HUMAN:BRCA1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BRCA1 (synonyms: RNF53)
Protein Name(s)	Breast cancer type 1 susceptibility protein RING finger protein 53
External Links
UniProt	P38398
EMBL	U14680 L78833 U64805 AF005068 DQ190450 DQ190451 DQ190452 DQ190453 DQ190454 DQ190455 DQ190456 AY273801 AC060780 AC135721 BC072418 BC115037
CCDS	CCDS11453.1 CCDS11454.2 CCDS11455.2 CCDS11456.2 CCDS11459.2
PIR	A58881
RefSeq	NP_009225.1 NP_009228.2 NP_009229.2 NP_009230.2 NP_009231.2
UniGene	Hs.194143
PDB	1JM7 1JNX 1N5O 1OQA 1T15 1T29 1T2U 1T2V 1Y98 2ING 3COJ 3K0H 3K0K 3K15 3K16 3PXA 3PXB 3PXC 3PXD 3PXE 4IFI 4IGK 4JLU 4OFB 4U4A 4Y18 4Y2G
PDBsum	1JM7 1JNX 1N5O 1OQA 1T15 1T29 1T2U 1T2V 1Y98 2ING 3COJ 3K0H 3K0K 3K15 3K16 3PXA 3PXB 3PXC 3PXD 3PXE 4IFI 4IGK 4JLU 4OFB 4U4A 4Y18 4Y2G
DisProt	DP00238
ProteinModelPortal	P38398
SMR	P38398
BioGrid	107140
DIP	DIP-5971N
IntAct	P38398
MINT	MINT-90433
STRING	9606.ENSP00000418960
BindingDB	P38398
ChEMBL	CHEMBL5990
iPTMnet	P38398
PhosphoSite	P38398
BioMuta	BRCA1
DMDM	728984
EPD	P38398
PaxDb	P38398
PRIDE	P38398
DNASU	672
Ensembl	ENST00000352993 ENST00000357654 ENST00000461221 ENST00000461798 ENST00000468300 ENST00000471181 ENST00000491747 ENST00000493795
GeneID	672
KEGG	hsa:672
UCSC	uc002icq.4
CTD	672
GeneCards	BRCA1
GeneReviews	BRCA1
HGNC	HGNC:1100
HPA	CAB001946 CAB018369 HPA034966
MalaCards	BRCA1
MIM	113705 114480 167000 604370 614320
neXtProt	NX_P38398
Orphanet	1333 1331 145 227535 213524 168829
PharmGKB	PA25411
eggNOG	ENOG410ITQ4 ENOG4112BIH
GeneTree	ENSGT00440000034289
HOGENOM	HOG000230969
HOVERGEN	HBG050730
InParanoid	P38398
KO	K10605
OMA	FQHLLFG
OrthoDB	EOG79CXXK
PhylomeDB	P38398
BRENDA	6.3.2.19
Reactome	R-HSA-1221632 R-HSA-3108214 R-HSA-5685938 R-HSA-5685942 R-HSA-5693554 R-HSA-5693565 R-HSA-5693568 R-HSA-5693571 R-HSA-5693579 R-HSA-5693607 R-HSA-5693616 R-HSA-69473 R-HSA-912446
SignaLink	P38398
UniPathway	UPA00143
ChiTaRS	BRCA1
EvolutionaryTrace	P38398
GeneWiki	BRCA1
GenomeRNAi	672
NextBio	2752
PMAP-CutDB	P38398
PRO	PR:P38398
Proteomes	UP000005640
Bgee	P38398
CleanEx	HS_BRCA1
ExpressionAtlas	P38398
Genevisible	P38398
GO	GO:0070531 GO:0031436 GO:0005694 GO:0000794 GO:0005737 GO:0008274 GO:0030529 GO:0005759 GO:0005654 GO:0005634 GO:0005886 GO:0043234 GO:0000151 GO:0050681 GO:0003682 GO:0003684 GO:0003677 GO:0019899 GO:0016874 GO:0003723 GO:0003713 GO:0044212 GO:0015631 GO:0031625 GO:0004842 GO:0008270 GO:0030521 GO:0006915 GO:0007420 GO:0044267 GO:0006974 GO:0071681 GO:0071356 GO:0007098 GO:0043009 GO:0031052 GO:0007059 GO:0006978 GO:0006281 GO:0006260 GO:0009048 GO:0006302 GO:0000724 GO:0006303 GO:0045003 GO:0006633 GO:0031572 GO:0008630 GO:0046600 GO:1902042 GO:0045717 GO:0035067 GO:0051572 GO:0051573 GO:0033147 GO:2000378 GO:0045892 GO:0045766 GO:0071158 GO:0045739 GO:0010628 GO:0035066 GO:0051571 GO:2000617 GO:0051574 GO:2000620 GO:0070512 GO:0033160 GO:0031398 GO:0045944 GO:0045893 GO:0010575 GO:0043687 GO:0006301 GO:0051865 GO:0085020 GO:0016925 GO:0016567 GO:0042981 GO:0042127 GO:0044030 GO:0006349 GO:0006357 GO:0006359 GO:0032355 GO:0043627 GO:0010212 GO:0007584 GO:0006351
Gene3D	3.30.40.10 3.40.50.10190
InterPro	IPR011364 IPR031099 IPR025994 IPR001357 IPR018957 IPR001841 IPR013083 IPR017907
PANTHER	PTHR13763 PTHR13763:SF0
Pfam	PF00533 PF12820 PF00097
PIRSF	PIRSF001734
PRINTS	PR00493
SMART	SM00292 SM00184
SUPFAM	SSF52113
PROSITE	PS50172 PS00518 PS50089

