HUMAN:PLAK

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	JUP (synonyms: CTNNG, DP3)
Protein Name(s)	Junction plakoglobin Catenin gamma Desmoplakin III Desmoplakin-3
External Links
UniProt	P14923
EMBL	M23410 Z68228 AF306723 AF233882 AY243535 AC109319 CH471152 BC000441 BC011865 AJ249711
CCDS	CCDS11407.1
PIR	A32905
RefSeq	NP_002221.1 NP_068831.1 XP_006721936.1 XP_006721937.1 XP_006721938.1 XP_006721939.1 XP_006721940.1 XP_006721941.1
UniGene	Hs.514174
PDB	3IFQ
PDBsum	3IFQ
ProteinModelPortal	P14923
SMR	P14923
BioGrid	109931
IntAct	P14923
MINT	MINT-105053
STRING	9606.ENSP00000311113
PhosphoSite	P14923
DMDM	205371866
MaxQB	P14923
PaxDb	P14923
PRIDE	P14923
DNASU	3728
Ensembl	ENST00000310706 ENST00000393930 ENST00000393931
GeneID	3728
KEGG	hsa:3728
UCSC	uc002hxq.2
CTD	3728
GeneCards	GC17M039776
GeneReviews	JUP
HGNC	HGNC:6207
HPA	CAB002139 HPA032047
MIM	173325 601214 611528
neXtProt	NX_P14923
Orphanet	293899 293888 293910 158687 34217
PharmGKB	PA30009
eggNOG	NOG297695
GeneTree	ENSGT00730000110821
HOVERGEN	HBG000919
InParanoid	P14923
KO	K10056
OMA	MNLIEQP
PhylomeDB	P14923
TreeFam	TF317997
Reactome	REACT_19195 REACT_228016
SignaLink	P14923
ChiTaRS	JUP
EvolutionaryTrace	P14923
GeneWiki	Plakoglobin
GenomeRNAi	3728
NextBio	14595
PMAP-CutDB	P14923
PRO	PR:P14923
Proteomes	UP000005640
Bgee	P14923
CleanEx	HS_JUP
ExpressionAtlas	P14923
Genevestigator	P14923
GO	GO:0015629 GO:0016327 GO:0016323 GO:0016342 GO:0005913 GO:0005911 GO:0005737 GO:0009898 GO:0005856 GO:0005829 GO:0030057 GO:0070062 GO:0005916 GO:0005925 GO:0071665 GO:0014704 GO:0005882 GO:0016328 GO:0005634 GO:0005886 GO:0032993 GO:0030018 GO:0005915 GO:0045294 GO:0045296 GO:0042803 GO:0019901 GO:0019903 GO:0005199 GO:0005198 GO:0003713 GO:0034332 GO:0003181 GO:0086069 GO:0034329 GO:0016477 GO:0000902 GO:0045216 GO:0071681 GO:0007016 GO:0002159 GO:0050982 GO:0007398 GO:0071603 GO:0090002 GO:0007369 GO:0016331 GO:0003136 GO:0003308 GO:0007399 GO:0048599 GO:0090263 GO:0042307 GO:0051091 GO:0051291 GO:0042127 GO:0086091 GO:0016337 GO:0043588 GO:0086005
Gene3D	1.25.10.10
InterPro	IPR011989 IPR016024 IPR000225 IPR013284
Pfam	PF00514
PRINTS	PR01869
SMART	SM00185
SUPFAM	SSF48371
PROSITE	PS50176

