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HUMAN:MTA3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MTA3 (synonyms: KIAA1266)
Protein Name(s) Metastasis-associated protein MTA3
External Links
UniProt Q9BTC8
EMBL AB033092
AK027304
BC004227
BC053631
AL161954
CCDS CCDS46267.1
PIR T47180
RefSeq NP_001269684.1
NP_001269685.1
NP_065795.1
XP_005264513.1
UniGene Hs.435413
Hs.646800
Hs.745162
ProteinModelPortal Q9BTC8
SMR Q9BTC8
BioGrid 121568
DIP DIP-47460N
IntAct Q9BTC8
MINT MINT-4538323
STRING 9606.ENSP00000385045
PhosphoSite Q9BTC8
DMDM 29840798
MaxQB Q9BTC8
PaxDb Q9BTC8
PRIDE Q9BTC8
DNASU 57504
Ensembl ENST00000405094
ENST00000407270
GeneID 57504
KEGG hsa:57504
UCSC uc002rsq.3
CTD 57504
GeneCards GC02P042722
HGNC HGNC:23784
HPA HPA039433
MIM 609050
neXtProt NX_Q9BTC8
PharmGKB PA134953540
eggNOG NOG252834
GeneTree ENSGT00580000081398
HOGENOM HOG000045387
HOVERGEN HBG002598
InParanoid Q9BTC8
KO K11660
OMA HMSRQAT
PhylomeDB Q9BTC8
TreeFam TF106444
Reactome REACT_228222
REACT_953
ChiTaRS MTA3
GeneWiki MTA3
GenomeRNAi 57504
NextBio 63833
PRO PR:Q9BTC8
Proteomes UP000005640
Bgee Q9BTC8
CleanEx HS_MTA3
ExpressionAtlas Q9BTC8
Genevestigator Q9BTC8
GO GO:0043231
GO:0005634
GO:0003682
GO:0043565
GO:0003700
GO:0008270
InterPro IPR001025
IPR000949
IPR009057
IPR001005
IPR017884
IPR000679
Pfam PF01426
PF01448
PF00320
SMART SM00439
SM00717
SM00401
SUPFAM SSF46689
PROSITE PS51038
PS51156
PS51293

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0045892

negative regulation of transcription, DNA-dependent

PMID:15454082[1]

ECO:0000315

P

Figure 3D shows that repression, driven by the central region of BCL-6, was affected by MTA3 depletion. It can be concluded that MTA3 contributes to transcriptional repression by Gal4-BCL-6 through interaction with a transcriptional repression domain in the central region of BCL-6.

complete
CACAO 7304

part_of

GO:0016581

NuRD complex

PMID:22926524[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:P17679

F

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:15454082[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042826

histone deacetylase binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001328846
RGD:1306743
UniProtKB:Q8N108
UniProtKB:Q8N344

F

Seeded From UniProt

complete

part_of

GO:0016581

NuRD complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1346340
MGI:MGI:2150037
PANTHER:PTN000852793
UniProtKB:A0A0B4KG70
UniProtKB:O94776

C

Seeded From UniProt

complete

involved_in

GO:0016575

histone deacetylation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001328846
UniProtKB:Q7Z3K6
UniProtKB:Q8N108
UniProtKB:Q8N344

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001328846
UniProtKB:O94776
UniProtKB:Q13330
UniProtKB:Q7Z3K6
UniProtKB:Q8N108

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1346340
MGI:MGI:2150037
MGI:MGI:2151172
PANTHER:PTN001328846
RGD:1306743
RGD:621018
UniProtKB:Q13330
UniProtKB:Q7Z3K6
UniProtKB:Q8N108
UniProtKB:Q8N344
UniProtKB:Q9BTC8

C

Seeded From UniProt

complete

enables

GO:0003714

transcription corepressor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001328846
UniProtKB:Q13330

F

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2150037
PANTHER:PTN000852793
UniProtKB:Q13330

F

Seeded From UniProt

complete

enables

GO:0001103

RNA polymerase II repressing transcription factor binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001328846
UniProtKB:O94776
UniProtKB:Q13330

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1346340
PANTHER:PTN001328846

P

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1903508

positive regulation of nucleic acid-templated transcription

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0003713

P

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q924K8
ensembl:ENSMUSP00000068931

F

Seeded From UniProt

complete

involved_in

GO:0010971

positive regulation of G2/M transition of mitotic cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q924K8
ensembl:ENSMUSP00000068931

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q924K8
ensembl:ENSMUSP00000068931

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q924K8
ensembl:ENSMUSP00000068931

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q924K8
ensembl:ENSMUSP00000068931

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009057

F

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001025

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000679

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000679

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000679

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8943780
Reactome:R-HSA-3769447

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Fujita, N et al. (2004) MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. Cell 119 75-86 PubMed GONUTS page
  2. ↑ Xuan, C et al. (2013) RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. Oncogene 32 3711-21 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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