HUMAN:ZEB1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ZEB1 (synonyms: AREB6, TCF8)
Protein Name(s)	Zinc finger E-box-binding homeobox 1 NIL-2-A zinc finger protein Negative regulator of IL2 Transcription factor 8 TCF-8
External Links
UniProt	P37275
EMBL	D15050 U12170 AK091478 AK296244 AK300830 AL158080 AL117340 AL161935 AL355148 AL161935 AL117340 AL158080 AL355148 AL117340 AL158080 AL161935 AL355148 AL355148 AL117340 AL158080 AL161935 CH471072 BC112392 M81699
CCDS	CCDS44370.1 CCDS53505.1 CCDS53506.1 CCDS53507.1 CCDS7169.1
PIR	JX0293
RefSeq	NP_001121600.1 NP_001167564.1 NP_001167565.1 NP_001167566.1 NP_001167567.1 NP_110378.3
UniGene	Hs.124503
PDB	2E19
PDBsum	2E19
ProteinModelPortal	P37275
SMR	P37275
BioGrid	112796
IntAct	P37275
MINT	MINT-94525
STRING	9606.ENSP00000319248
PhosphoSite	P37275
DMDM	6166575
MaxQB	P37275
PaxDb	P37275
PRIDE	P37275
Ensembl	ENST00000320985 ENST00000361642 ENST00000446923 ENST00000542815 ENST00000560721
GeneID	6935
KEGG	hsa:6935
UCSC	uc001ivr.4 uc001ivu.4
CTD	6935
GeneCards	GC10P031648
HGNC	HGNC:11642
HPA	CAB058686 HPA027524
MIM	189909 609141 613270
neXtProt	NX_P37275
Orphanet	98974 98973
PharmGKB	PA162409589
eggNOG	COG5048
GeneTree	ENSGT00630000089829
HOGENOM	HOG000264256
HOVERGEN	HBG004697
InParanoid	P37275
KO	K09299
OMA	ECEKPQG
OrthoDB	EOG790G0D
PhylomeDB	P37275
TreeFam	TF331759
SignaLink	P37275
ChiTaRS	ZEB1
EvolutionaryTrace	P37275
GeneWiki	ZEB1
GenomeRNAi	6935
NextBio	27137
PRO	PR:P37275
Proteomes	UP000005640
Bgee	P37275
CleanEx	HS_ZEB1
ExpressionAtlas	P37275
Genevestigator	P37275
GO	GO:0005737 GO:0005634 GO:0005667 GO:0003682 GO:0003690 GO:0070888 GO:0003700 GO:0003713 GO:0003714 GO:0008270 GO:0051216 GO:0008283 GO:0071230 GO:0071560 GO:0090103 GO:0048596 GO:0048704 GO:0030900 GO:0006955 GO:0008285 GO:0030857 GO:0000122 GO:0045892 GO:0007389 GO:0045666 GO:0045944 GO:0010464 GO:0051150 GO:0033081 GO:0006357 GO:0017015 GO:0014823 GO:0031667 GO:0048752 GO:0006351
Gene3D	1.10.10.60 3.30.160.60
InterPro	IPR008598 IPR001356 IPR009057 IPR007087 IPR015880 IPR013087
Pfam	PF00046 PF05605
SMART	SM00389 SM00355
SUPFAM	SSF46689
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
Contributes to	GO:0044212	transcription regulatory region DNA binding	PMID:20036349^[1]	ECO:0000314			F		Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon	complete CACAO 9660
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001356	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q64318	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:23765923^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000179776)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:23765923^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSG00000179776)	Seeded From UniProt	complete
involved_in	GO:0045602	negative regulation of endothelial cell differentiation	PMID:23765923^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23814079^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:23814079^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:23814079^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25190660^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64318	F		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:12937339^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:20418909^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64318	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20418909^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090103	cochlea morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	P		Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	F		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	P		Seeded From UniProt	complete
involved_in	GO:0051150	regulation of smooth muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	P		Seeded From UniProt	complete
involved_in	GO:0048752	semicircular canal morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	P		Seeded From UniProt	complete
involved_in	GO:0048704	embryonic skeletal system morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	P		Seeded From UniProt	complete
involved_in	GO:0048598	embryonic morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	P		Seeded From UniProt	complete
involved_in	GO:0048596	embryonic camera-type eye morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	P		Seeded From UniProt	complete
involved_in	GO:0048513	animal organ development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	P		Seeded From UniProt	complete
involved_in	GO:0033081	regulation of T cell differentiation in thymus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	P		Seeded From UniProt	complete
involved_in	GO:0030857	negative regulation of epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	P		Seeded From UniProt	complete
involved_in	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	P		Seeded From UniProt	complete
involved_in	GO:0010464	regulation of mesenchymal cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	F		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	P		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64318 ensembl:ENSMUSP00000025081	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:8138542^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:8138542^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:8138542^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:8138542^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:8138542^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:1840704^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6790036	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238 UniProtKB-KW:KW-0371	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Riazuddin, SA et al. (2010) Missense mutations in TCF8 cause late-onset Fuchs corneal dystrophy and interact with FCD4 on chromosome 9p. Am. J. Hum. Genet. 86 45-53 PubMed GONUTS page
↑ ^2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Luo, Z et al. (2013) MicroRNA-200C and -150 play an important role in endothelial cell differentiation and vasculogenesis by targeting transcription repressor ZEB1. Stem Cells 31 1749-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Werner, S et al. (2013) Dual roles of the transcription factor grainyhead-like 2 (GRHL2) in breast cancer. J. Biol. Chem. 288 22993-3008 PubMed GONUTS page
↑ Chung, DW et al. (2014) Functional impact of ZEB1 mutations associated with posterior polymorphous and Fuchs' endothelial corneal dystrophies. Invest. Ophthalmol. Vis. Sci. 55 6159-66 PubMed GONUTS page
↑ Ohira, T et al. (2003) WNT7a induces E-cadherin in lung cancer cells. Proc. Natl. Acad. Sci. U.S.A. 100 10429-34 PubMed GONUTS page
↑ ^7.0 ^7.1 Sánchez-Tilló, E et al. (2010) ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1. Oncogene 29 3490-500 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Watanabe, Y et al. (1993) Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene. J. Biochem. 114 849-55 PubMed GONUTS page
↑ Williams, TM et al. (1991) Identification of a zinc finger protein that inhibits IL-2 gene expression. Science 254 1791-4 PubMed GONUTS page

