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PMID:20798359

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Citation

Iwasaki, H, Kovacic, JC, Olive, M, Beers, JK, Yoshimoto, T, Crook, MF, Tonelli, LH and Nabel, EG (2010) Disruption of protein arginine N-methyltransferase 2 regulates leptin signaling and produces leanness in vivo through loss of STAT3 methylation. Circ. Res. 107:992-1001

Abstract

Arginine methylation by protein N-arginine methyltransferases (PRMTs) is an important posttranslational modification in the regulation of protein signaling. PRMT2 contains a highly conserved catalytic Ado-Met binding domain, but the enzymatic function of PRMT2 with respect to methylation is unknown. The JAK-STAT pathway is proposed to be regulated through direct arginine methylation of STAT transcription factors, and STAT3 signaling is known to be required for leptin regulation of energy balance.

Links

PubMed PMC2997704 Online version:10.1161/CIRCRESAHA.110.225326

Keywords

Animals; Arcuate Nucleus/metabolism; Body Weight/physiology; Eating/physiology; Energy Metabolism/physiology; Glycogen/metabolism; Leptin/metabolism; Liver/metabolism; Methylation; Methyltransferases/genetics; Methyltransferases/metabolism; Mice; Mice, Mutant Strains; Obesity/metabolism; Obesity/physiopathology; Phosphorylation/physiology; Protein Structure, Tertiary; Protein-Arginine N-Methyltransferases/chemistry; Protein-Arginine N-Methyltransferases/genetics; Protein-Arginine N-Methyltransferases/metabolism; STAT3 Transcription Factor/metabolism; Signal Transduction/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:ANM2

enables

GO:0016274: protein-arginine N-methyltransferase activity

ECO:0000315: mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:ANM2

involved_in

GO:0048588: developmental cell growth

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:ANM2

involved_in

GO:0032259: methylation

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

MOUSE:ANM2

involved_in

GO:0033210: leptin-mediated signaling pathway

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

MOUSE:ANM2

involved_in

GO:0042509: regulation of tyrosine phosphorylation of STAT protein

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete


See also

References

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