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:2000047	regulation of cell-cell adhesion mediated by cadherin	PMID:7806582^[1]	ECO:0000314			P		Cumulative evidence. Fig 6 shows plakoglobin mediating catenin - cadherin complex formation, and alpha cadherin binding. Alpha cadherin knwon to be involved with cell adhesion therefore Plakoglobin is medicating cell adhesion via cadherin	complete CACAO 2923
involved_in	GO:0043537	negative regulation of blood vessel endothelial cell migration	PMID:28115160^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS00005A31EB_9606	P	results_in_movement_of:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0001954	positive regulation of cell-matrix adhesion	PMID:28115160^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS00005A31EB_9606	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:28115160^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS00005A31EB_9606	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:25468996^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0086083	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication	PMID:17924338^[4]	ECO:0000305	curator inference used in manual assertion	GO:0086073	F		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:23381804^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000948)	Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:22781308^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000948)	Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	PMID:17559062^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q14126	F		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	PMID:23136403^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UI47	F		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	PMID:20859650^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:Q9Y446)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[11]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	PMID:20859650^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20859650^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002159	desmosome assembly	PMID:20859650^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:14661054^[12]	ECO:0000305	curator inference used in manual assertion	GO:0042307	P		Seeded From UniProt	complete
involved_in	GO:0086091	regulation of heart rate by cardiac conduction	PMID:17924338^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication	PMID:17924338^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0098911	regulation of ventricular cardiac muscle cell action potential	PMID:17924338^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0071665	gamma-catenin-TCF7L2 complex	PMID:14661054^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071603	endothelial cell-cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8SPJ1	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:14661054^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050982	detection of mechanical stimulus	PMID:18937352^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:1639850^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10288	F		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:1639850^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P12830	F		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:7650039^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P19022	F		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	PMID:7890674^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35221	F		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	PMID:7650039^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35221	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8SPJ1	F		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	PMID:10825188^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	PMID:14661054^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:17924338^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:14661054^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030057	desmosome	PMID:1639850^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
NOT\|part_of	GO:0030056	hemidesmosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8SPJ1	C		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:18937352^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	PMID:7650039^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	PMID:18937352^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:22889254^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0006566)	Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8SPJ1	C		Seeded From UniProt	complete
involved_in	GO:0007016	cytoskeletal anchoring at plasma membrane	PMID:22889254^[18]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005915	zonula adherens	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8SPJ1	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:1639850^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:14661054^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:7650039^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:7983064^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:14661054^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8SPJ1	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8SPJ1	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14661054^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14661054^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005199	structural constituent of cell wall	PMID:7650039^[15]	ECO:0000305	curator inference used in manual assertion	GO:0016342	F		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	PMID:22889254^[18]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:14661054^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002159	desmosome assembly	PMID:22889254^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071681	cellular response to indole-3-methanol	PMID:10868478^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:8663237^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15262	F		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:10403777^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:10460003^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000117 MGI:MGI:88276 PANTHER:PTN001153077 UniProtKB:P35222 WB:WBGene00000238 WB:WBGene00001979	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 PANTHER:PTN001153077 RGD:70487 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00001979	F		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 MGI:MGI:96650 PANTHER:PTN001153077 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00001979	F		Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 PANTHER:PTN001153077 UniProtKB:P35222	F		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 PANTHER:PTN001153077 UniProtKB:P14923 UniProtKB:P35222	F		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000117 MGI:MGI:88276 MGI:MGI:96650 PANTHER:PTN001153077 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00001979 ZFIN:ZDB-GENE-980526-362	C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 MGI:MGI:96650 PANTHER:PTN001153077 RGD:620412 RGD:70487 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00000238 WB:WBGene00001979	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 PANTHER:PTN001153077 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00000238 WB:WBGene00001979	F		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02257 ensembl:ENSMUSP00000001592	P		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02257 ensembl:ENSMUSP00000001592	F		Seeded From UniProt	complete
