MOUSE:ANM2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Prmt2 (synonyms: Hrmt1l1)
Protein Name(s)	Protein arginine N-methyltransferase 2 Histone-arginine N-methyltransferase PRMT2
External Links
UniProt	Q9R144
EMBL	AF169620
UniGene	Mm.32020
ProteinModelPortal	Q9R144
SMR	Q9R144
IntAct	Q9R144
STRING	10090.ENSMUSP00000097167
PhosphoSite	Q9R144
PRIDE	Q9R144
MGI	MGI:1316652
eggNOG	COG0500
HOGENOM	HOG000198521
HOVERGEN	HBG105734
InParanoid	Q9R144
PhylomeDB	Q9R144
PRO	PR:Q9R144
Proteomes	UP000000589
CleanEx	MM_PRMT2
Genevestigator	Q9R144
GO	GO:0005737 GO:0005829 GO:0005634 GO:0050681 GO:0008013 GO:0030331 GO:0042054 GO:0008469 GO:0042975 GO:0033142 GO:0042803 GO:0016274 GO:0035242 GO:0042974 GO:0046966 GO:0003713 GO:0048588 GO:0034969 GO:0016571 GO:0033210 GO:0032259 GO:2000134 GO:0043433 GO:0045892 GO:0019919 GO:0043065 GO:0045893 GO:0060765 GO:0042516 GO:0001666
Gene3D	3.40.50.150
InterPro	IPR025799 IPR029063 IPR001452
PANTHER	PTHR11006
Pfam	PF05185 PF14604
SMART	SM00326
SUPFAM	SSF50044 SSF53335
PROSITE	PS51678 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0033210	leptin-mediated signaling pathway	PMID:16648481^[1]	ECO:0000314			P	Figure 2	complete CACAO 3512
enables	GO:0050681	androgen receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55345	F	Seeded From UniProt	complete
enables	GO:0046966	thyroid hormone receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55345	F	Seeded From UniProt	complete
enables	GO:0042975	peroxisome proliferator activated receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55345	F	Seeded From UniProt	complete
enables	GO:0042974	retinoic acid receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55345	F	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55345	F	Seeded From UniProt	complete
involved_in	GO:0042509	regulation of tyrosine phosphorylation of STAT protein	PMID:20798359^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	PMID:20798359^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0033142	progesterone receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55345	F	Seeded From UniProt	complete
involved_in	GO:0032259	methylation	PMID:20798359^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55345	C	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:16690984^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	PMID:16616919^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060765	regulation of androgen receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55345	P	Seeded From UniProt	complete
involved_in	GO:0048588	developmental cell growth	PMID:20798359^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55345	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:16616919^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:16616919^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55345	P	Seeded From UniProt	complete
enables	GO:0042054	histone methyltransferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55345	F	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:16616919^[4]	ECO:0000353	physical interaction evidence used in manual assertion	ComplexPortal:CPX-160	F	Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55345	F	Seeded From UniProt	complete
involved_in	GO:0016571	histone methylation	PMID:20708585^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016274	protein-arginine N-methyltransferase activity	PMID:20798359^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008469	histone-arginine N-methyltransferase activity	PMID:20708585^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:20708585^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P26233	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55345	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55345	C	Seeded From UniProt	complete
enables	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037770 FB:FBgn0037834 MGI:MGI:107846 MGI:MGI:1913208 PANTHER:PTN000109455 RGD:62020 RGD:620413 SGD:S000000238 TAIR:locus:2010607 TAIR:locus:2077567 TAIR:locus:2154339 UniProtKB:Q7Q2B7 UniProtKB:Q96LA8 UniProtKB:Q99873 UniProtKB:Q9NR22 WB:WBGene00013766	F	Seeded From UniProt	complete
involved_in	GO:0034969	histone arginine methylation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1913208 MGI:MGI:2384879 PANTHER:PTN000109455 UniProtKB:Q582G4	P	Seeded From UniProt	complete
involved_in	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037770 FB:FBgn0037834 MGI:MGI:107846 PANTHER:PTN000109455 PomBase:SPAC890.07c PomBase:SPBC8D2.10c RGD:62020 RGD:620413 TAIR:locus:2010607 TAIR:locus:2077567 TAIR:locus:2154339 UniProtKB:Q7Q2B7 UniProtKB:Q96LA8 UniProtKB:Q9NR22 WB:WBGene00013766	P	Seeded From UniProt	complete
