MOUSE:ENY2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Eny2
Protein Name(s)	Transcription and mRNA export factor ENY2 (ECO:0000255 with HAMAP-Rule:MF_03046) Enhancer of yellow 2 transcription factor homolog (ECO:0000255 with HAMAP-Rule:MF_03046)
External Links
UniProt	Q9JIX0
EMBL	AF173297 AK032957 BC048361
CCDS	CCDS27456.1
RefSeq	NP_778174.1
UniGene	Mm.291828 Mm.490404
ProteinModelPortal	Q9JIX0
SMR	Q9JIX0
BioGrid	230155
IntAct	Q9JIX0
MINT	MINT-4129828
STRING	10090.ENSMUSP00000052905
iPTMnet	Q9JIX0
PhosphoSite	Q9JIX0
EPD	Q9JIX0
MaxQB	Q9JIX0
PaxDb	Q9JIX0
PRIDE	Q9JIX0
DNASU	223527
Ensembl	ENSMUST00000060652
GeneID	223527
KEGG	mmu:223527
UCSC	uc007vpu.1
CTD	56943
MGI	MGI:1919286
eggNOG	KOG4479 ENOG4111PHC
GeneTree	ENSGT00390000011748
HOGENOM	HOG000007355
HOVERGEN	HBG107852
InParanoid	Q9JIX0
KO	K11368
OMA	AHCKDVI
OrthoDB	EOG7B8S6B
PhylomeDB	Q9JIX0
TreeFam	TF326556
NextBio	376743
PRO	PR:Q9JIX0
Proteomes	UP000000589
Bgee	Q9JIX0
CleanEx	MM_ENY2
Genevisible	Q9JIX0
GO	GO:0071819 GO:0005643 GO:0000124 GO:0070390 GO:0003682 GO:0030374 GO:0003713 GO:0016578 GO:0061179 GO:0016973 GO:0045893 GO:0015031 GO:0006357 GO:0006368
HAMAP	MF_03046
InterPro	IPR018783