involved_in	GO:0043588	skin development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02257 ensembl:ENSMUSP00000001592	P		Seeded From UniProt	complete
part_of	GO:0030057	desmosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02257 ensembl:ENSMUSP00000001592	C		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02257 ensembl:ENSMUSP00000001592	C		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02257 ensembl:ENSMUSP00000001592	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02257 ensembl:ENSMUSP00000001592	P		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02257 ensembl:ENSMUSP00000001592	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02257 ensembl:ENSMUSP00000001592	C		Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02257 ensembl:ENSMUSP00000001592	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02257 ensembl:ENSMUSP00000001592	C		Seeded From UniProt	complete
involved_in	GO:0002159	desmosome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02257 ensembl:ENSMUSP00000001592	P		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	P		Seeded From UniProt	complete
involved_in	GO:0051291	protein heterooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	P		Seeded From UniProt	complete
part_of	GO:0030057	desmosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	F		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	C		Seeded From UniProt	complete
part_of	GO:0016327	apicolateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	C		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	C		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	C		Seeded From UniProt	complete
part_of	GO:0005916	fascia adherens	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	C		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P0K8 ensembl:ENSRNOP00000070840	F		Seeded From UniProt	complete
involved_in	GO:0002159	desmosome assembly	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030461	P		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030461	F		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030461	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013284 InterPro:IPR030461	P		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030461	C		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030461	F		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013284 InterPro:IPR030461	F		Seeded From UniProt	complete
part_of	GO:1904813	ficolin-1-rich granule lumen	Reactome:R-HSA-6800434	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070268	cornification	Reactome:R-HSA-6809371	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035580	specific granule lumen	Reactome:R-HSA-6798749	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034332	adherens junction organization	Reactome:R-HSA-418990	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031424	keratinization	Reactome:R-HSA-6805567	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-8942224 Reactome:R-HSA-6814764 Reactome:R-HSA-6814734 Reactome:R-HSA-6814695 Reactome:R-HSA-6814387 Reactome:R-HSA-6814298 Reactome:R-HSA-6811539 Reactome:R-HSA-6810937 Reactome:R-HSA-6810357 Reactome:R-HSA-6809393 Reactome:R-HSA-5357477 Reactome:R-HSA-419002	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6800434 Reactome:R-HSA-6798749	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0001533	cornified envelope	Reactome:R-HSA-6814764	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0009	C		Seeded From UniProt	complete
part_of	GO:0030057	desmosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0092	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Hülsken, J et al. (1994) E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J. Cell Biol. 127 2061-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Hou, S et al. (2017) MicroRNA-939 governs vascular integrity and angiogenesis through targeting γ-catenin in endothelial cells. Biochem. Biophys. Res. Commun. 484 27-33 PubMed GONUTS page
↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Asimaki, A et al. (2007) A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy. Am. J. Hum. Genet. 81 964-73 PubMed GONUTS page
↑ Rasmussen, TB et al. (2013) Mutated desmoglein-2 proteins are incorporated into desmosomes and exhibit dominant-negative effects in arrhythmogenic right ventricular cardiomyopathy. Hum. Mutat. 34 697-705 PubMed GONUTS page
↑ Kirchner, F et al. (2012) Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations. Circ Cardiovasc Genet 5 400-11 PubMed GONUTS page
↑ Cirillo, N et al. (2008) The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery. J. Cell. Biochem. 103 598-606 PubMed GONUTS page
↑ van Hengel, J et al. (2013) Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. Eur. Heart J. 34 201-10 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Gosavi, P et al. (2011) E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly. Cell. Mol. Life Sci. 68 1439-54 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 ^12.8 ^12.9 Maeda, O et al. (2004) Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line. Oncogene 23 964-72 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Huang, H et al. (2008) Disparate effects of different mutations in plakoglobin on cell mechanical behavior. Cell Motil. Cytoskeleton 65 964-78 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Knudsen, KA & Wheelock, MJ (1992) Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin. J. Cell Biol. 118 671-9 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Sacco, PA et al. (1995) Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin. J. Biol. Chem. 270 20201-6 PubMed GONUTS page
↑ Rubinfeld, B et al. (1995) The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin. J. Biol. Chem. 270 5549-55 PubMed GONUTS page
↑ Zhurinsky, J et al. (2000) Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin. Mol. Cell. Biol. 20 4238-52 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Roberts, JD et al. (2013) Detection of genomic deletions of PKP2 in arrhythmogenic right ventricular cardiomyopathy. Clin. Genet. 83 452-6 PubMed GONUTS page
↑ Kowalczyk, AP et al. (1994) Posttranslational regulation of plakoglobin expression. Influence of the desmosomal cadherins on plakoglobin metabolic stability. J. Biol. Chem. 269 31214-23 PubMed GONUTS page
↑ Meng, Q et al. (2000) Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes. J. Mol. Med. 78 155-65 PubMed GONUTS page
↑ Fuchs, M et al. (1996) Association of human protein-tyrosine phosphatase kappa with members of the armadillo family. J. Biol. Chem. 271 16712-9 PubMed GONUTS page
↑ Hegland, DD et al. (1999) Regulation of endothelial cell adherens junctions by a Ras-dependent signal transduction pathway. Biochem. Biophys. Res. Commun. 260 371-6 PubMed GONUTS page
↑ Smythe, WR et al. (1999) Cadherin and catenin expression in normal human bronchial epithelium and non-small cell lung cancer. Lung Cancer 24 157-68 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 ^24.4 ^24.5 ^24.6 ^24.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7806582-1] Hülsken, J et al. (1994) E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J. Cell Biol. 127 2061-9 PubMed GONUTS page

