MOUSE:PO4F2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pou4f2 (synonyms: Brn3b)
Protein Name(s)	POU domain, class 4, transcription factor 2 Brain-specific homeobox/POU domain protein 3B Brain-3B Brn-3B Brn-3.2
External Links
UniProt	Q63934
EMBL	S68377 AK087546 S69351
CCDS	CCDS22429.1
RefSeq	NP_620394.2
UniGene	Mm.234261
ProteinModelPortal	Q63934
SMR	Q63934
BioGrid	202311
STRING	10090.ENSMUSP00000034115
PhosphoSite	Q63934
PaxDb	Q63934
PRIDE	Q63934
Ensembl	ENSMUST00000034115
GeneID	18997
KEGG	mmu:18997
UCSC	uc009mhy.1
CTD	5458
MGI	MGI:102524
eggNOG	NOG289030
GeneTree	ENSGT00760000118935
HOGENOM	HOG000116305
HOVERGEN	HBG031829
InParanoid	Q63934
KO	K09366
OMA	THAPHMA
OrthoDB	EOG7RV9G7
PhylomeDB	Q63934
TreeFam	TF316413
NextBio	295402
PRO	PR:Q63934
Proteomes	UP000000589
Bgee	Q63934
CleanEx	MM_POU4F2
Genevestigator	Q63934
GO	GO:0016607 GO:0005634 GO:0003682 GO:0000978 GO:0001078 GO:0001077 GO:0003700 GO:0048675 GO:0007411 GO:0007409 GO:0030520 GO:0000165 GO:0000122 GO:0050885 GO:0030182 GO:0045597 GO:0045944 GO:0060041 GO:0031290 GO:0007605
Gene3D	1.10.10.60 1.10.260.40
InterPro	IPR017970 IPR001356 IPR009057 IPR010982 IPR013847 IPR000327
Pfam	PF00046 PF00157
PRINTS	PR00028
SMART	SM00389 SM00352
SUPFAM	SSF46689 SSF47413
PROSITE	PS00027 PS50071 PS00035 PS00465 PS51179

