PMID:10918303

Citation	Deng, CX and Brodie, SG (2000) Roles of BRCA1 and its interacting proteins. Bioessays 22:728-37
Abstract	Germline mutations of BRCA1 predispose women to breast and ovarian cancers. BRCA1 contains several functional domains that interact directly or indirectly with a variety of molecules, including tumor suppressors (p53, RB, BRCA2 and ATM), oncogenes (c-Myc, casein kinase II and E2F), DNA damage repair proteins (RAD50 and RAD51), cell-cycle regulators (cyclins and cyclin-dependent kinases), transcriptional activators and repressors (RNA polymerase II, RHA, histone deacetylase complex and CtIP) and others. Mounting evidence indicates that these physical associations are not artifacts; rather, BRCA1 is likely to serve as an important central component in multiple biological pathways that regulate cell-cycle progression, centrosome duplication, DNA damage repair, cell growth and apoptosis, and transcriptional activation and repression. This review examines our understanding of the significance of the interactions between BRCA1 and other proteins, through which BRCA1 maintains genome integrity and represses tumor formation. Published 2000 John Wiley & Sons, Inc.
Links	PubMed Online version:<728::AID-BIES6>3.0.CO;2-B 10.1002/1521-1878(200008)22:8<728::AID-BIES6>3.0.CO;2-B
Keywords	BRCA1 Protein/chemistry; BRCA1 Protein/genetics; BRCA1 Protein/metabolism; Binding Sites; Breast Neoplasms/genetics; Cell Cycle; Cell Division; Centrosome/metabolism; DNA Damage; DNA Repair; Female; Genes, p53; Humans; Models, Biological; Mutation; Transcription, Genetic
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:BRCA1	involved_in	GO:0006359: regulation of transcription by RNA polymerase III	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
HUMAN:BRCA1	involved_in	GO:0006915: apoptotic process	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
HUMAN:BRCA1	involved_in	GO:0006978: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
HUMAN:BRCA1	involved_in	GO:0042127: regulation of cell population proliferation	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
HUMAN:BRCA1	involved_in	GO:0042981: regulation of apoptotic process	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
HUMAN:BRCA1	involved_in	GO:0045893: positive regulation of transcription, DNA-templated	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete

References

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