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PMID:12130536
| Citation |
Sugitani, Y, Nakai, S, Minowa, O, Nishi, M, Jishage, K, Kawano, H, Mori, K, Ogawa, M and Noda, T (2002) Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons. Genes Dev. 16:1760-5 |
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| Abstract |
Formation of highly organized neocortical structure depends on the production and correct placement of the appropriate number and types of neurons. POU homeodomain proteins Brn-1 and Brn-2 are coexpressed in the developing neocortex, both in the late precursor cells and in the migrating neurons. Here we show that double disruption of both Brn-1 and Brn-2 genes in mice leads to abnormal formation of the neocortex with dramatically reduced production of layer IV-II neurons and defective migration of neurons unable to express mDab1. These data indicate that Brn-1 and Brn-2 share roles in the production and positioning of neocortical neuron development. |
| Links |
PubMed PMC186401 Online version:10.1101/gad.978002 |
| Keywords |
Animals; Biological Markers; Cell Differentiation; Cell Lineage; Embryonic and Fetal Development; Gene Expression; Homeodomain Proteins/genetics; Homeodomain Proteins/physiology; Mice; Mice, Knockout; Neocortex/cytology; Neocortex/embryology; Nerve Tissue Proteins/genetics; Neurons/cytology; Neurons/metabolism; Neuropeptides/genetics; Neuropeptides/physiology; POU Domain Factors; Trans-Activators/genetics; Trans-Activators/physiology; Transcription Factors/genetics; Transcription Factors/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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