GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:TFDP1

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TFDP1 (synonyms: DP1)
Protein Name(s) Transcription factor Dp-1

DRTF1-polypeptide 1 DRTF1 E2F dimerization partner 1

External Links
UniProt Q14186
EMBL L23959
AK297114
AL442125
CH471085
BC011685
AF550129
CCDS CCDS9538.1
PIR A48585
RefSeq NP_009042.1
XP_005268384.1
XP_005268388.1
UniGene Hs.79353
PDB 2AZE
5GOW
PDBsum 2AZE
5GOW
ProteinModelPortal Q14186
SMR Q14186
BioGrid 112885
DIP DIP-238N
IntAct Q14186
MINT MINT-3029193
STRING 9606.ENSP00000364519
iPTMnet Q14186
PhosphoSitePlus Q14186
BioMuta TFDP1
DMDM 3122926
EPD Q14186
MaxQB Q14186
PaxDb Q14186
PeptideAtlas Q14186
PRIDE Q14186
DNASU 7027
Ensembl ENST00000375370
GeneID 7027
KEGG hsa:7027
UCSC uc001vtw.4
CTD 7027
DisGeNET 7027
GeneCards TFDP1
H-InvDB HIX0002608
HIX0033825
HGNC HGNC:11749
HPA CAB033605
HPA044754
HPA068909
MIM 189902
neXtProt NX_Q14186
OpenTargets ENSG00000198176
PharmGKB PA36464
eggNOG KOG2829
ENOG410Y9QP
GeneTree ENSGT00390000018222
HOGENOM HOG000030696
HOVERGEN HBG009894
InParanoid Q14186
KO K04683
OMA HPSTVNT
OrthoDB EOG091G0AVY
PhylomeDB Q14186
TreeFam TF314396
Reactome [www.reactome.org/content/detail/R-HSA-111448 R-HSA-111448]
[www.reactome.org/content/detail/R-HSA-113501 R-HSA-113501]
[www.reactome.org/content/detail/R-HSA-113510 R-HSA-113510]
[www.reactome.org/content/detail/R-HSA-139915 R-HSA-139915]
[www.reactome.org/content/detail/R-HSA-1538133 R-HSA-1538133]
[www.reactome.org/content/detail/R-HSA-1912408 R-HSA-1912408]
[www.reactome.org/content/detail/R-HSA-2173796 R-HSA-2173796]
[www.reactome.org/content/detail/R-HSA-2559580 R-HSA-2559580]
[www.reactome.org/content/detail/R-HSA-2559585 R-HSA-2559585]
[www.reactome.org/content/detail/R-HSA-6804114 R-HSA-6804114]
[www.reactome.org/content/detail/R-HSA-69205 R-HSA-69205]
[www.reactome.org/content/detail/R-HSA-69231 R-HSA-69231]
SIGNOR Q14186
ChiTaRS TFDP1
EvolutionaryTrace Q14186
GeneWiki TFDP1
GenomeRNAi 7027
PRO PR:Q14186
Proteomes UP000005640
Bgee ENSG00000198176
CleanEx HS_TFDP1
ExpressionAtlas Q14186
Genevisible Q14186
GO GO:0005829
GO:0005739
GO:0005654
GO:0005634
GO:0005667
GO:0003677
GO:0019904
GO:0000981
GO:0003713
GO:0003700
GO:0008134
GO:0008283
GO:0006977
GO:0070345
GO:1900740
GO:0045944
GO:0006357
GO:0006351
CDD cd14458
Gene3D 1.10.10.10
InterPro IPR028313
IPR003316
IPR014889
IPR015648
IPR011991
PANTHER PTHR12548
PTHR12548:SF19
Pfam PF08781
PF02319
PIRSF PIRSF009404
SMART SM01138
SM01372
SUPFAM SSF46785

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR003316
InterPro:IPR015648

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:A0A0G2JXE8
UniProtKB:A0A0G2JXN0
UniProtKB:D4ACR8
UniProtKB:F1Q0Q6
UniProtKB:F1Q0W2
UniProtKB:F6U0I3
UniProtKB:F6X5K4
UniProtKB:F6ZPV4
UniProtKB:F7A3K9
UniProtKB:F7A997
UniProtKB:F7ED92
UniProtKB:F7FYS0
UniProtKB:F7HDM2
UniProtKB:H2R4J2
UniProtKB:M3VZP2
UniProtKB:M3W3Z8
UniProtKB:O54917
UniProtKB:Q08639
UniProtKB:Q17QZ4
UniProtKB:Q32KX6

F

Seeded From UniProt

complete

contributes_to

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:7739537[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:7739537[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0090575

RNA polymerase II transcription factor complex

PMID:7739537[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

contributes_to

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:7739537[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0070345

negative regulation of fat cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q08639

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:20176812[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P05554

