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PMID:10398678

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Citation

Miyata, T, Maeda, T and Lee, JE (1999) NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus. Genes Dev. 13:1647-52

Abstract

NeuroD, a bHLH transcription factor, is implicated in differentiation of neurons and pancreatic beta cells. NeuroD-null mice die shortly after birth due to severe neonatal diabetes. To examine if there is postnatal neuronal phenotype in these mice, we rescued them from neonatal lethality by introducing a transgene encoding the mouse neuroD gene under the insulin promoter. These mice survive to adulthood but display severe neurological phenotype due to neuronal deficit in the granule layers of the cerebellum and hippocampus. We show here that NeuroD is required for these postnatally generated microneurons to undergo proper differentiation, the absence of which results in cell death.

Links

PubMed PMC316850

Keywords

Animals; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Cell Count; Cell Differentiation; Cerebellum/cytology; Cerebellum/growth & development; Cerebellum/pathology; Gene Therapy; Hippocampus/cytology; Hippocampus/growth & development; Hippocampus/pathology; In Situ Nick-End Labeling; Insulin/genetics; Mice; Mice, Knockout; Mice, Neurologic Mutants; Mice, Transgenic; Nerve Tissue Proteins/deficiency; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/physiology; Neurons/cytology; Phenotype; Promoter Regions, Genetic; Recombinant Fusion Proteins/physiology; Transgenes

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:NDF1

involved_in

GO:0021549: cerebellum development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:NDF1

involved_in

GO:0021542: dentate gyrus development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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