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	PMID:17505062^[1]	ECO:0000315			P		Figure 6 and 7 D. When BRCA1 is silenced in the presence of E2, there is an increase in the phosphorylation of ER-alpha receptor.	complete CACAO 9376
	GO:0005634	nucleus	PMID:23855721^[2]	ECO:0000314			C		As seen in figure 3B, consecutive section of the normal tissue stained with the MS110 antibody showed strong epithelial cell nuclear staining.	complete CACAO 8516
	GO:0006302	double-strand break repair	PMID:22186889^[3]	ECO:0000314			P		Figure 6c & 6d. Higher levels of γH2A.X signal for double strand break repair.	complete CACAO 3909
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:9662397^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:9662397^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070063	RNA polymerase binding	PMID:9662397^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	PMID:17505062^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20160719^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20160719^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20160719^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23855721^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:22186889^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	PMID:23415688^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618) has_regulation_target:(UniProtKB:P15692)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23415688^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618) has_regulation_target:(UniProtKB:P29474)	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:23415688^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:2000378	negative regulation of reactive oxygen species metabolic process	PMID:23415688^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	PMID:23415688^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	PMID:23415688^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:2000620	positive regulation of histone H4-K16 acetylation	PMID:20820192^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000617	positive regulation of histone H3-K9 acetylation	PMID:20820192^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071158	positive regulation of cell cycle arrest	PMID:21102443^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070512	positive regulation of histone H4-K20 methylation	PMID:20820192^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051573	negative regulation of histone H3-K9 methylation	PMID:20820192^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051571	positive regulation of histone H3-K4 methylation	PMID:20820192^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20820192^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:20820192^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035066	positive regulation of histone acetylation	PMID:20820192^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21282464^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:17349954^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006301	postreplication repair	PMID:17349954^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:17349954^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	PMID:17349954^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0085020	protein K6-linked ubiquitination	PMID:12890688^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0085020	protein K6-linked ubiquitination	PMID:20351172^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071681	cellular response to indole-3-methanol	PMID:10868478^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070531	BRCA1-A complex	PMID:19261749^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070531	BRCA1-A complex	PMID:19261748^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070531	BRCA1-A complex	PMID:17525342^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070531	BRCA1-A complex	PMID:17525340^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070531	BRCA1-A complex	PMID:17525341^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	PMID:12890688^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	PMID:20351172^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	PMID:15572661^[19]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046600	negative regulation of centriole replication	PMID:12214252^[20]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16331276^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15572661^[19]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:16288014^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045739	positive regulation of DNA repair	PMID:19261748^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045739	positive regulation of DNA repair	PMID:17525340^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045739	positive regulation of DNA repair	PMID:17643121^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045717	negative regulation of fatty acid biosynthetic process	PMID:16326698^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	PMID:8895509^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:9774970^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:17873885^[27]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P61086	F		Seeded From UniProt	complete
