MOUSE:PRGC1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ppargc1a (synonyms: Pgc1, Pgc1a, Ppargc1)
Protein Name(s)	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha PGC-1-alpha PPAR-gamma coactivator 1-alpha PPARGC-1-alpha
External Links
UniProt	O70343
EMBL	AF049330 JX866946 JX866947 JX866948 AK138668 AK143753 CH466524 BC066868
CCDS	CCDS19282.1
RefSeq	NP_032930.1
UniGene	Mm.259072
PDB	3F7D
PDBsum	3F7D
ProteinModelPortal	O70343
SMR	O70343
BioGrid	202321
DIP	DIP-38447N
IntAct	O70343
PhosphoSite	O70343
PaxDb	O70343
PRIDE	O70343
Ensembl	ENSMUST00000132734
GeneID	19017
KEGG	mmu:19017
UCSC	uc008xkc.2
CTD	10891
MGI	MGI:1342774
eggNOG	NOG78353
GeneTree	ENSGT00530000063196
HOGENOM	HOG000037431
HOVERGEN	HBG053678
InParanoid	O70343
KO	K07202
OMA	SPPKSLF
OrthoDB	EOG7S4X5H
PhylomeDB	O70343
TreeFam	TF343068
Reactome	REACT_118837 REACT_198351 REACT_198352 REACT_198602 REACT_205251 REACT_205688 REACT_241925 REACT_24972 REACT_252217 REACT_27166
EvolutionaryTrace	O70343
NextBio	295448
PRO	PR:O70343
Proteomes	UP000000589
Bgee	O70343
ExpressionAtlas	O70343
Genevestigator	O70343
GO	GO:0005829 GO:0005654 GO:0005634 GO:0016605 GO:0031490 GO:0003677 GO:0030374 GO:0000166 GO:0003723 GO:0043565 GO:0003713 GO:0008134 GO:0008209 GO:0071398 GO:0071456 GO:0071250 GO:0034599 GO:0097067 GO:0071356 GO:0032922 GO:0051552 GO:0006012 GO:0007005 GO:0045820 GO:0043524 GO:1901215 GO:2000272 GO:0070997 GO:2001171 GO:1901857 GO:2000507 GO:0046321 GO:1901860 GO:0010822 GO:1901863 GO:0051091 GO:0048661 GO:0045944 GO:0045893 GO:0042752 GO:2000310 GO:0006355 GO:0022904 GO:0009409 GO:0071871 GO:0043201 GO:0014850 GO:0071873 GO:0042594 GO:0036273 GO:0006351
Gene3D	3.30.70.330
InterPro	IPR012677 IPR000504
Pfam	PF00076
SMART	SM00360
PROSITE	PS50102

