. 17 490-505 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Pierrou, S et al. (1994) Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. EMBO J. 13 5002-12 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Han, B et al. (2015) FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer. Cell Rep 13 1046-58 PubMed GONUTS page
↑ Zhou, Y et al. (2002) Identification of FOXC1 as a TGF-beta1 responsive gene and its involvement in negative regulation of cell growth. Genomics 80 465-72 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Murphy, TC et al. (2004) The wing 2 region of the FOXC1 forkhead domain is necessary for normal DNA-binding and transactivation functions. Invest. Ophthalmol. Vis. Sci. 45 2531-8 PubMed GONUTS page
↑ Hromas, R et al. (1993) Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells. Blood 81 2854-9 PubMed GONUTS page
↑ Honkanen, RA et al. (2003) A family with Axenfeld-Rieger syndrome and Peters Anomaly caused by a point mutation (Phe112Ser) in the FOXC1 gene. Am. J. Ophthalmol. 135 368-75 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 Berry, FB et al. (2005) FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner. Mol. Cell. Biol. 25 1415-24 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Xu, ZY et al. (2012) FOXC1 contributes to microvascular invasion in primary hepatocellular carcinoma via regulating epithelial-mesenchymal transition. Int. J. Biol. Sci. 8 1130-41 PubMed GONUTS page
↑ ^23.0 ^23.1 Berry, FB et al. (2006) Regulation of FOXC1 stability and transcriptional activity by an epidermal growth factor-activated mitogen-activated protein kinase signaling cascade. J. Biol. Chem. 281 10098-104 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 ^24.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Agarwala, KL et al. (2001) DSCAM, a highly conserved gene in mammals, expressed in differentiating mouse brain. Biochem. Biophys. Res. Commun. 281 697-705 PubMed GONUTS page
↑ Swiderski, RE et al. (1999) Expression of the Mf1 gene in developing mouse hearts: implication in the development of human congenital heart defects. Dev. Dyn. 216 16-27 PubMed GONUTS page
↑ Kume, T et al. (2001) The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev. 15 2470-82 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 Saleem, RA et al. (2001) Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1. Am. J. Hum. Genet. 68 627-41 PubMed GONUTS page
↑ Mears, AJ et al. (1998) Mutations of the forkhead/winged-helix gene, FKHL7, in patients with Axenfeld-Rieger anomaly. Am. J. Hum. Genet. 63 1316-28 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:14578375-2] 2.0 ^2.1 ^2.2 ^2.3 Saleem, RA et al. (2003) Identification and analysis of a novel mutation in the FOXC1 forkhead domain. Invest. Ophthalmol. Vis. Sci. 44 4608-12 PubMed GONUTS page

[PMID:25786029-3] 3.0 ^3.1 ^3.2 ^3.3 Medina-Trillo, C et al. (2015) Hypo- and hypermorphic FOXC1 mutations in dominant glaucoma: transactivation and phenotypic variability. PLoS ONE 10 e0119272 PubMed GONUTS page

[PMID:19793056-4] 4.0 ^4.1 ^4.2 Fetterman, CD et al. (2009) Characterization of a novel FOXC1 mutation, P297S, identified in two individuals with anterior segment dysgenesis. Clin. Genet. 76 296-9 PubMed GONUTS page

[PMID:27804176-5] 5.0 ^5.1 ^5.2 ^5.3 Seifi, M et al. (2017) Comparison of Bioinformatics Prediction, Molecular Modeling, and Functional Analyses of FOXC1 Mutations in Patients with Axenfeld-Rieger Syndrome. Hum. Mutat. 38 169-179 PubMed GONUTS page

[PMID:27907090-6] 6.0 ^6.1 Bin, L et al. (2016) Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation. PLoS ONE 11 e0167392 PubMed GONUTS page

[PMID:19279310-7] 7.0 ^7.1 ^7.2 ^7.3 Ito, YA et al. (2009) Severe molecular defects of a novel FOXC1 W152G mutation result in aniridia. Invest. Ophthalmol. Vis. Sci. 50 3573-9 PubMed GONUTS page

[PMID:17210863-8] 8.0 ^8.1 ^8.2 ^8.3 Ito, YA et al. (2007) Analyses of a novel L130F missense mutation in FOXC1. Arch. Ophthalmol. 125 128-35 PubMed GONUTS page

