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PMID:7904822
| Citation |
Turner, EE, Jenne, KJ and Rosenfeld, MG (1994) Brn-3.2: a Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid. Neuron 12:205-18 |
|---|---|
| Abstract |
The identification and molecular characterization of Brn-3.2 has revealed a family of Brn-3-related mammalian POU proteins that share homology with the C. elegans developmental regulator Unc-86 and extended similarity with the Drosophila neurodevelopmental gene I-POU, which defines a novel POU-IV box. Brn-3.2 exhibits DNA binding properties similar to those of Brn-3.0, but its expression is uniquely regulated by retinoic acid in teratocarcinoma and neuroblastoma cells. In the developing PNS and retina, the expression pattern of Brn-3.2 is similar to that of Brn-3.0. In the caudal CNS (spinal cord, hindbrain, and midbrain) Brn-3.2 and Brn-3.0 are initially coexpressed, but diverge later in development. Rostral to the midbrain, Brn-3.2 and Brn-3.0 exhibit nonoverlapping patterns of expression, suggesting divergence of gene function in more recently evolved structures. Our analysis suggests that in the CNS Brn-3.2 is selectively expressed in postmitotic neurons, implying a role in specifying terminally differentiated neuronal phenotypes. |
| Links | |
| Keywords |
Amino Acid Sequence; Animals; Base Sequence; Brain/metabolism; Cell Differentiation; Cell Line; DNA, Complementary/metabolism; DNA-Binding Proteins/biosynthesis; Drosophila/physiology; Embryo, Mammalian; Embryo, Nonmammalian; Gene Expression/drug effects; Gene Expression Regulation/drug effects; Gene Expression Regulation/physiology; Gene Library; Genes, Homeobox; Homeodomain Proteins; In Situ Hybridization; Mesencephalon/metabolism; Mice; Mitosis; Molecular Sequence Data; Neuroblastoma; Neurons/cytology; Neurons/drug effects; Neurons/metabolism; Organ Specificity; Rhombencephalon/metabolism; Sequence Homology, Amino Acid; Spinal Cord/metabolism; Teratoma; Transcription Factor Brn-3; Transcription Factor Brn-3A; Transcription Factor Brn-3B; Transcription Factors/biosynthesis; Transfection; Tretinoin/pharmacology; Tumor Cells, Cultured |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0045944: positive regulation of transcription by RNA polymerase II |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043565: sequence-specific DNA binding |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
Notes
See also
References
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