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HUMAN:E4F1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) E4F1 (synonyms: E4F)
Protein Name(s) Transcription factor E4F1

E4F transcription factor 1 Putative E3 ubiquitin-protein ligase E4F1 Transcription factor E4F p120E4F p50E4F

External Links
UniProt Q66K89
EMBL U87269
AK290329
AC009065
CH471112
BC080524
CCDS CCDS32370.1
RefSeq NP_001275705.1
NP_001275707.1
NP_004415.3
UniGene Hs.513268
ProteinModelPortal Q66K89
SMR Q66K89
BioGrid 108209
IntAct Q66K89
MINT MINT-137139
STRING 9606.ENSP00000301727
PhosphoSite Q66K89
DMDM 296434488
MaxQB Q66K89
PaxDb Q66K89
PRIDE Q66K89
Ensembl ENST00000301727
GeneID 1877
KEGG hsa:1877
UCSC uc002cpm.3
CTD 1877
GeneCards GC16P002276
HGNC HGNC:3121
HPA HPA052042
MIM 603022
neXtProt NX_Q66K89
PharmGKB PA27579
eggNOG COG5048
GeneTree ENSGT00390000006768
HOGENOM HOG000168447
HOVERGEN HBG052707
InParanoid Q66K89
OMA CQFCSRG
OrthoDB EOG761BT6
PhylomeDB Q66K89
TreeFam TF315387
SignaLink Q66K89
UniPathway UPA00143
GeneWiki E4F1
GenomeRNAi 1877
NextBio 7679
PRO PR:Q66K89
Proteomes UP000005640
Bgee Q66K89
CleanEx HS_E4F1
ExpressionAtlas Q66K89
Genevestigator Q66K89
GO GO:0005737
GO:0005654
GO:0005634
GO:0005819
GO:0035497
GO:0003677
GO:0016874
GO:0046872
GO:0000977
GO:0001227
GO:0003700
GO:0003713
GO:0003714
GO:0008283
GO:0006260
GO:0071850
GO:0007067
GO:0000122
GO:0016567
GO:0010564
GO:0040008
GO:0009794
GO:0016032
Gene3D 3.30.160.60
InterPro IPR007087
IPR015880
IPR013087
Pfam PF00096
SMART SM00355
PROSITE PS00028
PS50157

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:Q8VIG1

F

Seeded From UniProt

complete

enables

GO:0001227

DNA-binding transcription repressor activity, RNA polymerase II-specific

GO_REF:0000036

ECO:0000305

curator inference used in manual assertion

GO:0000122,GO:0000977

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:2169022[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:16652157[3]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(NCBI_Gene:890)

Seeded From UniProt

complete

enables

GO:0035497

cAMP response element binding

PMID:14645522[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0010564

regulation of cell cycle process

PMID:14645522[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:14645522[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1903508

positive regulation of nucleic acid-templated transcription

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0003713

P

Seeded From UniProt

complete

involved_in

GO:0010564

regulation of cell cycle process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CCE9
ensembl:ENSMUSP00000062344

P

Seeded From UniProt

complete

involved_in

GO:0009794

regulation of mitotic cell cycle, embryonic

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CCE9
ensembl:ENSMUSP00000062344

P

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CCE9
ensembl:ENSMUSP00000062344

P

Seeded From UniProt

complete

part_of

GO:0005819

spindle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CCE9
ensembl:ENSMUSP00000062344

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CCE9
ensembl:ENSMUSP00000062344

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CCE9
ensembl:ENSMUSP00000062344

F

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013087

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:9121437[5]
PMID:10869426[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

enables

GO:0003714

transcription corepressor activity

PMID:10869426[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

PMID:9121437[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:10869426[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0071850

mitotic cell cycle arrest

PMID:14645522[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0040008

regulation of growth

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0341

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0190

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  2. Rooney, RJ et al. (1990) E4F and ATF, two transcription factors that recognize the same site, can be distinguished both physically and functionally: a role for E4F in E1A trans activation. Mol. Cell. Biol. 10 5138-49 PubMed GONUTS page
  3. Paul, C et al. (2006) The LIM-only protein FHL2 is a negative regulator of E4F1. Oncogene 25 5475-84 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Tessari, MA et al. (2003) Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2. Mol. Cell. Biol. 23 9104-16 PubMed GONUTS page
  5. 5.0 5.1 Fernandes, ER & Rooney, RJ (1997) The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3. Mol. Cell. Biol. 17 1890-903 PubMed GONUTS page
  6. 6.0 6.1 6.2 Fajas, L et al. (2000) pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F. Proc. Natl. Acad. Sci. U.S.A. 97 7738-43 PubMed GONUTS page