MOUSE:NDF1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Neurod1 (synonyms: Neurod)
Protein Name(s)	Neurogenic differentiation factor 1 NeuroD1 Beta-cell E-box transcriptional activator 2 Beta2
External Links
UniProt	Q60867
EMBL	U28068 U28888 AK005073 AK018781 BC018241
CCDS	CCDS16169.1
PIR	I49338
RefSeq	NP_035024.1
UniGene	Mm.4636
PDB	2QL2
PDBsum	2QL2
ProteinModelPortal	Q60867
SMR	Q60867
BioGrid	201733
IntAct	Q60867
MINT	MINT-8396397
PhosphoSite	Q60867
PRIDE	Q60867
Ensembl	ENSMUST00000041099
GeneID	18012
KEGG	mmu:18012
UCSC	uc008kgt.1
CTD	4760
MGI	MGI:1339708
eggNOG	NOG287211
GeneTree	ENSGT00680000099860
HOGENOM	HOG000049256
HOVERGEN	HBG000250
InParanoid	Q60867
KO	K08033
OMA	MNAQLNA
OrthoDB	EOG722J8S
PhylomeDB	Q60867
TreeFam	TF315153
Reactome	REACT_214529 REACT_221082
EvolutionaryTrace	Q60867
NextBio	293037
PRO	PR:Q60867
Proteomes	UP000000589
Bgee	Q60867
CleanEx	MM_NEUROD1
Genevestigator	Q60867
GO	GO:0005737 GO:0005622 GO:0005654 GO:0005634 GO:0003682 GO:0003677 GO:0003690 GO:0070888 GO:0046982 GO:0000978 GO:0001077 GO:0001105 GO:0043565 GO:0035881 GO:0009952 GO:0043010 GO:0045165 GO:0071333 GO:0021549 GO:0021542 GO:0048562 GO:0031018 GO:0035883 GO:0042593 GO:0030902 GO:0048839 GO:0030073 GO:0046426 GO:2000675 GO:0007263 GO:0006913 GO:0003326 GO:0003329 GO:0043065 GO:0045597 GO:0045666 GO:0051091 GO:0045944 GO:2000679 GO:0045893 GO:0071156 GO:0060730 GO:0045664 GO:0042493 GO:0023019
Gene3D	4.10.280.10
InterPro	IPR011598 IPR022575 IPR016637
Pfam	PF00010 PF12533
PIRSF	PIRSF015618
SMART	SM00353
SUPFAM	SSF47459
PROSITE	PS50888

