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PMID:8895509
| Citation |
Spillman, MA and Bowcock, AM (1996) BRCA1 and BRCA2 mRNA levels are coordinately elevated in human breast cancer cells in response to estrogen. Oncogene 13:1639-45 |
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| Abstract |
The steady state levels of BRCA1 and BRCA2 mRNAs were shown to be coordinately elevated by the steroid hormone estrogen but not progesterone in the human breast cancer cell lines BT-483 and MCF-7. Two different antiestrogens, trans 4'-hydroxytamoxifen and ICI 182,780, blocked the elevation of BRCA1 and BRCA2 mRNA levels, confirming that the effect was mediated through the estrogen receptor. In BT-483 cells, BRCA1 and BRCA2 mRNA levels were both elevated 18 to 24 h after estrogen stimulation, suggesting that the effect of estrogen was indirect. Cycloheximide blocked the estrogen effect implying that estrogen induces synthesis of an unidentified estrogen-responsive protein(s) that then result in the elevation of BRCA1 and BRCA2 mRNAs. |
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| Keywords |
BRCA1 Protein/genetics; BRCA2 Protein; Breast Neoplasms/genetics; Breast Neoplasms/physiopathology; Cycloheximide/pharmacology; Estrogen Antagonists/pharmacology; Estrogens/physiology; Gene Expression Regulation, Neoplastic/drug effects; Gene Expression Regulation, Neoplastic/physiology; Humans; Neoplasm Proteins/genetics; RNA, Messenger/genetics; RNA, Messenger/metabolism; Transcription Factors/genetics; Tumor Cells, Cultured |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0043627: response to estrogen |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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