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PMID:20661474
| Citation |
Kong, X, Wang, R, Xue, Y, Liu, X, Zhang, H, Chen, Y, Fang, F and Chang, Y (2010) Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis. PLoS ONE 5:e11707 |
|---|---|
| Abstract |
Sirtuin 3 (SIRT3) is one of the seven mammalian sirtuins, which are homologs of the yeast Sir2 gene. SIRT3 is the only sirtuin with a reported association with the human life span. Peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) plays important roles in adaptive thermogenesis, gluconeogenesis, mitochondrial biogenesis and respiration. PGC-1alpha induces several key reactive oxygen species (ROS)-detoxifying enzymes, but the molecular mechanism underlying this is not well understood. |
| Links |
PubMed PMC2908542 Online version:10.1371/journal.pone.0011707 |
| Keywords |
Animals; Blotting, Western; Cell Line; Chromatin Immunoprecipitation; DNA, Mitochondrial/genetics; Electrophoretic Mobility Shift Assay; Heat-Shock Proteins/genetics; Heat-Shock Proteins/metabolism; Hep G2 Cells; Humans; Mice; Mitochondria/metabolism; Promoter Regions, Genetic/genetics; Protein Binding; Reactive Oxygen Species/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Sirtuin 3/genetics; Sirtuin 3/metabolism; Trans-Activators/genetics; Trans-Activators/metabolism; Transcription Factors/genetics; Transcription Factors/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0045893: positive regulation of transcription, DNA-dependent |
ECO:0000315: |
P |
Figure 1. |
complete | ||||
|
involved_in |
GO:0045893: positive regulation of transcription, DNA-templated |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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