HUMAN:CDK7

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CDK7 (synonyms: CAK, CAK1, CDKN7, MO15, STK1)
Protein Name(s)	Cyclin-dependent kinase 7 39 kDa protein kinase p39 Mo15 CDK-activating kinase 1 Cell division protein kinase 7 Serine/threonine-protein kinase 1 TFIIH basal transcription factor complex kinase subunit
External Links
UniProt	P50613
EMBL	X79193 L20320 X77743 X77303 Y13120 AY130859 BC000834 BC005298
CCDS	CCDS3999.1
PIR	A54820 I37215
RefSeq	NP_001310998.1 NP_001310999.1 NP_001311000.1 NP_001311006.1 NP_001790.1
UniGene	Hs.184298
PDB	1LG3 1PA8 1UA2 2HIC
PDBsum	1LG3 1PA8 1UA2 2HIC
ProteinModelPortal	P50613
SMR	P50613
BioGrid	107457
DIP	DIP-5995N
IntAct	P50613
MINT	MINT-3018528
STRING	9606.ENSP00000256443
BindingDB	P50613
ChEMBL	CHEMBL3055
DrugBank	DB03496 DB02482
GuidetoPHARMACOLOGY	1979
iPTMnet	P50613
PhosphoSitePlus	P50613
BioMuta	CDK7
DMDM	1705722
EPD	P50613
MaxQB	P50613
PaxDb	P50613
PeptideAtlas	P50613
PRIDE	P50613
DNASU	1022
Ensembl	ENST00000256443 ENST00000615305
GeneID	1022
KEGG	hsa:1022
UCSC	uc003jvs.5
CTD	1022
DisGeNET	1022
GeneCards	CDK7
HGNC	HGNC:1778
HPA	CAB004364 HPA007932
MIM	601955
neXtProt	NX_P50613
OpenTargets	ENSG00000134058
PharmGKB	PA26314
eggNOG	KOG0659 ENOG410XQDH
GeneTree	ENSGT00830000128262
HOGENOM	HOG000233024
HOVERGEN	HBG014652
InParanoid	P50613
KO	K02202
OMA	DAEWPHL
OrthoDB	EOG091G0CI9
PhylomeDB	P50613
TreeFam	TF101024
BRENDA	2.7.11.22 2.7.11.23
Reactome	[www.reactome.org/content/detail/R-HSA-112382 R-HSA-112382] [www.reactome.org/content/detail/R-HSA-113418 R-HSA-113418] [www.reactome.org/content/detail/R-HSA-167152 R-HSA-167152] [www.reactome.org/content/detail/R-HSA-167158 R-HSA-167158] [www.reactome.org/content/detail/R-HSA-167160 R-HSA-167160] [www.reactome.org/content/detail/R-HSA-167161 R-HSA-167161] [www.reactome.org/content/detail/R-HSA-167162 R-HSA-167162] [www.reactome.org/content/detail/R-HSA-167172 R-HSA-167172] [www.reactome.org/content/detail/R-HSA-167200 R-HSA-167200] [www.reactome.org/content/detail/R-HSA-167246 R-HSA-167246] [www.reactome.org/content/detail/R-HSA-427413 R-HSA-427413] [www.reactome.org/content/detail/R-HSA-5696395 R-HSA-5696395] [www.reactome.org/content/detail/R-HSA-674695 R-HSA-674695] [www.reactome.org/content/detail/R-HSA-6781823 R-HSA-6781823] [www.reactome.org/content/detail/R-HSA-6781827 R-HSA-6781827] [www.reactome.org/content/detail/R-HSA-6782135 R-HSA-6782135] [www.reactome.org/content/detail/R-HSA-6782210 R-HSA-6782210] [www.reactome.org/content/detail/R-HSA-6796648 R-HSA-6796648] [www.reactome.org/content/detail/R-HSA-6807505 R-HSA-6807505] [www.reactome.org/content/detail/R-HSA-69202 R-HSA-69202] [www.reactome.org/content/detail/R-HSA-69231 R-HSA-69231] [www.reactome.org/content/detail/R-HSA-69273 R-HSA-69273] [www.reactome.org/content/detail/R-HSA-69656 R-HSA-69656] [www.reactome.org/content/detail/R-HSA-72086 R-HSA-72086] [www.reactome.org/content/detail/R-HSA-73762 R-HSA-73762] [www.reactome.org/content/detail/R-HSA-73772 R-HSA-73772] [www.reactome.org/content/detail/R-HSA-73776 R-HSA-73776] [www.reactome.org/content/detail/R-HSA-73777 R-HSA-73777] [www.reactome.org/content/detail/R-HSA-73779 R-HSA-73779] [www.reactome.org/content/detail/R-HSA-73863 R-HSA-73863] [www.reactome.org/content/detail/R-HSA-75953 R-HSA-75953] [www.reactome.org/content/detail/R-HSA-75955 R-HSA-75955] [www.reactome.org/content/detail/R-HSA-76042 R-HSA-76042] [www.reactome.org/content/detail/R-HSA-77075 R-HSA-77075]
SignaLink	P50613
SIGNOR	P50613
EvolutionaryTrace	P50613
GeneWiki	Cyclin-dependent_kinase_7
GenomeRNAi	1022
PRO	PR:P50613
Proteomes	UP000005640
Bgee	ENSG00000134058
CleanEx	HS_CDK7
ExpressionAtlas	P50613
Genevisible	P50613
GO	GO:0005737 GO:0005675 GO:0005654 GO:0005634 GO:0048471 GO:0070985 GO:0050681 GO:0005524 GO:0004693 GO:0008094 GO:0016301 GO:0008022 GO:0004672 GO:0004674 GO:0008353 GO:0003713 GO:0006370 GO:0030521 GO:0007050 GO:0051301 GO:0008283 GO:0000082 GO:0000086 GO:0006294 GO:0045944 GO:0045893 GO:0000079 GO:0042795 GO:0006363 GO:0006362 GO:0006368 GO:0006366 GO:0006361 GO:0006367 GO:0006283
InterPro	IPR011009 IPR000719 IPR017441 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0050821	protein stabilization	PMID:23393140^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex	PMID:23393140^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	PMID:15572661^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:8692841^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15572661^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030521	androgen receptor signaling pathway	PMID:15572661^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	PMID:9852112^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	PMID:12721286^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008094	DNA-dependent ATPase activity	PMID:9852112^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:10801852^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P51948	