HUMAN:PARK7

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PARK7
Protein Name(s)	Protein DJ-1 Oncogene DJ1 Parkinson disease protein 7
External Links
UniProt	Q99497
EMBL	D61380 AF021819 AB073864 AK312000 AL034417 CH471130 BC008188 AB045294 AY648999
CCDS	CCDS93.1
PIR	JC5394
RefSeq	NP_001116849.1 NP_009193.2 XP_005263481.1
UniGene	Hs.419640
PDB	1J42 1P5F 1PDV 1PDW 1PE0 1Q2U 1SOA 1UCF 2OR3 2R1T 2R1U 2R1V 2RK3 2RK4 2RK6 3B36 3B38 3B3A 3BWE 3CY6 3CYF 3CZ9 3CZA 3EZG 3F71 3SF8 4BTE 4MNT 4MTC 4N0M 4N12 4OGF 4OQ4 4P2G 4P34 4P35 4P36
PDBsum	1J42 1P5F 1PDV 1PDW 1PE0 1Q2U 1SOA 1UCF 2OR3 2R1T 2R1U 2R1V 2RK3 2RK4 2RK6 3B36 3B38 3B3A 3BWE 3CY6 3CYF 3CZ9 3CZA 3EZG 3F71 3SF8 4BTE 4MNT 4MTC 4N0M 4N12 4OGF 4OQ4 4P2G 4P34 4P35 4P36
ProteinModelPortal	Q99497
SMR	Q99497
BioGrid	116446
DIP	DIP-35515N
IntAct	Q99497
MINT	MINT-5003468
STRING	9606.ENSP00000340278
MEROPS	C56.002
PhosphoSite	Q99497
DMDM	56404943
OGP	Q99497
REPRODUCTION-2DPAGE	IPI00298547
UCD-2DPAGE	O14805 Q99497
MaxQB	Q99497
PaxDb	Q99497
PeptideAtlas	Q99497
PRIDE	Q99497
DNASU	11315
Ensembl	ENST00000338639 ENST00000377488 ENST00000377491 ENST00000493373 ENST00000493678
GeneID	11315
KEGG	hsa:11315
UCSC	uc001aou.4
CTD	11315
GeneCards	GC01P008014
GeneReviews	PARK7
HGNC	HGNC:16369
HPA	CAB005870 HPA004190
MIM	168600 602533 606324
neXtProt	NX_Q99497
Orphanet	90020 2828
PharmGKB	PA32946
eggNOG	COG0693
HOGENOM	HOG000063194
HOVERGEN	HBG053511
InParanoid	Q99497
KO	K05687
OMA	MAGDHYK
OrthoDB	EOG7CVPZX
PhylomeDB	Q99497
TreeFam	TF300119
SignaLink	Q99497
ChiTaRS	PARK7
EvolutionaryTrace	Q99497
GeneWiki	PARK7
GenomeRNAi	11315
NextBio	42983
PMAP-CutDB	Q99497
PRO	PR:Q99497
Proteomes	UP000005640
Bgee	Q99497
CleanEx	HS_PARK7
ExpressionAtlas	Q99497
Genevestigator	Q99497
GO	GO:0030424 GO:0000785 GO:0005737 GO:0005829 GO:0070062 GO:0045121 GO:0005739 GO:0005634 GO:0005886 GO:0016605 GO:0050681 GO:1903135 GO:1903136 GO:0019955 GO:0019899 GO:1990422 GO:0019172 GO:0042802 GO:0036478 GO:0003729 GO:0016684 GO:0008233 GO:0004601 GO:0051920 GO:0042803 GO:0005102 GO:0070491 GO:0097110 GO:0044388 GO:0044390 GO:0016532 GO:0003713 GO:0008134 GO:0036470 GO:1990381 GO:0032148 GO:0008344 GO:0006914 GO:0036471 GO:0070301 GO:0034599 GO:0051583 GO:0046295 GO:1903190 GO:0042743 GO:0006954 GO:0019249 GO:0051899 GO:0060081 GO:0019243 GO:0007005 GO:0043066 GO:0060548 GO:2001268 GO:1903073 GO:2001237 GO:0010629 GO:1903206 GO:1903208 GO:0043524 GO:1901215 GO:1903202 GO:1903377 GO:0032435 GO:1901984 GO:0032091 GO:0046826 GO:1903094 GO:0006469 GO:0001933 GO:0033234 GO:0031397 GO:1903122 GO:0051444 GO:2000157 GO:2000825 GO:1903181 GO:0010628 GO:0032757 GO:1903197 GO:1903200 GO:1902958 GO:2000277 GO:0033138 GO:0090073 GO:0051897 GO:1900182 GO:1903168 GO:0051091 GO:1901671 GO:0045944 GO:2000679 GO:1903178 GO:0050821 GO:0007265 GO:0060765 GO:1902903 GO:0050727 GO:0051881 GO:0043523 GO:0007338
Gene3D	3.40.50.880
InterPro	IPR029062 IPR006287 IPR002818
Pfam	PF01965
SUPFAM	SSF52317
TIGRFAMs	TIGR01383