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0046326	positive regulation of glucose import	PMID:26670484^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0032869) occurs_in:(UBERON:0035818)\|part_of(GO:0032869) occurs_in:(UBERON:0001134)	Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:26670484^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0032869) occurs_in:(UBERON:0035818)\|part_of(GO:0032869) occurs_in:(UBERON:0001134)	Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:17145718^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:28594399^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P17208	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:17145718^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952) has_regulation_target:(ENSEMBL:ENSMUSG00000003873)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17145718^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSMUSG00000003873)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:26670484^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(ENSEMBL:ENSMUSG00000020681) occurs_in:(UBERON:0001134)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:26670484^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(ENSEMBL:ENSG00000082701) occurs_in:(UBERON:0001134)	Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	PMID:26670484^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001013)\|part_of:(UBERON:0001134)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:26670484^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(ENSEMBL:ENSMUSG00000018566) occurs_at:(SO:0001055) occurs_in:(UBERON:0001013)\|has_input(ENSEMBL:ENSMUSG00000018566) occurs_at:(SO:0001055) occurs_in:(UBERON:0001134)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:26670484^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(ENSEMBL:ENSMUSG00000018566) occurs_at:(SO:0001055) occurs_in:(UBERON:0001013)\|has_input(ENSEMBL:ENSMUSG00000018566) occurs_at:(SO:0001055) occurs_in:(UBERON:0001134)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:26670484^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(ENSEMBL:ENSMUSG00000018566) occurs_in:(UBERON:0001013) part_of:(GO:0032869) part_of:(GO:0046326)\|has_regulation_target(ENSEMBL:ENSMUSG00000018566) occurs_in:(UBERON:0001134) part_of:(GO:0032869) part_of:(GO:0046326)	Seeded From UniProt	complete
involved_in	GO:1904178	negative regulation of adipose tissue development	PMID:26670484^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	PMID:24643061^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24643061^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:17668438^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17668438^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17668438^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045672	positive regulation of osteoclast differentiation	PMID:17668438^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	PMID:17668438^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045596	negative regulation of cell differentiation	PMID:21875655^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	PMID:21875655^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902870	negative regulation of amacrine cell differentiation	PMID:21875655^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:21875655^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090259	regulation of retinal ganglion cell axon guidance	PMID:11163266^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990791	dorsal root ganglion development	PMID:10357904^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045773	positive regulation of axon extension	PMID:10357904^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12837	C		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	PMID:25775587^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18368538^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030520	intracellular estrogen receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12837	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12609742^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1000451)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7623109^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:8670054^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:18368538^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12837	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:8670054^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071453	cellular response to oxygen levels	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060041	retina development in camera-type eye	PMID:9630743^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176272	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060041	retina development in camera-type eye	PMID:8637595^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3582493	P	results_in_development_of:(EMAPA:17168)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050885	neuromuscular process controlling balance	PMID:11807038^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102523	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048675	axon extension	PMID:11807038^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102523	P	occurs_in:(EMAPA:17168) occurs_in:(CL:0000740)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18434421^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101791	P	has_regulation_target:(MGI:MGI:102525)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18434421^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:102525)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12837	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045597	positive regulation of cell differentiation	PMID:18367606^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176272	P	occurs_in:(EMAPA:17168)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031290	retinal ganglion cell axon guidance	PMID:11807038^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102523	P	occurs_in:(EMAPA:16894) occurs_in:(CL:0000740)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031290	retinal ganglion cell axon guidance	PMID:18434421^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429634	P	occurs_in:(EMAPA:16896) occurs_in:(CL:0000740)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030520	intracellular estrogen receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12837	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	PMID:18434421^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101791	P	occurs_in:(EMAPA:17168) results_in_acquisition_of_features_of:(CL:0000740)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	PMID:9630743^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176272	P	occurs_in:(EMAPA:17168) results_in_acquisition_of_features_of:(CL:0000740)\|occurs_in(EMAPA:17168) results_in_acquisition_of_features_of:(CL:0000740)\|occurs_in(EMAPA:17168) results_in_acquisition_of_features_of:(CL:0000740)\|occurs_in(EMAPA:17168) results_in_acquisition_of_features_of:(CL:0000740)\|occurs_in(EMAPA:17168) results_in_acquisition_of_features_of:(CL:0000740)\|occurs_in(EMAPA:17168) results_in_acquisition_of_features_of:(CL:0000740)\|occurs_in(EMAPA:17168) results_in_acquisition_of_features_of:(CL:0000740)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	PMID:8637595^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3582493	P	occurs_in:(EMAPA:17168) results_in_acquisition_of_features_of:(CL:0000740)	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12837	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:11807038^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102523	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:11163266^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3582493	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007409	axonogenesis	PMID:10357904^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429632 MGI:MGI:2429634	P	occurs_in:(EMAPA:17171) occurs_in:(CL:0000740)	Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12837	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9735355^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19389377^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17168) part_of:(CL:0000740)\|part_of:(EMAPA:17168) part_of:(CL:0000740)\|part_of:(EMAPA:17168) part_of:(CL:0000740)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18434421^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17168) part_of:(CL:0000740)\|part_of:(EMAPA:17168) part_of:(CL:0000740)\|part_of:(EMAPA:17168) part_of:(CL:0000740)\|part_of:(EMAPA:17168) part_of:(CL:0000740)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12837	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:8166682^[21]	ECO:0000250	sequence similarity evidence used in manual assertion		F		Seeded From UniProt	Missing: with/from
