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PMID:7691107
| Citation |
Xiang, M, Zhou, L, Peng, YW, Eddy, RL, Shows, TB and Nathans, J (1993) Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells. Neuron 11:689-701 |
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| Abstract |
A search for POU domain transcription factors in human retina cDNA has led to the identification of Brn-3b, a class IV POU domain protein. Immunohistochemical experiments show that chicken, mouse, rabbit, monkey, and human retinas contain Brn-3b exclusively within a subpopulation of ganglion cells. In the adult mouse brain, Brn-3b is found only within cells in the deep layers of the superior colliculus, in the dorsal periaqueductal gray, and in a small cluster of cells in the brain stem near the area postrema. During the immediate postnatal period, cells containing Brn-3b are distributed in a number of regions within the brain stem and cerebellum. These data suggest that Brn-3b plays a role in determining and/or maintaining the identities of a small number of neurons, including a subset of visual system neurons. |
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| Keywords |
Amino Acid Sequence; Animals; Animals, Newborn; Base Sequence; Blotting, Western; Brain/metabolism; Cattle; Cell Line; Chromosome Mapping; Cloning, Molecular; DNA Primers; DNA-Binding Proteins/biosynthesis; DNA-Binding Proteins/genetics; Gene Expression; Gene Library; Humans; Hybrid Cells; Immunohistochemistry; Mice; Molecular Sequence Data; Organ Specificity; Poly A/analysis; Poly A/metabolism; Polymerase Chain Reaction/methods; RNA/analysis; RNA/metabolism; RNA, Messenger; Rats; Restriction Mapping; Retinal Ganglion Cells/cytology; Retinal Ganglion Cells/metabolism; Sequence Homology, Amino Acid; Transcription Factor Brn-3; Transcription Factor Brn-3B; Transcription Factors/biosynthesis; Transcription Factors/genetics; Vertebrates |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005634: nucleus |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
Notes
See also
References
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