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0034599	cellular response to oxidative stress	PMID:14662519^[1]	ECO:0000315			P		Fig. 6	complete
	GO:0006979	response to oxidative stress	PMID:18309325^[2]	ECO:0000314			P		Figure 1: DJ-1 suppresses oxidative stress-induced JNK1 activation	complete
involved_in	GO:0033864	positive regulation of NAD(P)H oxidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99LX0	P		Seeded From UniProt	complete
involved_in	GO:0002866	positive regulation of acute inflammatory response to antigenic stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99LX0	P		Seeded From UniProt	complete
involved_in	GO:1905259	negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway	PMID:14752510^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0036531	glutathione deglycation	PMID:25416785^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0036524	protein deglycase activity	PMID:25416785^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0036528)\|part_of:(GO:0036526)\|part_of:(GO:0036527)\|part_of:(GO:0036529)\|part_of:(GO:0036530)	Seeded From UniProt	complete
involved_in	GO:0036526	peptidyl-cysteine deglycation	PMID:25416785^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P04406)	Seeded From UniProt	complete
involved_in	GO:0036528	peptidyl-lysine deglycation	PMID:25416785^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036527	peptidyl-arginine deglycation	PMID:25416785^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036530	protein deglycation, methylglyoxal removal	PMID:25416785^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P04406)	Seeded From UniProt	complete
involved_in	GO:0036529	protein deglycation, glyoxal removal	PMID:25416785^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:28596309^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0106046	guanine deglycation, glyoxal removal	PMID:28596309^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0106044	guanine deglycation	PMID:28596309^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0106045	guanine deglycation, methylglyoxal removal	PMID:28596309^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019249	lactate biosynthetic process	PMID:22523093^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903189	glyoxal metabolic process	PMID:22523093^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009438	methylglyoxal metabolic process	PMID:22523093^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99LX0	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99LX0	P		Seeded From UniProt	complete
involved_in	GO:0030073	insulin secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99LX0	P		Seeded From UniProt	complete
involved_in	GO:0006517	protein deglycosylation	PMID:26995087^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0036530	protein deglycation, methylglyoxal removal	PMID:27903648^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0009438	methylglyoxal metabolic process	PMID:27903648^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0006517	protein deglycosylation	PMID:27903648^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:25468996^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:25468996^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:25468996^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:1990381	ubiquitin-specific protease binding	PMID:21097510^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q6GQQ9	F		Seeded From UniProt	complete
involved_in	GO:0006517	protein deglycosylation	PMID:25416785^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	PMID:23792957^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010273	detoxification of copper ion	PMID:23792957^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050787	detoxification of mercury ion	PMID:23792957^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0045340	mercury ion binding	PMID:23792957^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1903599	positive regulation of autophagy of mitochondrion	PMID:24531622^[12]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	PMID:14652021^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q99LX0	P		Seeded From UniProt	complete
involved_in	GO:1903384	negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway	PMID:14652021^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q99LX0	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:19229105^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:19229105^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:19229105^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	PMID:19229105^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9BXM7	F		Seeded From UniProt	complete
involved_in	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:17015834^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q16236)	Seeded From UniProt	complete
involved_in	GO:0032091	negative regulation of protein binding	PMID:17015834^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q14145) has_regulation_target:(UniProtKB:Q16236)	Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	PMID:17015834^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q16236) part_of:(GO:0032435)	Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:17015834^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	stabilizes:(UniProtKB:Q16236)	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:17015834^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q16236)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17015834^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q16236	P	has_regulation_target:(UniProtKB:P15559)	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O88767	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:14662519^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000127) part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14662519^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000127) part_of:(UBERON:0000956)	Seeded From UniProt	complete
involved_in	GO:2000679	positive regulation of transcription regulatory region DNA binding	PMID:22492997^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q16236)	Seeded From UniProt	complete
involved_in	GO:1900182	positive regulation of protein localization to nucleus	PMID:22492997^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q16236)	Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:22492997^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0070301) has_regulation_target:(UniProtKB:P31749)	Seeded From UniProt	complete
involved_in	GO:0032148	activation of protein kinase B activity	PMID:22492997^[16]	ECO:0000305	curator inference used in manual assertion	GO:0033138	P	has_regulation_target:(UniProtKB:P31749) part_of:(GO:0070301)	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:22492997^[16]	ECO:0000305	curator inference used in manual assertion	GO:0033138	P	part_of:(GO:0070301)	Seeded From UniProt	complete