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:11981044^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:11981044^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:11981044^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000675	negative regulation of type B pancreatic cell apoptotic process	PMID:9308961^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048562	embryonic organ morphogenesis	PMID:9308961^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:9308961^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031018	endocrine pancreas development	PMID:9308961^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071156	regulation of cell cycle arrest	PMID:9512516^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:14697366^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060730	regulation of intestinal epithelial structure maintenance	PMID:9512516^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:14697366^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	PMID:11152640^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9512516^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18007592^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:14697366^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	PMID:18007592^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	PMID:9512516^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	PMID:11861467^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:9512516^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035883	enteroendocrine cell differentiation	PMID:9308961^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035881	amacrine cell differentiation	PMID:11861467^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031018	endocrine pancreas development	PMID:10639171^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021549	cerebellum development	PMID:10398678^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021542	dentate gyrus development	PMID:10398678^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021542	dentate gyrus development	PMID:10639171^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:18007592^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000679	positive regulation of transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13562	P		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13562	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071333	cellular response to glucose stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3165	P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13562	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13562	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:18388149^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15806	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13562	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	PMID:18848628^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:16895) regulates_o_occurs_in:(CL:0000337)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15701640^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1352454 MGI:MGI:97874	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15793245^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148229	P	regulates_o_occurs_in:(EMAPA:17503) has_regulation_target:(MGI:MGI:104716)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15121856^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13562	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3165	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12368292^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3165	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045664	regulation of neuron differentiation	PMID:22513373^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102780 MGI:MGI:107754 MGI:MGI:109344	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045165	cell fate commitment	PMID:11861467^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108055	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:18388149^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:15793245^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(MGI:MGI:104716)	Seeded From UniProt	complete
contributes_to	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13562	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043010	camera-type eye development	PMID:11861467^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108055	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030902	hindbrain development	PMID:16368089^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148229	P	results_in_development_of:(EMAPA:17787)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030073	insulin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13562	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0023019	signal transduction involved in regulation of gene expression	PMID:18462699^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021542	dentate gyrus development	PMID:10804213^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:106593	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:16368089^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148229	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009749	response to glucose	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13562	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13562	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007263	nitric oxide mediated signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13562	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006913	nucleocytoplasmic transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3165	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18388149^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35998)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3165	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18388149^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16898)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11891657^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16999) part_of:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12368292^[15]	ECO:0000305	curator inference used in manual assertion	GO:0003700	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13562	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3165	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13562	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13562	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3165	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:12368292^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003329	pancreatic PP cell fate commitment	PMID:17988662^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97347	P	occurs_in:(EMAPA:18816) results_in_commitment_to:(CL:0000696)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003326	pancreatic A cell fate commitment	PMID:17988662^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97347	P	occurs_in:(EMAPA:18816) results_in_commitment_to:(CL:0000171)	Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13562	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13562	F		Seeded From UniProt	complete
involved_in	GO:2000679	positive regulation of transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13562 ensembl:ENSP00000295108	P		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13562 ensembl:ENSP00000295108	C		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13562 ensembl:ENSP00000295108	F		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13562 ensembl:ENSP00000295108	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13562 ensembl:ENSP00000295108	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13562 ensembl:ENSP00000295108	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13562 ensembl:ENSP00000295108	F		Seeded From UniProt	complete
involved_in	GO:0030073	insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13562 ensembl:ENSP00000295108	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13562 ensembl:ENSP00000295108	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13562 ensembl:ENSP00000295108	F		Seeded From UniProt	complete
involved_in	GO:0007263	nitric oxide mediated signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13562 ensembl:ENSP00000295108	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13562 ensembl:ENSP00000295108	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13562 ensembl:ENSP00000295108	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13562 ensembl:ENSP00000295108	F		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13562 ensembl:ENSP00000295108	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13562 ensembl:ENSP00000295108	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64289 ensembl:ENSRNOP00000007662	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64289 ensembl:ENSRNOP00000007662	C		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64289 ensembl:ENSRNOP00000007662	F		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64289 ensembl:ENSRNOP00000007662	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64289 ensembl:ENSRNOP00000007662	P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64289 ensembl:ENSRNOP00000007662	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64289 ensembl:ENSRNOP00000007662	P		Seeded From UniProt	complete
involved_in	GO:0021549	cerebellum development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64289 ensembl:ENSRNOP00000007662	P		Seeded From UniProt	complete
involved_in	GO:0006913	nucleocytoplasmic transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64289 ensembl:ENSRNOP00000007662	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016637 InterPro:IPR032652	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016637	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011598 InterPro:IPR036638	F		Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032652	P		Seeded From UniProt	complete
involved_in	GO:0031018	endocrine pancreas development	Reactome:R-MMU-210774	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-186544	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Kim, JW et al. (2002) Transactivation of the mouse sulfonylurea receptor I gene by BETA2/NeuroD. Mol. Endocrinol. 16 1097-107 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Naya, FJ et al. (1997) Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev. 11 2323-34 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Mutoh, H et al. (1998) The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Genes Dev. 12 820-30 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Lin, CH et al. (2004) Regulation of neuroD2 expression in mouse brain. Dev. Biol. 265 234-45 PubMed GONUTS page
↑ Kim, WY et al. (2001) NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development. Development 128 417-26 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Seo, S et al. (2007) Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers. EMBO J. 26 5093-108 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Inoue, T et al. (2002) Math3 and NeuroD regulate amacrine cell fate specification in the retina. Development 129 831-42 PubMed GONUTS page
↑ ^8.0 ^8.1 Liu, M et al. (2000) Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy. Proc. Natl. Acad. Sci. U.S.A. 97 865-70 PubMed GONUTS page
↑ ^9.0 ^9.1 Miyata, T et al. (1999) NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus. Genes Dev. 13 1647-52 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Lavoie, PL et al. (2008) Developmental dependence on NurRE and EboxNeuro for expression of pituitary proopiomelanocortin. Mol. Endocrinol. 22 1647-57 PubMed GONUTS page
↑ Kwon, IS et al. (2009) Expression of Disabled 1 suppresses astroglial differentiation in neural stem cells. Mol. Cell. Neurosci. 40 50-61 PubMed GONUTS page
↑ Batsché, E et al. (2005) Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription. J. Biol. Chem. 280 16088-95 PubMed GONUTS page
↑ ^13.0 ^13.1 Chu, K & Tsai, MJ (2005) Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion. Diabetes 54 1064-73 PubMed GONUTS page
↑ Liu, A et al. (2004) Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity. Mol. Cell. Biol. 24 4372-83 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Kataoka, K et al. (2002) MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. J. Biol. Chem. 277 49903-10 PubMed GONUTS page
↑ Ahmed, M et al. (2012) EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. Development 139 1965-77 PubMed GONUTS page
↑ ^17.0 ^17.1 Cho, JH & Tsai, MJ (2006) Preferential posterior cerebellum defect in BETA2/NeuroD1 knockout mice is the result of differential expression of BETA2/NeuroD1 along anterior-posterior axis. Dev. Biol. 290 125-38 PubMed GONUTS page
↑ Lee, D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2 497-507 PubMed GONUTS page
↑ Schwab, MH et al. (2000) Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus. J. Neurosci. 20 3714-24 PubMed GONUTS page
↑ Davies, D & Holley, MC (2002) Differential expression of alpha 3 and alpha 6 integrins in the developing mouse inner ear. J. Comp. Neurol. 445 122-32 PubMed GONUTS page
↑ ^21.0 ^21.1 Chao, CS et al. (2007) Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells. Dev. Biol. 312 523-32 PubMed GONUTS page