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060612	adipose tissue development	PMID:22237023^[1]	ECO:0000315			P		Figure 1	complete CACAO 5214
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:20661474^[2]	ECO:0000315			P		Figure 1.	complete CACAO 8095
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:15454086^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20661474^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060612	adipose tissue development	PMID:22237023^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:19651776^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21106753^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014850	response to muscle activity	PMID:21106753^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:19345188^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P26687	F		Seeded From UniProt	complete
involved_in	GO:2001171	positive regulation of ATP biosynthetic process	PMID:23150719^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	PMID:23150719^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901863	positive regulation of muscle tissue development	PMID:23150719^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901860	positive regulation of mitochondrial DNA metabolic process	PMID:23150719^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901857	positive regulation of cellular respiration	PMID:23150719^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBK2	F		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	PMID:17476214^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:17476214^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBK2	P		Seeded From UniProt	complete
involved_in	GO:0010822	positive regulation of mitochondrion organization	PMID:23150719^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBK2	P		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:16271724^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:17476214^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1342774 PANTHER:PTN000399017 UniProtKB:Q9UBK2	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1342774 PANTHER:PTN000399017 RGD:620925 UniProtKB:Q86YN6 UniProtKB:Q9UBK2	P		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000399017 UniProtKB:Q86YN6 UniProtKB:Q9UBK2	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1342774 PANTHER:PTN000399017 RGD:620925	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037248 MGI:MGI:1342774 PANTHER:PTN000399017 RGD:620925 UniProtKB:Q86YN6 UniProtKB:Q9UBK2	C		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000399017 UniProtKB:Q86YN6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000272	negative regulation of signaling receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000184	positive regulation of progesterone biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	P		Seeded From UniProt	complete
part_of	GO:1990844	interfibrillar mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	C		Seeded From UniProt	complete
part_of	GO:1990843	subsarcolemmal mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	C		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904635	positive regulation of glomerular visceral epithelial cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901215	negative regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBK2	P		Seeded From UniProt	complete
part_of	GO:0097440	apical dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097067	cellular response to thyroid hormone stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090258	negative regulation of mitochondrial fission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071372	cellular response to follicle-stimulating hormone stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBK2	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046321	positive regulation of fatty acid oxidation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20385772^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104740	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15199055^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104661 MGI:MGI:1276116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBK2	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15681609^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:14744933^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBK2	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045820	negative regulation of glycolytic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBK2	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:20566846^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBK2	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	C		Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	F		Seeded From UniProt	complete
enables	GO:0042975	peroxisome proliferator activated receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034599	cellular response to oxidative stress	PMID:20566846^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBK2	F		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	PMID:17952069^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031325	positive regulation of cellular metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	P		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBK2	F		Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022904	respiratory electron transport chain	PMID:14744933^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0022626	cytosolic ribosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	C		Seeded From UniProt	complete
enables	GO:0016922	nuclear receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBK2	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014912	negative regulation of smooth muscle cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014850	response to muscle activity	PMID:20086200^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014823	response to activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010822	positive regulation of mitochondrion organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBK2	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBK2	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007005	mitochondrion organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBK2	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	C		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBK2	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17952069^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBK2	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBK2	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15681609^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002021	response to dietary excess	PMID:24726645^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620925	P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:2000272	negative regulation of signaling receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:2000184	positive regulation of progesterone biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:1990845	adaptive thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
part_of	GO:1990844	interfibrillar mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	C		Seeded From UniProt	complete
part_of	GO:1990843	subsarcolemmal mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	C		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	F		Seeded From UniProt	complete
involved_in	GO:1904640	response to methionine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:1904639	cellular response to resveratrol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:1904637	cellular response to ionomycin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:1904635	positive regulation of glomerular visceral epithelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:1901558	response to metformin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
part_of	GO:0097440	apical dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	C		Seeded From UniProt	complete
involved_in	GO:0097067	cellular response to thyroid hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0097066	response to thyroid hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0090258	negative regulation of mitochondrial fission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071873	response to norepinephrine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071871	response to epinephrine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071398	cellular response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071392	cellular response to estradiol stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071372	cellular response to follicle-stimulating hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071354	cellular response to interleukin-6	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071332	cellular response to fructose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071313	cellular response to caffeine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071250	cellular response to nitrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0051602	response to electrical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0051552	flavone metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0046321	positive regulation of fatty acid oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0045820	negative regulation of glycolytic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0043201	response to leucine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	C		Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	F		Seeded From UniProt	complete
enables	GO:0042975	peroxisome proliferator activated receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	F		Seeded From UniProt	complete
involved_in	GO:0042594	response to starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0035865	cellular response to potassium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0031325	positive regulation of cellular metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	F		Seeded From UniProt	complete
part_of	GO:0022626	cytosolic ribosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	C		Seeded From UniProt	complete
involved_in	GO:0021549	cerebellum development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0019395	fatty acid oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0014912	negative regulation of smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0014878	response to electrical stimulus involved in regulation of muscle adaptation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0014850	response to muscle activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0014732	skeletal muscle atrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0009750	response to fructose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0009409	response to cold	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0008209	androgen metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	F		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0006094	gluconeogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0006012	galactose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	C		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	F		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0000422	autophagy of mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:0000302	response to reactive oxygen species	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYK2 ensembl:ENSRNOP00000006071	P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBK2 ensembl:ENSP00000264867	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBK2 ensembl:ENSP00000264867	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBK2 ensembl:ENSP00000264867	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBK2 ensembl:ENSP00000264867	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBK2 ensembl:ENSP00000264867	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBK2 ensembl:ENSP00000264867	C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBK2 ensembl:ENSP00000264867	F		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBK2 ensembl:ENSP00000264867	F		Seeded From UniProt	complete
enables	GO:0016922	nuclear receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBK2 ensembl:ENSP00000264867	F		Seeded From UniProt	complete
involved_in	GO:0010822	positive regulation of mitochondrion organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBK2 ensembl:ENSP00000264867	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBK2 ensembl:ENSP00000264867	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBK2 ensembl:ENSP00000264867	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBK2 ensembl:ENSP00000264867	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBK2 ensembl:ENSP00000264867	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBK2 ensembl:ENSP00000264867	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R9Q9 ensembl:ENSP00000264867	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R9Q9 ensembl:ENSP00000264867	C		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000504 InterPro:IPR035979	F		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034605 InterPro:IPR034625	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034625	F		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034625	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034605 InterPro:IPR034625	F		Seeded From UniProt	complete
involved_in	GO:0050873	brown fat cell differentiation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034625	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-9623284 Reactome:R-MMU-9623232 Reactome:R-MMU-9623231 Reactome:R-MMU-5663294 Reactome:R-MMU-556760 Reactome:R-MMU-3903005 Reactome:R-MMU-1605475 Reactome:R-MMU-1605464 Reactome:R-MMU-1368101	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	PMID:25775561^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(EMAPA:17373)	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Boström, P et al. (2012) A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481 463-8 PubMed GONUTS page
↑ ^2.0 ^2.1 Kong, X et al. (2010) Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis. PLoS ONE 5 e11707 PubMed GONUTS page
↑ Lin, J et al. (2004) Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 119 121-35 PubMed GONUTS page
↑ Nedumaran, B et al. (2009) DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression. J. Biol. Chem. 284 27511-23 PubMed GONUTS page
↑ ^5.0 ^5.1 Rasbach, KA et al. (2010) PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proc. Natl. Acad. Sci. U.S.A. 107 21866-71 PubMed GONUTS page
↑ Pan, D et al. (2009) Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism. Cell 137 73-86 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Hasumi, H et al. (2012) Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN. J. Natl. Cancer Inst. 104 1750-64 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Liu, C et al. (2007) Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism. Nature 447 477-81 PubMed GONUTS page
↑ Napal, L et al. (2005) An intronic peroxisome proliferator-activated receptor-binding sequence mediates fatty acid induction of the human carnitine palmitoyltransferase 1A. J. Mol. Biol. 354 751-9 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Kim, HB et al. (2010) Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. Mol. Cell. Biol. 30 3126-39 PubMed GONUTS page
↑ Lau, P et al. (2004) RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR. J. Biol. Chem. 279 36828-40 PubMed GONUTS page
↑ ^13.0 ^13.1 Guan, HP et al. (2005) Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev. 19 453-61 PubMed GONUTS page
↑ ^14.0 ^14.1 Fan, M et al. (2004) Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev. 18 278-89 PubMed GONUTS page
↑ ^15.0 ^15.1 Volakakis, N et al. (2010) NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection. Proc. Natl. Acad. Sci. U.S.A. 107 12317-22 PubMed GONUTS page
↑ ^16.0 ^16.1 Compe, E et al. (2007) Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH. Nat. Neurosci. 10 1414-22 PubMed GONUTS page
↑ Aoi, W et al. (2010) The microRNA miR-696 regulates PGC-1{alpha} in mouse skeletal muscle in response to physical activity. Am. J. Physiol. Endocrinol. Metab. 298 E799-806 PubMed GONUTS page
↑ Reed, C et al. (2014) RB tumor suppressive function in response to xenobiotic hepatocarcinogens. Am. J. Pathol. 184 1853-9 PubMed GONUTS page
↑ Hasumi, H et al. (2015) Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn. Proc. Natl. Acad. Sci. U.S.A. 112 E1624-31 PubMed GONUTS page