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0006006	glucose metabolic process	PMID:22649445^[1]	ECO:0000315			P	Figure 3(d) - Glucose metabolism as measured by an MTT assay Increased after ENY2 knockdown.	complete CACAO 11609
	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	PMID:22649445^[1]	ECO:0000315			P	Figure 3(e) - Insulin secretion increases in response to Tolbutamide stimulus after ENY2 supression.	complete CACAO 11619
	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	PMID:22649445^[1]	ECO:0000315			P	Figure 4(c) - Insulin secretion increased in response to stimulation with 50nmol/l exendin-4 and 10μmol/1 forskolin.	complete CACAO 11620
part_of	GO:0070390	transcription export complex 2	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NPA8	C	Seeded From UniProt	complete
part_of	GO:0044615	nuclear pore nuclear basket	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NPA8	C	Seeded From UniProt	complete
involved_in	GO:0016973	poly(A)+ mRNA export from nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NPA8	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NPA8	P	Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NPA8	F	Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NPA8	F	Seeded From UniProt	complete
part_of	GO:0000124	SAGA complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NPA8	C	Seeded From UniProt	complete
part_of	GO:0071819	DUBm complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NPA8	C	Seeded From UniProt	complete
part_of	GO:0071819	DUBm complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000618 PANTHER:PTN000282153 SGD:S000028510 UniProtKB:Q9NPA8	C	Seeded From UniProt	complete
involved_in	GO:0016973	poly(A)+ mRNA export from nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000618 PANTHER:PTN000282153 SGD:S000028510	P	Seeded From UniProt	complete
involved_in	GO:0016578	histone deubiquitination	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000618 PANTHER:PTN000282153 SGD:S000028510 UniProtKB:Q9NPA8	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000282153 PomBase:SPBC6B1.12c	P	Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000282153 UniProtKB:Q9NPA8	F	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000618 PANTHER:PTN000282153	F	Seeded From UniProt	complete
part_of	GO:0000124	SAGA complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000618 PANTHER:PTN000282153 PomBase:SPBC6B1.12c SGD:S000028510 UniProtKB:Q9NPA8	C	Seeded From UniProt	complete
part_of	GO:0071819	DUBm complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPA8	C	Seeded From UniProt	complete
part_of	GO:0070390	transcription export complex 2	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPA8	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1596439	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPA8	P	Seeded From UniProt	complete
part_of	GO:0044615	nuclear pore nuclear basket	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPA8	C	Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPA8	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016973	poly(A)+ mRNA export from nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPA8	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016578	histone deubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPA8	P	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPA8	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPA8	C	Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPA8	F	Seeded From UniProt	complete
part_of	GO:0000124	SAGA complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPA8	C	Seeded From UniProt	complete
involved_in	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZWF5 ensembl:ENSRNOP00000006402	P	Seeded From UniProt	complete
part_of	GO:0071819	DUBm complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPA8 ensembl:ENSP00000429986	C	Seeded From UniProt	complete
part_of	GO:0070390	transcription export complex 2	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPA8 ensembl:ENSP00000429986	C	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPA8 ensembl:ENSP00000429986	P	Seeded From UniProt	complete
part_of	GO:0044615	nuclear pore nuclear basket	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPA8 ensembl:ENSP00000429986	C	Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPA8 ensembl:ENSP00000429986	F	Seeded From UniProt	complete
involved_in	GO:0016973	poly(A)+ mRNA export from nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPA8 ensembl:ENSP00000429986	P	Seeded From UniProt	complete
involved_in	GO:0016578	histone deubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPA8 ensembl:ENSP00000429986	P	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPA8 ensembl:ENSP00000429986	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPA8 ensembl:ENSP00000429986	C	Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPA8 ensembl:ENSP00000429986	F	Seeded From UniProt	complete
part_of	GO:0000124	SAGA complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPA8 ensembl:ENSP00000429986	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R9D9 ensembl:ENSP00000429986	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R9D9 ensembl:ENSP00000429986	C	Seeded From UniProt	complete
part_of	GO:0000124	SAGA complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018783	C	Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018783	F	Seeded From UniProt	complete
part_of	GO:0005643	nuclear pore	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018783	C	Seeded From UniProt	complete
involved_in	GO:0006406	mRNA export from nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018783	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018783	P	Seeded From UniProt	complete
part_of	GO:0000124	SAGA complex	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112776	C	Seeded From UniProt	complete
involved_in	GO:0006406	mRNA export from nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112776	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112776	C	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112776	P	Seeded From UniProt	complete
involved_in	GO:0006368	transcription elongation from RNA polymerase II promoter	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112776	P	Seeded From UniProt	complete
part_of	GO:0071819	DUBm complex	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112776	C	Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112776	F	Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112776	F	Seeded From UniProt	complete
part_of	GO:0005643	nuclear pore	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112776	C	Seeded From UniProt	complete
involved_in	GO:0016578	histone deubiquitination	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112776	P	Seeded From UniProt	complete
part_of	GO:0070390	transcription export complex 2	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000112776	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
part_of	GO:0005643	nuclear pore	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0906 UniProtKB-SubCell:SL-0185	C	Seeded From UniProt	complete
involved_in	GO:0051028	mRNA transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0509	P	Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653 UniProtKB-KW:KW-0811	P	Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Dames, P et al. (2012) Suppression of the nuclear factor Eny2 increases insulin secretion in poorly functioning INS-1E insulinoma cells. Exp Diabetes Res 2012 460869 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22649445-1] 1.0 ^1.1 ^1.2 Dames, P et al. (2012) Suppression of the nuclear factor Eny2 increases insulin secretion in poorly functioning INS-1E insulinoma cells. Exp Diabetes Res 2012 460869 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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MOUSE:ENY2

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Notes

References

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