[PMID:20036349-1] Riazuddin, SA et al. (2010) Missense mutations in TCF8 cause late-onset Fuchs corneal dystrophy and interact with FCD4 on chromosome 9p. Am. J. Hum. Genet. 86 45-53 PubMed GONUTS page

[PMID:19274049-2] 2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:23765923-3] 3.0 ^3.1 ^3.2 Luo, Z et al. (2013) MicroRNA-200C and -150 play an important role in endothelial cell differentiation and vasculogenesis by targeting transcription repressor ZEB1. Stem Cells 31 1749-62 PubMed GONUTS page

[PMID:23814079-4] 4.0 ^4.1 ^4.2 Werner, S et al. (2013) Dual roles of the transcription factor grainyhead-like 2 (GRHL2) in breast cancer. J. Biol. Chem. 288 22993-3008 PubMed GONUTS page

[PMID:25190660-5] Chung, DW et al. (2014) Functional impact of ZEB1 mutations associated with posterior polymorphous and Fuchs' endothelial corneal dystrophies. Invest. Ophthalmol. Vis. Sci. 55 6159-66 PubMed GONUTS page

[PMID:12937339-6] Ohira, T et al. (2003) WNT7a induces E-cadherin in lung cancer cells. Proc. Natl. Acad. Sci. U.S.A. 100 10429-34 PubMed GONUTS page

[PMID:20418909-7] 7.0 ^7.1 Sánchez-Tilló, E et al. (2010) ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1. Oncogene 29 3490-500 PubMed GONUTS page

[PMID:8138542-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Watanabe, Y et al. (1993) Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene. J. Biochem. 114 849-55 PubMed GONUTS page

[PMID:1840704-9] Williams, TM et al. (1991) Identification of a zinc finger protein that inhibits IL-2 gene expression. Science 254 1791-4 PubMed GONUTS page

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HUMAN:ZEB1

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