enables	GO:0008469	histone-arginine N-methyltransferase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1316652 MGI:MGI:2139971 PANTHER:PTN000109455 RGD:62020 TAIR:locus:2010607 TAIR:locus:2077567 TAIR:locus:2154339 UniProtKB:C8V494 UniProtKB:C8VIM6 UniProtKB:Q86X55 UniProtKB:Q96LA8 UniProtKB:Q9NR22 UniProtKB:Q9NVM4 WB:WBGene00013766	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1913208 PANTHER:PTN000109455 UniProtKB:Q7Q2B7	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1913208 MGI:MGI:1919224 PANTHER:PTN000109455 RGD:62020 TAIR:locus:2010607 TAIR:locus:2051995 TAIR:locus:2082244 TAIR:locus:2134328 UniProtKB:P55345 UniProtKB:Q86X55 UniProtKB:Q9NVM4	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060765	regulation of androgen receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55345	P	Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55345	F	Seeded From UniProt	complete
enables	GO:0046966	thyroid hormone receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55345	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55345	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55345	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55345	P	Seeded From UniProt	complete
enables	GO:0042975	peroxisome proliferator activated receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55345	F	Seeded From UniProt	complete
enables	GO:0042974	retinoic acid receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55345	F	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55345	F	Seeded From UniProt	complete
enables	GO:0042054	histone methyltransferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55345	F	Seeded From UniProt	complete
enables	GO:0033142	progesterone receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55345	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55345	P	Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55345	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016571	histone methylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55345	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55345	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55345	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55345	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55345	C	Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55345	F	Seeded From UniProt	complete
involved_in	GO:0006479	protein methylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR025799	P	Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007848 InterPro:IPR025799	F	Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	F	Seeded From UniProt	complete
involved_in	GO:0032259	methylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ganesh, L et al. (2006) Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis. Mol. Cell. Biol. 26 3864-74 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Iwasaki, H et al. (2010) Disruption of protein arginine N-methyltransferase 2 regulates leptin signaling and produces leanness in vivo through loss of STAT3 methylation. Circ. Res. 107 992-1001 PubMed GONUTS page
↑ Yildirim, AO et al. (2006) Increased protein arginine methylation in chronic hypoxia: role of protein arginine methyltransferases. Am. J. Respir. Cell Mol. Biol. 35 436-43 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Yoshimoto, T et al. (2006) The arginine methyltransferase PRMT2 binds RB and regulates E2F function. Exp. Cell Res. 312 2040-53 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Blythe, SA et al. (2010) beta-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2. Dev. Cell 19 220-31 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16648481-1] Ganesh, L et al. (2006) Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis. Mol. Cell. Biol. 26 3864-74 PubMed GONUTS page

[PMID:20798359-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Iwasaki, H et al. (2010) Disruption of protein arginine N-methyltransferase 2 regulates leptin signaling and produces leanness in vivo through loss of STAT3 methylation. Circ. Res. 107 992-1001 PubMed GONUTS page

[PMID:16690984-3] Yildirim, AO et al. (2006) Increased protein arginine methylation in chronic hypoxia: role of protein arginine methyltransferases. Am. J. Respir. Cell Mol. Biol. 35 436-43 PubMed GONUTS page

[PMID:16616919-4] 4.0 ^4.1 ^4.2 ^4.3 Yoshimoto, T et al. (2006) The arginine methyltransferase PRMT2 binds RB and regulates E2F function. Exp. Cell Res. 312 2040-53 PubMed GONUTS page

[PMID:20708585-5] 5.0 ^5.1 ^5.2 Blythe, SA et al. (2010) beta-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2. Dev. Cell 19 220-31 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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MOUSE:ANM2

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