involved_in	GO:0072425	signal transduction involved in G2 DNA damage checkpoint	PMID:19261748^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072425	signal transduction involved in G2 DNA damage checkpoint	PMID:17525340^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072425	signal transduction involved in G2 DNA damage checkpoint	PMID:17643121^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031436	BRCA1-BARD1 complex	PMID:19117993^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031436	BRCA1-BARD1 complex	PMID:12890688^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031436	BRCA1-BARD1 complex	PMID:20351172^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031436	BRCA1-BARD1 complex	PMID:15265711^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	PMID:15965487^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030521	androgen receptor signaling pathway	PMID:15572661^[19]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:15965487^[30]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11388	F		Seeded From UniProt	complete
enables	GO:0015631	tubulin binding	PMID:12214252^[20]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	PMID:19261748^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	PMID:17525340^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	PMID:17643121^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0008274	gamma-tubulin ring complex	PMID:12214252^[20]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007059	chromosome segregation	PMID:15965487^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:19261748^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:17525340^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:17643121^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48754	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17643121^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17525340^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:19117993^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:12890688^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:20351172^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:15572661^[19]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	PMID:14976165^[31]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071158	positive regulation of cell cycle arrest	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000349139 UniProtKB:P38398	P		Seeded From UniProt	complete
part_of	GO:0070531	BRCA1-A complex	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000349139 UniProtKB:P38398	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104537 PANTHER:PTN000349139 UniProtKB:P38398	P		Seeded From UniProt	complete
involved_in	GO:0045717	negative regulation of fatty acid biosynthetic process	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000349139 UniProtKB:P38398	P		Seeded From UniProt	complete
involved_in	GO:0043009	chordate embryonic development	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104537 PANTHER:PTN000349142	P		Seeded From UniProt	complete
involved_in	GO:0035067	negative regulation of histone acetylation	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104537 PANTHER:PTN000349139	P		Seeded From UniProt	complete
involved_in	GO:0035066	positive regulation of histone acetylation	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104537 PANTHER:PTN000349139 UniProtKB:P38398	P		Seeded From UniProt	complete
part_of	GO:0031436	BRCA1-BARD1 complex	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000349139 UniProtKB:P38398 WB:WBGene00000264	C		Seeded From UniProt	complete
involved_in	GO:0009048	dosage compensation by inactivation of X chromosome	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104537 PANTHER:PTN000349142	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000349139 UniProtKB:P38398	C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000349139 TAIR:locus:2133109 UniProtKB:P38398	F		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000349139 TAIR:locus:2133109 UniProtKB:P38398 WB:WBGene00000264	P		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	PMID:18809582^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:9774970^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:14654789^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:12419249^[35]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000800	lateral element	PMID:9774970^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:8944023^[36]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P38398	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:29656893^[37]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P38398	F		Seeded From UniProt	complete
involved_in	GO:2000620	positive regulation of histone H4-K16 acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	P		Seeded From UniProt	complete
involved_in	GO:2000617	positive regulation of histone H3-K9 acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	P		Seeded From UniProt	complete
involved_in	GO:0070512	positive regulation of histone H4-K20 methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	P		Seeded From UniProt	complete
