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PMID:8637595
| Citation |
Erkman, L, McEvilly, RJ, Luo, L, Ryan, AK, Hooshmand, F, O'Connell, SM, Keithley, EM, Rapaport, DH, Ryan, AF and Rosenfeld, MG (1996) Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature 381:603-6 |
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| Abstract |
The neurally expressed genes Brn-3.1 and Brn-3.2 (refs 1-6) are mammalian orthologues of the Caenorhabditis elegans unc-86 gene that constitute, with Brn-3.0 (refs 1-3,8,9), the class IV POU-domain transcription factors. Brn-3.1 and Brn-3.2 provide a means of exploring the potentially distinct biological functions of expanded gene families in neural development. The highly related members of the Brn-3 family have similar DNA-binding preferences and overlapping expression patterns in the sensory nervous system, midbrain and hindbrain, suggesting functional redundancy. Here we report that Brn-3.1 and Brn-3.2 critically modulate the terminal differentiation of distinct sensorineural cells in which they exhibit selective spatial and temporal expression patterns. Deletion of the Brn-3.2 gene causes the loss of most retinal ganglion cells, defining distinct ganglion cell populations. Mutation of Brn-3.1 results in complete deafness, owing to a failure of hair cells to appear in the inner ear, with subsequent loss of cochlear and vestibular ganglia. |
| Links |
PubMed Online version:10.1038/381603a0 |
| Keywords |
Animals; Cell Differentiation/genetics; Cell Differentiation/physiology; DNA-Binding Proteins/genetics; DNA-Binding Proteins/physiology; Deafness/embryology; Deafness/genetics; Ear, Inner/embryology; Embryonic and Fetal Development/genetics; Embryonic and Fetal Development/physiology; Eye/embryology; Gene Deletion; Hair Cells, Auditory/abnormalities; Hair Cells, Auditory/embryology; Homeodomain Proteins; In Situ Hybridization; Mice; Multigene Family; Retina/embryology; Retinal Ganglion Cells/cytology; Transcription Factor Brn-3B; Transcription Factors/genetics; Transcription Factors/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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References
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