F	Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:9852112^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005675	transcription factor TFIIH holo complex	PMID:9852112^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:15572661^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0070985	transcription factor TFIIK complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000624096 PomBase:SPBC19F8.07 SGD:S000002266	C	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000624096 SGD:S000002266 UniProtKB:P50613	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004106 FB:FBgn0005640 FB:FBgn0013435 FB:FBgn0013762 FB:FBgn0015618 FB:FBgn0263237 MGI:MGI:101765 MGI:MGI:104772 MGI:MGI:88351 MGI:MGI:88357 PANTHER:PTN000623091 RGD:621124 RGD:70514 SGD:S000001622 SGD:S000001865 SGD:S000005488 SGD:S000005952 SGD:S000005963 SGD:S000006365 TAIR:locus:2119961 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P21127 UniProtKB:P24941 UniProtKB:P50750 UniProtKB:Q00534 UniProtKB:Q00646 UniProtKB:Q9UQ88 WB:WBGene00000405 WB:WBGene00000407 WB:WBGene00019362 ZFIN:ZDB-GENE-040808-34 dictyBase:DDB_G0267442 dictyBase:DDB_G0272813 dictyBase:DDB_G0288677	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0263237 PANTHER:PTN000624096 SGD:S000001865 TAIR:locus:2033349 UniProtKB:C9K505	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015618 FB:FBgn0019949 FB:FBgn0263237 MGI:MGI:101765 MGI:MGI:102956 MGI:MGI:104772 MGI:MGI:1328368 MGI:MGI:88353 MGI:MGI:88357 MGI:MGI:894318 PANTHER:PTN000623091 PomBase:SPAC2F3.15 PomBase:SPBC11B10.09 PomBase:SPBC32H8.10 RGD:1305435 RGD:1359638 RGD:2319 RGD:619874 RGD:621120 RGD:621124 RGD:70486 RGD:70514 SGD:S000000364 SGD:S000001622 SGD:S000002266 SGD:S000005952 TAIR:locus:2008595 TAIR:locus:2027819 TAIR:locus:2033349 TAIR:locus:2080290 TAIR:locus:2084086 TAIR:locus:2099478 TAIR:locus:2119961 TAIR:locus:2158554 TAIR:locus:2194045 UniProtKB:O76039 UniProtKB:O94921 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P21127 UniProtKB:P24941 UniProtKB:P49336 UniProtKB:P50613 UniProtKB:P61075 UniProtKB:P79432 UniProtKB:Q00534 UniProtKB:Q00535 UniProtKB:Q00646 UniProtKB:Q5B3E4 UniProtKB:Q8IDW1 UniProtKB:Q8IIL5 UniProtKB:Q8IJQ1 UniProtKB:Q8RWN3 UniProtKB:Q8W4P1 UniProtKB:Q92772 UniProtKB:Q96VK3 UniProtKB:Q9NYV4 UniProtKB:Q9UQ88 WB:WBGene00000405 dictyBase:DDB_G0267442 dictyBase:DDB_G0288677	C	Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004106 FB:FBgn0005640 FB:FBgn0013762 FB:FBgn0019949 FB:FBgn0263237 MGI:MGI:104772 MGI:MGI:88351 MGI:MGI:88357 PANTHER:PTN000623091 PomBase:SPAC23H4.17c PomBase:SPAC2F3.15 PomBase:SPBC11B10.09 PomBase:SPBC19F8.07 PomBase:SPBC32H8.10 RGD:2319 RGD:621120 RGD:621124 RGD:70486 RGD:70514 SGD:S000000364 SGD:S000001622 SGD:S000005952 SGD:S000005963 SGD:S000006365 TAIR:locus:2011761 UniProtKB:A0A1D8PDA6 UniProtKB:C9K505 UniProtKB:O94921 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P24941 UniProtKB:P50750 UniProtKB:P61075 UniProtKB:Q00534 UniProtKB:Q00646 UniProtKB:Q8IJQ1 WB:WBGene00000405 ZFIN:ZDB-GENE-010131-2 dictyBase:DDB_G0272813 dictyBase:DDB_G0288677	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16109376^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03147 ensembl:ENSMUSP00000088845	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03147 ensembl:ENSMUSP00000088845	C	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03147 ensembl:ENSMUSP00000088845	F	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F	Seeded From UniProt	complete
part_of	GO:0005675	transcription factor TFIIH holo complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037770	C	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P	Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037770	F	Seeded From UniProt	complete
part_of	GO:0070985	transcription factor TFIIK complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037770	C	Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.22	F	Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.23	F	Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	PMID:7533895^[9] Reactome:R-HSA-75953 Reactome:R-HSA-73779	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7936635^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	PMID:8208544^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:7533895^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	PMID:7533895^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	PMID:15876871^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	Reactome:R-HSA-69206	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042795	snRNA transcription by RNA polymerase II	Reactome:R-HSA-6807505	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	Reactome:R-HSA-77071	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006370	7-methylguanosine mRNA capping	Reactome:R-HSA-72086	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006368	