involved_in	GO:1903206	negative regulation of hydrogen peroxide-induced cell death	PMID:22492997^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22492997^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P10599)	Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	PMID:24899725^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q16665) has_direct_input:(UniProtKB:P40337)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15790595^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	PMID:15790595^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P23246	F	occurs_in:(CL:0000031)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[19]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051444	negative regulation of ubiquitin-protein transferase activity	PMID:24899725^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P40337)	Seeded From UniProt	complete
involved_in	GO:0032091	negative regulation of protein binding	PMID:24899725^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P40337) has_regulation_target:(UniProtKB:Q16665) part_of:(GO:0051444)	Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:24899725^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:19703902^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903181	positive regulation of dopamine biosynthetic process	PMID:19703902^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0036470	tyrosine 3-monooxygenase activator activity	PMID:19703902^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P07101)	Seeded From UniProt	complete
involved_in	GO:1903178	positive regulation of tyrosine 3-monooxygenase activity	PMID:19703902^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903200	positive regulation of L-dopa decarboxylase activity	PMID:19703902^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|enables	GO:0001047	core promoter binding	PMID:15790595^[18]	ECO:0000305	curator inference used in manual assertion	GO:0003713	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:15790595^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P23246 UniProtKB:Q15233	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15790595^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P23246 UniProtKB:Q15233	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:15790595^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:16731528^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1902958	positive regulation of mitochondrial electron transport, NADH to ubiquinone	PMID:19822128^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19822128^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19822128^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:19822128^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005747	mitochondrial respiratory chain complex I	PMID:19822128^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:19822128^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75489	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:19822128^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P03886	F	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:22523093^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0036471)	Seeded From UniProt	complete
involved_in	GO:0046295	glycolate biosynthetic process	PMID:22523093^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903181	positive regulation of dopamine biosynthetic process	PMID:16731528^[21]	ECO:0000305	curator inference used in manual assertion	GO:1903197	P		Seeded From UniProt	complete
involved_in	GO:0032091	negative regulation of protein binding	PMID:16731528^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q13547) has_regulation_target:(UniProtKB:P23246)	Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	PMID:16731528^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P23246	F		Seeded From UniProt	complete
involved_in	GO:0033234	negative regulation of protein sumoylation	PMID:16731528^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P23246) part_of:(GO:0045944)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16731528^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P07101)	Seeded From UniProt	complete
involved_in	GO:1903206	negative regulation of hydrogen peroxide-induced cell death	PMID:23743200^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903168	positive regulation of pyrroline-5-carboxylate reductase activity	PMID:23743200^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P32322)	Seeded From UniProt	complete
enables	GO:0036478	L-dopa decarboxylase activator activity	PMID:19703902^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P20711)	Seeded From UniProt	complete
involved_in	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	PMID:15790595^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903202	negative regulation of oxidative stress-induced cell death	PMID:16632486^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903197	positive regulation of L-dopa biosynthetic process	PMID:16731528^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036471	cellular response to glyoxal	PMID:22523093^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:20969476^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051881	regulation of mitochondrial membrane potential	PMID:23743200^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:23743200^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:23743200^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P32322	F		Seeded From UniProt	complete
involved_in	GO:0042743	hydrogen peroxide metabolic process	PMID:20969476^[25]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(CHEBI:16240)	Seeded From UniProt	complete
involved_in	GO:1903208	negative regulation of hydrogen peroxide-induced neuron death	PMID:24947010^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:19703902^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P20711	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:19703902^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P07101	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19703902^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P07101)	Seeded From UniProt	complete
involved_in	GO:0090073	positive regulation of protein homodimerization activity	PMID:24947010^[26]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P63244)	Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:24947010^[26]	ECO:0000314	direct assay evidence used in manual assertion		P	stabilizes:(UniProtKB:P63244)	Seeded From UniProt	complete
