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PMID:23855721
Citation |
Tulchin, N, Ornstein, L, Dikman, S, Strauchen, J, Jaffer, S, Nagi, C, Bleiweiss, I, Kornreich, R, Edelmann, L, Brown, K, Bodian, C, Nair, VD, Chambon, M, Woods, NT and Monteiro, AN (2013) Localization of BRCA1 protein in breast cancer tissue and cell lines with mutations. Cancer Cell Int. 13:70 |
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Abstract |
The breast and ovarian cancer susceptibility gene (BRCA1) encodes a tumor suppressor. The BRCA1 protein is found primarily in cell nuclei and plays an important role in the DNA damage response and transcriptional regulation. Deficiencies in DNA repair capabilities have been associated with higher histopathological grade and worse prognosis in breast cancer. |
Links |
PubMed PMC3720266 Online version:10.1186/1475-2867-13-70 |
Keywords |
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Significance
Annotations
Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|
GO:0005634: nucleus |
ECO:0000314: |
C |
As seen in figure 3B, consecutive section of the normal tissue stained with the MS110 antibody showed strong epithelial cell nuclear staining. |
complete | ||||
part_of |
GO:0005634: nucleus |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
See also
References
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