HUMAN:PO4F2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	POU4F2 (synonyms: BRN3B)
Protein Name(s)	POU domain, class 4, transcription factor 2 Brain-specific homeobox/POU domain protein 3B Brain-3B Brn-3B
External Links
UniProt	Q12837
EMBL	U06233 AK314982 AC093887 BC136344 BC136345 EU439706 X71488 L20434
CCDS	CCDS34074.1
PIR	I38502
RefSeq	NP_004566.2
UniGene	Hs.266
ProteinModelPortal	Q12837
SMR	Q12837
BioGrid	111454
STRING	9606.ENSP00000281321
PhosphoSite	Q12837
DMDM	290457652
PaxDb	Q12837
PRIDE	Q12837
Ensembl	ENST00000281321
GeneID	5458
KEGG	hsa:5458
UCSC	uc003ikv.3
CTD	5458
GeneCards	GC04P147560
H-InvDB	HIX0031516
HGNC	HGNC:9219
MIM	113725
neXtProt	NX_Q12837
PharmGKB	PA33543
eggNOG	NOG289030
GeneTree	ENSGT00760000118935
HOGENOM	HOG000116305
HOVERGEN	HBG031829
InParanoid	Q12837
KO	K09366
OMA	THAPHMA
OrthoDB	EOG7RV9G7
PhylomeDB	Q12837
TreeFam	TF316413
SignaLink	Q12837
GeneWiki	POU4F2
GenomeRNAi	5458
NextBio	21127
PRO	PR:Q12837
Proteomes	UP000005640
Bgee	Q12837
CleanEx	HS_POU4F2
Genevestigator	Q12837
GO	GO:0016607 GO:0005634 GO:0003682 GO:0000978 GO:0001078 GO:0001077 GO:0048675 GO:0007411 GO:0030520 GO:0000165 GO:0000122 GO:0050885 GO:0030182 GO:0045597 GO:0045944 GO:0060041 GO:0031290 GO:0007605
Gene3D	1.10.10.60 1.10.260.40
InterPro	IPR017970 IPR001356 IPR009057 IPR010982 IPR013847 IPR000327
Pfam	PF00046 PF00157
PRINTS	PR00028
SMART	SM00389 SM00352
SUPFAM	SSF46689 SSF47413
PROSITE	PS00027 PS50071 PS00035 PS00465 PS51179