enables	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	PMID:24567322^[27]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:15944198^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:15944198^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:24144264^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:1903136	cuprous ion binding	PMID:24144264^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:1903136	cuprous ion binding	PMID:24567322^[27]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1901671	positive regulation of superoxide dismutase activity	PMID:24567322^[27]	ECO:0000314	direct assay evidence used in manual assertion		P	activated_by:(CHEBI:23378) has_regulation_target:(UniProtKB:P00441)	Seeded From UniProt	complete
enables	GO:0016532	superoxide dismutase copper chaperone activity	PMID:24567322^[27]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042743	hydrogen peroxide metabolic process	PMID:24567322^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:24567322^[27]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:1903135	cupric ion binding	PMID:24567322^[27]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22683601^[30]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0034599) exists_during:(GO:1901215)\|part_of(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:22683601^[30]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q96PG8) part_of:(GO:0034599)	Seeded From UniProt	complete
involved_in	GO:1901984	negative regulation of protein acetylation	PMID:22683601^[30]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P04637)	Seeded From UniProt	complete
part_of	GO:0016605	PML body	PMID:22683601^[30]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0034599) part_of:(CL:0000540)	Seeded From UniProt	complete
NOT\|enables	GO:0003690	double-stranded DNA binding	PMID:22683601^[30]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
NOT\|enables	GO:0003697	single-stranded DNA binding	PMID:22683601^[30]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:22683601^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	PMID:22683601^[30]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0034599)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:22683601^[30]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	PMID:14749723^[31]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0034599)	Seeded From UniProt	complete
involved_in	GO:1903122	negative regulation of TRAIL-activated apoptotic signaling pathway	PMID:21785459^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	PMID:21785459^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q14790) part_of:(GO:1903122)	Seeded From UniProt	complete
involved_in	GO:2000825	positive regulation of androgen receptor activity	PMID:17510388^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000157	negative regulation of ubiquitin-specific protease activity	PMID:21097510^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q6GQQ9)	Seeded From UniProt	complete
enables	GO:1990381	ubiquitin-specific protease binding	PMID:21097510^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:B2RUR8	F		Seeded From UniProt	complete
involved_in	GO:1903094	negative regulation of protein K48-linked deubiquitination	PMID:21097510^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903073	negative regulation of death-inducing signaling complex assembly	PMID:21785459^[32]	ECO:0000305	curator inference used in manual assertion	GO:0032091	P		Seeded From UniProt	complete
involved_in	GO:1903208	negative regulation of hydrogen peroxide-induced neuron death	PMID:15983381^[34]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0070301)	Seeded From UniProt	complete
involved_in	GO:1900182	positive regulation of protein localization to nucleus	PMID:21097510^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q04206)	Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:21785459^[32]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13158	F		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	PMID:17510388^[33]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10275	F	occurs_in:(GO:0005634)	Seeded From UniProt	complete
involved_in	GO:0046826	negative regulation of protein export from nucleus	PMID:15983381^[34]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q99683 UniProtKB:Q9UER7	P	has_regulation_target:(UniProtKB:Q9UER7)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21097510^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P05362)\|has_regulation_target:(UniProtKB:P10145)	Seeded From UniProt	complete
NOT\|involved_in	GO:0045560	regulation of TRAIL receptor biosynthetic process	PMID:21785459^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044390	ubiquitin-like protein conjugating enzyme binding	PMID:15983381^[34]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63279	F		Seeded From UniProt	complete
enables	GO:0044388	small protein activating enzyme binding	PMID:15983381^[34]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UBT2	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:15983381^[34]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99497	F		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:15983381^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032757	positive regulation of interleukin-8 production	PMID:21097510^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P10145)	Seeded From UniProt	complete
involved_in	GO:0032091	negative regulation of protein binding	PMID:15983381^[34]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q99683 UniProtKB:Q9UER7	P	has_regulation_target:(UniProtKB:Q9UER7) has_regulation_target:(UniProtKB:Q99683)	Seeded From UniProt	complete
involved_in	GO:0032091	negative regulation of protein binding	PMID:21785459^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q13158) has_regulation_target:(UniProtKB:Q14790)\|has_regulation_target:(UniProtKB:Q14790) has_regulation_target:(UniProtKB:O00220)	Seeded From UniProt	complete
enables	GO:0019955	cytokine binding	PMID:21097510^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9QZM3	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21097510^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8CHZ9	F		Seeded From UniProt	complete