transcription elongation from RNA polymerase II promoter	Reactome:R-HSA-75955 Reactome:R-HSA-73776 Reactome:R-HSA-112382	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	Reactome:R-HSA-73857	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006363	termination of RNA polymerase I transcription	Reactome:R-HSA-73863	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006362	transcription elongation from RNA polymerase I promoter	Reactome:R-HSA-73777	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006361	transcription initiation from RNA polymerase I promoter	Reactome:R-HSA-73772 Reactome:R-HSA-73762	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006294	nucleotide-excision repair, preincision complex assembly	Reactome:R-HSA-5691000 Reactome:R-HSA-5689861	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006283	transcription-coupled nucleotide-excision repair	Reactome:R-HSA-6781827	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-9613497 Reactome:R-HSA-9613494 Reactome:R-HSA-8942836 Reactome:R-HSA-77090 Reactome:R-HSA-77085 Reactome:R-HSA-77083 Reactome:R-HSA-77081 Reactome:R-HSA-77078 Reactome:R-HSA-77077 Reactome:R-HSA-77073 Reactome:R-HSA-77071 Reactome:R-HSA-77069 Reactome:R-HSA-77068 Reactome:R-HSA-76576 Reactome:R-HSA-75949 Reactome:R-HSA-75891 Reactome:R-HSA-75873 Reactome:R-HSA-75869 Reactome:R-HSA-75866 Reactome:R-HSA-75864 Reactome:R-HSA-75862 Reactome:R-HSA-75861 Reactome:R-HSA-75856 Reactome:R-HSA-75850 Reactome:R-HSA-74994 Reactome:R-HSA-74993 Reactome:R-HSA-74992 Reactome:R-HSA-74986 Reactome:R-HSA-73946 Reactome:R-HSA-73769 Reactome:R-HSA-73758 Reactome:R-HSA-6814885 Reactome:R-HSA-6814559 Reactome:R-HSA-6814555 Reactome:R-HSA-6814549 Reactome:R-HSA-6810238 Reactome:R-HSA-6810235 Reactome:R-HSA-6810234 Reactome:R-HSA-6810233 Reactome:R-HSA-6797616 Reactome:R-HSA-6797606 Reactome:R-HSA-6782234 Reactome:R-HSA-6782227 Reactome:R-HSA-6782224 Reactome:R-HSA-6782211 Reactome:R-HSA-6782208 Reactome:R-HSA-6782204 Reactome:R-HSA-6782141 Reactome:R-HSA-6782138 Reactome:R-HSA-6782131 Reactome:R-HSA-6782069 Reactome:R-HSA-6782004 Reactome:R-HSA-6781867 Reactome:R-HSA-6781840 Reactome:R-HSA-6781833 Reactome:R-HSA-6781824 Reactome:R-HSA-6781818 Reactome:R-HSA-5691000 Reactome:R-HSA-5689861 Reactome:R-HSA-188350 Reactome:R-HSA-187949 Reactome:R-HSA-170087 Reactome:R-HSA-170076 Reactome:R-HSA-113430 Reactome:R-HSA-112385 Reactome:R-HSA-112383 Reactome:R-HSA-112379 Reactome:R-HSA-111264 Reactome:R-HSA-109639	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-HSA-6810233	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000086	G2/M transition of mitotic cell cycle	Reactome:R-HSA-69275	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C	Seeded From UniProt	complete
	GO:0010467	gene expression	PMID:27759017^[13]	ECO:0000315			P	figure 1 showed T. gondii genes cdk7, cyclinH and mat1 were expressed in the respective transformants as shown by Western blotting using ant-His antibody. S. cerevisiae GAPDH was used as a loading control	complete CACAO 12856
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Wang, Y et al. (2013) Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CDK7) stabilizes C-terminal binding protein 2 (CtBP2) and promotes cancer cell migration. J. Biol. Chem. 288 9028-34 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Lin, DY et al. (2004) Negative modulation of androgen receptor transcriptional activity by Daxx. Mol. Cell. Biol. 24 10529-41 PubMed GONUTS page
↑ Reardon, JT et al. (1996) Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH. Proc. Natl. Acad. Sci. U.S.A. 93 6482-7 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Kershnar, E et al. (1998) Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. J. Biol. Chem. 273 34444-53 PubMed GONUTS page
↑ Yeo, M et al. (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J. Biol. Chem. 278 26078-85 PubMed GONUTS page
↑ Busso, D et al. (2000) Distinct regions of MAT1 regulate cdk7 kinase and TFIIH transcription activities. J. Biol. Chem. 275 22815-23 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Jang, MK et al. (2005) The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol. Cell 19 523-34 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Shiekhattar, R et al. (1995) Cdk-activating kinase complex is a component of human transcription factor TFIIH. Nature 374 283-7 PubMed GONUTS page
↑ Darbon, JM et al. (1994) Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase. Oncogene 9 3127-38 PubMed GONUTS page
↑ Levedakou, EN et al. (1994) Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. Oncogene 9 1977-88 PubMed GONUTS page
↑ Lolli, G & Johnson, LN (2005) CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs? Cell Cycle 4 572-7 PubMed GONUTS page
↑ Deshmukh, AS et al. (2016) Cdk7 mediates RPB1-driven mRNA synthesis in Toxoplasma gondii. Sci Rep 6 35288 PubMed GONUTS page