involved_in	GO:0051574	positive regulation of histone H3-K9 methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	P		Seeded From UniProt	complete
involved_in	GO:0051573	negative regulation of histone H3-K9 methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	P		Seeded From UniProt	complete
involved_in	GO:0051572	negative regulation of histone H3-K4 methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	P		Seeded From UniProt	complete
involved_in	GO:0051571	positive regulation of histone H3-K4 methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	P		Seeded From UniProt	complete
involved_in	GO:0044818	mitotic G2/M transition checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	F		Seeded From UniProt	complete
involved_in	GO:0044030	regulation of DNA methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	P		Seeded From UniProt	complete
involved_in	GO:0043009	chordate embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	P		Seeded From UniProt	complete
involved_in	GO:0035067	negative regulation of histone acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	P		Seeded From UniProt	complete
involved_in	GO:0035066	positive regulation of histone acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	P		Seeded From UniProt	complete
involved_in	GO:0009048	dosage compensation by inactivation of X chromosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	P		Seeded From UniProt	complete
involved_in	GO:0007098	centrosome cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	P		Seeded From UniProt	complete
involved_in	GO:0006349	regulation of gene expression by genetic imprinting	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	C		Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	F		Seeded From UniProt	complete
part_of	GO:0000794	condensed nuclear chromosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	C		Seeded From UniProt	complete
part_of	GO:0000793	condensed chromosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48754 ensembl:ENSMUSP00000017290	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011364	F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011364	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011364	C		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011364 InterPro:IPR031099	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031099	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011364	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018957	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:8944023^[36]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:10910365^[38]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:10910365^[38]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:9662397^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10918303^[39]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:10918303^[39]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:10918303^[39]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	PMID:10918303^[39]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:10918303^[39]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006359	regulation of transcription by RNA polymerase III	PMID:10918303^[39]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070317	negative regulation of G0 to G1 transition	Reactome:R-HSA-8953750	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	Reactome:R-HSA-5693571	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	Reactome:R-HSA-5684887 Reactome:R-HSA-5684875	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-9007605 Reactome:R-HSA-69891 Reactome:R-HSA-6799332 Reactome:R-HSA-6797712 Reactome:R-HSA-5693620 Reactome:R-HSA-5693608 Reactome:R-HSA-5693593 Reactome:R-HSA-5693589 Reactome:R-HSA-5693584 Reactome:R-HSA-5693580 Reactome:R-HSA-5693564 Reactome:R-HSA-5693561 Reactome:R-HSA-5693551 Reactome:R-HSA-5693542 Reactome:R-HSA-5693539 Reactome:R-HSA-5691411 Reactome:R-HSA-5686685 Reactome:R-HSA-5686657 Reactome:R-HSA-5686642 Reactome:R-HSA-5686483 Reactome:R-HSA-5686469 Reactome:R-HSA-5686440 Reactome:R-HSA-5686410 Reactome:R-HSA-5685994 Reactome:R-HSA-5685985 Reactome:R-HSA-5685838 Reactome:R-HSA-5685341 Reactome:R-HSA-5685156 Reactome:R-HSA-5685011 Reactome:R-HSA-5684887 Reactome:R-HSA-5684882 Reactome:R-HSA-5684875 Reactome:R-HSA-5684108 Reactome:R-HSA-5684071 Reactome:R-HSA-5684052 Reactome:R-HSA-5683801 Reactome:R-HSA-5683735 Reactome:R-HSA-5683385 Reactome:R-HSA-5659781 Reactome:R-HSA-2997709 Reactome:R-HSA-2997616	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000729	DNA double-strand break processing	Reactome:R-HSA-5693608	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0233	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0275	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ma, Y et al. (2007) Growth factor signaling pathways modulate BRCA1 repression of estrogen receptor-alpha activity. Mol. Endocrinol. 21 1905-23 PubMed GONUTS page
↑ ^2.0 ^2.1 Tulchin, N et al. (2013) Localization of BRCA1 protein in breast cancer tissue and cell lines with mutations. Cancer Cell Int. 13 70 PubMed GONUTS page