F

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

PMID:16360038[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P28749

F

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

PMID:16360038[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P06400

F

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:16360038[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q01094

F

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:16360038[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q15329

F

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:16360038[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q14209

F

Seeded From UniProt

complete

GO:0006366

transcription from RNA polymerase II promoter

PMID:27825926[5]

ECO:0000315

P

Human. Figure 4. F403A expression vector showed clearly weaker enhancement as compared with the WT expression vector, suggesting that the acidic string of DP1 contributes to E2F1-mediated transcriptional activation.

complete
CACAO 12771

part_of

GO:0005634

nucleus

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101934
PANTHER:PTN000284480
TAIR:locus:1005716177
WB:WBGene00001061

C

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011763
PANTHER:PTN000284480

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:1900740

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:1900740

C

Seeded From UniProt

complete

involved_in

GO:2000278

regulation of DNA biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08639
ensembl:ENSMUSP00000147881

P

Seeded From UniProt

complete

involved_in

GO:0070345

negative regulation of fat cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08639
ensembl:ENSMUSP00000147881

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08639
ensembl:ENSMUSP00000147881

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08639
ensembl:ENSMUSP00000147881

P

Seeded From UniProt

complete

involved_in

GO:0043276

anoikis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08639
ensembl:ENSMUSP00000147881

P

Seeded From UniProt

complete

involved_in

GO:0008544

epidermis development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08639
ensembl:ENSMUSP00000147881

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08639
ensembl:ENSMUSP00000147881

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08639
ensembl:ENSMUSP00000147881

C

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08639
ensembl:ENSMUSP00000147881

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08639
ensembl:ENSMUSP00000147881

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08639
ensembl:ENSMUSP00000147881

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08639
ensembl:ENSMUSP00000147881

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003316
InterPro:IPR015648
InterPro:IPR028313

F

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003316
InterPro:IPR015648
InterPro:IPR028313

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003316

P

Seeded From UniProt

complete

involved_in

GO:0051726

regulation of cell cycle

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015648

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:8405995[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

PMID:8405995[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:8405995[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1900740

positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Reactome:R-HSA-139915
Reactome:R-HSA-111448

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0070317

negative regulation of G0 to G1 transition

Reactome:R-HSA-8953750

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

Reactome:R-HSA-2173796

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

Reactome:R-HSA-6791312

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-NUL-8963657
Reactome:R-HSA-9018017
Reactome:R-HSA-9007283
Reactome:R-HSA-8964498
Reactome:R-HSA-8964492
Reactome:R-HSA-8964482
Reactome:R-HSA-8964475
Reactome:R-HSA-8964471
Reactome:R-HSA-8964465
Reactome:R-HSA-8961961
Reactome:R-HSA-8961946
Reactome:R-HSA-8961920
Reactome:R-HSA-8961907
Reactome:R-HSA-8961888
Reactome:R-HSA-8961863
Reactome:R-HSA-8961840
Reactome:R-HSA-8961688
Reactome:R-HSA-8961671
Reactome:R-HSA-8961651
Reactome:R-HSA-8961636
Reactome:R-HSA-8961620
Reactome:R-HSA-8954117
Reactome:R-HSA-8954110
Reactome:R-HSA-8953452
Reactome:R-HSA-8953418
Reactome:R-HSA-8953115
Reactome:R-HSA-8953111
Reactome:R-HSA-6798282
Reactome:R-HSA-4395231
Reactome:R-HSA-4331327
Reactome:R-HSA-4331324
Reactome:R-HSA-3240777
Reactome:R-HSA-3240766
Reactome:R-HSA-3240765
Reactome:R-HSA-3209096
Reactome:R-HSA-2127257
Reactome:R-HSA-1363311
Reactome:R-HSA-1363303
Reactome:R-HSA-1362261
Reactome:R-HSA-1227671
Reactome:R-HSA-1227670
Reactome:R-HSA-1226095
Reactome:R-HSA-1226094

ECO:0000304

author statement supported by traceable reference used in manual assertion











































C

Seeded From UniProt

complete

involved_in

GO:0000083

regulation of transcription involved in G1/S transition of mitotic cell cycle

Reactome:R-HSA-69205

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Wu, CL et al. (1995) In vivo association of E2F and DP family proteins. Mol. Cell. Biol. 15 2536-46 PubMed GONUTS page
  3. ↑ Zaragoza, K et al. (2010) Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. Mol. Cell. Biol. 30 2293-304 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Rubin, SM et al. (2005) Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell 123 1093-106 PubMed GONUTS page
  5. ↑ Okuda, M et al. (2016) The Interaction Mode of the Acidic Region of the Cell Cycle Transcription Factor DP1 with TFIIH. J. Mol. Biol. 428 4993-5006 PubMed GONUTS page
  6. ↑ 6.0 6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Helin, K et al. (1993) Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev. 7 1850-61 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:TFDP1&oldid=5957417"