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HUMAN:NSD3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) WHSC1L1 (synonyms: NSD3)
Protein Name(s) Histone-lysine N-methyltransferase NSD3

Nuclear SET domain-containing protein 3 Protein whistle WHSC1-like 1 isoform 9 with methyltransferase activity to lysine Wolf-Hirschhorn syndrome candidate 1-like protein 1 WHSC1-like protein 1

External Links
UniProt Q9BZ95
EMBL AF332468
AF332469
AJ295990
AJ295991
AJ295992
AF255649
AK000360
AK022560
AK127594
CH471080
CH471080
BC012059
BC062631
BC101717
BC107734
BC113469
BC115006
BC143510
AC087362
AC087623
CCDS CCDS43729.1
CCDS6105.1
RefSeq NP_060248.2
NP_075447.1
XP_005273604.1
XP_005273605.1
UniGene Hs.434966
Hs.608111
Hs.655314
PDB 2DAQ
4GND
4GNE
4GNF
4GNG
PDBsum 2DAQ
4GND
4GNE
4GNF
4GNG
ProteinModelPortal Q9BZ95
SMR Q9BZ95
BioGrid 120250
IntAct Q9BZ95
MINT MINT-4830664
ChEMBL CHEMBL3108646
PhosphoSite Q9BZ95
DMDM 74761342
MaxQB Q9BZ95
PaxDb Q9BZ95
PRIDE Q9BZ95
DNASU 54904
Ensembl ENST00000316985
ENST00000317025
ENST00000433384
ENST00000527502
GeneID 54904
KEGG hsa:54904
UCSC uc003xli.3
uc003xlj.3
uc010lwe.3
uc011lbm.2
CTD 54904
GeneCards GC08M038132
HGNC HGNC:12767
HPA CAB013721
HPA005659
HPA018893
MIM 607083
neXtProt NX_Q9BZ95
PharmGKB PA37370
eggNOG COG2940
GeneTree ENSGT00760000118855
HOVERGEN HBG079979
InParanoid Q9BZ95
KO K11425
OMA MEKDIHK
OrthoDB EOG7Z69BG
PhylomeDB Q9BZ95
TreeFam TF329088
ChiTaRS WHSC1L1
EvolutionaryTrace Q9BZ95
GeneWiki WHSC1L1
GenomeRNAi 54904
NextBio 35481221
PRO PR:Q9BZ95
Proteomes UP000005640
Bgee Q9BZ95
ExpressionAtlas Q9BZ95
Genevestigator Q9BZ95
GO GO:0005694
GO:0005634
GO:0018024
GO:0008270
GO:0034968
GO:0016571
GO:0006355
GO:0006351
Gene3D 3.30.40.10
InterPro IPR006560
IPR003616
IPR000313
IPR001214
IPR019786
IPR011011
IPR001965
IPR019787
IPR001841
IPR013083
Pfam PF00855
PF00856
SMART SM00570
SM00249
SM00508
SM00293
SM00184
SM00317
SUPFAM SSF57903
PROSITE PS51215
PS50868
PS50812
PS50280
PS01359
PS50016

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0008168

methyltransferase activity

PMID:25657825[1]

ECO:0000315

F

Figure 2; determined by nucleotide primer

complete
CACAO 10635

involved_in

GO:2001255

positive regulation of histone H3-K36 trimethylation

PMID:21555454[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

PMID:21555454[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

has_direct_input:(UniProtKB:O60885)

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:21555454[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q9P1W9)|has_regulation_target:(UniProtKB:P24385)|has_regulation_target:(UniProtKB:Q96C86)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21555454[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0018024

histone-lysine N-methyltransferase activity

PMID:16682010[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0016571

histone methylation

PMID:16682010[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16682010[3]

ECO:0000305

curator inference used in manual assertion

GO:0016571

C

Seeded From UniProt

complete

enables

GO:0046975

histone methyltransferase activity (H3-K36 specific)

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0030486
MGI:MGI:1276545
PANTHER:PTN002739645
PomBase:SPAC29B12.02c
SGD:S000003704
UniProtKB:Q8IE95
UniProtKB:Q96L73
WB:WBGene00003222

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1276545
MGI:MGI:1276574
MGI:MGI:2142581
PANTHER:PTN002739645
SGD:S000003704
UniProtKB:Q8IE95
UniProtKB:Q96L73
UniProtKB:Q9BZ95
WB:WBGene00003040
WB:WBGene00016603

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0030486
MGI:MGI:1276545
MGI:MGI:1276574
PANTHER:PTN002739645
SGD:S000003704
TAIR:locus:2030131
TAIR:locus:2126714
UniProtKB:O96028
UniProtKB:Q2LAE1
UniProtKB:Q8IE95
UniProtKB:Q9BZ95
WB:WBGene00003222

C

Seeded From UniProt

complete

part_of

GO:0000785

chromatin

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0039559
PANTHER:PTN002739645
TAIR:locus:2126714

C

Seeded From UniProt

complete

involved_in

GO:0010452

histone H3-K36 methylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0046975

P

Seeded From UniProt

complete

involved_in

GO:0034968

histone lysine methylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0018024

P

Seeded From UniProt

complete

involved_in

GO:0034968

histone lysine methylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0018024

P

Seeded From UniProt

complete

involved_in

GO:0034968

histone lysine methylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0018024

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006560

C

Seeded From UniProt

complete

enables

GO:0018024

histone-lysine N-methyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006560

F

Seeded From UniProt

complete

enables

GO:0018024

histone-lysine N-methyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.1.1.43

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-5649802
Reactome:R-HSA-5649800
Reactome:R-HSA-5638333
Reactome:R-HSA-5637686
Reactome:R-HSA-5159245

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158
UniProtKB-SubCell:SL-0468

C

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Guo, S et al. (2015) Identification and validation of the methylation biomarkers of non-small cell lung cancer (NSCLC). Clin Epigenetics 7 3 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Rahman, S et al. (2011) The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Mol. Cell. Biol. 31 2641-52 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Kim, SM et al. (2006) Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity. Biochem. Biophys. Res. Commun. 345 318-23 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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