[PMID:20406990-9] 9.0 ^9.1 ^9.2 Ray, PS et al. (2010) FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer. Cancer Res. 70 3870-6 PubMed GONUTS page

[PMID:14506133-10] 10.0 ^10.1 ^10.2 ^10.3 Saleem, RA et al. (2003) Structural and functional analyses of disease-causing missense mutations in the forkhead domain of FOXC1. Hum. Mol. Genet. 12 2993-3005 PubMed GONUTS page

[PMID:11782474-11] 11.0 ^11.1 ^11.2 Berry, FB et al. (2002) FOXC1 transcriptional regulation is mediated by N- and C-terminal activation domains and contains a phosphorylated transcriptional inhibitory domain. J. Biol. Chem. 277 10292-7 PubMed GONUTS page

[PMID:15299087-12] 12.0 ^12.1 ^12.2 Saleem, RA et al. (2004) Essential structural and functional determinants within the forkhead domain of FOXC1. Nucleic Acids Res. 32 4182-93 PubMed GONUTS page

[PMID:16449236-13] 13.0 ^13.1 ^13.2 Berry, FB et al. (2006) Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis. Hum. Mol. Genet. 15 905-19 PubMed GONUTS page

[PMID:17993506-14] Berry, FB et al. (2008) FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A. Hum. Mol. Genet. 17 490-505 PubMed GONUTS page

[PMID:7957066-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Pierrou, S et al. (1994) Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. EMBO J. 13 5002-12 PubMed GONUTS page

[PMID:26565916-16] 16.0 ^16.1 ^16.2 Han, B et al. (2015) FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer. Cell Rep 13 1046-58 PubMed GONUTS page

[PMID:12408963-17] Zhou, Y et al. (2002) Identification of FOXC1 as a TGF-beta1 responsive gene and its involvement in negative regulation of cell growth. Genomics 80 465-72 PubMed GONUTS page

[PMID:15277473-18] 18.0 ^18.1 ^18.2 ^18.3 Murphy, TC et al. (2004) The wing 2 region of the FOXC1 forkhead domain is necessary for normal DNA-binding and transactivation functions. Invest. Ophthalmol. Vis. Sci. 45 2531-8 PubMed GONUTS page

[PMID:8499623-19] Hromas, R et al. (1993) Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells. Blood 81 2854-9 PubMed GONUTS page

[PMID:12614756-20] Honkanen, RA et al. (2003) A family with Axenfeld-Rieger syndrome and Peters Anomaly caused by a point mutation (Phe112Ser) in the FOXC1 gene. Am. J. Ophthalmol. 135 368-75 PubMed GONUTS page

[PMID:15684392-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 Berry, FB et al. (2005) FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner. Mol. Cell. Biol. 25 1415-24 PubMed GONUTS page

[PMID:22991501-22] 22.0 ^22.1 ^22.2 Xu, ZY et al. (2012) FOXC1 contributes to microvascular invasion in primary hepatocellular carcinoma via regulating epithelial-mesenchymal transition. Int. J. Biol. Sci. 8 1130-41 PubMed GONUTS page

[PMID:16492674-23] 23.0 ^23.1 Berry, FB et al. (2006) Regulation of FOXC1 stability and transcriptional activity by an epidermal growth factor-activated mitogen-activated protein kinase signaling cascade. J. Biol. Chem. 281 10098-104 PubMed GONUTS page

[PMID:21873635-24] 24.0 ^24.1 ^24.2 ^24.3 ^24.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11237714-25] Agarwala, KL et al. (2001) DSCAM, a highly conserved gene in mammals, expressed in differentiating mouse brain. Biochem. Biophys. Res. Commun. 281 697-705 PubMed GONUTS page

[PMID:10474162-26] Swiderski, RE et al. (1999) Expression of the Mf1 gene in developing mouse hearts: implication in the development of human congenital heart defects. Dev. Dyn. 216 16-27 PubMed GONUTS page

[PMID:11562355-27] Kume, T et al. (2001) The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev. 15 2470-82 PubMed GONUTS page

[PMID:11179011-28] 28.0 ^28.1 ^28.2 Saleem, RA et al. (2001) Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1. Am. J. Hum. Genet. 68 627-41 PubMed GONUTS page

[PMID:9792859-29] Mears, AJ et al. (1998) Mutations of the forkhead/winged-helix gene, FKHL7, in patients with Axenfeld-Rieger anomaly. Am. J. Hum. Genet. 63 1316-28 PubMed GONUTS page

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