enables	GO:0003682	chromatin binding	PMID:20826655^[22]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:894289)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:18434421^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:17168) has_participant:(MGI:MGI:102524)\|occurs_in(EMAPA:17168) has_participant:(MGI:MGI:98297)\|occurs_in(EMAPA:17168) has_participant:(MGI:MGI:102525)\|occurs_in(EMAPA:17168) has_participant:(MGI:MGI:109156)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12837	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12837	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12837	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000165	MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12837	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:18367606^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176272	P	occurs_in:(EMAPA:17168)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12837	P		Seeded From UniProt	complete
involved_in	GO:0071453	cellular response to oxygen levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7L5 ensembl:ENSRNOP00000016422	P		Seeded From UniProt	complete
involved_in	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7L5 ensembl:ENSRNOP00000016422	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7L5 ensembl:ENSRNOP00000016422	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7L5 ensembl:ENSRNOP00000016422	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12837 ensembl:ENSP00000281321	P		Seeded From UniProt	complete
involved_in	GO:0030520	intracellular estrogen receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12837 ensembl:ENSP00000281321	P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12837 ensembl:ENSP00000281321	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12837 ensembl:ENSP00000281321	C		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12837 ensembl:ENSP00000281321	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12837 ensembl:ENSP00000281321	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12837 ensembl:ENSP00000281321	F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12837 ensembl:ENSP00000281321	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057 InterPro:IPR010982 InterPro:IPR013847	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000327	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000327 InterPro:IPR017970	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001387 InterPro:IPR017970	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:24643061^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:7904822^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:7904822^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:8537352^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:8290353^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000679	positive regulation of transcription regulatory region DNA binding	PMID:9448000^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051090	regulation of DNA-binding transcription factor activity	PMID:9448000^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071392	cellular response to estradiol stimulus	PMID:9448000^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17145718^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	PMID:17145718^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:17145718^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043068	positive regulation of programmed cell death	PMID:17145718^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	PMID:17145718^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:7935408^[27]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:7935408^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903508	positive regulation of nucleic acid-templated transcription	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003713	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:11163266^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238 UniProtKB-KW:KW-0371	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0186	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Bitsi, S et al. (2016) Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes. Am. J. Physiol. Endocrinol. Metab. 310 E303-12 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Budhram-Mahadeo, VS et al. (2006) Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. Nucleic Acids Res. 34 6640-52 PubMed GONUTS page
↑ Maskell, LJ et al. (2017) Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart. Cell Death Dis 8 e2861 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Li, R et al. (2014) Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells. PLoS ONE 9 e92105 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Schulze-Späte, U et al. (2007) Brn3 transcription factors control terminal osteoclastogenesis. J. Cell. Biochem. 102 1-12 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Feng, L et al. (2011) Brn-3b inhibits generation of amacrine cells by binding to and negatively regulating DLX1/2 in developing retina. Neuroscience 195 9-20 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Erkman, L et al. (2000) A POU domain transcription factor-dependent program regulates axon pathfinding in the vertebrate visual system. Neuron 28 779-92 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Gan, L et al. (1999) POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification. Dev. Biol. 210 469-80 PubMed GONUTS page
↑ Wu, F et al. (2015) Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate. Proc. Natl. Acad. Sci. U.S.A. 112 E1559-68 PubMed GONUTS page
↑ ^10.0 ^10.1 Farooqui-Kabir, SR et al. (2008) Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression. Cell Stress Chaperones 13 297-312 PubMed GONUTS page
↑ Wagner, KD et al. (2003) The Wilms' tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b). Gene 305 217-23 PubMed GONUTS page
↑ Xiang, M et al. (1995) The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. J. Neurosci. 15 4762-85 PubMed GONUTS page
↑ ^13.0 ^13.1 Dawson, SJ et al. (1996) The ability of POU family transcription factors to activate or repress gene expression is dependent on the spacing and context of their specific response elements. Biochem. J. 314 ( Pt 2) 439-43 PubMed GONUTS page
↑ ^14.0 ^14.1 Xiang, M (1998) Requirement for Brn-3b in early differentiation of postmitotic retinal ganglion cell precursors. Dev. Biol. 197 155-69 PubMed GONUTS page
↑ ^15.0 ^15.1 Erkman, L et al. (1996) Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature 381 603-6 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Wang, SW et al. (2002) Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development 129 467-77 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Pan, L et al. (2008) ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells. Development 135 1981-90 PubMed GONUTS page
↑ ^18.0 ^18.1 Qiu, F et al. (2008) A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors. J. Neurosci. 28 3392-403 PubMed GONUTS page
↑ Xiang, M et al. (1998) Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells. Development 125 3935-46 PubMed GONUTS page
↑ Rocha, SF et al. (2009) Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity. Dev. Biol. 328 54-65 PubMed GONUTS page
↑ Jehn, B et al. (1994) Isolation of three novel POU-domain containing cDNA clones from lactating mouse mammary gland. Biochem. Biophys. Res. Commun. 200 156-62 PubMed GONUTS page
↑ Jin, K et al. (2010) Early B-cell factors are required for specifying multiple retinal cell types and subtypes from postmitotic precursors. J. Neurosci. 30 11902-16 PubMed GONUTS page
↑ ^23.0 ^23.1 Turner, EE et al. (1994) Brn-3.2: a Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid. Neuron 12 205-18 PubMed GONUTS page
↑ Theil, T et al. (1995) Short isoform of POU factor Brn-3b can form a heterodimer with Brn-3a that is inactive for octamer motif binding. J. Biol. Chem. 270 30958-64 PubMed GONUTS page
↑ Theil, T et al. (1993) Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a. Nucleic Acids Res. 21 5921-9 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Budhram-Mahadeo, V et al. (1998) POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element. Mol. Cell. Biol. 18 1029-41 PubMed GONUTS page
↑ ^27.0 ^27.1 Morris, PJ et al. (1994) The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain. Mol. Cell. Biol. 14 6907-14 PubMed GONUTS page