[PMID:22237023-1] 1.0 ^1.1 Boström, P et al. (2012) A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481 463-8 PubMed GONUTS page

[PMID:20661474-2] 2.0 ^2.1 Kong, X et al. (2010) Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis. PLoS ONE 5 e11707 PubMed GONUTS page

[PMID:15454086-3] Lin, J et al. (2004) Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 119 121-35 PubMed GONUTS page

[PMID:19651776-4] Nedumaran, B et al. (2009) DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression. J. Biol. Chem. 284 27511-23 PubMed GONUTS page

[PMID:21106753-5] 5.0 ^5.1 Rasbach, KA et al. (2010) PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proc. Natl. Acad. Sci. U.S.A. 107 21866-71 PubMed GONUTS page

[PMID:19345188-6] Pan, D et al. (2009) Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism. Cell 137 73-86 PubMed GONUTS page

[PMID:23150719-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Hasumi, H et al. (2012) Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN. J. Natl. Cancer Inst. 104 1750-64 PubMed GONUTS page

[PMID:17476214-8] 8.0 ^8.1 ^8.2 Liu, C et al. (2007) Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism. Nature 447 477-81 PubMed GONUTS page

[PMID:16271724-9] Napal, L et al. (2005) An intronic peroxisome proliferator-activated receptor-binding sequence mediates fatty acid induction of the human carnitine palmitoyltransferase 1A. J. Mol. Biol. 354 751-9 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20385772-11] Kim, HB et al. (2010) Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. Mol. Cell. Biol. 30 3126-39 PubMed GONUTS page

[PMID:15199055-12] Lau, P et al. (2004) RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR. J. Biol. Chem. 279 36828-40 PubMed GONUTS page

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