MOUSE:PO3F2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pou3f2 (synonyms: Brn-2, Brn2, Otf7)
Protein Name(s)	POU domain, class 3, transcription factor 2 Brain-specific homeobox/POU domain protein 2 Brain-2 Brn-2 Nervous system-specific octamer-binding transcription factor N-Oct-3 Octamer-binding protein 7 Oct-7 Octamer-binding transcription factor 7 OTF-7
External Links
UniProt	P31360
EMBL	M88300 AL772230
CCDS	CCDS18005.1
PIR	S31224
RefSeq	NP_032925.1
UniGene	Mm.129387 Mm.389520 Mm.487875
ProteinModelPortal	P31360
SMR	P31360
PhosphoSite	P31360
MaxQB	P31360
PRIDE	P31360
Ensembl	ENSMUST00000178174
GeneID	18992
KEGG	mmu:18992
UCSC	uc008sdp.2
CTD	5454
MGI	MGI:101895
eggNOG	NOG261729
GeneTree	ENSGT00760000118935
HOGENOM	HOG000116303
HOVERGEN	HBG053120
InParanoid	P31360
KO	K09365
OMA	MHNSSNN
OrthoDB	EOG7DJSMG
PhylomeDB	P31360
TreeFam	TF316413
NextBio	295386
PRO	PR:P31360
Proteomes	UP000000589
Bgee	P31360
CleanEx	MM_POU3F2
Genevestigator	P31360
GO	GO:0005634 GO:0005667 GO:0003677 GO:0001105 GO:0043565 GO:0003700 GO:0014002 GO:0071310 GO:0021799 GO:0008544 GO:0021869 GO:0021979 GO:0022011 GO:0021985 GO:0030182 GO:0008284 GO:0040018 GO:0045944 GO:0050770 GO:0045595 GO:0006357 GO:0014044
Gene3D	1.10.10.60 1.10.260.40
InterPro	IPR017970 IPR001356 IPR009057 IPR010982 IPR013847 IPR000327 IPR016362
Pfam	PF00046 PF00157
PIRSF	PIRSF002629
PRINTS	PR00028
SMART	SM00389 SM00352
SUPFAM	SSF46689 SSF47413
PROSITE	PS00027 PS50071 PS00035 PS00465 PS51179