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005667	transcription factor complex	PMID:17145718^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04637	C	regulates_transcription_of:(ENSEMBL:ENSMUSG00000003873)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR000327 InterPro:IPR001356 InterPro:IPR009057 InterPro:IPR010982 InterPro:IPR013847 InterPro:IPR015584	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P20263	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:17145718^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934	F	occurs_at:(SO:0001952) has_regulation_target:(ENSEMBL:ENSG00000087088)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17145718^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934	P	regulates_transcription_of:(ENSEMBL:ENSG00000087088)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:23805044^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:Q99578) occurs_in:(CL:0000540)	Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934	C		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934	P		Seeded From UniProt	complete
involved_in	GO:0045672	positive regulation of osteoclast differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934	P		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934	F		Seeded From UniProt	complete
involved_in	GO:1902870	negative regulation of amacrine cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934	P		Seeded From UniProt	complete
involved_in	GO:0045596	negative regulation of cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934	P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934-2	P		Seeded From UniProt	complete
involved_in	GO:2000679	positive regulation of transcription regulatory region DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934-2	P		Seeded From UniProt	complete
involved_in	GO:0071392	cellular response to estradiol stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934-2	P		Seeded From UniProt	complete
involved_in	GO:0051090	regulation of DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934-2	P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934-2	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934-2	F		Seeded From UniProt	complete
involved_in	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934-2	P		Seeded From UniProt	complete
involved_in	GO:0043068	positive regulation of programmed cell death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934-2	P		Seeded From UniProt	complete
involved_in	GO:0090259	regulation of retinal ganglion cell axon guidance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934	P		Seeded From UniProt	complete
involved_in	GO:1990791	dorsal root ganglion development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934	P		Seeded From UniProt	complete
involved_in	GO:0045773	positive regulation of axon extension	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934	P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	PMID:19266028^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17637757^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:595)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:17637757^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:17637757^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060041	retina development in camera-type eye	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21241485^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934	P		Seeded From UniProt	complete
involved_in	GO:0030520	intracellular estrogen receptor signaling pathway	PMID:21241485^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934	P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21241485^[6]	ECO:0000305	curator inference used in manual assertion	GO:0001228	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934	C		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934	F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:21241485^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21241485^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:21241485^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63934	P		Seeded From UniProt	complete
involved_in	GO:0071453	cellular response to oxygen levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7L5 ensembl:ENSRNOP00000016422	P		Seeded From UniProt	complete
involved_in	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7L5 ensembl:ENSRNOP00000016422	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7L5 ensembl:ENSRNOP00000016422	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7L5 ensembl:ENSRNOP00000016422	P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	F		Seeded From UniProt	complete
involved_in	GO:1990791	dorsal root ganglion development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
involved_in	GO:1904178	negative regulation of adipose tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
involved_in	GO:1902870	negative regulation of amacrine cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
involved_in	GO:0090259	regulation of retinal ganglion cell axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
involved_in	GO:0060041	retina development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
involved_in	GO:0050885	neuromuscular process controlling balance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
involved_in	GO:0048675	axon extension	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
involved_in	GO:0045773	positive regulation of axon extension	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
involved_in	GO:0045672	positive regulation of osteoclast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
involved_in	GO:0045596	negative regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	F		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
involved_in	GO:0031290	retinal ganglion cell axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	C		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	C		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63934 ensembl:ENSMUSP00000034115	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057 InterPro:IPR010982 InterPro:IPR013847	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000327	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000327 InterPro:IPR017970	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001387 InterPro:IPR017970	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7691107^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19266028^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23805044^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P61371	P	has_regulation_target:(UniProtKB:Q99578) occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23805044^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q99578) occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:23805044^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q99578) occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6804425	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0371 UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0186	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Budhram-Mahadeo, VS et al. (2006) Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. Nucleic Acids Res. 34 6640-52 PubMed GONUTS page
↑ ^2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Zhang, L et al. (2013) RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors. Mol. Vis. 19 1371-86 PubMed GONUTS page
↑ ^4.0 ^4.1 Salichs, E et al. (2009) Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment. PLoS Genet. 5 e1000397 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Budhram-Mahadeo, VS et al. (2008) Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells. Oncogene 27 145-54 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Ounzain, S et al. (2011) Proliferation-associated POU4F2/Brn-3b transcription factor expression is regulated by oestrogen through ERα and growth factors via MAPK pathway. Breast Cancer Res. 13 R5 PubMed GONUTS page
↑ Xiang, M et al. (1993) Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells. Neuron 11 689-701 PubMed GONUTS page

[PMID:17145718-1] 1.0 ^1.1 ^1.2 Budhram-Mahadeo, VS et al. (2006) Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. Nucleic Acids Res. 34 6640-52 PubMed GONUTS page

[PMID:19274049-2] 2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:23805044-3] 3.0 ^3.1 ^3.2 ^3.3 Zhang, L et al. (2013) RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors. Mol. Vis. 19 1371-86 PubMed GONUTS page

[PMID:19266028-4] 4.0 ^4.1 Salichs, E et al. (2009) Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment. PLoS Genet. 5 e1000397 PubMed GONUTS page

[PMID:17637757-5] 5.0 ^5.1 ^5.2 Budhram-Mahadeo, VS et al. (2008) Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells. Oncogene 27 145-54 PubMed GONUTS page

[PMID:21241485-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Ounzain, S et al. (2011) Proliferation-associated POU4F2/Brn-3b transcription factor expression is regulated by oestrogen through ERα and growth factors via MAPK pathway. Breast Cancer Res. 13 R5 PubMed GONUTS page

[PMID:7691107-7] Xiang, M et al. (1993) Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells. Neuron 11 689-701 PubMed GONUTS page

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HUMAN:PO4F2

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