↑ ^3.0 ^3.1 Shukla, PC et al. (2011) BRCA1 is an essential regulator of heart function and survival following myocardial infarction. Nat Commun 2 593 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Anderson, SF et al. (1998) BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nat. Genet. 19 254-6 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Hiraike, H et al. (2010) Identification of DBC1 as a transcriptional repressor for BRCA1. Br. J. Cancer 102 1061-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Singh, KK et al. (2013) BRCA1 is a novel target to improve endothelial dysfunction and retard atherosclerosis. J. Thorac. Cardiovasc. Surg. 146 949-960.e4 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Shukla, V et al. (2010) BRCA1 affects global DNA methylation through regulation of DNMT1. Cell Res. 20 1201-15 PubMed GONUTS page
↑ Di, LJ et al. (2010) Transcriptional regulation of BRCA1 expression by a metabolic switch. Nat. Struct. Mol. Biol. 17 1406-13 PubMed GONUTS page
↑ Coene, ED et al. (2011) A novel role for BRCA1 in regulating breast cancer cell spreading and motility. J. Cell Biol. 192 497-512 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Zhao, GY et al. (2007) A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. Mol. Cell 25 663-75 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Wu-Baer, F et al. (2003) The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin. J. Biol. Chem. 278 34743-6 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Wu-Baer, F et al. (2010) The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function. Mol. Cell. Biol. 30 2787-98 PubMed GONUTS page
↑ Meng, Q et al. (2000) Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes. J. Mol. Med. 78 155-65 PubMed GONUTS page
↑ Wang, B et al. (2009) NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev. 23 729-39 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Feng, L et al. (2009) MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes Dev. 23 719-28 PubMed GONUTS page
↑ Kim, H et al. (2007) Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science 316 1202-5 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Wang, B et al. (2007) Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science 316 1194-8 PubMed GONUTS page
↑ Sobhian, B et al. (2007) RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science 316 1198-202 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Lin, DY et al. (2004) Negative modulation of androgen receptor transcriptional activity by Daxx. Mol. Cell. Biol. 24 10529-41 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Deng, CX (2002) Roles of BRCA1 in centrosome duplication. Oncogene 21 6222-7 PubMed GONUTS page
↑ Williamson, EA et al. (2006) BRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27(Kip1). Oncogene 25 1391-9 PubMed GONUTS page
↑ Kennedy, RD et al. (2005) BRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-inducible gene. Cancer Res. 65 10265-72 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 Liu, Z et al. (2007) CCDC98 targets BRCA1 to DNA damage sites. Nat. Struct. Mol. Biol. 14 716-20 PubMed GONUTS page
↑ Moreau, K et al. (2006) BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase. J. Biol. Chem. 281 3172-81 PubMed GONUTS page
↑ Spillman, MA & Bowcock, AM (1996) BRCA1 and BRCA2 mRNA levels are coordinately elevated in human breast cancer cells in response to estrogen. Oncogene 13 1639-45 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Chen, J et al. (1998) Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol. Cell 2 317-28 PubMed GONUTS page
↑ Christensen, DE et al. (2007) E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. Nat. Struct. Mol. Biol. 14 941-8 PubMed GONUTS page
↑ ^28.0 ^28.1 Nishikawa, H et al. (2009) BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity. Cancer Res. 69 111-9 PubMed GONUTS page
↑ Fabbro, M et al. (2004) BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention. Exp. Cell Res. 298 661-73 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Lou, Z et al. (2005) BRCA1 participates in DNA decatenation. Nat. Struct. Mol. Biol. 12 589-93 PubMed GONUTS page
↑ Morris, JR & Solomon, E (2004) BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair. Hum. Mol. Genet. 13 807-17 PubMed GONUTS page
↑ ^32.00 ^32.01 ^32.02 ^32.03 ^32.04 ^32.05 ^32.06 ^32.07 ^32.08 ^32.09 ^32.10 ^32.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Maggi, LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol. Cell. Biol. 28 7050-65 PubMed GONUTS page
↑ Aglipay, JA et al. (2003) A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. Oncogene 22 8931-8 PubMed GONUTS page
↑ Ganesan, S et al. (2002) BRCA1 supports XIST RNA concentration on the inactive X chromosome. Cell 111 393-405 PubMed GONUTS page
↑ ^36.0 ^36.1 Wu, LC et al. (1996) Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nat. Genet. 14 430-40 PubMed GONUTS page
↑ Gupta, R et al. (2018) DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. Cell 173 972-988.e23 PubMed GONUTS page
↑ ^38.0 ^38.1 Li, S et al. (2000) Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature 406 210-5 PubMed GONUTS page
↑ ^39.0 ^39.1 ^39.2 ^39.3 ^39.4 ^39.5 Deng, CX & Brodie, SG (2000) Roles of BRCA1 and its interacting proteins. Bioessays 22 728-37 PubMed GONUTS page

