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PMID:23855721

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Citation

Tulchin, N, Ornstein, L, Dikman, S, Strauchen, J, Jaffer, S, Nagi, C, Bleiweiss, I, Kornreich, R, Edelmann, L, Brown, K, Bodian, C, Nair, VD, Chambon, M, Woods, NT and Monteiro, AN (2013) Localization of BRCA1 protein in breast cancer tissue and cell lines with mutations. Cancer Cell Int. 13:70

Abstract

The breast and ovarian cancer susceptibility gene (BRCA1) encodes a tumor suppressor. The BRCA1 protein is found primarily in cell nuclei and plays an important role in the DNA damage response and transcriptional regulation. Deficiencies in DNA repair capabilities have been associated with higher histopathological grade and worse prognosis in breast cancer.

Links

PubMed PMC3720266 Online version:10.1186/1475-2867-13-70

Keywords


Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:BRCA1

GO:0005634: nucleus

ECO:0000314:

C

As seen in figure 3B, consecutive section of the normal tissue stained with the MS110 antibody showed strong epithelial cell nuclear staining.

complete
CACAO 8516

HUMAN:BRCA1

part_of

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

See also

References

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