involved_in	GO:0006469	negative regulation of protein kinase activity	PMID:15983381^[34]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q99683 UniProtKB:Q9UER7	P	has_regulation_target:(UniProtKB:Q99683)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15983381^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17510388^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15983381^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	PMID:15983381^[34]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q99683 UniProtKB:Q9UER7	P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[35]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[36]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[37]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21630459^[38]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:22511790^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	PMID:21785459^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q13158)	Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	PMID:14749723^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060765	regulation of androgen receptor signaling pathway	PMID:11477070^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	PMID:14749723^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:17015834^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99LX0	P		Seeded From UniProt	complete
involved_in	GO:0043523	regulation of neuron apoptotic process	PMID:20304780^[41]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043523	regulation of neuron apoptotic process	PMID:18711745^[42]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:18711745^[42]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032091	negative regulation of protein binding	PMID:11477070^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:20304780^[41]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99LX0	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21785459^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21785459^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18711745^[42]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18711745^[42]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18711745^[42]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11477070^[40]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:21785459^[32]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O00220	F	happens_during:(GO:0043066)	Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:18626009^[43]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0106046	guanine deglycation, glyoxal removal	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000111103 UniProtKB:Q99497	P		Seeded From UniProt	complete
involved_in	GO:0036529	protein deglycation, glyoxal removal	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000111103 UniProtKB:Q99497	P		Seeded From UniProt	complete
enables	GO:0036524	protein deglycase activity	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG13272 PANTHER:PTN000111103 UniProtKB:Q99497	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG13272 MGI:MGI:2135637 PANTHER:PTN000111103 PomBase:SPAC22E12.03c RGD:621808 TAIR:locus:2086295 UniProtKB:C6KTB1 UniProtKB:Q99497	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2135637 PANTHER:PTN000111108 PomBase:SPAC22E12.03c RGD:621808 TAIR:locus:2086295 UniProtKB:Q99497 WB:WBGene00015184	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12446870^[45]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12446870^[45]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:24947010^[26]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99497	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:15983381^[34]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99497	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:15502874^[46]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99497	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0051583	C		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0051920	P		Seeded From UniProt	complete
involved_in	GO:2000277	positive regulation of oxidative phosphorylation uncoupler activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:1903384	negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:1903208	negative regulation of hydrogen peroxide-induced neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:1903204	negative regulation of oxidative stress-induced neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:1903189	glyoxal metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:1902958	positive regulation of mitochondrial electron transport, NADH to ubiquinone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0060081	membrane hyperpolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
enables	GO:0051920	peroxiredoxin activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	F		Seeded From UniProt	complete
involved_in	GO:0051899	membrane depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0051583	dopamine uptake involved in synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0050787	detoxification of mercury ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0046295	glycolate biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
part_of	GO:0044297	cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	C		Seeded From UniProt	complete
involved_in	GO:0042743	hydrogen peroxide metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0036471	cellular response to glyoxal	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0033864	positive regulation of NAD(P)H oxidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0030073	insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0018323	enzyme active site formation via L-cysteine sulfinic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0010273	detoxification of copper ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0008344	adult locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	C		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	C		Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	C		Seeded From UniProt	complete
involved_in	GO:0002866	positive regulation of acute inflammatory response to antigenic stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0001963	synaptic transmission, dopaminergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LX0 ensembl:ENSMUSP00000101299	P		Seeded From UniProt	complete
involved_in	GO:0007265	Ras protein signal transduction	PMID:14662519^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902903	regulation of supramolecular fiber organization	PMID:23626584^[47]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_regulation_target:(UniProtKB:P37840)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:24252804^[48]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_regulation_target:(UniProtKB:Q05940)	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:22492997^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_regulation_target:(UniProtKB:Q16236)	Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:16731528^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-4085331	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