[PMID:17505062-1] 1.0 ^1.1 Ma, Y et al. (2007) Growth factor signaling pathways modulate BRCA1 repression of estrogen receptor-alpha activity. Mol. Endocrinol. 21 1905-23 PubMed GONUTS page

[PMID:23855721-2] 2.0 ^2.1 Tulchin, N et al. (2013) Localization of BRCA1 protein in breast cancer tissue and cell lines with mutations. Cancer Cell Int. 13 70 PubMed GONUTS page

[PMID:22186889-3] 3.0 ^3.1 Shukla, PC et al. (2011) BRCA1 is an essential regulator of heart function and survival following myocardial infarction. Nat Commun 2 593 PubMed GONUTS page

[PMID:9662397-4] 4.0 ^4.1 ^4.2 ^4.3 Anderson, SF et al. (1998) BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nat. Genet. 19 254-6 PubMed GONUTS page

[PMID:20160719-5] 5.0 ^5.1 ^5.2 Hiraike, H et al. (2010) Identification of DBC1 as a transcriptional repressor for BRCA1. Br. J. Cancer 102 1061-7 PubMed GONUTS page

[PMID:23415688-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Singh, KK et al. (2013) BRCA1 is a novel target to improve endothelial dysfunction and retard atherosclerosis. J. Thorac. Cardiovasc. Surg. 146 949-960.e4 PubMed GONUTS page

[PMID:20820192-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Shukla, V et al. (2010) BRCA1 affects global DNA methylation through regulation of DNMT1. Cell Res. 20 1201-15 PubMed GONUTS page

[PMID:21102443-8] Di, LJ et al. (2010) Transcriptional regulation of BRCA1 expression by a metabolic switch. Nat. Struct. Mol. Biol. 17 1406-13 PubMed GONUTS page

[PMID:21282464-9] Coene, ED et al. (2011) A novel role for BRCA1 in regulating breast cancer cell spreading and motility. J. Cell Biol. 192 497-512 PubMed GONUTS page

[PMID:17349954-10] 10.0 ^10.1 ^10.2 ^10.3 Zhao, GY et al. (2007) A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. Mol. Cell 25 663-75 PubMed GONUTS page

[PMID:12890688-11] 11.0 ^11.1 ^11.2 ^11.3 Wu-Baer, F et al. (2003) The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin. J. Biol. Chem. 278 34743-6 PubMed GONUTS page

[PMID:20351172-12] 12.0 ^12.1 ^12.2 ^12.3 Wu-Baer, F et al. (2010) The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function. Mol. Cell. Biol. 30 2787-98 PubMed GONUTS page

[PMID:10868478-13] Meng, Q et al. (2000) Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes. J. Mol. Med. 78 155-65 PubMed GONUTS page

