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HUMAN:PSIP1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PSIP1 (synonyms: DFS70, LEDGF, PSIP2)
Protein Name(s) PC4 and SFRS1-interacting protein

CLL-associated antigen KW-7 Dense fine speckles 70 kDa protein DFS 70 Lens epithelium-derived growth factor Transcriptional coactivator p75/p52

External Links
UniProt O75475
EMBL AF098483
AF098482
AF063020
AF199339
AF199339
AF432220
AL359998
AL441925
AL513423
AL441925
AL359998
AL513423
CH471071
CH471071
CH471071
BC044568
BC064135
U94319
CCDS CCDS6479.1
CCDS6480.1
CCDS83348.1
PIR JC7168
RefSeq NP_001121689.1
NP_001304827.1
NP_001304829.1
NP_066967.3
NP_150091.2
UniGene Hs.658434
PDB 1Z9E
2B4J
2M16
2MSR
2MTN
2N3A
3F9K
3HPG
3HPH
3U88
3ZEH
4FU6
PDBsum 1Z9E
2B4J
2M16
2MSR
2MTN
2N3A
3F9K
3HPG
3HPH
3U88
3ZEH
4FU6
ProteinModelPortal O75475
SMR O75475
BioGrid 116339
DIP DIP-46656N
IntAct O75475
MINT MINT-4527154
STRING 9606.ENSP00000370109
BindingDB O75475
Allergome 2120
iPTMnet O75475
PhosphoSitePlus O75475
SwissPalm O75475
BioMuta PSIP1
EPD O75475
MaxQB O75475
PaxDb O75475
PeptideAtlas O75475
PRIDE O75475
TopDownProteomics O75475-1
O75475-2
DNASU 11168
Ensembl ENST00000380715
ENST00000380716
ENST00000380733
ENST00000380738
ENST00000397519
GeneID 11168
KEGG hsa:11168
UCSC uc003zlv.6
CTD 11168
DisGeNET 11168
GeneCards PSIP1
HGNC HGNC:9527
HPA CAB013718
HPA019697
MIM 603620
neXtProt NX_O75475
OpenTargets ENSG00000164985
PharmGKB PA33872
eggNOG KOG1904
ENOG410Y5WD
GeneTree ENSGT00530000063013
HOVERGEN HBG108300
InParanoid O75475
OMA GNLELWK
OrthoDB EOG091G045X
PhylomeDB O75475
TreeFam TF105385
Reactome [www.reactome.org/content/detail/R-HSA-162592 R-HSA-162592]
[www.reactome.org/content/detail/R-HSA-164843 R-HSA-164843]
[www.reactome.org/content/detail/R-HSA-175567 R-HSA-175567]
[www.reactome.org/content/detail/R-HSA-177539 R-HSA-177539]
[www.reactome.org/content/detail/R-HSA-180689 R-HSA-180689]
[www.reactome.org/content/detail/R-HSA-180910 R-HSA-180910]
SIGNOR O75475
ChiTaRS PSIP1
EvolutionaryTrace O75475
GeneWiki PSIP1
GenomeRNAi 11168
PMAP-CutDB O75475
PRO PR:O75475
Proteomes UP000005640
Bgee ENSG00000164985
CleanEx HS_PSIP1
ExpressionAtlas O75475
Genevisible O75475
GO GO:0005829
GO:0005720
GO:0034399
GO:0005654
GO:0005634
GO:0035327
GO:0033613
GO:0003682
GO:0003723
GO:0001105
GO:0097100
GO:0075713
GO:0000395
GO:0051169
GO:0045944
GO:0006355
GO:0009408
GO:0006979
GO:0006351
InterPro IPR021567
IPR000313
IPR017859
Pfam PF11467
PF00855
PRINTS PR01503
SMART SM00293
PROSITE PS50812

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0097100

supercoiled DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q812D1

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0035327

transcriptionally active chromatin

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q812D1

C

Seeded From UniProt

complete

involved_in

GO:0009408

response to heat

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99JF8

P

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99JF8

P

Seeded From UniProt

complete

involved_in

GO:0000395

mRNA 5'-splice site recognition

PMID:9885563[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0009408

response to heat

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JF8
ensembl:ENSMUSP00000030207

P

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99JF8
ensembl:ENSMUSP00000030207

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:9822615[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0033613

activating transcription factor binding

PMID:9822615[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

NOT|part_of

GO:0005730

nucleolus

PMID:11512661[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005720

nuclear heterochromatin

PMID:12796494[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:12796494[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:20974633[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

PMID:9822615[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:9885563[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:9822615[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0034399

nuclear periphery

PMID:11512661[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0033613

activating transcription factor binding

PMID:9822615[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

NOT|part_of

GO:0005730

nucleolus

PMID:11512661[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:9885563[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:12796494[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

PMID:9885563[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

PMID:9822615[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0075713

establishment of integrated proviral latency

Reactome:R-HSA-175567
Reactome:R-HSA-162592

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0051169

nuclear transport

Reactome:R-HSA-162590

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8951690
Reactome:R-HSA-180630
Reactome:R-HSA-180627
Reactome:R-HSA-180622
Reactome:R-HSA-173115
Reactome:R-HSA-164522
Reactome:R-HSA-164514
Reactome:R-HSA-162590

ECO:0000304

author statement supported by traceable reference used in manual assertion








C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-175250
Reactome:R-HSA-175174
Reactome:R-HSA-175117
Reactome:R-HSA-175108
Reactome:R-HSA-164845
Reactome:R-HSA-162590

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

complete

GO:0000790

nuclear chromatin

PMID:26721387[8]

ECO:0000314

C

In (Figure 1A) LEDGF/p75 displayed punctate and strictly nuclear localization in interphasic U2OS (Figure 1B) and HeLa cells and LEDGF/p75 remained tightly bound to the chromatin during mitosis

PSIP1_HUMAN/Lens epithelium-derived growth factor

complete
CACAO 12802

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  2. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Ge, H et al. (1998) A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2. Mol. Cell 2 751-9 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Ge, H et al. (1998) Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation. EMBO J. 17 6723-9 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Nishizawa, Y et al. (2001) Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (ledgf/p75) and p52, in the nucleus. Cell Tissue Res. 305 107-14 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Maertens, G et al. (2003) LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells. J. Biol. Chem. 278 33528-39 PubMed GONUTS page
  7. ↑ Hendrix, J et al. (2011) The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering. Nucleic Acids Res. 39 1310-25 PubMed GONUTS page
  8. ↑ Baude, A et al. (2016) Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination. Nucleic Acids Res. 44 2214-26 PubMed GONUTS page
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