involved_in	GO:0007338	single fertilization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0278	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0370	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Bandopadhyay, R et al. (2004) The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease. Brain 127 420-30 PubMed GONUTS page
↑ Mo, JS et al. (2008) DJ-1 modulates UV-induced oxidative stress signaling through the suppression of MEKK1 and cell death. Cell Death Differ. 15 1030-41 PubMed GONUTS page
↑ Gotoh, T et al. (2004) hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria. Cell Death Differ. 11 390-402 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Richarme, G et al. (2015) Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues. J. Biol. Chem. 290 1885-97 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Richarme, G et al. (2017) Guanine glycation repair by DJ-1/Park7 and its bacterial homologs. Science 357 208-211 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Lee, JY et al. (2012) Human DJ-1 and its homologs are novel glyoxalases. Hum. Mol. Genet. 21 3215-25 PubMed GONUTS page
↑ Advedissian, T et al. (2016) The Parkinsonism-associated protein DJ-1/Park7 prevents glycation damage in human keratinocyte. Biochem. Biophys. Res. Commun. 473 87-91 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Pfaff, DH et al. (2017) Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification. J. Biol. Chem. 292 685-690 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 McNally, RS et al. (2011) DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. J. Biol. Chem. 286 4098-106 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Björkblom, B et al. (2013) Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity. J. Biol. Chem. 288 22809-20 PubMed GONUTS page
↑ Siebert, M et al. (2014) Glucocerebrosidase is shaking up the synucleinopathies. Brain 137 1304-22 PubMed GONUTS page
↑ ^13.0 ^13.1 Yokota, T et al. (2003) Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition. Biochem. Biophys. Res. Commun. 312 1342-8 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Xiong, H et al. (2009) Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J. Clin. Invest. 119 650-60 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 Clements, CM et al. (2006) DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc. Natl. Acad. Sci. U.S.A. 103 15091-6 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 Im, JY et al. (2012) DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway. Hum. Mol. Genet. 21 3013-24 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Parsanejad, M et al. (2014) Regulation of the VHL/HIF-1 pathway by DJ-1. J. Neurosci. 34 8043-50 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 Xu, J et al. (2005) The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. Hum. Mol. Genet. 14 1231-41 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 ^20.7 ^20.8 Ishikawa, S et al. (2009) Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1. J. Biol. Chem. 284 28832-44 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 ^21.6 ^21.7 Zhong, N et al. (2006) DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor. J. Biol. Chem. 281 20940-8 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 ^22.6 Hayashi, T et al. (2009) DJ-1 binds to mitochondrial complex I and maintains its activity. Biochem. Biophys. Res. Commun. 390 667-72 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 Yasuda, T et al. (2013) DJ-1 cooperates with PYCR1 in cell protection against oxidative stress. Biochem. Biophys. Res. Commun. 436 289-94 PubMed GONUTS page
↑ Tang, B et al. (2006) Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease. Hum. Mol. Genet. 15 1816-25 PubMed GONUTS page
↑ ^25.0 ^25.1 Choi, DH et al. (2011) DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell death. Antioxid. Redox Signal. 14 2137-50 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 Ma, J et al. (2014) DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis. Biochem. J. 462 489-97 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 ^27.4 ^27.5 ^27.6 Girotto, S et al. (2014) DJ-1 is a copper chaperone acting on SOD1 activation. J. Biol. Chem. 289 10887-99 PubMed GONUTS page
↑ ^28.0 ^28.1 Zhang, L et al. (2005) Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis. Hum. Mol. Genet. 14 2063-73 PubMed GONUTS page
↑ ^29.0 ^29.1 Puno, MR et al. (2013) Structure of Cu(I)-bound DJ-1 reveals a biscysteinate metal binding site at the homodimer interface: insights into mutational inactivation of DJ-1 in Parkinsonism. J. Am. Chem. Soc. 135 15974-7 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 ^30.3 ^30.4 ^30.5 ^30.6 ^30.7 ^30.8 Kim, SJ et al. (2012) Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death. Free Radic. Biol. Med. 53 936-50 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 Taira, T et al. (2004) DJ-1 has a role in antioxidative stress to prevent cell death. EMBO Rep. 5 213-8 PubMed GONUTS page
↑ ^32.0 ^32.1 ^32.2 ^32.3 ^32.4 ^32.5 ^32.6 ^32.7 ^32.8 ^32.9 Fu, K et al. (2012) DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD. Oncogene 31 1311-22 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 Tillman, JE et al. (2007) DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells. Cancer Res. 67 4630-7 PubMed GONUTS page
↑ ^34.00 ^34.01 ^34.02 ^34.03 ^34.04 ^34.05 ^34.06 ^34.07 ^34.08 ^34.09 ^34.10 ^34.11 Junn, E et al. (2005) Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. Proc. Natl. Acad. Sci. U.S.A. 102 9691-6 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
↑ Haque, ME et al. (2012) Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1. J. Biol. Chem. 287 23162-70 PubMed GONUTS page
↑ ^40.0 ^40.1 ^40.2 Takahashi, K et al. (2001) DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. J. Biol. Chem. 276 37556-63 PubMed GONUTS page
↑ ^41.0 ^41.1 Chen, J et al. (2010) Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage. Hum. Mol. Genet. 19 2395-408 PubMed GONUTS page
↑ ^42.0 ^42.1 ^42.2 ^42.3 ^42.4 Junn, E et al. (2009) Mitochondrial localization of DJ-1 leads to enhanced neuroprotection. J. Neurosci. Res. 87 123-9 PubMed GONUTS page
↑ van der Brug, MP et al. (2008) RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways. Proc. Natl. Acad. Sci. U.S.A. 105 10244-9 PubMed GONUTS page
↑ ^44.0 ^44.1 ^44.2 ^44.3 ^44.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^45.0 ^45.1 Bonifati, V et al. (2003) Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 299 256-9 PubMed GONUTS page
↑ Shendelman, S et al. (2004) DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation. PLoS Biol. 2 e362 PubMed GONUTS page
↑ Trempe, JF & Fon, EA (2013) Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection. Front Neurol 4 38 PubMed GONUTS page
↑ Dias, V et al. (2013) The role of oxidative stress in Parkinson's disease. J Parkinsons Dis 3 461-91 PubMed GONUTS page