[PMID:19261749-14] Wang, B et al. (2009) NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev. 23 729-39 PubMed GONUTS page

[PMID:19261748-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Feng, L et al. (2009) MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes Dev. 23 719-28 PubMed GONUTS page

[PMID:17525342-16] Kim, H et al. (2007) Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science 316 1202-5 PubMed GONUTS page

[PMID:17525340-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Wang, B et al. (2007) Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science 316 1194-8 PubMed GONUTS page

[PMID:17525341-18] Sobhian, B et al. (2007) RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science 316 1198-202 PubMed GONUTS page

[PMID:15572661-19] 19.0 ^19.1 ^19.2 ^19.3 Lin, DY et al. (2004) Negative modulation of androgen receptor transcriptional activity by Daxx. Mol. Cell. Biol. 24 10529-41 PubMed GONUTS page

[PMID:12214252-20] 20.0 ^20.1 ^20.2 Deng, CX (2002) Roles of BRCA1 in centrosome duplication. Oncogene 21 6222-7 PubMed GONUTS page

[PMID:16331276-21] Williamson, EA et al. (2006) BRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27(Kip1). Oncogene 25 1391-9 PubMed GONUTS page

[PMID:16288014-22] Kennedy, RD et al. (2005) BRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-inducible gene. Cancer Res. 65 10265-72 PubMed GONUTS page

[PMID:17643121-23] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 Liu, Z et al. (2007) CCDC98 targets BRCA1 to DNA damage sites. Nat. Struct. Mol. Biol. 14 716-20 PubMed GONUTS page

[PMID:16326698-24] Moreau, K et al. (2006) BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase. J. Biol. Chem. 281 3172-81 PubMed GONUTS page

[PMID:8895509-25] Spillman, MA & Bowcock, AM (1996) BRCA1 and BRCA2 mRNA levels are coordinately elevated in human breast cancer cells in response to estrogen. Oncogene 13 1639-45 PubMed GONUTS page

[PMID:9774970-26] 26.0 ^26.1 ^26.2 Chen, J et al. (1998) Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol. Cell 2 317-28 PubMed GONUTS page

[PMID:17873885-27] Christensen, DE et al. (2007) E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. Nat. Struct. Mol. Biol. 14 941-8 PubMed GONUTS page

[PMID:19117993-28] 28.0 ^28.1 Nishikawa, H et al. (2009) BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity. Cancer Res. 69 111-9 PubMed GONUTS page

[PMID:15265711-29] Fabbro, M et al. (2004) BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention. Exp. Cell Res. 298 661-73 PubMed GONUTS page

[PMID:15965487-30] 30.0 ^30.1 ^30.2 Lou, Z et al. (2005) BRCA1 participates in DNA decatenation. Nat. Struct. Mol. Biol. 12 589-93 PubMed GONUTS page

[PMID:14976165-31] Morris, JR & Solomon, E (2004) BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair. Hum. Mol. Genet. 13 807-17 PubMed GONUTS page

[PMID:21873635-32] 32.00 ^32.01 ^32.02 ^32.03 ^32.04 ^32.05 ^32.06 ^32.07 ^32.08 ^32.09 ^32.10 ^32.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18809582-33] Maggi, LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol. Cell. Biol. 28 7050-65 PubMed GONUTS page

[PMID:14654789-34] Aglipay, JA et al. (2003) A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. Oncogene 22 8931-8 PubMed GONUTS page

[PMID:12419249-35] Ganesan, S et al. (2002) BRCA1 supports XIST RNA concentration on the inactive X chromosome. Cell 111 393-405 PubMed GONUTS page

[PMID:8944023-36] 36.0 ^36.1 Wu, LC et al. (1996) Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nat. Genet. 14 430-40 PubMed GONUTS page

[PMID:29656893-37] Gupta, R et al. (2018) DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. Cell 173 972-988.e23 PubMed GONUTS page

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