[PMID:23393140-1] 1.0 ^1.1 Wang, Y et al. (2013) Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CDK7) stabilizes C-terminal binding protein 2 (CtBP2) and promotes cancer cell migration. J. Biol. Chem. 288 9028-34 PubMed GONUTS page

[PMID:15572661-2] 2.0 ^2.1 ^2.2 ^2.3 Lin, DY et al. (2004) Negative modulation of androgen receptor transcriptional activity by Daxx. Mol. Cell. Biol. 24 10529-41 PubMed GONUTS page

[PMID:8692841-3] Reardon, JT et al. (1996) Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH. Proc. Natl. Acad. Sci. U.S.A. 93 6482-7 PubMed GONUTS page

[PMID:9852112-4] 4.0 ^4.1 ^4.2 ^4.3 Kershnar, E et al. (1998) Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. J. Biol. Chem. 273 34444-53 PubMed GONUTS page

[PMID:12721286-5] Yeo, M et al. (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J. Biol. Chem. 278 26078-85 PubMed GONUTS page

[PMID:10801852-6] Busso, D et al. (2000) Distinct regions of MAT1 regulate cdk7 kinase and TFIIH transcription activities. J. Biol. Chem. 275 22815-23 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16109376-8] Jang, MK et al. (2005) The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol. Cell 19 523-34 PubMed GONUTS page

[PMID:7533895-9] 9.0 ^9.1 ^9.2 Shiekhattar, R et al. (1995) Cdk-activating kinase complex is a component of human transcription factor TFIIH. Nature 374 283-7 PubMed GONUTS page

[PMID:7936635-10] Darbon, JM et al. (1994) Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase. Oncogene 9 3127-38 PubMed GONUTS page

[PMID:8208544-11] Levedakou, EN et al. (1994) Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. Oncogene 9 1977-88 PubMed GONUTS page

[PMID:15876871-12] Lolli, G & Johnson, LN (2005) CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs? Cell Cycle 4 572-7 PubMed GONUTS page

[PMID:27759017-13] Deshmukh, AS et al. (2016) Cdk7 mediates RPB1-driven mRNA synthesis in Toxoplasma gondii. Sci Rep 6 35288 PubMed GONUTS page

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HUMAN:CDK7

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