[PMID:14662519-1] 1.0 ^1.1 ^1.2 ^1.3 Bandopadhyay, R et al. (2004) The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease. Brain 127 420-30 PubMed GONUTS page

[PMID:18309325-2] Mo, JS et al. (2008) DJ-1 modulates UV-induced oxidative stress signaling through the suppression of MEKK1 and cell death. Cell Death Differ. 15 1030-41 PubMed GONUTS page

[PMID:14752510-3] Gotoh, T et al. (2004) hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria. Cell Death Differ. 11 390-402 PubMed GONUTS page

[PMID:25416785-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Richarme, G et al. (2015) Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues. J. Biol. Chem. 290 1885-97 PubMed GONUTS page

[PMID:28596309-5] 5.0 ^5.1 ^5.2 ^5.3 Richarme, G et al. (2017) Guanine glycation repair by DJ-1/Park7 and its bacterial homologs. Science 357 208-211 PubMed GONUTS page

[PMID:22523093-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Lee, JY et al. (2012) Human DJ-1 and its homologs are novel glyoxalases. Hum. Mol. Genet. 21 3215-25 PubMed GONUTS page

[PMID:26995087-7] Advedissian, T et al. (2016) The Parkinsonism-associated protein DJ-1/Park7 prevents glycation damage in human keratinocyte. Biochem. Biophys. Res. Commun. 473 87-91 PubMed GONUTS page

[PMID:27903648-8] 8.0 ^8.1 ^8.2 Pfaff, DH et al. (2017) Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification. J. Biol. Chem. 292 685-690 PubMed GONUTS page

[PMID:25468996-9] 9.0 ^9.1 ^9.2 Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:21097510-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 McNally, RS et al. (2011) DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. J. Biol. Chem. 286 4098-106 PubMed GONUTS page

[PMID:23792957-11] 11.0 ^11.1 ^11.2 ^11.3 Björkblom, B et al. (2013) Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity. J. Biol. Chem. 288 22809-20 PubMed GONUTS page

[PMID:24531622-12] Siebert, M et al. (2014) Glucocerebrosidase is shaking up the synucleinopathies. Brain 137 1304-22 PubMed GONUTS page

[PMID:14652021-13] 13.0 ^13.1 Yokota, T et al. (2003) Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition. Biochem. Biophys. Res. Commun. 312 1342-8 PubMed GONUTS page

[PMID:19229105-14] 14.0 ^14.1 ^14.2 ^14.3 Xiong, H et al. (2009) Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J. Clin. Invest. 119 650-60 PubMed GONUTS page

[PMID:17015834-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 Clements, CM et al. (2006) DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc. Natl. Acad. Sci. U.S.A. 103 15091-6 PubMed GONUTS page

[PMID:22492997-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 Im, JY et al. (2012) DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway. Hum. Mol. Genet. 21 3013-24 PubMed GONUTS page

[PMID:24899725-17] 17.0 ^17.1 ^17.2 ^17.3 Parsanejad, M et al. (2014) Regulation of the VHL/HIF-1 pathway by DJ-1. J. Neurosci. 34 8043-50 PubMed GONUTS page

[PMID:15790595-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 Xu, J et al. (2005) The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. Hum. Mol. Genet. 14 1231-41 PubMed GONUTS page

[PMID:23533145-19] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19703902-20] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 ^20.7 ^20.8 Ishikawa, S et al. (2009) Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1. J. Biol. Chem. 284 28832-44 PubMed GONUTS page

[PMID:16731528-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 ^21.6 ^21.7 Zhong, N et al. (2006) DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor. J. Biol. Chem. 281 20940-8 PubMed GONUTS page

[PMID:19822128-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 ^22.6 Hayashi, T et al. (2009) DJ-1 binds to mitochondrial complex I and maintains its activity. Biochem. Biophys. Res. Commun. 390 667-72 PubMed GONUTS page