[PMID:28115160-2] 2.0 ^2.1 ^2.2 Hou, S et al. (2017) MicroRNA-939 governs vascular integrity and angiogenesis through targeting γ-catenin in endothelial cells. Biochem. Biophys. Res. Commun. 484 27-33 PubMed GONUTS page

[PMID:25468996-3] Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:17924338-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Asimaki, A et al. (2007) A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy. Am. J. Hum. Genet. 81 964-73 PubMed GONUTS page

[PMID:23381804-5] Rasmussen, TB et al. (2013) Mutated desmoglein-2 proteins are incorporated into desmosomes and exhibit dominant-negative effects in arrhythmogenic right ventricular cardiomyopathy. Hum. Mutat. 34 697-705 PubMed GONUTS page

[PMID:22781308-6] Kirchner, F et al. (2012) Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations. Circ Cardiovasc Genet 5 400-11 PubMed GONUTS page

[PMID:17559062-7] Cirillo, N et al. (2008) The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery. J. Cell. Biochem. 103 598-606 PubMed GONUTS page

[PMID:23136403-8] van Hengel, J et al. (2013) Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. Eur. Heart J. 34 201-10 PubMed GONUTS page

[PMID:21423176-9] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:20859650-10] 10.0 ^10.1 ^10.2 ^10.3 Gosavi, P et al. (2011) E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly. Cell. Mol. Life Sci. 68 1439-54 PubMed GONUTS page

[PMID:19056867-11] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:14661054-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 ^12.8 ^12.9 Maeda, O et al. (2004) Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line. Oncogene 23 964-72 PubMed GONUTS page

[PMID:18937352-13] 13.0 ^13.1 ^13.2 Huang, H et al. (2008) Disparate effects of different mutations in plakoglobin on cell mechanical behavior. Cell Motil. Cytoskeleton 65 964-78 PubMed GONUTS page

[PMID:1639850-14] 14.0 ^14.1 ^14.2 ^14.3 Knudsen, KA & Wheelock, MJ (1992) Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin. J. Cell Biol. 118 671-9 PubMed GONUTS page

[PMID:7650039-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Sacco, PA et al. (1995) Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin. J. Biol. Chem. 270 20201-6 PubMed GONUTS page

[PMID:7890674-16] Rubinfeld, B et al. (1995) The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin. J. Biol. Chem. 270 5549-55 PubMed GONUTS page

[PMID:10825188-17] Zhurinsky, J et al. (2000) Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin. Mol. Cell. Biol. 20 4238-52 PubMed GONUTS page

[PMID:22889254-18] 18.0 ^18.1 ^18.2 ^18.3 Roberts, JD et al. (2013) Detection of genomic deletions of PKP2 in arrhythmogenic right ventricular cardiomyopathy. Clin. Genet. 83 452-6 PubMed GONUTS page

[PMID:7983064-19] Kowalczyk, AP et al. (1994) Posttranslational regulation of plakoglobin expression. Influence of the desmosomal cadherins on plakoglobin metabolic stability. J. Biol. Chem. 269 31214-23 PubMed GONUTS page

[PMID:10868478-20] Meng, Q et al. (2000) Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes. J. Mol. Med. 78 155-65 PubMed GONUTS page

[PMID:8663237-21] Fuchs, M et al. (1996) Association of human protein-tyrosine phosphatase kappa with members of the armadillo family. J. Biol. Chem. 271 16712-9 PubMed GONUTS page

[PMID:10403777-22] Hegland, DD et al. (1999) Regulation of endothelial cell adherens junctions by a Ras-dependent signal transduction pathway. Biochem. Biophys. Res. Commun. 260 371-6 PubMed GONUTS page

[PMID:10460003-23] Smythe, WR et al. (1999) Cadherin and catenin expression in normal human bronchial epithelium and non-small cell lung cancer. Lung Cancer 24 157-68 PubMed GONUTS page

[PMID:21873635-24] 24.0 ^24.1 ^24.2 ^24.3 ^24.4 ^24.5 ^24.6 ^24.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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