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010629	negative regulation of gene expression	PMID:23069940^[1]	ECO:0000315			P		Figure 2c shows loss of T-cadherin expression accompanied with the overexpression of BRN2	complete CACAO 5365
involved_in	GO:0048665	neuron fate specification	PMID:24243019^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048663	neuron fate commitment	PMID:24243019^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:24243019^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	PMID:24243019^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:24243019^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:24243019^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:24243019^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:23069940^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:15465489^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15465489^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:15465489^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:18505825^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0071837	HMG box domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61946	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071310	cellular response to organic substance	PMID:18794345^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050770	regulation of axonogenesis	PMID:8543156^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857996	P	regulates_o_occurs_in:(EMAPA:17519) regulates_o_occurs_in:(CL:0000165)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17141158^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96919	P	has_regulation_target:(MGI:MGI:104659)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045595	regulation of cell differentiation	PMID:8593698^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:17141158^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61946	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P20265	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040018	positive regulation of multicellular organism growth	PMID:8543156^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857996	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	PMID:17141158^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_acquisition_of_features_of:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022011	myelination in peripheral nervous system	PMID:12782656^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101896	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021985	neurohypophysis development	PMID:8543156^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857996	P	results_in_development_of:(EMAPA:17519)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021979	hypothalamus cell differentiation	PMID:8543156^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857996	P	occurs_in:(EMAPA:35665) results_in_acquisition_of_features_of:(CL:0000165)\|occurs_in(EMAPA:35843) results_in_acquisition_of_features_of:(CL:0000165)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021869	forebrain ventricular zone progenitor cell division	PMID:12130536^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102564	P	occurs_in:(EMAPA:17547)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021799	cerebral cortex radially oriented cell migration	PMID:12130536^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102564	P	occurs_in:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014044	Schwann cell development	PMID:12782656^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101896	P	occurs_in:(EMAPA:18577) results_in_development_of:(CL:0000218)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014002	astrocyte development	PMID:8543156^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857996	P	occurs_in:(EMAPA:17519) results_in_development_of:(CL:0000645)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008544	epidermis development	PMID:8543156^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857996	P	results_in_development_of:(EMAPA:17528)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:15024079^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P20265	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:15465489^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61946	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:12782656^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12782656^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P20265	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61946	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61946	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61946	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15465489^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:12782656^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61946	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20265 ensembl:ENSP00000329170	F		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20265 ensembl:ENSP00000329170	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20265 ensembl:ENSP00000329170	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057 InterPro:IPR010982 InterPro:IPR013847	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000327 InterPro:IPR016362	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016362	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000327 InterPro:IPR017970	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016362	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016362	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0371 UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ellmann, L et al. (2012) BRN2 is a transcriptional repressor of CDH13 (T-cadherin) in melanoma cells. Lab. Invest. 92 1788-800 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Wapinski, OL et al. (2013) Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons. Cell 155 621-35 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Pruitt, SC et al. (2004) Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo. Gene Expr. Patterns 4 671-85 PubMed GONUTS page
↑ Hoser, M et al. (2008) Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors. Mol. Cell. Biol. 28 4675-87 PubMed GONUTS page
↑ Arnold, SJ et al. (2008) The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone. Genes Dev. 22 2479-84 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Schonemann, MD et al. (1995) Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2. Genes Dev. 9 3122-35 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Castro, DS et al. (2006) Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif. Dev. Cell 11 831-44 PubMed GONUTS page
↑ Suzuki, T et al. (1996) Preferential differentiation of P19 mouse embryonal carcinoma cells into smooth muscle cells. Use of retinoic acid and antisense against the central nervous system-specific POU transcription factor Brn-2. Circ. Res. 78 395-404 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Jaegle, M et al. (2003) The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development. Genes Dev. 17 1380-91 PubMed GONUTS page
↑ ^10.0 ^10.1 Sugitani, Y et al. (2002) Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons. Genes Dev. 16 1760-5 PubMed GONUTS page
↑ Goodall, J et al. (2004) Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin. Mol. Cell. Biol. 24 2915-22 PubMed GONUTS page

[PMID:23069940-1] 1.0 ^1.1 Ellmann, L et al. (2012) BRN2 is a transcriptional repressor of CDH13 (T-cadherin) in melanoma cells. Lab. Invest. 92 1788-800 PubMed GONUTS page

[PMID:24243019-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Wapinski, OL et al. (2013) Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons. Cell 155 621-35 PubMed GONUTS page

[PMID:15465489-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Pruitt, SC et al. (2004) Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo. Gene Expr. Patterns 4 671-85 PubMed GONUTS page

[PMID:18505825-4] Hoser, M et al. (2008) Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors. Mol. Cell. Biol. 28 4675-87 PubMed GONUTS page

[PMID:18794345-5] Arnold, SJ et al. (2008) The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone. Genes Dev. 22 2479-84 PubMed GONUTS page

[PMID:8543156-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Schonemann, MD et al. (1995) Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2. Genes Dev. 9 3122-35 PubMed GONUTS page

[PMID:17141158-7] 7.0 ^7.1 ^7.2 Castro, DS et al. (2006) Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif. Dev. Cell 11 831-44 PubMed GONUTS page

[PMID:8593698-8] Suzuki, T et al. (1996) Preferential differentiation of P19 mouse embryonal carcinoma cells into smooth muscle cells. Use of retinoic acid and antisense against the central nervous system-specific POU transcription factor Brn-2. Circ. Res. 78 395-404 PubMed GONUTS page

[PMID:12782656-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Jaegle, M et al. (2003) The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development. Genes Dev. 17 1380-91 PubMed GONUTS page

[PMID:12130536-10] 10.0 ^10.1 Sugitani, Y et al. (2002) Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons. Genes Dev. 16 1760-5 PubMed GONUTS page

[PMID:15024079-11] Goodall, J et al. (2004) Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin. Mol. Cell. Biol. 24 2915-22 PubMed GONUTS page

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MOUSE:PO3F2

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