[PMID:23743200-23] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 Yasuda, T et al. (2013) DJ-1 cooperates with PYCR1 in cell protection against oxidative stress. Biochem. Biophys. Res. Commun. 436 289-94 PubMed GONUTS page

[PMID:16632486-24] Tang, B et al. (2006) Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease. Hum. Mol. Genet. 15 1816-25 PubMed GONUTS page

[PMID:20969476-25] 25.0 ^25.1 Choi, DH et al. (2011) DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell death. Antioxid. Redox Signal. 14 2137-50 PubMed GONUTS page

[PMID:24947010-26] 26.0 ^26.1 ^26.2 ^26.3 Ma, J et al. (2014) DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis. Biochem. J. 462 489-97 PubMed GONUTS page

[PMID:24567322-27] 27.0 ^27.1 ^27.2 ^27.3 ^27.4 ^27.5 ^27.6 Girotto, S et al. (2014) DJ-1 is a copper chaperone acting on SOD1 activation. J. Biol. Chem. 289 10887-99 PubMed GONUTS page

[PMID:15944198-28] 28.0 ^28.1 Zhang, L et al. (2005) Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis. Hum. Mol. Genet. 14 2063-73 PubMed GONUTS page

[PMID:24144264-29] 29.0 ^29.1 Puno, MR et al. (2013) Structure of Cu(I)-bound DJ-1 reveals a biscysteinate metal binding site at the homodimer interface: insights into mutational inactivation of DJ-1 in Parkinsonism. J. Am. Chem. Soc. 135 15974-7 PubMed GONUTS page

[PMID:22683601-30] 30.0 ^30.1 ^30.2 ^30.3 ^30.4 ^30.5 ^30.6 ^30.7 ^30.8 Kim, SJ et al. (2012) Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death. Free Radic. Biol. Med. 53 936-50 PubMed GONUTS page

[PMID:14749723-31] 31.0 ^31.1 ^31.2 Taira, T et al. (2004) DJ-1 has a role in antioxidative stress to prevent cell death. EMBO Rep. 5 213-8 PubMed GONUTS page

[PMID:21785459-32] 32.0 ^32.1 ^32.2 ^32.3 ^32.4 ^32.5 ^32.6 ^32.7 ^32.8 ^32.9 Fu, K et al. (2012) DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD. Oncogene 31 1311-22 PubMed GONUTS page

[PMID:17510388-33] 33.0 ^33.1 ^33.2 Tillman, JE et al. (2007) DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells. Cancer Res. 67 4630-7 PubMed GONUTS page

[PMID:15983381-34] 34.00 ^34.01 ^34.02 ^34.03 ^34.04 ^34.05 ^34.06 ^34.07 ^34.08 ^34.09 ^34.10 ^34.11 Junn, E et al. (2005) Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. Proc. Natl. Acad. Sci. U.S.A. 102 9691-6 PubMed GONUTS page

[PMID:19199708-35] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:19056867-36] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20458337-37] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:21630459-38] Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page

[PMID:22511790-39] Haque, ME et al. (2012) Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1. J. Biol. Chem. 287 23162-70 PubMed GONUTS page

[PMID:11477070-40] 40.0 ^40.1 ^40.2 Takahashi, K et al. (2001) DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. J. Biol. Chem. 276 37556-63 PubMed GONUTS page

[PMID:20304780-41] 41.0 ^41.1 Chen, J et al. (2010) Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage. Hum. Mol. Genet. 19 2395-408 PubMed GONUTS page

[PMID:18711745-42] 42.0 ^42.1 ^42.2 ^42.3 ^42.4 Junn, E et al. (2009) Mitochondrial localization of DJ-1 leads to enhanced neuroprotection. J. Neurosci. Res. 87 123-9 PubMed GONUTS page

[PMID:18626009-43] van der Brug, MP et al. (2008) RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways. Proc. Natl. Acad. Sci. U.S.A. 105 10244-9 PubMed GONUTS page

[PMID:21873635-44] 44.0 ^44.1 ^44.2 ^44.3 ^44.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12446870-45] 45.0 ^45.1 Bonifati, V et al. (2003) Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 299 256-9 PubMed GONUTS page

[PMID:15502874-46] Shendelman, S et al. (2004) DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation. PLoS Biol. 2 e362 PubMed GONUTS page

[PMID:23626584-47] Trempe, JF & Fon, EA (2013) Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection. Front Neurol 4 38 PubMed GONUTS page

[PMID:24252804-48] Dias, V et al. (2013) The role of oxidative stress in Parkinson's disease. J Parkinsons Dis 3 461-91 PubMed GONUTS page

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