CHICK:SIX3

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	SIX3
Protein Name(s)	Homeobox protein SIX3 CSIX3 Sine oculis homeobox homolog 3
External Links
UniProt	O42406
EMBL	Y15106 AY373324
RefSeq	NP_989695.1
UniGene	Gga.291
ProteinModelPortal	O42406
PRIDE	O42406
GeneID	378786
KEGG	gga:378786
CTD	6496
HOVERGEN	HBG003609
InParanoid	O42406
PhylomeDB	O42406
NextBio	20813819
PRO	PR:O42406
Proteomes	UP000000539
GO	GO:0005634 GO:0003677 GO:0003705 GO:0003700 GO:0003713 GO:1902742 GO:0007420 GO:0021846 GO:0002070 GO:0001654 GO:0021798 GO:0002088 GO:1990086 GO:0070306 GO:0045665 GO:0045892 GO:0030178 GO:0014016 GO:0097402 GO:0003404 GO:0021983 GO:0000060 GO:0009946 GO:1901987 GO:0042127 GO:2000177 GO:0061074 GO:1902692 GO:0006357 GO:0021537 GO:0021978 GO:0006366
Gene3D	1.10.10.60
InterPro	IPR001356 IPR009057
Pfam	PF00046
SMART	SM00389
SUPFAM	SSF46689
PROSITE	PS50071

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0003713	transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	F		Seeded From UniProt	complete
involved_in	GO:2000177	regulation of neural precursor cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:1990086	lens fiber cell apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:1902742	apoptotic process involved in development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:1902692	regulation of neuroblast proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:1901987	regulation of cell cycle phase transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:0097402	neuroblast migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:0070306	lens fiber cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:0061074	regulation of neural retina development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:0021983	pituitary gland development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:0021978	telencephalon regionalization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:0021846	cell proliferation in forebrain	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:0021537	telencephalon development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:0014016	neuroblast differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:0009946	proximal/distal axis specification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:0003404	optic vesicle morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:0002088	lens development in camera-type eye	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:0002070	epithelial cell maturation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95343	P		Seeded From UniProt	complete
involved_in	GO:0021798	forebrain dorsal/ventral pattern formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95343	P		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95343	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:0030178	negative regulation of Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	F		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62233	P		Seeded From UniProt	complete
involved_in	GO:0048856	anatomical structure development	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102780 MGI:MGI:106034 PANTHER:PTN000044272	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102764 MGI:MGI:106034 MGI:MGI:106220 PANTHER:PTN000044272 RGD:620909 UniProtKB:O95343	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102764 PANTHER:PTN002571848 ZFIN:ZDB-GENE-990415-127 ZFIN:ZDB-GENE-990415-128	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102780 PANTHER:PTN000044272	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003460 MGI:MGI:102764 MGI:MGI:102778 MGI:MGI:102780 MGI:MGI:106034 MGI:MGI:106220 MGI:MGI:1341840 PANTHER:PTN000044272 RGD:620906 UniProtKB:Q15475 WB:WBGene00000453 WB:WBGene00000455 WB:WBGene00006775	C		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102764 PANTHER:PTN002470536 UniProtKB:O95343 ZFIN:ZDB-GENE-050522-308 ZFIN:ZDB-GENE-990415-128 ZFIN:ZDB-GENE-990825-28	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000044272 ZFIN:ZDB-GENE-040718-155	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000044272 dictyBase:DDB_G0272967	F		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95343 ensembl:ENSP00000260653	P		Seeded From UniProt	complete
involved_in	GO:0021798	forebrain dorsal/ventral pattern formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95343 ensembl:ENSP00000260653	P		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95343 ensembl:ENSP00000260653	P		Seeded From UniProt	complete
enables	GO:0001222	transcription corepressor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95343 ensembl:ENSP00000260653	F		Seeded From UniProt	complete
involved_in	GO:2000177	regulation of neural precursor cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:1990086	lens fiber cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:1902742	apoptotic process involved in development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:1902692	regulation of neuroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:1901987	regulation of cell cycle phase transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0097402	neuroblast migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0070306	lens fiber cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0061074	regulation of neural retina development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0060235	lens induction in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0048512	circadian behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	F		Seeded From UniProt	complete
involved_in	GO:0043010	camera-type eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	F		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0030178	negative regulation of Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0021983	pituitary gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0021978	telencephalon regionalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0021846	cell proliferation in forebrain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0021797	forebrain anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0021537	telencephalon development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0021536	diencephalon development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0014016	neuroblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0009946	proximal/distal axis specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	F		Seeded From UniProt	complete
involved_in	GO:0003404	optic vesicle morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0002088	lens development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0002070	epithelial cell maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	F		Seeded From UniProt	complete
enables	GO:0001222	transcription corepressor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62233 ensembl:ENSMUSP00000135312	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032949	F		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032949	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032949	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032949	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0371 UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:SIX3

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