HUMAN:ELF3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ELF3 (ECO:0000312 with HGNC:HGNC:3318)
Protein Name(s)	ETS-related transcription factor Elf-3 E74-like factor 3 Epithelial-restricted with serine box Epithelium-restricted Ets protein ESX Epithelium-specific Ets transcription factor 1 ESE-1
External Links
UniProt	P78545
EMBL	U73843 U73844 U97156 U66894 AF016295 AF017307 AF110184 BN000001 AF517841 CR457106 AK312273 BX537368 AL691482 CH471067 BC003569
CCDS	CCDS1419.1
RefSeq	NP_001107781.1 NP_004424.3
UniGene	Hs.603657
PDB	2E8P
PDBsum	2E8P
ProteinModelPortal	P78545
SMR	P78545
BioGrid	108314
IntAct	P78545
STRING	9606.ENSP00000352673
ChEMBL	CHEMBL2111426
PhosphoSite	P78545
DMDM	74739735
MaxQB	P78545
PaxDb	P78545
PRIDE	P78545
DNASU	1999
Ensembl	ENST00000359651 ENST00000367283 ENST00000367284
GeneID	1999
KEGG	hsa:1999
UCSC	uc001gxg.4
CTD	1999
GeneCards	GC01P201977
HGNC	HGNC:3318
HPA	HPA003316 HPA003479
MIM	602191
neXtProt	NX_P78545
PharmGKB	PA27746
eggNOG	NOG299956
GeneTree	ENSGT00760000118996
HOVERGEN	HBG074143
InParanoid	P78545
KO	K09429
OMA	QLWSKAQ
OrthoDB	EOG7M0NRR
PhylomeDB	P78545
TreeFam	TF318679
ChiTaRS	ELF3
EvolutionaryTrace	P78545
GenomeRNAi	1999
NextBio	8087
PRO	PR:P78545
Proteomes	UP000005640
Bgee	P78545
CleanEx	HS_ELF3
ExpressionAtlas	P78545
Genevestigator	P78545
GO	GO:0005737 GO:0005634 GO:0000978 GO:0001077 GO:0000981 GO:0003700 GO:0003713 GO:0001824 GO:0008544 GO:0030855 GO:0030198 GO:0006954 GO:0060056 GO:0007275 GO:0045892 GO:0045893 GO:0006357 GO:0006366
Gene3D	1.10.10.10 1.10.150.50
InterPro	IPR017956 IPR000418 IPR003118 IPR013761 IPR011991
Pfam	PF00178 PF02198
PRINTS	PR00454
SMART	SM00384 SM00413 SM00251
SUPFAM	SSF47769
PROSITE	PS50061 PS51433

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR000418 InterPro:IPR000637	F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q8R4Z4	F	Seeded From UniProt	complete
involved_in	GO:0060056	mammary gland involution	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3UPW2	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9234700^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:10773884^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030855	epithelial cell differentiation	PMID:9234700^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008544	epidermis development	PMID:9234700^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:14715662^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9234700^[2]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:12624109^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:9234700^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109336 PANTHER:PTN000218930	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95455 MGI:MGI:95610 MGI:MGI:98282 PANTHER:PTN000218930 UniProtKB:Q15723	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000097 FB:FBgn0000567 FB:FBgn0003118 MGI:MGI:101762 MGI:MGI:107180 MGI:MGI:109637 MGI:MGI:1335079 MGI:MGI:1353422 MGI:MGI:2449712 MGI:MGI:95455 MGI:MGI:95554 MGI:MGI:95610 MGI:MGI:98282 MGI:MGI:99423 PANTHER:PTN000218930 RGD:1359607 RGD:1598663 RGD:2583 UniProtKB:P14921 UniProtKB:P17947 UniProtKB:P19419 UniProtKB:P32519 UniProtKB:P41161 UniProtKB:Q01543 UniProtKB:Q06546 WB:WBGene00002990 WB:WBGene00017687	C	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218930 UniProtKB:Q15723	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0060056	mammary gland involution	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UPW2 ensembl:ENSMUSP00000003135	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UPW2 ensembl:ENSMUSP00000003135	P	Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UPW2 ensembl:ENSMUSP00000003135	P	Seeded From UniProt	complete
involved_in	GO:0009653	anatomical structure morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UPW2 ensembl:ENSMUSP00000003135	P	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UPW2 ensembl:ENSMUSP00000003135	P	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UPW2 ensembl:ENSMUSP00000003135	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UPW2 ensembl:ENSMUSP00000003135	F	Seeded From UniProt	complete
involved_in	GO:0001824	blastocyst development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UPW2 ensembl:ENSMUSP00000003135	P	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UPW2 ensembl:ENSMUSP00000003135	F	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UPW2 ensembl:ENSMUSP00000003135	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000418 InterPro:IPR033074	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003118 InterPro:IPR033074	C	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000418	P	Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033074	P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033074	P	Seeded From UniProt	complete
involved_in	GO:0030855	epithelial cell differentiation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033074	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000418 InterPro:IPR003118	F	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:9234700^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:9234700^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:9234700^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:9234700^[2] PMID:10821850^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045747	positive regulation of Notch signaling pathway	Reactome:R-HSA-9021364	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-9021364 Reactome:R-HSA-9021357	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Oettgen, P et al. (1997) Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family. Mol. Cell. Biol. 17 4419-33 PubMed GONUTS page
↑ Brembeck, FH et al. (2000) Dual function of the epithelial specific ets transcription factor, ELF3, in modulating differentiation. Oncogene 19 1941-9 PubMed GONUTS page
↑ Brown, C et al. (2004) ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation. J. Biol. Chem. 279 12794-803 PubMed GONUTS page
↑ Cabral, A et al. (2003) Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation. J. Biol. Chem. 278 17792-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Choi, Y et al. (2000) Divergent hTAFII31-binding motifs hidden in activation domains. J. Biol. Chem. 275 15912-6 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:9234700-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Oettgen, P et al. (1997) Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family. Mol. Cell. Biol. 17 4419-33 PubMed GONUTS page

[PMID:10773884-3] Brembeck, FH et al. (2000) Dual function of the epithelial specific ets transcription factor, ELF3, in modulating differentiation. Oncogene 19 1941-9 PubMed GONUTS page

[PMID:14715662-4] Brown, C et al. (2004) ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation. J. Biol. Chem. 279 12794-803 PubMed GONUTS page

[PMID:12624109-5] Cabral, A et al. (2003) Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation. J. Biol. Chem. 278 17792-9 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10821850-7] Choi, Y et al. (2000) Divergent hTAFII31-binding motifs hidden in activation domains. J. Biol. Chem. 275 15912-6 PubMed GONUTS page

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HUMAN:ELF3

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Annotations

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References

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