[PMID:26670484-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Bitsi, S et al. (2016) Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes. Am. J. Physiol. Endocrinol. Metab. 310 E303-12 PubMed GONUTS page

[PMID:17145718-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Budhram-Mahadeo, VS et al. (2006) Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. Nucleic Acids Res. 34 6640-52 PubMed GONUTS page

[PMID:28594399-3] Maskell, LJ et al. (2017) Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart. Cell Death Dis 8 e2861 PubMed GONUTS page

[PMID:24643061-4] 4.0 ^4.1 ^4.2 Li, R et al. (2014) Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells. PLoS ONE 9 e92105 PubMed GONUTS page

[PMID:17668438-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Schulze-Späte, U et al. (2007) Brn3 transcription factors control terminal osteoclastogenesis. J. Cell. Biochem. 102 1-12 PubMed GONUTS page

[PMID:21875655-6] 6.0 ^6.1 ^6.2 ^6.3 Feng, L et al. (2011) Brn-3b inhibits generation of amacrine cells by binding to and negatively regulating DLX1/2 in developing retina. Neuroscience 195 9-20 PubMed GONUTS page

[PMID:11163266-7] 7.0 ^7.1 ^7.2 Erkman, L et al. (2000) A POU domain transcription factor-dependent program regulates axon pathfinding in the vertebrate visual system. Neuron 28 779-92 PubMed GONUTS page

[PMID:10357904-8] 8.0 ^8.1 ^8.2 Gan, L et al. (1999) POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification. Dev. Biol. 210 469-80 PubMed GONUTS page

[PMID:25775587-9] Wu, F et al. (2015) Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate. Proc. Natl. Acad. Sci. U.S.A. 112 E1559-68 PubMed GONUTS page

[PMID:18368538-10] 10.0 ^10.1 Farooqui-Kabir, SR et al. (2008) Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression. Cell Stress Chaperones 13 297-312 PubMed GONUTS page

[PMID:12609742-11] Wagner, KD et al. (2003) The Wilms' tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b). Gene 305 217-23 PubMed GONUTS page

[PMID:7623109-12] Xiang, M et al. (1995) The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. J. Neurosci. 15 4762-85 PubMed GONUTS page

[PMID:8670054-13] 13.0 ^13.1 Dawson, SJ et al. (1996) The ability of POU family transcription factors to activate or repress gene expression is dependent on the spacing and context of their specific response elements. Biochem. J. 314 ( Pt 2) 439-43 PubMed GONUTS page

[PMID:9630743-14] 14.0 ^14.1 Xiang, M (1998) Requirement for Brn-3b in early differentiation of postmitotic retinal ganglion cell precursors. Dev. Biol. 197 155-69 PubMed GONUTS page

[PMID:8637595-15] 15.0 ^15.1 Erkman, L et al. (1996) Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature 381 603-6 PubMed GONUTS page

[PMID:11807038-16] 16.0 ^16.1 ^16.2 ^16.3 Wang, SW et al. (2002) Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development 129 467-77 PubMed GONUTS page

[PMID:18434421-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Pan, L et al. (2008) ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells. Development 135 1981-90 PubMed GONUTS page

[PMID:18367606-18] 18.0 ^18.1 Qiu, F et al. (2008) A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors. J. Neurosci. 28 3392-403 PubMed GONUTS page

[PMID:9735355-19] Xiang, M et al. (1998) Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells. Development 125 3935-46 PubMed GONUTS page

[PMID:19389377-20] Rocha, SF et al. (2009) Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity. Dev. Biol. 328 54-65 PubMed GONUTS page

[PMID:8166682-21] Jehn, B et al. (1994) Isolation of three novel POU-domain containing cDNA clones from lactating mouse mammary gland. Biochem. Biophys. Res. Commun. 200 156-62 PubMed GONUTS page

[PMID:20826655-22] Jin, K et al. (2010) Early B-cell factors are required for specifying multiple retinal cell types and subtypes from postmitotic precursors. J. Neurosci. 30 11902-16 PubMed GONUTS page

[PMID:7904822-23] 23.0 ^23.1 Turner, EE et al. (1994) Brn-3.2: a Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid. Neuron 12 205-18 PubMed GONUTS page

[PMID:8537352-24] Theil, T et al. (1995) Short isoform of POU factor Brn-3b can form a heterodimer with Brn-3a that is inactive for octamer motif binding. J. Biol. Chem. 270 30958-64 PubMed GONUTS page

[PMID:8290353-25] Theil, T et al. (1993) Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a. Nucleic Acids Res. 21 5921-9 PubMed GONUTS page

[PMID:9448000-26] 26.0 ^26.1 ^26.2 Budhram-Mahadeo, V et al. (1998) POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element. Mol. Cell. Biol. 18 1029-41 PubMed GONUTS page

[PMID:7935408-27] 27.0 ^27.1 Morris, PJ et al. (1994) The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain. Mol. Cell. Biol. 14 6907-14 PubMed GONUTS page

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MOUSE:PO4F2

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