[PMID:11981044-1] 1.0 ^1.1 ^1.2 Kim, JW et al. (2002) Transactivation of the mouse sulfonylurea receptor I gene by BETA2/NeuroD. Mol. Endocrinol. 16 1097-107 PubMed GONUTS page

[PMID:9308961-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Naya, FJ et al. (1997) Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev. 11 2323-34 PubMed GONUTS page

[PMID:9512516-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Mutoh, H et al. (1998) The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Genes Dev. 12 820-30 PubMed GONUTS page

[PMID:14697366-4] 4.0 ^4.1 ^4.2 Lin, CH et al. (2004) Regulation of neuroD2 expression in mouse brain. Dev. Biol. 265 234-45 PubMed GONUTS page

[PMID:11152640-5] Kim, WY et al. (2001) NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development. Development 128 417-26 PubMed GONUTS page

[PMID:18007592-6] 6.0 ^6.1 ^6.2 Seo, S et al. (2007) Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers. EMBO J. 26 5093-108 PubMed GONUTS page

[PMID:11861467-7] 7.0 ^7.1 ^7.2 ^7.3 Inoue, T et al. (2002) Math3 and NeuroD regulate amacrine cell fate specification in the retina. Development 129 831-42 PubMed GONUTS page

[PMID:10639171-8] 8.0 ^8.1 Liu, M et al. (2000) Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy. Proc. Natl. Acad. Sci. U.S.A. 97 865-70 PubMed GONUTS page

[PMID:10398678-9] 9.0 ^9.1 Miyata, T et al. (1999) NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus. Genes Dev. 13 1647-52 PubMed GONUTS page

[PMID:18388149-10] 10.0 ^10.1 ^10.2 ^10.3 Lavoie, PL et al. (2008) Developmental dependence on NurRE and EboxNeuro for expression of pituitary proopiomelanocortin. Mol. Endocrinol. 22 1647-57 PubMed GONUTS page

[PMID:18848628-11] Kwon, IS et al. (2009) Expression of Disabled 1 suppresses astroglial differentiation in neural stem cells. Mol. Cell. Neurosci. 40 50-61 PubMed GONUTS page

[PMID:15701640-12] Batsché, E et al. (2005) Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription. J. Biol. Chem. 280 16088-95 PubMed GONUTS page

[PMID:15793245-13] 13.0 ^13.1 Chu, K & Tsai, MJ (2005) Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion. Diabetes 54 1064-73 PubMed GONUTS page

[PMID:15121856-14] Liu, A et al. (2004) Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity. Mol. Cell. Biol. 24 4372-83 PubMed GONUTS page

[PMID:12368292-15] 15.0 ^15.1 ^15.2 Kataoka, K et al. (2002) MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. J. Biol. Chem. 277 49903-10 PubMed GONUTS page

[PMID:22513373-16] Ahmed, M et al. (2012) EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. Development 139 1965-77 PubMed GONUTS page

[PMID:16368089-17] 17.0 ^17.1 Cho, JH & Tsai, MJ (2006) Preferential posterior cerebellum defect in BETA2/NeuroD1 knockout mice is the result of differential expression of BETA2/NeuroD1 along anterior-posterior axis. Dev. Biol. 290 125-38 PubMed GONUTS page

[PMID:18462699-18] Lee, D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2 497-507 PubMed GONUTS page

[PMID:10804213-19] Schwab, MH et al. (2000) Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus. J. Neurosci. 20 3714-24 PubMed GONUTS page

[PMID:11891657-20] Davies, D & Holley, MC (2002) Differential expression of alpha 3 and alpha 6 integrins in the developing mouse inner ear. J. Comp. Neurol. 445 122-32 PubMed GONUTS page

[PMID:17988662-21] 21.0 ^21.1 Chao, CS et al. (2007) Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells. Dev. Biol. 312 523-32 PubMed GONUTS page

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MOUSE:NDF1

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